Lucas P Carlstrom, Christopher S Graffeo, Avital Perry, Denise B Klinkner, David J Daniels
Penetrating spinal cord injuries are rare in children but result in devastating impacts on long-term morbidity and mortality-with little known about the recovery capacity in this age group. We present the case of an eight-year-old child who sustained a penetrating injury through the right anterior thorax. Thoracic CT showed the arrow tip extending through the spinal canal at T6. Neurologic examination revealed no motor or sensory function below T6. The arrow was surgically removed without complications through an anterior-only approach...
August 5, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ashish Acharya, Sarvpreet Singh Grewal, Paul Sudhakar John, Ravindra Kumar Bind, Ankita Khurana
Background: Osteochondroma is a common benign tumor arising from the long bones. It rarely arises in the spine, where it can cause mild symptoms such as backache all the way up to compressive myelopathy. Malignant transformation has also been reported. Here, the authors present a 52-year-old male with myelopathy attributed to a rare thoracic solitary osteochondroma. Case Description: A 52-year-old male presented back pain radiating into both lower extremities with paresthesia to the toes of 1 year's duration...
2020: Surgical Neurology International
Hilal Abboud, Hanane Kharbouch, Yasser Arkha, Mohamed Choukri
Background: Cerebrospinal fluid (CSF) fistula represents a rare neurosurgical entity that can be defined as a communication between the subarachnoid space and nasal fossa or less commonly the ear cavity. It can be spontaneous without an evident etiology or secondary following a skull base surgery or trauma. The early diagnosis of spontaneous forms remains a challenge as clinical signs (e.g., unilateral rhinorrhea) can be absent or neglected by patients and can result in meningitis. Case Description: Here, we report the case of a 31-year-old man with chronic constipation complicated by chronic intracranial hypertension, and resulting in rhinorrhea with bacterial meningitis...
2020: Surgical Neurology International
Keith Freeman, Richard Hays, Joshua Kouri
Background: Perivascular spaces are interstitial fluid-filled regions located deep to the pia mater. They play roles in lymphatic drainage and the central nervous system immunological function. When they enlarge, they are referred to as giant tumefactive perivascular spaces. Often misdiagnosed as cystic neoplasms, they require a high degree of clinical suspicion and key radiological features to be accurately diagnosed. We describe an interesting case in which a man presented with worsening headache, subsequently found on neuroimaging to have this phenomenon...
2020: Surgical Neurology International
Toyin Ayofe Oyemolade, Augustine Abiodun Adeolu
Severe vertebral scalloping in spinal schwannoma is very rare. When present, extensive scalloping of the vertebral bodies possesses significant treatment challenges in patients with spinal tumors. We present the computed tomography scan and magnetic resonance images of spinal schwannoma with marked vertebral scalloping in a 40-year-old Nigerian.
2020: Surgical Neurology International
Massood Hosseinzadeh, Sahand Mohammadzadeh
Primary Squamous cell carcinoma (SCC) of the kidney is rarely reported in the literature. It is usually associated with renal stone, and due to lack of clinical symptoms and radiological diagnostic features, patients often present at the late stages of the disease. We reported a 59-year-old woman presented with a longstanding history of flank pain and hematuria. Imaging techniques revealed enlargement of the right kidney associated with multiple staghorn stones. The patient subsequently underwent right radical nephrectomy, and histopathological examination of the mass revealed well-differentiated keratinized squamous cell carcinoma...
2020: International Medical Case Reports Journal
Yubin Hu, Hailan Lin, Mingzhi Hao, Yan Zhou, Qizhong Chen, Zhangxian Chen
Purpose: Unresectable intrahepatic cholangiocarcinoma (ICC) has a poor prognosis. The aim of this study was to evaluate the efficacy and safety of apatinib for patients with unresectable ICC. Patients and Methods: A total of 10 patients with unresectable ICC were enrolled for this single-center observational study between March 2, 2016, and August 27, 2019. Subjects received 500 mg apatinib on a daily basis. Tumor response was assessed by 1.1 response evaluation criteria in solid tumors...
2020: Cancer Management and Research
Sudha Menon, Sandesh O, Debish Anand, Girish Menon
Background  Spheno-orbital meningiomas (SOMs) constitute a rare cause for orbital proptosis and visual impairment. This study aims to share our outcome experience with regard to vision and exophthalmos following the surgical management of 17 patients with SOM. Methods  Retrospective analysis of the case records of all surgically treated SOMs in the last 10 years. Exophthalmos index (EI) was calculated based on preoperative magnetic resonance imaging/computed tomography imaging. Vision was assessed using the Snellen's chart and Goldman's perimeter...
July 2020: Journal of Neurosciences in Rural Practice
Stine Rasch, Thomas Lund, Jon Thor Asmussen, Anne Lerberg Nielsen, Rikke Faebo Larsen, Mikkel Østerheden Andersen, Niels Abildgaard
The lytic bone disease is a hallmark of multiple myeloma, being present in about 80% of patients with newly diagnosed MM, and in more during the disease course. The myeloma associated bone disease (MBD) severely affects the morbidity and quality of life of the patients. MBD defines treatment demanding MM. In recent years, knowledge of the underlying pathophysiology has increased, and novel imaging technologies, medical and non-pharmaceutical treatments have improved. In this review, we highlight the major achievements in understanding, diagnosing and treating MBD...
July 30, 2020: Cancers
Bastien Jamet, Elena Zamagni, Cristina Nanni, Clément Bailly, Thomas Carlier, Cyrille Touzeau, Anne-Victoire Michaud, Philippe Moreau, Caroline Bodet-Milin, Françoise Kraeber-Bodere
Serum markers and bone marrow examination are commonly used for monitoring therapy response in multiple myeloma (MM), but this fails to identify minimal residual disease (MRD), which frequently persists after therapy even in complete response patients, and extra-medullary disease escape. Positron emission tomography with computed tomography using 18F-deoxyglucose (FDG-PET/CT) is the reference imaging technique for therapeutic assessment and MRD detection in MM. To date, all large prospective cohort studies of transplant-eligible newly diagnosed MM patients have shown a strong and independent pejorative prognostic impact of not obtaining complete metabolic response by FDG-PET/CT after therapy, especially before maintenance...
July 29, 2020: International Journal of Molecular Sciences
Du Hwan Kim, Dae-Hyun Jang, Ja-Hyun Jang
Limb-girdle muscular dystrophy type R2 dysferin-related (LGMD R2 dysferin-related), a phenotype of dysferlinopathy, usually begins with pelvic girdle weakness. A 35-year-old male presented with right leg pain for 2 weeks without a previous history of limb weakness. Magnetic resonance imaging of the lumbar spine showed disc extrusion at L5-S1 and incidental severe fatty degeneration of the lumbar erector spinae. Physical examination demonstrated no definite limb weakness. Serum creatine kinase levels were elevated...
July 29, 2020: Diagnostics
Aleksandra Morka, Joanna Kohut, Beata Radzymińska-Chruściel, Tomasz Mroczek, Marcin Gładki, Piotr Weryński, Andrzej Rudziński, Janusz Skalski, Lesław Szydłowski
BACKGROUND: Primary heart tumors (PHTs) in the pediatric population are very rare and do not manifest any characteristic symptoms. METHODS: A retrospective analysis of 61 cases was undertaken. Data from three centers for the years 2003-2018 were gathered. The tumors' clinical course, location, number, hemodynamic, treatment, and follow-up were evaluated. Echocardiography was complemented with magnetic resonance imaging, computer tomography, and histopathological examination...
July 29, 2020: International Journal of Environmental Research and Public Health
Sinan Çelen, Aziz Gültekin, Yusuf Özlülerden, Aslı Mete, Ergin Sağtaş, Furkan Ufuk, Doğangün Yüksel, Baki Yağcı, Ali Ersin Zümrütbaş
BACKGROUND/AIM: The objective of this work was to assess the value of 68Ga-DOTAGA-(3-iodo-y)fk(Sub-KuE) positron emission tomography (68Ga-PSMA-I/T PET-CT) and multiparametric magnetic resonance imaging (mp-MRI) for preoperative staging in prostate cancer (PCa) patients who underwent radical prostatectomy (RP) by validating with postoperative histopathology data. MATERIALS AND METHODS: We prospectively investigated 30 consecutive PCa patients who had both mp-MRI and 68Ga-PSMA-I/T PET-CT before laparoscopic RP...
August 4, 2020: Urologia Internationalis
Claes Nøhr Ladefoged, Adam Espe Hansen, Otto Mølby Henriksen, Frederik Jager Bruun, Live Eikenes, Silje Kjærnes Øen, Anna Karlberg, Liselotte Højgaard, Ian Law, Flemming Littrup Andersen
INTRODUCTION: Robust and reliable attenuation correction (AC) is a prerequisite for accurate quantification of activity concentration. In combined PET/MRI, AC is challenged by the lack of bone signal in the MRI from which the AC maps has to be derived. Deep learning-based image-to-image translation networks present itself as an optimal solution for MRI-derived AC (MR-AC). High robustness and generalizability of these networks are expected to be achieved through large training cohorts...
August 1, 2020: NeuroImage
Dávid Süvegh, Árpád Viola
Our objective is to propose a novel surgical technique, the microscope-assisted odontoid resection via submandibular retropharyngeal "key-hole" approach. The patient suffered a traumatic cervical spine injury due to a motorcycle accident. We removed the upper two-thirds of the CII vertebra's odontoid process along with the cortical fragment causing the medullar compression. With this surgical technique the velopharyngeal insufficiency, occurring at the traditional transoral surgery, is avoidable while the access to the odontoid process is insured...
August 2020: Orvosi Hetilap
Ping Liang, Chuou Xu, Pratik Tripathi, Jiali Li, Anqin Li, Daoyu Hu, Ihab Kamel, Zhen Li
OBJECTIVES: To assess whether spatial labeling with multiple inversion pulses (SLEEK) sequence can be employed as a one-stop assessment method for evaluating renal function and displaying renal artery in hypertensive patients with suspected renal dysfunction. METHODS: A total of 78 patients with suspected hypertensive renal damage were enrolled in this retrospective study. All patients underwent MRI examinations, and both SLEEK and DWI sequences were performed simultaneously...
August 4, 2020: European Radiology
Pablo Caro-Dominguez, Susan Cheng Shelmerdine, Seema Toso, Aurelio Secinaro, Paolo Toma, Maria Beatrice Damasio, María Navallas, Lucia Riaza-Martin, David Gomez-Pastrana, Maryam Ghadimi Mahani, Sarah M Desoky, Carlos F Ugas Charcape, Judith Almanza-Aranda, Maria Elena Ucar, Jovan Lovrenski, Sureyya Burcu Gorkem, Efthymia Alexopoulou, Pierluigi Ciet, Joost van Schuppen, Hubert Ducou le Pointe, Hyun Woo Goo, Christian J Kellenberger, Maria Raissaki, Catherine M Owens, Franz Wolfgang Hirsch, Rick R van Rijn
BACKGROUND: Pulmonary infection with SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2; COVID-19) has rapidly spread worldwide to become a global pandemic. OBJECTIVE: To collect paediatric COVID-19 cases worldwide and to summarize both clinical and imaging findings in children who tested positive on polymerase chain reaction testing for SARS-CoV-2. MATERIALS AND METHODS: Data were collected by completion of a standardised case report form submitted to the office of the European Society of Paediatric Radiology from March 12 to April 8, 2020...
August 4, 2020: Pediatric Radiology
May Zaw Thin, Helen Allan, Robin Bofinger, Tomas D Kostelec, Simon Guillaume, John J Connell, P Stephen Patrick, Helen C Hailes, Alethea B Tabor, Mark F Lythgoe, Daniel J Stuckey, Tammy L Kalber
Stem cells have been utilised as anti-cancer agents due to their ability to home to and integrate within tumours. Methods to augment stem cell homing to tumours are being investigated with the goal of enhancing treatment efficacy. However, it is currently not possible to evaluate both cell localisation and cell viability after engraftment, hindering optimisation of therapy. In this study, luciferase-expressing human adipocyte-derived stem cells (ADSCs) were incubated with Indium-111 radiolabelled iron oxide nanoparticles to produce cells with tri-modal imaging capabilities...
August 4, 2020: Nanoscale
Jonathan D Dodd, Jonathon Leipsic
Cardiac imaging is becoming commonplace throughout radiology practices and is increasingly important in large-cohort prospective cardiovascular trials and in statements and guidelines. In this review, the authors summarize some of the most important imaging findings relevant to clinical practice in the past year. Key coronary CT angiography studies have included rigorous meta-analysis of its diagnostic accuracy, prognostic implications of adverse coronary plaque features, and sex differences. The value of CT for catheter-delivered valve implantation (eg, transcatheter aortic and mitral valve replacements) was further elucidated in large-cohort outcome trials...
August 4, 2020: Radiology
Toru Higaki, Yuko Nakamura, Fuminari Tatsugami, Wataru Fukumoto, Kazuo Awai
BACKGROUND: While iodine-enhanced computed tomography has been studied, detailed information on gadolinium-enhanced magnetic resonance imaging has not been reported. OBJECTIVE: The purpose of this study was to evaluate the effect of various gadolinium contrast agent (Gd-CA) factors on enhancement on aortic magnetic resonance angiography (MRA) using computer simulation. METHODS: We developed a computer simulation software combines pharmacokinetic models and tables that converts the blood concentration of particular Gd-CAs into the signal intensity (SI)...
July 30, 2020: Current medical imaging
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