Ronan M N Noble, Raven Kirschenman, Alyssa Wiedemeyer, Vaishvi Patel, Jad-Julian Rachid, Roger J Zemp, Sandra T Davidge, Stephane L Bourque
We aimed to evaluate fetal and placental oxygen saturation (sO2) in anemic and non-anemic pregnant rats throughout gestation using photoacoustic imaging (PAI). Female Sprague-Dawley rats were fed an iron-restricted or iron-replete diet before and during pregnancy. On gestational days 13, 18, and 21, PAI was coupled with high resolution ultrasound to measure oxygenation of the fetus, whole placenta, mesometrial triangle, as well as the maternal and fetal faces of the placenta. PAI was performed in 3D, which allowed sO2 to be measured within an entire region, as well as in 2D, which enabled sO2 measurements in response to a hypoxic event in real time...
November 27, 2023: Reproductive Sciences
Emmanuel Attali, Daniel Gabbai, Lee Reicher, Yoav Baruch, Anat Lavie, Yariv Yogev, Ariel Many
The relation between grand multiparity and poor pregnancy outcome, especially postpartum hemorrhage and blood transfusion, has displayed inconsistent findings. Some studies have identified an increased maternal and neonatal morbidity, but the more recent literature is less clear about the risks. The objective of the study is to determine the association of grand multiparity with postpartum blood transfusion. We conducted a retrospective cohort study in a single tertiary university-affiliated medical center between 2011 and 2019...
November 27, 2023: Reproductive Sciences
Oyewole K Oyedele
Understanding population discrepancy in maternity continuum of care (CoC) completion, particularly in sub-Saharan Africa is significant for interventional plan to achieve optimal pregnancy outcome and child survival. This study thus investigated the magnitudes, distribution, and drivers of maternity CoC completion in Nigeria. A secondary analysis of 19,474 reproductive age (15-49 years) women with at least a birth (level 1) in 1400 communities (level 2) across 37 states covered in the 2018 cross-sectional survey...
November 27, 2023: Scientific Reports
Will W Minuth
BACKGROUND: The kidneys of preterm and low birth weight babies reflect vulnerability, since several noxae can evoke the termination of nephron formation. This again leads to oligonephropathy with severe consequences for health in the later life. While the clinical parameters have been intensely investigated, only little is known about the initial traces left by the noxae. For the fetal human kidney, solely the lack of basophilic S-shaped bodies and the reduction in width of the nephrogenic zone were registered...
November 28, 2023: Molecular and Cellular Pediatrics
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2023: Nature Medicine
Mahmut Kılıç, Şeyda Koçak
This study aims to examine the pandemic's effect on the psycho-motor development of children aged 6-36 months during the Covid 19 pandemic period and now aged 2-5 years. This study was cross-sectional and children (n = 150) aged 2-5 years were included in the study. Data were collected using the Ankara Developmental Screening Inventory (ADSI) in 2022. The proportion of children included in the study who have general development, language-cognitive, fine motor, gross motor, and social skill-self-care development levels at a delay-suspiciously were 25...
November 27, 2023: Scientific Reports
Jun Liu, Yan Deng, An Wang, Bowen Liu, Xi Zhou, Tailang Yin, Yan Wang, Tao Tang, Yang Qiu, Jiao Chen, Jing Yang
The maternal-fetal interface shares similarities with tumor tissues in terms of the immune microenvironment. Normal pregnancy is maintained due to the immunosuppressed state, but pyroptosis induced by MITA can trigger the body's immune response and disrupt the immunosuppressed state of the maternal-fetal interface, leading to abortion. In this study, we explored the role of MITA and TRIM38 in regulating pyroptosis and maintaining the immune tolerance of the maternal-fetal interface during pregnancy. Our findings show that the interaction between MITA and TRIM38 plays a crucial role in maintaining the immunosuppressed state of the maternal-fetal interface...
November 28, 2023: Cell Death & Disease
Lorena Suárez-Idueta, Eric O Ohuma, Chia-Jung Chang, Elizabeth A Hazel, Judith Yargawa, Yemisrach B Okwaraji, Ellen Bradley, Adrienne Gordon, Jessica Sexton, Harriet L S Lawford, Enny S Paixao, Ila R Falcão, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jírová, Erzsebet Horváth-Puhó, Henrik T Sørensen, Luule Sakkeus, Lili Abuladze, Khalid A Yunis, Ayah Al Bizri, Sonia Lopez Alvarez, Lisa Broeders, Aimée E van Dijk, Fawziya Alyafei, Mai AlQubaisi, Neda Razaz, Jonas Söderling, Lucy K Smith, Ruth J Matthews, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Joy E Lawn, Hannah Blencowe
OBJECTIVE: We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6 million live births in 15 countries, between 2000 and 2020. DESIGN: Population-based, multi-country study. SETTING: National healthcare systems. POPULATION: Liveborn infants. METHODS: We used individual-level data identified for the Vulnerable Newborn Measurement Collaboration...
November 27, 2023: BJOG: An International Journal of Obstetrics and Gynaecology
Xianya Zou, Yukiko Nakura, Haruna Kawaguchi, Fumiko Nishiumi, Heng Ning Wu, Itaru Yanagihara
AIMS: Approximately 10% of children are born prematurely, and bacterial vaginosis during pregnancy is associated with preterm delivery. Highly accurate species-level vaginal microflora analysis helps control bacteria-induced preterm birth. Therefore, we aimed to conduct a bioinformatic analysis of gene sequences using 16S databases and compare their efficacy in comprehensively identifying potentially pathogenic vaginal microbiota in Japanese women. METHODS AND RESULTS: The 16s rRNA databases, Silva, Greengenes, and basic local alignment search tool (BLAST) were compared to determine whether the classification quality could be improved using the V3-V4 region next-generation sequencing (NGS) sequences...
November 27, 2023: Journal of Applied Microbiology
Yanxia Liu, Weiling Liu, Guiying Zhuang, Weiqi Liu, Cuiqing Qiu
OBJECTIVES: This study was to investigate the colonisation rate of Group B Streptococcus (GBS) during pregnancy, and to evaluate the influence of GBS colonisation on pregnancy outcomes. DESIGN: A retrospective cohort study. SETTING: Data of 47 380 pregnant women from 2016 to 2022 were collected from the Maternal and Child Health Hospital of Huadu District, Guangzhou City, China. PARTICIPANTS: A total of 15 040 pregnant women were eligible for this study, of which 32 340 were excluded due to non-native pregnant women, in vitro fertilization infants, malformed fetuses, habitual abortion, abortions due to poor reproductive or obstetrical history, artificial insemination, umbilical cord torsion, and other diseases during pregnancy...
November 27, 2023: BMJ Open
Roisin Mulholland, Madeleine Reece, Oluwafemi Coker, Kirstin Silf
No abstract text is available yet for this article.
November 27, 2023: BMJ Case Reports
M Bourdon, A S Maget, M Jeljeli, L Doridot, L Marcellin, M Thomas, C Chêne, S Chouzenoux, F Batteux, C Chapron, P Santullli
STUDY QUESTION: Does a reduction in fertility and/or systemic immune cell change occur during the early implantation period in a mouse model of adenomyosis? SUMMARY ANSWER: A reduction in fertility was observed in mice with adenomyosis, coinciding with local and systemic immune changes observed during the implantation period. WHAT IS KNOWN ALREADY: Adenomyosis is a pathology responsible for impaired fertility in humans, with a still unclear pathophysiology...
November 27, 2023: Human Reproduction
Ying-Jie Niu, Wenjie Ren, Guangzheng Liu, Kai Jin, Dan Zheng, Qisheng Zuo, Yani Zhang, Xiang-Shun Cui, Guohong Chen, Bichun Li
Chicken primordial germ cells (PGCs) are important cells with significant implications in preserving genetic resources, chicken breeding and production, and basic research on genetics and development. Currently, chicken PGCs can be cultured long-term in vitro to produce single-cell clones. However, systematic exploration of the cellular characteristics of these single-cell clonal lines has yet to be conducted. In this study, single-cell clonal lines were established from male and female PGCs of Rugao Yellow Chicken and Shouguang Black Chicken, respectively, using a micropipette-based method for single-cell isolation and culture...
November 22, 2023: Theriogenology
Aikaterini Berdiaki, Eleni Vergadi, Fanourios Makrygiannakis, Thomas Vrekoussis, Antonios Makrigiannakis
Repeated implantation failure (RIF) is a significant limiting factor in assisted reproduction. Chronic endometrial inflammation has been noted in RIF women, therefore we sought to investigate the potential association of endometrial Th17/Treg ratio and endometrial inflammation in these cases. Endometrial pipelle biopsies were obtained from volunteers, 29 women with RIF (failure to achieve pregnancy following at least 3 transfers of high-grade embryos in IVF-cycles) and 27 fertile women (at least one child) in total, at the secretory phase of the menstrual cycle...
November 19, 2023: Journal of Reproductive Immunology
Purvasha Patnaik, Afsoon Khodaee, Goutham Vasam, Anika Mukherjee, Sina Salsabili, Eranga Ukwatta, David Grynspan, Adrian D C Chan, Shannon Bainbridge
INTRODUCTION: Hypertensive disorders of pregnancy (HDP) and fetal growth restriction (FGR) are common obstetrical complications, often with pathological features of maternal vascular malperfusion (MVM) in the placenta. Currently, clinical placental pathology methods involve a manual visual examination of histology sections, a practice that can be resource-intensive and demonstrates moderate-to-poor inter-pathologist agreement on diagnostic outcomes, dependant on the degree of pathologist sub-specialty training...
November 15, 2023: Placenta
Lawrence M Barat, Nicole Whitehurst, Meera Venkatesan, Kim Connolly, Emmanuel Yamo, Paul Psychas, Yves-Marie Bernard
Since its launch in 2005, the U.S. President's Malaria Initiative's (PMI) investment in malaria case management has evolved based on lessons learned from its support to countries. An initial focus on updating malaria treatment policies to adopt artemisinin-based combination therapies achieved limited success, in part because of the poor quality of diagnostic and treatment services in targeted countries. In response, the PMI supported the development, refinement, and expansion of Outreach Training and Supportive Supervision (OTSS), a quality improvement approach that combines structured, competency-based supervision with corrective measures, including on-the-job training, coaching, troubleshooting, action planning, and timely follow-up...
November 27, 2023: American Journal of Tropical Medicine and Hygiene
Kassie J Bollig, Suneeta Senapati, Peter Takacs, Jared C Robins, Daniel J Haisenleder, Lynn A Beer, David W Speicher, Nathanael C Koelper, Kurt T Barnhart
OBJECTIVE: To assess performance and discriminatory capacity of commercially available enzyme-linked immunosorbent assays (ELISAs) of biomarkers for predicting first trimester pregnancy outcome in a multi-center cohort. DESIGN: In a case-control study at three academic centers of women with pain and bleeding in early pregnancy, ELISAs of biomarkers were screened for assay performance. Performance was assessed via functional sensitivity, assay reportable range, recovery/linearity, and intra-assay precision (%CV)...
November 27, 2023: Biology of Reproduction
Wei Wei, Na Wang, Yanwen Zhu, Maokun Liao, Bian Wang, Tong Du, Jie Zhang, Xiaoyan Mao
Endometrial receptivity is a prerequisite for the success of assisted reproduction., Patients with a consistently thin endometrium frequently fail to conceive, owing to low endometrial receptivity, and there are currently very few therapeutic options available. Our previous study demonstrated that intrauterine granulocyte-macrophage colony-stimulating factor (GM-CSF) administration resulted in a significant improvement in clinical pregnancy and implantation rates and was an effective means of increasing endometrial thickness on the day of embryo transfer in patients with thin endometrium...
November 27, 2023: Molecular Human Reproduction
Emma Thalia Conde-Rico, Jaime Naves-Sánchez, Alma Patricia González, José Luis Felipe Luna-Anguiano, Carlos Paque-Bautista, Gloria Patricia Sosa-Bustamante
BACKGROUND: Recent studies have confirmed the relationship between some inflammatory indexes and preeclampsia (PE); however, they have not been analyzed in PE with and without severity criteria. OBJECTIVE: To know the association between inflammatory indexes and the severity of PE. MATERIAL AND METHODS: Analytical cross-sectional prolective study. Pregnant patients were included, divided into group 1 (PE without severity criteria); group 2 (PE with severity criteria); group 3 (normotensive pregnant women)...
September 18, 2023: Revista Médica del Instituto Mexicano del Seguro Social
Samantha A Devlin, Jessica P Ridgway, Alicia Dawdani, Ososese E Enaholo, Geoffroy Liegeon, Nikki Kasal, Maria Pyra, Lisa R Hirschhorn, Jodi Simon, Sadia Haider, Kelly Ducheny, Amy K Johnson
Black cisgender women (hereafter referred to as "women") have disproportionately high rates of HIV infection yet low rates of pre-exposure prophylaxis (PrEP) utilization. Barriers to PrEP uptake exist at the system, provider, and individual/client level. To learn how existing training and advertising can be adapted to address race- and sex-based gaps within PrEP service delivery, we conducted focus groups with providers and Black women. Participants were recruited at three health care organizations in the Midwest and South, screened for eligibility, and consented verbally...
November 21, 2023: AIDS Patient Care and STDs
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