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JOURNAL ARTICLE
Chenghao Yang, Lingxiao Zhang, Xinyue Ding, Zhang Hui, Junqing Gao, Zongjun Liu
BACKGROUND The correlation between serum creatinine levels and the long-term prognosis of patients undergoing percutaneous coronary intervention (PCI) has not yet been systematically investigated. This study aimed to evaluate the association between long-term prognosis and serum creatinine levels in patients after PCI. MATERIAL AND METHODS This was an observational cohort study of 2533 patients who received PCI and completed serum creatinine and other tests in China. The study's primary prognostic indicators were the frequency of clinical adverse events, all-cause death, cardiac death, acute myocardial infarction, and stroke...
May 29, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#2
JOURNAL ARTICLE
Ximena Castillo, Georgina Ortiz, Edith Arnold, Zhijian Wu, Luis B Tovar Y Romo, Carmen Clapp, Gonzalo Martínez de la Escalera
Ischemic stroke is a significant global health issue, ranking fifth among all causes of death and a leading cause of serious long-term disability. Ischemic stroke leads to severe outcomes, including permanent brain damage and neuronal dysfunction. Therefore, decreasing and preventing neuronal injuries caused by stroke has been the focus of therapeutic research. In recent years, many studies have shown that fluctuations in hormonal levels influence the prognosis of ischemic stroke. Thus, it is relevant to understand the role of hormones in the pathophysiological mechanisms of ischemic stroke for preventing and treating this health issue...
May 29, 2024: Journal of Neuroendocrinology
#3
JOURNAL ARTICLE
Meng Dai, Jinglei Yang, Zhaoyang Wang, Fangli Xue, Yourui Wang, Enjie Hu, Yunyun Gong, Michael N Routledge, Boling Qiao
BACKGROUND: Restoration of blood supply is a desired goal for the treatment of acute ischemic stroke. However, the restoration often leads to cerebral ischemia-reperfusion injury (CIR/I), which greatly increases the risk of non-neural organ damage. In particular, the acute kidney injury might be one of the most common complications. AIMS: The study aimed to understand the damage occurred and the potential molecular mechanisms. METHODS: The study was explored on the CIR/I rats generated by performing middle cerebral artery occlusion/reperfusion (MCAO/Reperfusion)...
May 30, 2024: Heliyon
#4
JOURNAL ARTICLE
Tao Ye, Ning Zhang, Anbang Zhang, Xiuqi Sun, Bo Pang, Xuemei Wu
OBJECTIVE: To explore the preventive effect of electroacupuncture pretreatment on stroke in rats by inhibiting ferroptosis and oxidative stress. METHODS: Rats were randomly assigned to the sham, middle cerebral artery occlusion/reperfusion (MCAO/R), MCAO/R + EP, MCAO/R + EP + erastin, and MCAO/R + EP + ferrostatin 1 groups. Daily electroacupuncture was performed 2 weeks before establishing the MCAO/R model utilizing the modified Zea Longa suture method...
May 15, 2024: Heliyon
#5
REVIEW
Aline Renata Pavan, Barbara Terroni, Jean Leandro Dos Santos
Sickle Cell Anemia(SCA), is an inherited hemoglobinopathy characterized by the presence of an abnormal hemoglobin (HbS), being the most prevalent sickle cell disease (SCD). SCA is characterized by vascular endothelial dysfunction, which contributes significantly to various clinical conditions, including but not limited to pulmonary hypertension, priapism, cutaneous leg ulceration, and stroke. The pathophysiology of endothelial dysfunction (ED) in SCA is a multifaceted process involving a chronic inflammatory and hypercoagulable state...
May 26, 2024: Nitric Oxide: Biology and Chemistry
#6
JOURNAL ARTICLE
Ying Gao, Lingling Jiang, Yuesong Pan, Weiqi Chen, Jing Jing, Chunjuan Wang, S Claiborne Johnston, Pierre Amarenco, Philip M Bath, Yingying Yang, Tingting Wang, Shangrong Han, Xia Meng, Jinxi Lin, Xingquan Zhao, Liping Liu, Jinguo Zhao, Ying Li, Yingzhuo Zang, Shuo Zhang, Hongqin Yang, Jianbo Yang, Yuanwei Wang, Dali Li, Yanxia Wang, Dongqi Liu, Guangming Kang, Yongjun Wang, Yilong Wang
IMPORTANCE: Comparisons are limited for immediate-intensive and delayed-intensive statin for secondary stroke prevention and neuroprotection in patients with acute mild ischemic stroke or transient ischemic attack (TIA) from atherosclerosis. OBJECTIVE: To estimate whether immediate-intensive statin therapy is safe and can lower the risk of recurrent stroke compared with delayed-intensive statin in patients with acute mild ischemic stroke or high-risk TIA from atherosclerosis...
May 28, 2024: JAMA Neurology
#7
JOURNAL ARTICLE
Lihua Dai, Zheqian Wu, Liili Yin, Longjian Cheng, Qiang Zhou, Fei Ding
BACKGROUND: Upon uptake by stressed cells, functional mitochondria can perform their normal functions, ultimately enhancing the survival of host cells. However, despite the promising results of this approach, there is still a lack of understanding of the specific relationship between nerve cells and functional mitochondria. METHODS: Functional mitochondria (F-Mito) were isolated from bone marrow-derived mesenchymal stem cells (BMSCs). The ability of microglia cells to internalize F-Mito was evaluated using a middle cerebral artery occlusion (MCAO) model in C57BL/6J mice and an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model...
2024: Journal of Inflammation Research
#8
JOURNAL ARTICLE
V A Palikov, N B Pavlov, R R Amirov, A M Ismailova, N A Borozdina, Yu A Palikova, I A Dyachenko, O N Khokhlova, T I Ponomareva, V A Rykov, A T Logunov, A N Murashev, V M Baranov
Introduction: Cerebral arterial air embolism (CAE) is a serious and potentially dangerous condition that can interrupt the blood supply to the brain and cause stroke. One of the promising gas mixtures for emergency treatment of air embolism is an oxygen-helium mixture. Methods: We modeled CAE in awake rats by injecting air into the common carotid artery. Immediately after CAE, animals were either untreated or underwent hyperbaria, oxygen inhalation, heated air inhalation, or helium-oxygen mixture inhalation...
2024: Frontiers in Physiology
#9
JOURNAL ARTICLE
Yong Wang, Zhuohang Liu, Luyu Li, Zengyu Zhang, Kai Zhang, Min Chu, Yang Liu, Xueyu Mao, Di Wu, Dongsheng Xu, Jing Zhao
BACKGROUND: Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke. In the acute phase of ischemic stroke, there is a transient increase in anti-inflammatory M2 microglia followed by a rapid decline. Due to the abundant phospholipid in brain tissue, lipid peroxidation is a notable characteristic of ischemia/reperfusion (I/R), constituting a structural foundation for ferroptosis in M2 microglia...
May 27, 2024: Journal of Nanobiotechnology
#10
JOURNAL ARTICLE
Huiying Sun, Yuchen Yang, Ruizhe Yang, Xu Tian, Yang Zhao, Haiyan Wu, Zhiqiang Gao
Objective: Paradoxical embolism from right-to-left shunting is a common cause of cryptogenic stroke in the young. Circulatory ischemia of the cochlea is closely connected with severe-to-profound sudden sensorineural hearing loss. This study aimed to explore the role of paradoxical embolism in severe-to-profound sudden sensorineural hearing loss in juveniles and young adults. Methods: From August 2021 to September 2022, consecutive outpatients under 35 years of age with severe-to-profound sudden hearing loss were included in the study...
May 27, 2024: Ear, Nose, & Throat Journal
#11
JOURNAL ARTICLE
Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao
Choline acetyltransferase (ChAT)-positive neurons in neural stem cell (NSC) niches can evoke adult neurogenesis (AN) and restore impaired brain function after injury, such as acute ischemic stroke (AIS). However, the relevant mechanism by which ChAT+ neurons develop in NSC niches is poorly understood. Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a hydrolase for asymmetric N G , N G -dimethylarginine (ADMA), regulated genes responsible for the synthesis and transportation of acetylcholine (ACh) ( Chat , Slc5a7 and Slc18a3 ) after stroke insult...
May 2024: Acta Pharmaceutica Sinica. B
#12
JOURNAL ARTICLE
Yuanfang Yu, Pan Li, Mengyuan Chen, Wenfeng Zhan, Ting Zhu, Ling Min, Hao Liu, Bo Lv
BACKGROUND: Ischemic stroke (IS) is a neurological disease with significant disability and mortality. MicroRNAs were proven to be associated with cerebral ischemia. Previous studies have demonstrated miR-122 downregulation in both animal models of IS and the blood of IS patients. Nonetheless, the role and mechanism of miR-122-5p in IS remain unclear. METHODS: We established primary human and mouse astrocytes, along with HT22 mouse hippocampal neuronal cells, through oxygen-glucose deprivation/reoxygenation (OGD/R) treatment...
2024: Frontiers in Neurology
#13
Seok Joon Won, Yiguan Zhang, Nicholas J Butler, Kyungsoo Kim, Ebony Mocanu, Olive Tambou Nzoutchoum, Ramya Lakkaraju, Jacqueline Davis, Soumitra Ghosh, Raymond A Swanson
Post-stroke hyperglycemia occurs in 30% - 60% of ischemic stroke patients as part of the systemic stress response, but neither clinical evidence nor pre-clinical studies indicate whether post-stroke hyperglycemia affects stroke outcome. Here we investigated this issue using a mouse model of permanent ischemia. Mice were maintained either normoglycemic or hyperglycemic during the interval of 17 - 48 hours after ischemia onset. Post-stroke hyperglycemia was found to increase infarct volume, blood-brain barrier disruption, and hemorrhage formation, and to impair motor recovery...
May 14, 2024: bioRxiv
#14
JOURNAL ARTICLE
Thomas Gomes Nørgaard Dos Santos Nielsen, Numa Dancause, Taha Al Muhammadee Janjua, Felipe Rettore Andreis, Benedict Kjærgaard, Winnie Jensen
PURPOSE: Our aim was to use intracortical recording to enable the tracking of ischemic infarct development over the first few critical hours of ischemia with a high time resolution in pigs. We employed electrophysiological measurements to obtain quick feedback on neural function, which might be useful for screening, e.g., for the optimal dosage and timing of agents prior to further pre-clinical evaluation. METHODS: Micro-electrode arrays containing 16 (animal 1) or 32 electrodes (animal 2-7) were implanted in the primary somatosensory cortex of seven female pigs, and continuous electrical stimulation was applied at 0...
May 7, 2024: Sensors
#15
JOURNAL ARTICLE
Agnė Šmigelskytė, Gabija Rimkuvienė, Dominyka Žukaitė, Gerta Repečkaitė, Giedrė Jurkevičienė
Background and objectives : while acute ischemic stroke is the leading cause of epilepsy in the elderly population, data about its risk factors have been conflicting. Therefore, the aim of our study is to determine the association of early and late epileptic seizures after acute ischemic stroke with cerebral cortical involvement and electroencephalographic changes. Materials and methods : a prospective cohort study in the Hospital of the Lithuanian University of Health Sciences Kaunas Clinics Department of Neurology was conducted and enrolled 376 acute ischemic stroke patients...
May 6, 2024: Medicina
#16
REVIEW
Ana Arnalich-Montiel, Alba Burgos-Santamaría, Laia Pazó-Sayós, Begoña Quintana-Villamandos
Acute ischemic stroke (AIS) is a challenging disease, which needs urgent comprehensive management. Endovascular thrombectomy (EVT), alone or combined with iv thrombolysis, is currently the most effective therapy for patients with acute ischemic stroke (AIS). However, only a limited number of patients are eligible for this time-sensitive treatment. Even though there is still significant room for improvement in the management of this group of patients, up until now there have been no alternative therapies approved for use in clinical practice...
May 11, 2024: International Journal of Molecular Sciences
#17
JOURNAL ARTICLE
Jolene Phelps, David A Hart, Alim P Mitha, Neil A Duncan, Arindom Sen
Interrupted blood flow in the brain due to ischemic injuries such as ischemic stroke or traumatic brain injury results in irreversible brain damage, leading to cognitive impairment associated with inflammation, disruption of the blood-brain barrier (BBB), and cell death. Since the BBB only allows entry to a small class of drugs, many drugs used to treat ischemia in other tissues have failed in brain-related disorders. The administration of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) has shown promise in improving the functional recovery of the brain following cerebral ischemia by inducing blood vessel formation...
May 10, 2024: International Journal of Molecular Sciences
#18
REVIEW
Elena D'Apolito, Maria Josè Sisalli, Michele Tufano, Lucio Annunziato, Antonella Scorziello
Brain ischemia is one of the major causes of chronic disability and death worldwide. It is related to insufficient blood supply to cerebral tissue, which induces irreversible or reversible intracellular effects depending on the time and intensity of the ischemic event. Indeed, neuronal function may be restored in some conditions, such as transient ischemic attack (TIA), which may be responsible for protecting against a subsequent lethal ischemic insult. It is well known that the brain requires high levels of oxygen and glucose to ensure cellular metabolism and energy production and that damage caused by oxygen impairment is tightly related to the brain's low antioxidant capacity...
April 29, 2024: Antioxidants (Basel, Switzerland)
#19
JOURNAL ARTICLE
Paola Gargiulo, Christian Basile, Gennaro Galasso, Michele Bellino, Debora D'Elia, Giuseppe Patti, Manuel Bosco, Matteo Prinetti, Giuseppe Andò, Francesca Campanella, Giovanni Taverna, Paolo Calabrò, Arturo Cesaro, Fabio Fimiani, Angelo Catalano, Ferdinando Varbella, Antonella Corleto, Francesco Barillà, Saverio Muscoli, Giuseppe Musumeci, Fabrizio Delnevo, Francesco Giallauria, Raffaele Napoli, Italo Porto, Alberto Polimeni, Rossella Quarta, Alessandro Maloberti, Piera Angelica Merlini, Leonardo De Luca, Gavino Casu, Natale Daniele Brunetti, Mario Crisci, Leonardo Paloscia, Claudio Bilato, Ciro Indolfi, Federica Marzano, Sara Fontanarosa, Davide Buonocore, Antonio Luca Maria Parlati, Ermanno Nardi, Maria Prastaro, Andrea Soricelli, Marco Salvatore, Stefania Paolillo, Pasquale Perrone-Filardi
AIMS: No data are available on early initiation of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) in patients with acute coronary syndrome (ACS) in real-world. This study investigates the effects of PCSK9i started at time of ACS hospitalization on lipid control and major CV events in real-world. METHODS: The lipid control outcome was the percentage of patients reaching the LDL-C target of < 55 mg/dL at first lipid control. The clinical outcome was the incidence of composite major CV events (all cause death, non-fatal MI, non-fatal stroke, and ischemia-driven revascularization) during follow-up in relation to quartiles of LDL-C at first lipid control...
May 24, 2024: European Journal of Preventive Cardiology
#20
JOURNAL ARTICLE
Zhijie Ou, Yanting Deng, Yan Wu, Yuanqi Wang, Yijing Zhao, Chang Liu, Zhuoyu Wang, Manhua Liu, Xin Hu, Li Fang, Juping Chen
BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI) refers to brain tissue injury caused by the temporary interruption of cerebral blood flow ischemia followed by the restoration of reperfusion, which is the main cause of post-stroke brain injury. A traditional Chinese herbal preparation called Tongqiao Huoxue Decoction (TQHX) has shown promise in reducing CIRI in rats. However, the mechanism of this herbal preparation for CIRI remains unclear. PURPOSE: This study aimed to evaluate the therapeutic effect of TQHX extract on rats with CIRI and to further explore the underlying mechanisms...
May 1, 2024: Phytomedicine
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