R Dale Brown, Kendall S Hunter, Min Li, Maria G Frid, Julie W Harral, Greta M Krafsur, Timothy N Holt, Jason Williams, Hui Zhang, Suzette R Riddle, Michael G Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B Graham, Lori A Walker, Franklyn B Garry, Peter M Buttrick, Tim Lahm, Vitaly O Kheyfets, Kirk C Hansen, Kurt R Stenmark
Right ventricular (RV) failure is the major determinant of outcome in pulmonary hypertension (PH). Calves exposed to 2-wks hypoxia develop severe PH and unlike rodents, hypoxia-induced PH in this species can lead to right heart failure. We therefore sought to examine the molecular and structural changes in the RV in calves with hypoxia-induced PH, hypothesizing that we could identify mechanisms underlying compensated physiological function in the face of developing severe PH. Calves were exposed to 14d of hypobaric hypoxia (PB =430 mm Hg, equivalent to 4570m elevation, n=29) or ambient normoxia (1525m, n=25)...
March 24, 2023: American Journal of Physiology. Heart and Circulatory Physiology