Andrea Aroldi, Mario Mauri, Daniele Ramazzotti, Matteo Villa, Federica Malighetti, Valentina Crippa, Federica Cocito, Chiara Borella, Elisa Bossi, Carolina Steidl, Chiara Scollo, Claudia Voena, Roberto Chiarle, Luca Mologni, Rocco Piazza, Carlo Gambacorti-Passerini
Mantle-cell lymphoma (MCL) is a B-cell non-Hodgkin Lymphoma (NHL) with a poor prognosis, at high risk of relapse after conventional treatment. MCL-associated tumour microenvironment (TME) is characterized by M2-like tumour-associated macrophages (TAMs), able to interact with cancer cells, providing tumour survival and resistance to immuno-chemotherapy. Likewise, monocyte-derived nurse-like cells (NLCs) present M2-like profile and provide proliferation signals to chronic lymphocytic leukaemia (CLL), a B-cell malignancy sharing with MCL some biological and phenotypic features...
August 31, 2023: Journal of Cellular and Molecular Medicine