A Lokki, Michael Triebwasser, Emma Daly, Finnpec Cohort, Mrtja Kurki, Markus Perola, Kirsi Auro, Jane Salmon, Anuja Java, Mark Daly, John Atkinson, Hannele Laivuori, Seppo Meri
Preeclampsia is a common multifactorial disease of pregnancy. Dysregulation of the complement activation is among emerging candidates responsible for disease pathogenesis. In a targeted exomic sequencing study we identified 14 variants within nine genes coding for components of the membrane attack complex (MAC, C5b-9) that are associated with preeclampsia. We found two rare missense variants in the C5 gene that predispose to preeclampsia (rs200674959: I1296V, OR (CI95) = 24.13 (1.25-467.43), p-value = 0...
April 2, 2024: Research Square