Rebecca L Fix, Colleen S Walsh, Ashli J Sheidow, Michael R McCart, Jason E Chapman, Tess K Drazdowski
BACKGROUND: Risky sexual behaviour (RSB) is a serious public health problem for adolescents. We examined whether a contingency management intervention implemented by juvenile probation officers (JPOs) targeting substance use also impacted RSB. METHODS: A total of 218 adolescents on probation were randomly assigned to contingency management or to probation as usual. RESULTS: The substance use intervention delivered by JPOs reduced rates of RSB over time (β=-0...
February 26, 2024: Sexual Health
Xiaoge Huang, Ting Yin, Min Song, Jing Pan
OBJECTIVE: Estrogen and progesterone play key roles in the maintenance of pregnancy, and their function is mediated via estrogen receptor 1 (ESR1)/estrogen receptor 2 (ESR2) and progesterone receptor (PGR), respectively. It has been suggested the genetic variations in ESR1, ESR2, and PGR may contribute to recurrent pregnancy loss (RPL); however, the available evidence remains controversial. This meta-analysis aimed to explore the relation of various polymorphisms in ESR1, ESR2, and PGR genes to the risk of RPL...
January 19, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Sarah El-Heis, Sheila J Barton, Hsin Fang Chang, Heidi Nield, Vanessa Cox, Sevasti Galani, Wayne Cutfield, Shiao-Yng Chan, Keith M Godfrey
Observational studies have reported associations between nutrition during pregnancy and mental wellbeing. As secondary outcomes, the NiPPeR double-blind randomized trial in women planning conception investigated whether a myo-inositol, probiotics and enriched micronutrients formulation (intervention) taken preconception and throughout pregnancy could improve mental wellbeing during pregnancy and post-delivery, compared with a standard micronutrient supplement (control). Mood and anxiety symptoms were ascertained (Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI-state)) at preconception (baseline), 7, 28 and 34 weeks gestation, 3-weeks and 6-months post-delivery...
February 23, 2024: Psychiatry Research
K Domrazek, P Konieczny, M Majka, M Czopowicz, A Cywińska, P Jurka
Mycoplasmas colonize fish, reptiles, birds and mammals, being commensals or causing diseases, sometimes severe in ruminants, swine, poultry, or wildlife animals. So far, 15 species of canine Mycoplasma spp. have been described. Conflicting results have been presented regarding the pathogenicity of Mycoplasma spp. Although many virulence factors of these bacteria have been described, they still require attention. The main aim of our study was to evaluate the presence of known canine Mycoplasmas in the male reproductive tract of clinically healthy dogs...
February 22, 2024: Theriogenology
Yalin Zhang, Yujie Zhuang, Jin Zhou, Xiaoyu Xie, Mingzhu Sun, Mengyao Zheng, Keyun Yuan, Zhiping Zhang, Juntao Zhang
Endometritis is a disease caused by a postpartum bacterial infection with a poor prognosis that primarily affects dairy cows. Three-dimensional organoids have been used as a model for endometritis, because they exhibit a structure comparable to that of the endometrium, demonstrating both expansibility and hormone responsiveness. These characteristics render them an ideal platform for in vitro investigations of endometrial diseases. Estradiol (E2) is an endogenous steroid hormone with demonstrated anti-inflammatory properties, and the objective of this study was to determine the mechanism by which E2 modulates the inflammatory response and the Wnt signal transduction pathway in bovine endometrial epithelial cells and organoids following E...
February 22, 2024: Theriogenology
Yaju Tang, Sihai Lu, Juncai Wei, Rui Xu, Hui Zhang, Qiang Wei, Bin Han, Yan Gao, Xiaoe Zhao, Sha Peng, Menghao Pan, Baohua Ma
Both oocyte secretory factors (OSFs) and estrogen are essential for the development and function of mammalian ovarian follicles, playing synergistic role in regulating oocyte growth. OSFs can significantly affect the biological processes regulated by estrogen in cumulus cells (CCs). It is a scientific question worth investigating whether oocyte secretory factors can influence the expression of estrogen receptors in CCs. In our study, we observed a significant increase in the mRNA and protein expressions of estrogen receptor β (Esr2/ERβ) and G-protein-coupled estrogen receptor (GPER) in cumulus cells of goat cumulus-oocyte complexes (COCs) cultured in vitro for 6 h...
February 22, 2024: Theriogenology
Tiffany R Ernst, R M H W Hogers, A Korosi, J L van Leeuwen, A Kotrschal, Bart J A Pollux
Coercive mating is a sexual selection strategy that is likely to influence female cognition. Female harassment levels have been linked to altered brain gene expression patterns and brain size evolution, suggesting females may respond to coercive mating by investing energy into "outsmarting" males. However, females exposed to coercive males have decreased foraging efficiency and likely increased stress levels, suggesting their brain function might instead be impaired. While it is therefore likely that coercive mating impacts female cognitive abilities, a direct test of this idea is currently lacking...
February 25, 2024: Journal of Fish Biology
Takashi Morimoto, Tomohiro Maekawa, Shimpei Mizuta, Hidehiko Matsubayashi, Takumi Takeuchi, Yutaka Hata, Tomomoto Ishikawa
RESEARCH QUESTION: Would the use of the intracytoplasmic sperm injection (ICSI) position detector (IPD) make it possible to identify the optimal puncture position on oolemma during Piezo-ICSI and reduce oocyte degeneration and unintentional membrane rupture (UMR)? DESIGN: This sibling oocyte study included 917 inseminated oocytes from 113 infertile patients undergoing Piezo-ICSI. Oocytes were randomly divided into two groups: with or without IPD. The rates of UMR, degeneration, fertilization and embryonic development were compared between the two groups...
November 27, 2023: Reproductive Biomedicine Online
Miriam S Johnson, Nora Skjerdingstad, Omid V Ebrahimi, Asle Hoffart, Sverre Urnes Johnson
BACKGROUND: Psychological distress during pregnancy is a well-documented risk factor for adverse maternal outcomes. Distress related to the COVID-19 pandemic may further increase the vulnerability of pregnant women to negative mental health outcomes. AIM: To explore the mental health experiences of pregnant women, focusing on mental health outcomes, challenges related to the pandemic, coping strategies, and factors buffering mental health factors during the restricted COVID-19 lockdown period...
February 12, 2024: Midwifery
Joyce D Asseler, Julieta S Del Valle, Susana M Chuva de Sousa Lopes, Marieke O Verhoeven, Mariette Goddijn, Judith A F Huirne, Norah M van Mello
Transmasculine people usually reach amenorrhea within 6 months of adequate testosterone treatment. It is often assumed that no ovulation occurs during amenorrhea. However, in this study, we report recent ovulatory activity in amenorrheic transmasculine people on testosterone therapy at gender-affirming oophorectomy. Histological signs of recent ovulatory activity, including the presence of ovulatory follicles, corpus luteum, and corpus albicans, are observed in 17 of 52 individuals (33%). This is not significantly correlated to the duration, testosterone serum levels, or type of testosterone used...
February 19, 2024: Cell reports medicine
Mary Lou O'Neil, Amrutha Ramaswamy, Deniz Altuntaş
Turkey currently pursues an aggressive pronatalist population politics which has created wide-reaching reproductive governance regulating reproductive health care and family planning choices. One aspect of this orientation centres on restricting access to abortion services despite the fact that abortion is legal through ten weeks of pregnancy. This article uses nationwide data collected from mystery patient surveys administered to all public (in 2016 and 2020), and all private (2021) hospitals in the country to determine the availability of abortion services in Turkey...
February 25, 2024: Culture, Health & Sexuality
Ozan Kaplan, Sezin Ertürk Aksakal, Bilge Başak Fidan, Yaprak Engin-Üstün, Mustafa Çelebier
Metabolomics is a relatively novel omics tool to provide potential biomarkers for early diagnosis of the diseases and to insight the pathophysiology not having discussed ever before. In the present study, an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was employed to the plasma samples of Group T1: Patients with ectopic pregnancy diagnosed using ultrasound, and followed-up with beta-hCG level ( n  = 40), Group T2: Patients with ectopic pregnancy diagnosed using ultrasound, underwent surgical treatment and confirmed using histopathology ( n  = 40), Group P: Healthy pregnant women ( n  = 40) in the first prenatal visit of pregnancy, Group C: Healthy volunteers ( n  = 40) scheduling a routine gynecological examination...
February 25, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
Emily Ana Butler, Sonia M Grandi, Lavina Matai, Xuesong Wang, Eyal Cohen, Joel G Ray
BACKGROUND: During pregnancy, various maternal IgG antibodies are transferred to the developing fetus, some of which may protect the newborn against infection. If a mother and her fetus have different ABO blood groups, then transferred maternal antibodies may plausibly protect the infant against infection. AIM: To determine if maternal-newborn ABO blood group incongruence vs. congruence is associated with a lower risk of serious infection in the infant. DESIGN: Retrospective population-based cohort...
February 24, 2024: QJM: Monthly Journal of the Association of Physicians
Brenda Caira-Chuquineyra, Daniel Fernandez-Guzman, Andrea G Cortez-Soto, Diego Urrunaga-Pastor, Guido Bendezu-Quispe, Carlos J Toro-Huamanchumo
BACKGROUND: Intimate partner violence (IPV) in Peru represents a significant public health challenge. IPV can influence women's reproductive and social behaviors, undermining fertility control, and exacerbating unintended pregnancies. Our objective was to assess the association between IPV and pregnancy intention among Peruvian women of reproductive age. METHODS: We conducted a secondary analysis of Peru's 2020 Demographic and Family Health Survey data. The independent variable in this study was IPV against women, which includes psychological IPV, sexual IPV, and physical IPV...
February 24, 2024: BMC Women's Health
Zian Liao, Suni Tang, Peixin Jiang, Ting Geng, Dominique I Cope, Timothy N Dunn, Joie Guner, Linda Alpuing Radilla, Xiaoming Guan, Diana Monsivais
Endometriosis is linked to increased infertility and pregnancy complications due to defective endometrial decidualization. We hypothesized that identification of altered signaling pathways during decidualization could identify the underlying cause of infertility and pregnancy complications. Our study reveals that transforming growth factor β (TGFβ) pathways are impaired in the endometrium of individuals with endometriosis, leading to defective decidualization. Through detailed transcriptomic analyses, we discovered abnormalities in TGFβ signaling pathways and key regulators, such as SMAD4, in the endometrium of affected individuals...
February 24, 2024: Communications Biology
Bum-Kyu Lee, Joudi Salamah, Elisha Cheeran, Enoch Appiah Adu-Gyamfi
The placenta serves as an essential organ for fetal growth throughout pregnancy. Histone modification is a crucial regulatory mechanism involved in numerous biological processes and development. Nevertheless, there remains a significant gap in our understanding regarding the epigenetic regulations that influence trophoblast lineage differentiation, a fundamental aspect of placental development. Here, through comprehensive mapping of H3K4me3, H3K27me3, H3K9me3, and H3K27ac loci during the differentiation of trophoblast stem cells (TSCs) into syncytiotrophoblasts (STs) and extravillous trophoblasts (EVTs), we reveal dynamic reconfiguration in H3K4me3 and H3K27ac patterns that establish an epigenetic landscape conducive to proper trophoblast lineage differentiation...
February 24, 2024: Scientific Reports
Kenta Inoue, Shinichiro Yabe, Soichiro Kashiwabara, Yukiko Itaya, Sumiko Era, Akihiko Kikuchi, Yasushi Takai
BACKGROUND: Most cases of traumatic injury during pregnancy involve blunt trauma, with penetrating trauma being uncommonly rare. In glass shard injuries, fragments often penetrate deeply, and multiple injuries may occur simultaneously; attention must be paid to the possibility of organ injury from the residual fragments. However, no case of this occurring during pregnancy has been reported yet. CASE PRESENTATION: We present the case of a 34-year-old pregnant Cameroonian woman who retained intraabdominal glass shards following a penetrating injury at 13 weeks gestation and not diagnosed until 22 weeks gestation...
February 25, 2024: Journal of Medical Case Reports
Yan Huang, Yi Cheng, Min Zhang, Yiqing Chen, Rong Zhou, Dewei Lin, Xinyu Guo
BACKGROUND: Repeated cryopreservation of embryos should occasionally be considered when embryos were not suitable for transfer. The effect of re-cryopreservation on embryos remains contentious. METHODS: This retrospective cohort study aimed to evaluate the pregnancy and neonatal outcomes of twice vitrificated blastocyst derived from once vitrified embryos. Total 410 vitrified-warmed blastocyst transfer cycles were divided into two groups according to the times of embryo vitrification: (1) vitrified blastocysts derived from fresh blastocysts (control group, n = 337); (2) twice vitrified blastocysts derived from once vitrified embryos (n = 73)...
February 24, 2024: Journal of Ovarian Research
Fiona Cody, Orla Franklin, Nicola Mc Cay, Zara Molphy, Patrick Dicker, Fionnuala M Breathnach
BACKGROUND: Prenatal detection of critical congenital heart disease (CCHD) optimises perinatal decision-making and neonatal outcomes. The objective of this study was to determine the prenatal screening performance, care pathways and perinatal outcomes for prenatally and postnatally diagnosed cases of CCHD over a four-year period. STUDY DESIGN: This retrospective cohort study in a tertiary centre and its two affiliated secondary sites examined all cases of CCHD, including cases of pregnancy termination and in-utero fetal death, neonatal death and liveborn babies that underwent cardiac catheterization or surgery in the first six weeks of life...
February 24, 2024: BMC Pregnancy and Childbirth
Carolina C Ribeiro-do-Valle, Mercedes Bonet, Vanessa Brizuela, Edgardo Abalos, Adama Baguiya, Fernando Bellissimo-Rodrigues, Mihaela Budianu, Lucian Puscasiu, Marian Knight, David Lissauer, Catherine Dunlop, Shevin T Jacob, Sadia Shakoor, Luis Gadama, Bouchra Assarag, João Paulo Souza, Jose G Cecatti
BACKGROUND: Pregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection and country income, among hospitalized women with suspected or confirmed pregnancy-related infections. METHODS: We used data from WHO Global Maternal Sepsis Study (GLOSS) on maternal infections in hospitalized women, in 52 low-middle- and high-income countries conducted between November 28th and December 4th, 2017, to describe the frequencies and medians of maternal demographic, obstetric, and clinical characteristics and outcomes, methods of infection diagnosis and causative pathogens, of single source pregnancy-related infection, other than breast, and initial use of therapeutic antibiotics...
February 24, 2024: Annals of Clinical Microbiology and Antimicrobials
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