Isma'il Kadam, Mudar Dalloul, Jeanette Hausser, Doron Vaday, Ella Gilboa, Liang Wang, Joan Hittelman, Lori Hoepner, Lawrence Fordjour, Pavani Chitamanni, Anjana Saxena, Xinyin Jiang
BACKGROUND & AIMS: Both maternal metabolic dysregulation, e.g., gestational diabetes mellitus (GDM), and maternal supply of nutrients that participate in one-carbon (1C) metabolism, e.g., folate, choline, betaine, and vitamin B12 , have been demonstrated to influence epigenetic modification such as DNA methylation, thereby exerting long-lasting impacts on growth and development of offspring. This study aimed to determine how maternal 1C nutrient intake was associated with DNA methylation and further, development of children, as well as whether maternal GDM status modified the association in a prospective cohort...
April 12, 2024: Clinical Nutrition
Jixing Zhou, Pengui Wu, Wenjing Cai, Jingru Lu, Yufan Guo, Yuzhu Teng, Juan Tong, Guopeng Gao, Shuangqin Yan, Fangbiao Tao, Kun Huang
OBJECTIVE: The objective of this study was to investigate the associations between maternal exposure to anxiety during pregnancy and the susceptibility of offspring to eczema and allergic rhinitis and the possibility of sensitivity periods and cumulative effects. METHODS: The study's sample consisted of 3160 mother-child pairs from the Ma'anshan Birth Cohort Study. Maternal anxiety was repeatedly measured in the 1st, 2nd, and 3rd trimesters of pregnancy using the Chinese version of the Pregnancy-Related Anxiety Scale...
February 21, 2024: Journal of Psychosomatic Research
Wendy Y Zhang, Megan McCracken, Lisandra Veliz Dominguez, Amy Zhang, Jasmyn Johal, Lusine Aghajanova
The impact of estrogen supplementation during the follicular/proliferative phase on the endometrial lining thickness (EMT) prior to intrauterine insemination (IUI) remains largely unstudied. Our study examined changes in EMT and rates of clinical pregnancy, miscarriage, and live birth for all patients who completed an IUI cycle at Stanford Fertility Center from 2017-2023 (n = 2281 cycles). Cycles with estradiol supplementation (n = 309) were compared to reference cycles without supplementation (n = 1972), with the reference cohort further categorized into cycles with a pre-ovulatory EMT of < 7 mm ("thin-lining", n = 536) and ≥ 7 mm ("normal-lining", n = 1436)...
April 17, 2024: Reproductive Biology
Yanping Ruan, Yaqi Wang, Jianhui Guo, Tingting Man, Xiaoyan Hao, Xiaoxue Zhou, Chenyu Wang, Hanyu Deng, Jing Li, Zhiyong Zou, Yihua He
BACKGROUND: The relationships between maternal genetic and environmental exposure and conotruncal heart defects (CTDs) have been extensively investigated. Nevertheless, there is limited knowledge regarding the impact of ozone (O3 ) on the risk of CTDs. OBJECTIVE: To explore the correlation between maternal exposure to O3 and CTDs in China. METHODS: Pregnant women who underwent fetal echocardiography at Beijing Anzhen Hospital between January 2013 and December 2021 were enrolled...
April 17, 2024: Ecotoxicology and Environmental Safety
Petra Pátková Daňsová, Edita Chvojka, Hynek Cígler, Lenka Lacinová
Depression is one of the most prevalent mental ailments in pregnancy. Many authors have discussed the appropriateness of somatic symptoms for depression assessment in pregnancy and postpartum. However, no study has examined the role of somatic symptoms in networks of pregnant and postpartum women compared to women outside peripartum. Here, we show that somatic symptoms are essential to depression assessment during pregnancy and postpartum. We compared networks of the nine PHQ-9 items across pregnant women (n = 894, Mage  = 29...
April 9, 2024: Journal of Psychiatric Research
Refaettin Sahin, Atakan Tanacan, Hakki Serbetci, Osman Onur Ozkavak, Murat Haksever, Alperen Simsek, Ozgur Kara, Dilek Sahin
OBJECTIVE: Evaluation of demographic characteristics and postnatal outcomes of patients with suspected fetal pelvic kidney diagnosis followed in a tertiary center. METHODS: This retrospective study was conducted in Ankara Bilkent City Hospital perinatology clinic between 2020-2023. Demographic features, prenatal ultrasound findings, and postnatal outcomes were reported. RESULTS: Pelvic kidney localization was on the left in 11(55 %) patients, on the right in 7(35 %), and bilateral in 2(10 %) patients in prenatal ultrasonography...
April 15, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Adugnaw Zeleke Alem, Biresaw Ayen Tegegne, Fantu Mamo Aragaw, Rediet Eristu Teklu, Tsegaw Amare Baykeda
BACKGROUND: Antenatal care (ANC) is one of the recommended interventions to reduce stillbirth, maternal, neonatal, and child mortality through early identification and management of pregnancy complications or pre-existing conditions. Although increasing number of ANC is a key priority of the 2016 WHO recommendations, ANC uptake in Low and Middle Income Countries (LMICs) is insufficient. Therefore, this study aimed to investigate factors associated with the number of ANC contacts in LMICs...
2024: PloS One
Nisha Jacob, Brian Rice, Alexa Heekes, Leigh F Johnson, Samantha Brinkmann, Tendesayi Kufa, Andrew Boulle
BACKGROUND: Accurate measurement of antenatal antiretroviral treatment (ART) coverage in pregnancy is imperative in tracking progress towards elimination of vertical HIV transmission. In the Western Cape, South Africa, public-sector individual-level routine data are consolidated from multiple sources, enabling the description of temporal changes in population-wide antenatal antiretroviral coverage. We evaluated the validity of different methods for measuring ART coverage among pregnant women...
2024: PloS One
Taco J Prins, Aung Myat Min, Mary E Gilder, Nay Win Tun, Janneke Schepens, Kathryn McGregor, Verena I Carrara, Jacher Wiladphaingern, Mu Koh Paw, Eh Moo, Julie A Simpson, Chaisiri Angkurawaranon, Marcus J Rijken, Michele van Vugt, François Nosten, Rose McGready
BACKGROUND: In low- and middle-income countries twin births have a high risk of complications partly due to barriers to accessing hospital care. This study compares pregnancy outcomes, maternal and neonatal morbidity and mortality of twin to singleton pregnancy in refugee and migrant clinics on the Thai Myanmar border. METHODS: A retrospective review of medical records of all singleton and twin pregnancies delivered or followed at antenatal clinics of the Shoklo Malaria Research Unit from 1986 to 2020, with a known outcome and estimated gestational age...
2024: PloS One
Rafaela Caroline C Melo, Mauro C Ramos, Maria Lúcia R Rossetti, Vera Mileide T Grassi, Maurício O Colvero, Thales Augusto Dt Marzarotto, Renan R Bonamigo
INTRODUCTION: Congenital syphilis (CS) has severe adverse outcomes, including abortion and death. Diagnosis of CS in asymptomatic newborns remains difficult. This study aims to evaluate an in-house polymerase chain reaction (PCR) on cerebrospinal fluid (CSF) and blood samples (BS) to identify T. pallidum DNA in newborns. METHODOLOGY: We performed an exploratory cross-sectional study that included newborns exposed to syphilis during pregnancy (SEG) and non-exposed (SNEG) newborns, between 2019 and 2020...
March 31, 2024: Journal of Infection in Developing Countries
Aza B Taha
INTRODUCTION: Urinary tract infection (UTI) is a common bacterial complication in pregnancy. The study aimed to estimate the prevalence, risk factors, and bacterial etiology of UTI during pregnancy and determine the efficacy of antimicrobial drugs in treating UTIs. METHODOLOGY: Urine specimens and clinical data were collected from pregnant women who attended primary health centers in Erbil, Iraq. All specimens were cultured on appropriate media and identified by standard microbiological methods...
March 31, 2024: Journal of Infection in Developing Countries
Abdeta Muktar Ahmed, Mohamed Abdilahi Ahmed, Mohammed Hassen Ahmed
BACKGROUND: About 287,000 mothers lost their lives due to pregnancy and delivery in 2020 worldwide. Birth preparedness and complication readiness (BPCR) is an approach used to utilize the timely use of skilled maternal and neonatal services. Preparing mothers for childbirth and against its dangers has great importance in reducing maternal mortality. Little is known about BPCR and influencing factors in Hargeisa town, Somaliland. OBJECTIVE: To assess the level of BPCR and its associated factors among recently delivered women in Hargeisa...
2024: PloS One
Nawrah Khader, Virlana M Shchuka, Anna Dorogin, Oksana Shynlova, Jennifer A Mitchell
The uterine muscular layer, or myometrium, undergoes profound changes in global gene expression during its progression from a quiescent state during pregnancy to a contractile state at the onset of labor. In this study, we investigate the role of SOX family transcription factors in myometrial cells and provide evidence for the role of SOX4 in regulating labor-associated genes. We show that Sox4 has elevated expression in the murine myometrium during a term laboring process and in two mouse models of preterm labor...
2024: PloS One
Ashwin A Pillai, Mai Badr, Xingchen Mai, Anum Dilip, Jennifer Bell
Cardiogenic shock (CS) occurs infrequently in pregnancy and has a high mortality rate. Medical treatment options are few, with limited evidence of efficacy. Temporary mechanical circulatory supports (tMCS) may play a key role in addressing this therapeutic lacuna. We report successfully managing second-trimester CS using an Impella 5.5 micro-axial pump. Our patient presented in the second-trimester with CS. Hemodynamic parameters indicated biventricular dysfunction (low cardiac index, low pulmonary artery pulsatility index)...
April 19, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Krisha H Avalani, Noah D Patterson, Kevin O Murray
No abstract text is available yet for this article.
April 18, 2024: Journal of Physiology
Ru Tao, Michele J Grimm
Vaginal childbirth is the final phase of pregnancy when one or more fetuses pass through the birth canal from the uterus, and it is a biomechanical process. The uterine active contraction, causing the pushing force on the fetus, plays a vital role in regulating the fetus delivery process. In this project, the active contraction behaviors of muscle tissue were first modeled and investigated. After that, a Finite Element Method (FEM) model to simulate the uterine cyclic active contraction and delivery of a fetus was developed in LS-DYNA...
April 18, 2024: Journal of Biomechanical Engineering
Jessica M Powers, Sarah F Maloney, Eva Sharma, Laura R Stroud
OBJECTIVE: Co-use of tobacco and cannabis may be prevalent in pregnancy, potentially leading to additional adverse health outcomes. Utilizing a national sample of women followed prospectively before, during, and after pregnancy, this study tested whether prepregnancy co-use of tobacco and cannabis (vs. tobacco-only use and cannabis-only use) was associated with greater likelihood of continuing to use tobacco and/or cannabis during pregnancy and postpartum. METHOD: Data were drawn from Waves 1-5 (2013-2019) of the Population Assessment of Tobacco and Health (PATH) Study...
April 18, 2024: Psychology of Addictive Behaviors
Riley J Jouppi, Shannon D Donofry, Christine C Call, Yu Cheng, Rachel P Kolko Conlon, Sarah Niemi, Michele D Levine
OBJECTIVE: Loss of control (LOC) eating (feeling unable to control food type/amount eaten) during pregnancy is common and linked to risk for poor cardiovascular health (CVH), but it is unclear whether prenatal LOC eating directly relates to CVH during pregnancy. The current study tested associations between prenatal LOC eating and CVH during pregnancy in a sample with prepregnancy body mass index (BMI) ≥ 25. METHOD: At 12-20 weeks' gestation, participants ( N = 124) self-reported: prenatal LOC eating, diet, physical activity, nicotine use, sleep; height/weight were measured...
April 18, 2024: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Arnold J Suda, Julia Pepke, Udo Obertacke, Holger Stadthalter
PURPOSE: Whole-body computer tomographic examinations (WBCT) are essential in diagnosing the severely injured. The structured clinical evaluation in the emergency trauma room, according to ATLS® and guidelines, helps to indicate the correct radiological imaging to avoid overtriage and undertriage. This retrospective, single-center study aimed to evaluate the value of WBCT in patients with an inconspicuous primary survey and whether there is any evidence for this investigation in this group of patients...
April 18, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Aleksandra Rasic-Markovic, Emilija Djuric, Daniel Skrijelj, Jelica Bjekic-Macut, Đurđica Ignjatovic, Nikola Sutulovic, Dragan Hrncic, Dusan Mladenovic, Aleksandra Marković, Saša Radenković, Lena Radić, Nebojsa Radunovic, Olivera Stanojlovic
Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent...
April 18, 2024: Endocrine
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