Lindsay A Kutash, Eleni H Moschonas, Darik A O'Neil, Timothy J Craine, Anna L Iouchmanov, Carlson R Sunleaf, Melissa A Nicholas, Katherine O Grobengieser, Aarti K Patel, Mihaela Toader, Tyler S Ranellone, Piper L Rennerfeldt, Jeffrey P Cheng, Nicholas S Race, Anthony E Kline, Corina O Bondi PhD
Impaired attention is central to the cognitive deficits associated with long-term sequelae for many traumatic brain injury (TBI) survivors. Assessing complex sustained attention post-TBI is clinically-relevant and may provide reliable avenues towards developing therapeutic and rehabilitation targets in both males and females. We hypothesized that adult rats subjected to a moderate TBI will exhibit attentional deficits seen as reduced accuracy and increased distractibility in an operant 3-choice serial reaction time task (3-CSRT), designed as an analogue of the clinical continuous performance test...
March 20, 2023: Brain Research