Fatemeh Zeynab Kiani, Ali Ahmadi
Comorbidities are common in chronic obstructive pulmonary disease (COPD) patients. This study was conducted to determine the prevalence of common comorbidities in patients with COPD compared with people without COPD. This cross-sectional, population-based study was performed on 6961 adults aged 35-70 years enrolled in the Shahrekord PERSIAN cohort study. Data (demographic and clinical characteristics, comorbidities, anthropometric and blood pressure measurements, laboratory, and spirometry tests) collection was performed according to the cohort protocol from 2015 to 2019...
January 15, 2021: Scientific Reports
Feng-You Kuo, Wei-Chun Huang, Pei-Ling Tang, Chin-Chang Cheng, Cheng-Hung Chiang, Hsiao-Chin Lin, Tzu-Jung Chuang, Shue-Ren Wann, Guang-Yuan Mar, Chun-Peng Liu, Juei-Tang Cheng, Ming-Chang Wu
BACKGROUND: Use of statin has been associated with reduced risk of cardiovascular diseases events and mortality. However, in patients with end-stage renal disease (ESRD), the protective effects of statin are controversial. To evaluate the impact of chronic statin use on clinical outcomes of patients with acute myocardial infarction (AMI) with ESRD. METHODS: We enrolled 8056 patients with ESRD who were initially diagnosed and admitted for first AMI from Taiwan's National Health Insurance Research Database...
January 15, 2021: Postgraduate Medical Journal
Natasha R Kumar, William A Grobman, Olivia Barry, Amelia C Clement, Nicola Lancki, Lynn M Yee
BACKGROUND: Hypertensive disorders of pregnancy are widespread and have long-standing implications for women's health. Historically, the management of "severe gestational hypertension," or the presence of severely elevated blood pressures without any other signs or symptoms of end-organ damage meeting the criteria for preeclampsia, has been unclear. The new American College of Obstetricians and Gynecologists guidelines based on expert opinion recommend that severe gestational hypertension be treated similarly to preeclampsia with severe features, but data regarding outcomes for women with this diagnosis have been limited...
January 2021: American journal of obstetrics & gynecology MFM
Gaurav Gulati, Robin Ruthazer, David DeNofrio, Amanda R Vest, David Kent, Michael S Kiernan
BACKGROUND: Elevated PVR is common in patients with advanced heart failure. PVR generally improves after LVAD implantation, but the rate of decrease has not been quantified and the patient characteristics most strongly associated with this improvement are unknown. METHODS AND RESULTS: We analyzed 1581 patients from the INTERMACS registry that received a primary continuous-flow LVAD, had baseline PVR ≥ 3 Wood units (WU), and had PVR measured at least once postoperatively...
January 12, 2021: Journal of Cardiac Failure
Danchen Wu, Asish Dasgupta, Austin D Read, Rachel E T Bentley, Mehras Motamed, Kuang-Hueih Chen, Ruaa Al-Qazazi, Jeffrey D Mewburn, Kimberly J Dunham-Snary, Elahe Alizadeh, Lian Tian, Stephen L Archer
The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO2 -responsive production of reactive oxygen species (ROS). These ROS are converted to a diffusible signaling molecule, hydrogen peroxide (H2 O2 ), by superoxide dismutase (SOD2). H2 O2 exits the mitochondria and regulates ion channels and enzymes, altering plasma membrane potential, intracellular Ca2+ and Ca2+ -sensitization and controlling acute, adaptive, responses to hypoxia that involve changes in ventilation, vascular tone and neurotransmitter release...
January 12, 2021: Free Radical Biology & Medicine
Hajime Yoshifuji, Sumika Kagebayashi, Hideyuki Kinoshita, Takao Fujii, Yoshiaki Okano, Masao Katsushima, Tsuneyo Mimori
Pulmonary arterial hypertension (PAH) is a rare complication of ANCA-associated vasculitis (AAV). We report a 37-year-old man with PAH complicated by both AAV and SSc who presented with dyspnea, cardiac enlargement, positive myeloperoxidase (MPO)-ANCA, anti-centromere antibodies, proteinuria, and urinary casts. Elevated pulmonary arterial pressure (58/22/34 mmHg) and low PAWP (2 mmHg) were confirmed by right heart catheterization. Treatment with glucocorticoids (GC) decreased urinary protein and serum MPO-ANCA; however, PAH did not respond to GC...
January 15, 2021: Immunological Medicine
Amber Bahorik, Kirsten Bobrow, Tina Hoang, Kristine Yaffe
AIM: To determine whether alcohol use disorder (AUD) is associated with increased dementia risk among older women veterans. DESIGN: Cohort study. SETTING: United States. PARTICIPANTS: Women veterans with AUD ≥55 years old (n=2207), receiving care from Veterans Health Administration medical centers from October 2004 to September 2015 with ≥1 follow-up visit, and an age-matched sample of women veterans without AUD (n=2207)...
January 15, 2021: Addiction
Ming Zhao, Jiali Wu, Haijing Wu, Amr H Sawalha, Qianjin Lu
There are two major clinical subsets of scleroderma: (i) systemic sclerosis (SSc) is a complex systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive fibrosis of the skin and multiple internal organs and (ii) localized scleroderma (LoS), also known as morphea, is confined to the skin and/or subcutaneous tissues resulting in collagen deposition and subsequent fibrosis. SSc is rare but is associated with significant morbidity and mortality compared with other rheumatic diseases...
January 15, 2021: Clinical Reviews in Allergy & Immunology
Haluk Türktaş, İ Kıvılcım Oğuzülgen
Though it has been 8 months since the beginning of COVID-19 pandemic, number of cases and deaths are still seriously increasing. We still don't have enough evidence about the prognosis of patients who had COVID-19 pneumonia. In long term follow up we wonder if they will have rapid FVC decline, widespread fibrosis in computed tomography, loss in quality of life or increased mortality that we experience in idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonia or autoimmune interstitial lung diseases...
December 2020: Tüberküloz Ve Toraks
Shinichiro Ikeda, Sathappan Kumar
No abstract text is available yet for this article.
September 2020: Journal of Cardiac Surgery
Zilong Zhang, Qiming Jing, Rui Qiao, Jiarui Yang, Haojie Chen, Lixiong Qian, Xuefang Zhang, Junsong Yang, Dingjun Hao
Objective: To investigate the risk factors of adjacent fractures after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fracture (OVCF). Methods: A total of 2 216 patients who received PVP due to symptomatic OVCF between January 2014 and January 2017 and met the selection criteria were selected as study subjects. The clinical data was collected, including gender, age, height, body mass, history of smoking and drinking, whether the combination of hypertension, diabetes, coronary arteriosclerosis, chronic obstructive pulmonary disease (COPD), bone mineral density, the number of fractured vertebrae, the amount of cement injected into single vertebra, the cement leakage, and whether regular exercise after operation, whether regular anti-osteoporosis treatment after operation...
January 15, 2021: Chinese Journal of Reparative and Reconstructive Surgery
Krishna Prasad, Pruthvi C Revaiah, Krishna Santosh Vemuri, Parag Barwad
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated pulmonary renal vasculitis is an uncommon disease entity. Its presentation as acute heart failure for the first time in a patient with established coronary artery disease (CAD) is even rarer. We present here a case of such an association and an approach to managing this clinical situation. Case summary: A 60-year-old male patient presented to the emergency room with recent-onset dyspnoea New York Heart Association Class IV...
December 2020: European Heart Journal. Case Reports
Yunshan Cao, Aqian Wang, Rong Wei, Yan Zhang
No abstract text is available yet for this article.
December 2020: European Heart Journal. Case Reports
Syed Aijaz Nasir, Sukhvinder Singh, Madhulata Fotedar, Sai Kiran Chaudhari, Kamal Kumar Sethi
Background: Chronic obstructive pulmonary disease (COPD) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload and subsequently right heart failure. Objectives: The aim of the study was to elucidate RV dysfunction at rest by echocardiography in a cohort of COPD patients and to study its impact on prognosis. Methods: 84 patients of COPD and 40 matching healthy controls were evaluated at baseline...
July 2020: Journal of Cardiovascular Echography
Jasmine L Dennis, Dustin Morrow, Julia A Cupp
Beta-thalassemia is an autosomal recessive hemoglobinopathy that can result in microcytic hypochromic anemia, splenomegaly, hypercoagulability, and long-term sequelae. Beta-thalassemia intermedia, specifically, is diagnosed based on the moderate severity of illness, which does not carry the early symptomatic urgency of beta-thalassemia major, although patients of both often become chronically or intermittently transfusion-dependent. A presenting symptom may be splenomegaly, which is most efficiently detected with a combination of physical examination and point-of-care ultrasound (POCUS)...
December 13, 2020: Curēus
Tao Zhang, Wei-Sen Huang, Weijie Guan, Ziying Hong, Jiabo Gao, Guoying Gao, Guofeng Wu, Yin-Yin Qin
Since December 2019, the pneumonia cases infected with 2019 novel coronavirus have appeared, posing a critical threat to global health. In this study, we performed a meta-analysis to discover the different clinical characteristics between severe and non-severe patients with COVID-19 to find the potential risk factors and predictors of this disease's severity, as well as to serve as a guidance for subsequent epidemic prevention and control work. PubMed, Cochrane Library, Medline, Embase and other databases were searched to collect studies on the difference of clinical characteristics of severe and non-severe patients...
December 2020: Journal of Thoracic Disease
Lili Li, Maojia Xu, Simon C Rowan, Katherine Howell, Adam Russell-Hallinan, Seamas C Donnelly, Paul McLoughlin, John A Baugh
While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory factor is a pleiotropic cytokine with endogenous tautomerase enzymatic activity as well as both intracellular and extracellular signalling functions. In several diseases, macrophage migration inhibitory factor has pro-inflammatory roles that are dependent upon signalling through the cell surface receptors CD74, CXCR2 and CXCR4...
October 2020: Pulmonary Circulation
Abdulrahman S Museedi, Abbas Alshami, Steven Douedi, Firas Ajam, Joseph Varon
Background: Several prediction models have been proposed to assess the short outcomes and in-hospital mortality among patients with heart failure (HF). Several variables were used in common among those models. We sought to focus on other, yet important risk factors that can predict outcomes. We also sought to stratify patients based on ejection fraction, matching both groups with different risk factors. Methods: We conducted a retrospective cohort study utilizing the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) 2016 database...
February 2021: Cardiology Research
Pengfei Li, Yan Wu, Andrew J Goodwin, Perry V Halushka, Carole L Wilson, Lynn M Schnapp, Hongkuan Fan
Pericytes apposed to the capillary endothelium are known to stabilize and promote endothelial integrity. Recent studies indicate that lung pericytes play a prominent role in lung physiology, and they are involved in the development of various lung diseases including lung injury in sepsis, pulmonary fibrosis, asthma, and pulmonary hypertension. Accordingly, human lung pericyte studies are important for understanding the mechanistic basis of lung physiology and pathophysiology; however, human lung pericytes can only be cultured for a few passages and no immortalized human lung pericyte cell line has been established so far...
January 14, 2021: Laboratory Investigation; a Journal of Technical Methods and Pathology
Kuang-Tsu Yang, Sin-Ei Juang, Yao-Min Hung, James Cheng-Chung Wei, Hei-Tung Yip, Renin Chang
Nontyphoidal salmonella (NTS) infection has a high mortality rate. Bowel resections affect gut microbiota and immune function, and the association between bowel resection and NTS infection in human beings has not been addressed. We conducted a nationwide propensity score (PS)-matched cohort study to clarify this association. Data from the Longitudinal Health Insurance Database of Taiwan were used to establish a case-cohort with bowel resections from 2000 to 2013. Informed consent was waived by the Institutional Review Board of China Medical University Hospital (CMUH104-REC2-115) because all personal identifying information used had been de-identified...
January 14, 2021: Scientific Reports
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