Daniel Enríquez-Vázquez, Jorge G Quintanilla, Alba García-Escolano, Marinela Couselo-Seijas, Ana Simón-Chica, Peter Lee, José Manuel Alfonso-Almazán, Patricia Mahía, Andrés Redondo-Rodríguez, Javier Modrego, Adriana Ortega-Hernández, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Rubén Gómez-Gordo, Ping Yan, Giulio La Rosa, José Bustamante-Madrión, Carlos Nicolás Pérez-García, F Javier Martín-Sánchez, David Calvo, Jesús M de la Hera, María Jesús García-Torrent, Álvaro García-Osuna, Jordi Ordonez-Llanos, Jesús Vázquez, Julián Pérez-Villacastín, Nicasio Pérez-Castellano, Leslie M Loew, Javier Sánchez-González, Dulcenombre Gómez-Garre, David Filgueiras-Rama
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins...
August 4, 2023: Nature Communications