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REVIEW
Edgard Andrade
Neonatal hypoxic ischemic encephalopathy (HIE) is a type of injury caused by lack of oxygen in the brain during the neonatal period. It is a clinical syndrome clearly recognizable in term and premature newborns secondary to asphyxia at the time of delivery. HIE is estimated to occur at a frequency of 1-3 for each 1000 alive newborns per year in developed countries. In countries of low or medium income, the incidence is up to 10-20 times higher, equivalent to 1-8 alive newborns per each 1000. The social and economic impact has been estimated near US$ 50...
September 2023: Medicina
#62
JOURNAL ARTICLE
Marjoriane de Amaral, Maiza Cristina Von Dentz, Leonardo Airton Ressel Simões, Éverton Vogt, Dener Heiermann, Pedro Fischer, Patrick Colombo, Luiz Carlos Kucharski
Frogs have developed biochemical and physiological adaptations to occupy diverse ecological niches on Earth successfully. Survival in frozen states is a fascinating strategy made possible by evolving adaptations to produce cryoprotectant solutes. The hylid frog Boana pulchella thrives in South American regions with cold climates, remaining active while enduring sporadic subzero temperatures during winter. The species' metabolic changes during subzero exposure remain unclear. Therefore, we exposed B. pulchella to cooling and recovery, assessing plasma and tissue metabolite changes...
September 11, 2023: Journal of Thermal Biology
#63
JOURNAL ARTICLE
Chelsea Q Wu, Frances M Cowan, Sally Jary, Marianne Thoresen, Ela Chakkarapani, Arthur P C Spencer
Children cooled for HIE and who did not develop cerebral palsy (CP) still underperform at early school age in motor and cognitive domains and have altered supra-tentorial brain volumes and white matter connectivity. We obtained T1-weighted and diffusion-weighted MRI, motor (MABC-2) and cognitive (WISC-IV) scores from children aged 6-8 years who were cooled for HIE secondary to perinatal asphyxia without CP (cases), and controls matched for age, sex, and socioeconomic status. In 35 case children, we measured cerebellar growth from infancy (age 4-15 days after birth) to childhood...
September 8, 2023: Scientific Reports
#64
JOURNAL ARTICLE
Xiang Ren Tan, Mary C Stephenson, Sharifah Badriyah Alhadad, Kelvin W Z Loh, Tuck Wah Soong, Jason K W Lee, Ivan C C Low
BACKGROUND: Excessive heat exposure can lead to hyperthermia in humans, which impairs physical performance and disrupts cognitive function. While heat is a known physiological stressor, it is unclear how severe heat stress affects brain physiology and function. METHODS: Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures (Tre ) attained 39.5°C, inducing exertional or passive hyperthermia, respectively...
September 9, 2023: Journal of Sport and Health Science
#65
JOURNAL ARTICLE
Helena Van Deynse, Wilfried Cools, Viktor-Jan De Deken, Bart Depreitere, Ives Hubloue, Eva Kimpe, Maarten Moens, Karen Pien, Ellen Tisseghem, Griet Van Belleghem, Koen Putman
BACKGROUND: Accurate patient-specific predictions on return-to-work after traumatic brain injury (TBI) can support both clinical practice and policymaking. The use of machine learning on large administrative data provides interesting opportunities to create such prognostic models. AIM: The current study assesses whether return-to-work one year after TBI can be predicted accurately from administrative data. Additionally, this study explores how model performance and feature importance change depending on whether a distinction is made between mild and moderate-to-severe TBI...
October 2023: International Journal of Medical Informatics
#66
JOURNAL ARTICLE
Lan Chen, Liyun Lu, Yuan Fang, Jingnan Ren, Xiaoling Yang, Zhumei Gong, Yuping Zhang, Xiuqin Feng
BACKGROUND: Transient neuronal dysfunction may occur in most brain regions with heatstroke (HS). This study aimed to explore the prognostic significance of initial Glasgow Coma Scale (GCS) scores in HS. METHODS: Retrospective data regarding HS were obtained from six hospitals. The primary outcome was neurological sequelae at discharge. Secondary outcomes included acute respiratory failure (ARF) and intensive care unit (ICU) admission. Logistic regression models and random forest imputation were used to assess the independent association between GCS score and outcomes...
August 30, 2023: Postgraduate Medical Journal
#67
JOURNAL ARTICLE
Andrew Whitelaw, Marianne Thoresen
Posthypoxic therapeutic hypothermia has been tested in newborn infants, with seven randomized trials showing consistent evidence of reduction in death, cerebral palsy, and cognitive impairment at school age. In contrast, randomized trials of hypothermia after cardiac arrest in adults have not shown consistent evidence of lasting neurological protection. The apparently greater effectiveness of therapeutic hypothermia in newborns may be due to important biological and clinical differences. One such difference is that adults are heavily colonized with microbes, and many have active inflammatory processes at the time of arrest, but few newborns are heavily colonized or infected at the time of birth...
August 28, 2023: Therapeutic Hypothermia and Temperature Management
#68
JOURNAL ARTICLE
Ok-Hap Kang, Peter Jahn, Joachim G Eichhorn, Till Dresbach, Andreas Müller, Hemmen Sabir
(1) Background: Cerebral MRI plays a significant role in assessing the extent of brain injury in neonates with neonatal encephalopathy after perinatal asphyxia. Over the last decades, several MRI scoring systems were developed to enhance the predictive accuracy of MRI. The aim of this study was to validate the correlation of four established MRI scoring systems with cognitive long-term outcomes in cooled asphyxiated newborns. (2) Methods: Forty neonates with neonatal encephalopathy treated with therapeutic hypothermia were included in this retrospective study...
July 27, 2023: Children
#69
JOURNAL ARTICLE
Vincenzo Salvo, Diego Gazzolo, Luc J Zimmermann
Asphyxiated newborns often require both therapeutic hypothermia (TH) and mechanical ventilation (MV) and the complex interrelationship between these two therapeutic interventions is very interesting, which could not only have several synergistic positive effects but also some risks. Perinatal asphyxia is the leading cause of neonatal hypoxic-ischemic encephalopathy (HIE) and TH is the only approved neuroprotective treatment to limit brain injury, improving the mortality rate and long-term neurological outcomes...
August 25, 2023: Therapeutic Hypothermia and Temperature Management
#70
JOURNAL ARTICLE
Xin Fang, Zihang Xu, Qizheng Dai, Aili Zhang
Mild hypothermia, as a common means of intraoperative nerve protection, has been used in clinical practice. Compared with the traditional methods such as freezing helmet and nasopharyngeal cooling, hypothermic blood perfusion is considered to be a promising treatment for mild hypothermia, but it lacks experimental and theoretical verification of its cooling effect. In this study, the commercial finite element simulation software COMSOL combined the Pennes equation with the cerebrovascular network model to construct a new simplified human brain model, which was further used to simulate the cooling process of cerebral hypothermic blood perfusion...
July 30, 2023: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
#71
JOURNAL ARTICLE
Wen-Jun Su, Ting Hu, Chun-Lei Jiang
BACKGROUND: Abundant evidence suggests that inflammatory cytokines contribute to the symptoms of major depressive disorder (MDD) by altering neurotransmission, neuroplasticity, and neu-roendocrine processes. Given the unsatisfactory response and remission of monoaminergic antidepres-sants, anti-inflammatory therapy is proposed as a feasible way to augment the antidepressant effect. Recently, there have been emerging studies investigating the efficiency and efficacy of anti-inflammatory agents in the treatment of MDD and depressive symptoms comorbid with somatic diseases...
August 9, 2023: Current Neuropharmacology
#72
JOURNAL ARTICLE
Andrea Lavinio, Erta Beqiri, Ketan Kataria
No abstract text is available yet for this article.
July 27, 2023: Neurocritical Care
#73
JOURNAL ARTICLE
Raymond C Koehler, Michael Reyes, C Danielle Hopkins, Jillian S Armstrong, Suyi Cao, Ewa Kulikowicz, Jennifer K Lee, Harikrishna Tandri
Neurologic outcome from out-of-hospital pediatric cardiac arrest remains poor. Although therapeutic hypothermia has been attempted in this patient population, a beneficial effect has yet to be demonstrated, possibly because of the delay in achieving target temperature. To minimize this delay, we developed a simple technique of transnasal cooling. Air at ambient temperature is passed through standard nasal cannula with an open mouth to produce evaporative cooling of the nasal passages. We evaluated efficacy of brain cooling with different airflows in different size piglets...
July 19, 2023: Journal of Cerebral Blood Flow and Metabolism
#74
JOURNAL ARTICLE
OsvaldoL da Costa, Henrique Barcellos, Hylton Matsuda, LuizC doA Sumiya, Fernando de C Junqueira, Margareth M N Matsuda, André L Lapolli
Since 2001, Nuclear and Energy Research Institute IPEN-CNEN has produced weekly ultrapure iodine-123, using a manual irradiation system, fully developed in IPEN. Iodine-123 radiopharmaceuticals have been produced and distributed to hospitals and clinics of nuclear medicine, where several diagnostic imaging procedures for thyroid, brain and cardiovascular functions are performed. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. In the present work, the technical and constructive aspects of a new fully automated irradiation system, dedicated to 123 I routine production, employing enriched xenon-124 gas as the target material is presented...
July 5, 2023: Applied Radiation and Isotopes
#75
JOURNAL ARTICLE
Venkata R Latha Gullapudi, Eleanor F Cox, Charlotte E Buchanan, Bernard Canaud, Kelly White, Maarten W Taal, Nicholas M Selby, Susan T Francis
BACKGROUND AND HYPOTHESIS: Ischemic end-organ damage during haemodialysis (HD) is a significant problem that may be ameliorated by intradialytic cooling. A randomised trial was performed to compare standard HD (SHD, dialysate temperature 37°C) and programmed cooling of the dialysate (thermocontrolled HD, TCHD) using multiparametric magnetic resonance imaging (MRI) to assess structural, functional and blood flow changes in the heart, brain and kidneys. METHODS: Prevalent HD patients were randomly allocated to receive either SHD or TCHD for two weeks before undergoing serial MRI at four time points: pre, during (30 min and 180 min) and post-dialysis...
July 11, 2023: Nephrology, Dialysis, Transplantation
#76
JOURNAL ARTICLE
Kalil Shaw, Constantine D Mavroudis, Tiffany S Ko, Jharna Jahnavi, Marin Jacobwitz, Nicolina Ranieri, Rodrigo M Forti, Richard W Melchior, Wesley B Baker, Arjun G Yodh, Daniel J Licht, Susan C Nicolson, Jennifer M Lynch
BACKGROUND: Surgical procedures involving the aortic arch present unique challenges to maintaining cerebral perfusion, and optimal neuroprotective strategies to prevent neurological injury during such high-risk procedures are not completely understood. The use of antegrade cerebral perfusion (ACP) has gained favor as a neuroprotective strategy over deep hypothermic circulatory arrest (DHCA) due to the ability to selectively perfuse the brain. Despite this theoretical advantage over DHCA, there has not been conclusive evidence that ACP is superior to DHCA...
2023: Frontiers in Pediatrics
#77
REVIEW
Odile Feys, Xavier De Tiège
Magnetoencephalography (MEG) is a neurophysiological technique based on the detection of brain magnetic fields. Whole-head MEG systems typically house a few hundred sensors requiring cryogenic cooling in a rigid one-size-fits-all (commonly adult-sized) helmet to keep a thermal insulation space. This leads to an increased brain-to-sensor distance in children, because of their smaller head circumference, and decreased signal-to-noise ratio. MEG allows detection and localization of interictal and ictal epileptiform discharges, and pathological high frequency oscillations, as a part of the presurgical assessment of children with refractory focal epilepsy, where electroencephalography is not contributive...
July 8, 2023: Developmental Medicine and Child Neurology
#78
JOURNAL ARTICLE
Jian Chen, Shuaili Xu, Hangil Lee, Longfei Wu, Xiaoduo He, Wenbo Zhao, Mo Zhang, Yanhui Ma, Yuchuan Ding, Yongjuan Fu, Chuanjie Wu, Ming Li, Miuwen Jiang, Huakun Cheng, Shengli Li, Ting Ma, Xunming Ji, Di Wu
Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in stroke models of lower-order species to stroke patients have failed. Potentially overlooked reasons may be biological gaps between different species and the mismatched initiation of therapeutic hypothermia in translational studies. Here, we introduce a novel strategy of selective therapeutic hypothermia in a non-human primate ischemia-reperfusion model, in which autologous blood was cooled ex vivo and the cool blood transfusion was administered at the middle cerebral artery just after the onset of reperfusion...
June 20, 2023: Science Bulletin
#79
JOURNAL ARTICLE
Michael Hawrylycz, Maryann E Martone, Giorgio A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Patrick R Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H Scheuermann, Shawn Zheng Kai Tan, Carol L Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L Athey, Cody Baker, Katherine S Baker, Pamela M Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D'Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O Halchenko, Nomi L Harris, Brian R Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L Mathews, Chris Mezias, Michael I Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J Mungall, Joshua Orvis, Maja A Puchades, Lei Qu, Joseph P Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T J van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W Jim Zheng, Brian Zingg
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell types in controlled ways and to understand their variation and vulnerability in brain disorders. The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization...
June 2023: PLoS Biology
#80
JOURNAL ARTICLE
Gorane Beldarrain, Enrique Hilario, Idoia Lara-Celador, Marc Chillida, Ana Catalan, Antonia Ángeles Álvarez-Diaz, Daniel Alonso-Alconada
Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic hypothermia; however, cooling is not always effective to prevent the deleterious effects of HI, so compounds such as cannabinoids are currently under research as new therapies. Modulating the endocannabinoid system (ECS) may reduce brain damage and/or stimulate cell proliferation at the neurogenic niches...
June 7, 2023: Pharmaceutics
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