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JOURNAL ARTICLE
Wei-Zhi Wang, Chao Liu, Jin-Que Luo, Li-Juan Lei, Ming-Hua Chen, Yu-Yan Zhang, Ren Sheng, Yi-Ning Li, Li Wang, Xin-Hai Jiang, Tong-Mei Xiao, Yu-Hao Zhang, Shun-Wang Li, Ye-Xiang Wu, Yang Xu, Yan-Ni Xu, Shu-Yi Si
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the epidermal growth factor precursor homologous domain A (EGF-A) of low-density lipoprotein receptor (LDLR) in the liver and triggers the degradation of LDLR via the lysosomal pathway, consequently leading to an elevation in plasma LDL-C levels. Inhibiting PCSK9 prolongs the lifespan of LDLR and maintains cholesterol homeostasis in the body. Thus, PCSK9 is an innovative pharmacological target for treating hypercholesterolemia and atherosclerosis...
May 29, 2024: Acta Pharmacologica Sinica
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JOURNAL ARTICLE
Lars Verschuren, Anne Linde Mak, Arianne van Koppen, Serdar Özsezen, Sonia Difrancesco, Martien P M Caspers, Jessica Snabel, David van der Meer, Anne-Marieke van Dijk, Elias Badal Rashu, Puria Nabilou, Mikkel Parsberg Werge, Koen van Son, Robert Kleemann, Amanda J Kiliaan, Eric J Hazebroek, André Boonstra, Willem P Brouwer, Michail Doukas, Saurabh Gupta, Cornelis Kluft, Max Nieuwdorp, Joanne Verheij, Lise Lotte Gluud, Adriaan G Holleboom, Maarten E Tushuizen, Roeland Hanemaaijer
Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibrosis detection in MASLD. A molecular gene expression signature identified from a diet-induced MASLD mouse model (LDLr-/-.Leiden) is translated into human blood-based biomarkers based on liver biopsy transcriptomic profiles and protein levels in MASLD patient serum samples...
May 29, 2024: Nature Communications
#43
JOURNAL ARTICLE
Rui Yang, Fengjiang Sun, Xiong-Fei Pan, Yingqian Su, Ping Wu, Jiaying Yuan, Yuwei Lai, An Pan, Wei Huang
Recognizing the risk factors for dyslipidemia during pregnancy is crucial for safeguarding the health of both the mothers and the offspring. Growing evidence emerged and suggested links between environmental factors, including metals, and alteration in lipid levels or dyslipidemia in general populations. However, knowledge of the associations during pregnancy remains extremely lacking. Herein, we aimed to explore whether elevated metal exposure constitutes a risk factor for dyslipidemia in pregnant women. Based on the Tongji-Shuangliu Birth Cohort (TSBC), a total of 663 pregnant women were recruited and their urinary levels of 17 metals and blood lipid biomarkers in early pregnancy were measured, namely triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)...
May 27, 2024: Environmental Pollution
#44
RANDOMIZED CONTROLLED TRIAL
Mario Daidone, Alessandra Casuccio, Maria Grazia Puleo, Alessandro Del Cuore, Gaetano Pacinella, Tiziana Di Chiara, Domenico Di Raimondo, Palmira Immordino, Antonino Tuttolomondo
BACKGROUND: A randomized clinical trial to evaluate the effect of a Mediterranean-style diet on vascular health indices such as endothelial function indices, serum lipid and ceramide plasma and some adipokine serum levels. We recruited all consecutive patients at high risk of cardiovascular diseases admitted to the Internal Medicine and Stroke Care ward at the University Hospital of Palermo between September 2017 and December 2020. MATERIALS AND METHODS: The enrolled subjects, after the evaluation of the degree of adherence to a dietary regimen of the Mediterranean-style diet, were randomised to a Mediterranean Diet (group A) assessing the adherence to a Mediterranean-style diet at each follow up visit (every three months) for the entire duration of the study (twelve months) and to a Low-fat diet (group B) with a dietary "counselling" starting every three months for the entire duration of the study (twelve months)...
2024: PloS One
#45
JOURNAL ARTICLE
A V Starodubova, N N Shaposhnikova, Yu R Varaeva, T V Kirichenko, Yu V Markina, T V Tolstik, D V Nikityuk
Chronic systemic inflammation is one of the leading pathogenetic pathways for the development of atherosclerosis in obese patients. In this regard, it seems promising to evaluate the effect of the diet and physical exertion on the proinflammatory activity of monocytes. The purpose of this research was to evaluate the effect of the diet and regular physical trainings on the secretion of monocyte chemotactic factor 1 (MCP-1) by monocytes in obese patients with coronary artery disease. Material and methods . 27 obese participants (body mass index >30 kg/m2) with a confirmed diagnosis of coronary heart disease were recruited...
2024: Voprosy Pitaniia
#46
JOURNAL ARTICLE
Janani Ramesh, Sathya Selvarajan, Sowmya Krishnamurthy, Sridharan Kopula Sathyamoorthy, Dhivya Senthil Kumar
BACKGROUND: LDL cholesterol (LDL-C) is regarded as a significant therapeutic target and a known risk factor for atherosclerosis. It can be calculated using the results of the other lipid tests or tested directly. Despite its shortcomings, the Friedewald formula is most frequently utilized since it is simple and practical. Until now, several formulae have been proposed for calculating LDL-C; however, their accuracy has not been evaluated across different populations. We sought to evaluate the validity of calculated LDL-C by comparing the findings with values acquired by the direct homogeneous technique, utilizing 13 distinct formulae from the literature...
May 29, 2024: Journal of Applied Laboratory Medicine
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JOURNAL ARTICLE
Robert S Rosenson, Daniel Gaudet, Robert A Hegele, Christie M Ballantyne, Stephen J Nicholls, Kathryn J Lucas, Javier San Martin, Rong Zhou, Ma'an Muhsin, Ting Chang, Jennifer Hellawell, Gerald F Watts
BACKGROUND: Angiopoietin-like 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases and hepatic uptake of triglyceride-rich lipoprotein remnants. ANGPTL3 loss-of-function carriers have lower levels of triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol and a lower risk of atherosclerotic cardiovascular disease than noncarriers. Zodasiran is an RNA interference (RNAi) therapy targeting expression of ANGPTL3 in the liver...
May 29, 2024: New England Journal of Medicine
#48
JOURNAL ARTICLE
Giovanni Musso, Silvia Pinach, Filippo Mariano, Francesca Saba, Franco De Michieli, Luciana Framarin, Mara Berrutti, Elena Paschetta, Renato Parente, Yanina Lizet Castillo, Nicola Leone, Francesca Castellino, Maurizio Cassader, Roberto Gambino
RESULTS: Compared with placebo, Meriva® improved eGFR(difference in adjusted eGFR change: +3.59[2.96-4.11] mL/min/1.73 m2/year, p=0.009), fasting glucose(-17 mg/dL;95%CI=-22, -12), HbA1c(-0.62%;95%CI=-0.87%, -0.37%), LDL-C(-39 mg/dL; 95%CI= -45, -33), triglycerides(-36 mg/dL, 95%CI= -46, -26), HDL-C(+10 mg/dL; 95%CI=+8, +11) and inflammatory markers. Adverse events were rare, mild and evenly distributed. CONCLUSION: In NASH patients, Meriva® administration for 72 weeks was safe, well-tolerated, improved liver histology, possibly through NF-kB inhibition, kidney disease, and metabolic profile...
May 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#49
REVIEW
Biagio Di Lorenzo, Stefano Zoroddu, Arduino A Mangoni, Salvatore Sotgia, Panagiotis Paliogiannis, Gian Luca Erre, Ciriaco Carru, Angelo Zinellu
BACKGROUND: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta-analysis comparing blood PTX-3 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics...
May 29, 2024: European Journal of Clinical Investigation
#50
JOURNAL ARTICLE
Fahimeh Bagheri Kholenjani, Shahla Shahidi, Golnaz Vaseghi, Vahid Ashoorion, Nizal Sarrafzadegan, Mansour Siavash, Maryam Heidarpour, Shahrzad Shahidi, Masoumeh Sadeghi, Noushin Mohammadifard, Masoumeh Jorjani, Majid Ghayour Mobarhan, Davood Shafie, Hossein Farshidi, Fariborz Khorvash, Mojdeh Ghabaei, Zahra Teimouri-Jervekani, Mojgan Mortazavi, Valiollah Hajhashemi, Neda Roshanravan, Leila Yazdanpanah, Majid Davari, Behzad Fatemi, Elaheh Khorasani, Ramesh Hoseinkhani, Elaheh Zarean, Alireza Ahmadi, Maryam Eghbali Babadi, Ahmadreza Assareh, Mehdi Shadmani, Javad Kojuri, Farimah Shirani, Mojgan Sanjari, Fahimeh Haghighatdoost, Razieh Hassannejad, Elham Hashemi, Mohammad Hassan Moaddab, Alaleh Gheisari, Bahar Dehghan, Mitra Naseri, Nosrat Ghaemi, Fereidoun Noohi, AliAkbar Haghdoost, Amin Salehi-Abargouei, Sara Beigrezaie, Amin Doosti-Irani, Nahid Ramezani-Jolfaie, Bijan Eraj, Mahin Hashemipour, Ebrahim Nematipour, Mahmoud Rafieian Kopaei
This guideline is the first Iranian guideline developed for the diagnosis, management, and treatment of hyperlipidemia in adults. The members of the guideline developing group (GDG) selected 9 relevant clinical questions and provided recommendations or suggestions to answer them based on the latest scientific evidence. Recommendations include the low-density lipoprotein cholesterol (LDL-C) threshold for starting drug treatment in adults lacking comorbidities was determined to be over 190 mg/dL and the triglyceride (TG) threshold had to be >500 mg/dl...
2024: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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JOURNAL ARTICLE
Ozgur Selim Ser, Serhat Sigirci, Kudret Keskin, Gokhan Cetinkal, Betul Balaban Kocas, Hakan Kilci, Yalcin Dalgic, Erol Kalender, Kadriye Kilickesmez
OBJECTIVES: Although the association of Atherogenic index of plasma (AIP) with coronary artery disease (CAD) and atherosclerosis is known, the relationship between AIP and in-stent restenosis (ISR) remains unclear. We aimed to investigate the relationship between AIP and ISR in patients with stable angina pectoris (SAP) treated with drug-eluting stent (DES). METHODS: Patients with a history of DES implantation following stable angina were evaluated between January 2015 and November 2019 in this observational and retrospective study...
2024: Şişli Etfal Hastanesi tıp bülteni
#52
REVIEW
Sheila Gato, Vanessa García-Fernández, Antonio Gil-Gómez, Ángela Rojas, Rocío Montero-Vallejo, Rocío Muñoz-Hernández, Manuel Romero-Gómez
The global prevalence of non-alcoholic fatty liver disease (NAFLD) is nearly 25% and is increasing rapidly. The spectrum of liver damage in NAFLD ranges from simple steatosis to non-alcoholic steatohepatitis, characterised by the presence of lobular inflammation and hepatocyte ballooning degeneration, with or without fibrosis, which can further develop into cirrhosis and hepatocellular carcinoma. Not only is NAFLD a progressive liver disease, but numerous pieces of evidence also point to extrahepatic consequences...
2024: European Cardiology
#53
JOURNAL ARTICLE
Sima Besharat, Farideh Sakhavi, Parsa Sookhtehsaraei, Mehrdad Teimoorian, Somayeh Livani, Alireza Norouzi, Taghi Amiriani
BACKGROUND: According to the significance of extraintestinal symptoms in inflammatory bowel disease (IBD) patients and their connection with obesity, we aimed to investigate the prevalence of fatty liver in IBD patients of Sayyad Shirazi Hospital in Gorgan, Iran, in relation to obesity, anthropometric indicators and body image in these patients. METHODS: Forty patients with IBD were recruited from all registered patients at the Golestan Research Center of Gastroenterology and Hepatology, following the specified inclusion and exclusion criteria...
2024: Caspian Journal of Internal Medicine
#54
RANDOMIZED CONTROLLED TRIAL
Ana Marija Masle, Aleksandar Kibel, Ivana Jukić, Petra Čičak, Kristina Selthofer-Relatić, Ana Stupin, Zrinka Mihaljević, Petar Šušnjara, Željka Breškić Ćurić, Tatjana Bačun, Ines Drenjančević
PURPOSE: This study investigated the effect of consumption of table eggs enriched with n-3 polyunsaturated fatty acids (n-3 PUFA), lutein, vitamin E and selenium on microvascular function, oxidative stress and inflammatory mediators in patients after acute coronary syndrome (ACS). PATIENTS AND METHODS: In a prospective, randomized, interventional, double-blind clinical trial, ACS patients were assigned to either the Nutri4 (N=15, mean age: 57.2 ± 9...
2024: Clinical Interventions in Aging
#55
JOURNAL ARTICLE
Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrera
BACKGROUND: Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich lipoproteins to the liver. Here, we examined whether the NAD(+ )-dependent deacetylase sirtuin 1 (SIRT1) regulates hepatic lipid accumulation by modulating VLDLR levels and the subsequent uptake of triglyceride-rich lipoproteins. METHODS: Rats fed with fructose in drinking water, Sirt1-/- mice, mice treated with the ER stressor tunicamycin with or without a SIRT1 activator, and human Huh-7 hepatoma cells transfected with siRNA or exposed to tunicamycin or different inhibitors were used...
May 28, 2024: Cell Communication and Signaling: CCS
#56
JOURNAL ARTICLE
Liangyun Guo, Huijing Yuan, Huayao Zhu, Jie Zhou, Zixin Wan, Yihua Zhou
BACKGROUND: Autophagy, as a regulator of cell survival, plays an important role in atherosclerosis (AS). Sperm associated antigen 5 (SPAG5) is closely associated with the classical autophagy pathway, PI3K/Akt/mTOR signaling pathway. This work attempted to investigate whether SPAG5 can affect AS development by regulating autophagy. METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with oxidized-low density lipoprotein (ox-LDL) to induce cell damage...
May 28, 2024: BMC Cardiovascular Disorders
#57
JOURNAL ARTICLE
Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly
The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here, by using gene silencing, blocking antibodies or soluble receptor fragments, we identify the low-density lipoprotein receptor (LDL-R) as a CCHFV entry factor. The LDL-R facilitates binding of CCHFV particles but does not allow entry of Hazara virus (HAZV), another member of the genus...
May 28, 2024: Nature Communications
#58
JOURNAL ARTICLE
Yi Jing, Ruo-Xin Cao, Xi Lei, Ze-Ling Wang, Xiang-Long Huang, Jing-Rui Di, Zhuo-Xin Mi, Xin Zhao, Meng Wang, Miao-Miao Jiang, Wen-Zhi Yang, Xue Li, Lin Miao, Han Zhang, Peng Zhang
The peel of Trichosanthes kirilowii Maxim, is considered one of the primary sources for Trichosanthis pericarpium in traditional Chinese medicine, exhibiting lipid-lowering properties. The impact on hyperlipidemia mice of the crude polysaccharide from the peel of T. Kirilowii (TRP) was investigated in this study. The findings revealed that TRP exhibited a significant improvement in hepatic lipid deposition. Moreover, it significantly decreased serum levels of TC, TG, and LDL-C, while concurrently increasing HDL-C...
May 23, 2024: Bioorganic Chemistry
#59
REVIEW
Amrita Shukla, Ankita Singh, Smriti Tripathi
The coronavirus disease 2019 (COVID-19) epidemic has evolved into an international public health concern. Its causing agent was SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a lipid bilayer encapsulated virus. Lipids have relevance in the host's viral cycle; additionally; viruses have been speculated to manipulate lipid signaling and production to influence the lipidome of host cells. SARS-CoV-2 engages the host lipid pathways for replication, like fatty acid synthesis activation via upregulation of AKT and SREBP pathway and inhibiting lipid catabolism by AMPK and PPAR deactivation...
May 28, 2024: J Am Nutr Assoc
#60
JOURNAL ARTICLE
Ogochukwu O Izuegbuna, Hannah O Olawumi, Olayide S Agodirin, Samuel A Olatoke
BACKGROUND: The lipid profile and atherogenic risk indices in Nigerian breast cancer patients are largely unknown. This study evaluated the lipid profile and atherogenic risk indices of breast cancer patients in Nigeria. METHODS: This study involved 45 primarily diagnosed breast cancer patients and 50 normal control subjects. Total cholesterol, triglyceride, and High-density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) was calculated according to Friedewald formula...
May 28, 2024: J Am Nutr Assoc
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