Yihui Wang, Yuan Song, Lingling Xu, Wuqi Zhou, Wenyuan Wang, Qiaofeng Jin, Yuji Xie, Junmin Zhang, Jing Liu, Wenqian Wu, He Li, Le Liang, Jing Wang, Yali Yang, Xiongwen Chen, Shuping Ge, Tang Gao, Li Zhang, Mingxing Xie
Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor is ischemia/reperfusion (I/R)-induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidation. However, the impact of lipid droplet (LD) changes on I/R-induced cardiomyocyte ferroptosis is unclear. In this study, an aggregation-induced emission probe, TPABTBP is developed that is used for imaging dynamic changes in LD during myocardial I/R-induced ferroptosis. TPABTBP exhibits excellent LD-specificity, superior capability for monitoring lipophagy, and remarkable photostability...
May 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)