Eleonora Faccioli, Federica Grosso, Andrea Dell'Amore, Sara Delfanti, Giovanni Zambello, Luigi Cerbone, Gianluca Canu, Antonina De Angelis, Viola Sambataro, Federica Pezzuto, Paola Barbieri, Giulia Pasello, Fiorella Calabrese, Federico Rea
The role of immunotherapy in the multimodal treatment for pleural mesothelioma (PM) is still under investigation, particularly in the preoperative setting. Pathological complete response (pCR) has been previously described after chemotherapy and immunotherapy; however, there is no prior experience reported with immunotherapy alone before surgery. We report the case of a 58-year-old male with biphasic PM treated with immunotherapy, resulting in a major clinical partial response. Following a multidisciplinary evaluation between thoracic surgeons, medical oncologists, pathologists, radiologists and radiation oncologists, the patient underwent surgery with radical intent through a right extended pleurectomy/decortication (eP/D)...
2024: Frontiers in Oncology