Irina Ponomarenko, Konstantin Pasenov, Maria Churnosova, Inna Sorokina, Inna Aristova, Vladimir Churnosov, Marina Ponomarenko, Yuliya Reshetnikova, Evgeny Reshetnikov, Mikhail Churnosov
The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was conducted on a sample of 1498 women (358 BC; 1140 controls) who, depending on the presence/absence of obesity, were divided into two groups: obese (119 BC; 253 controls) and non-obese (239 BC; 887 controls). Genotyping of nine SHBG-associated single nucleotide polymorphisms (SNP)-rs17496332 PRMT6 , rs780093 GCKR , rs10454142 PPP1R21 , rs3779195 BAIAP2L1 , rs440837 ZBTB10 , rs7910927 JMJD1C , rs4149056 SLCO1B1 , rs8023580 NR2F2 , and rs12150660 SHBG -was executed, and the BC-risk impact of these loci was analyzed by logistic regression separately in each group of obese/non-obese women...
April 8, 2024: Biomedicines