Monique Martins Melo, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco
INTRODUCTION: Cell therapy has emerged as an alternative option for chronic lung diseases with the highest rates of morbidity and mortality rates worldwide. AREAS COVERED: This review addresses the definition of mesenchymal stromal cells (MSCs), their properties, mechanisms of action, as well as preclinical and clinical studies that have used cell therapy in chronic lung diseases such as asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and silicosis...
March 25, 2023: Expert Review of Respiratory Medicine
Zhao Yang, Ping Li, Qun Yuan, Xi Wang, Hong-Hong Ma, Bing Zhuan
BACKGROUND: Pulmonary hypertension (PH) is a devastating disease characterized by vasoconstriction and vascular remodeling, leading to right ventricular failure and death. PH is a common complication of chronic obstructive pulmonary disease (COPD). Accumulating evidence demonstrate that microRNAs participate in the pathobiology of PH in COPD patients. In this study, we aimed to evaluate the expression and function of microRNA-4640-5p (miR-4640-5p) in PH. METHODS: The mRNA and protein levels were determined by quantitative polymerase chain reaction (qPCR) and western blot, separately...
March 24, 2023: Respiratory Research
Katherine Kearney, Edmund M Lau
No abstract text is available yet for this article.
March 24, 2023: Heart
Guolong Peng, Jialong Yan, Linxi Chen, Lanfang Li
Glycometabolism is well known for its roles as the main source of energy, which mainly includes three metabolic pathways: oxidative phosphorylation, glycolysis and pentose phosphate pathway. The orderly progress of glycometabolism is the basis for the maintenance of cardiovascular function. However, upon exposure to harmful stimuli, the intracellular glycometabolism changes or tends to shift toward another glycometabolism pathway more suitable for its own development and adaptation. This shift away from the normal glycometabolism is also known as glycometabolism reprogramming, which is commonly related to the occurrence and aggravation of cardiovascular diseases...
March 22, 2023: Progress in Biophysics and Molecular Biology
Antonio Siniscalchi, Cristiana Laici, Lucia Facciotto, Giovanni Vitale, Guido Fallani, Matteo Ravaioli, Amedeo Bianchini
Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for cardiovascular collapse during and after liver transplantation (LT). According to the most recent guidelines, patients with severe cardiomyopathy are excluded from LT because of high-mortality risk during surgery. Intraoperative ECMO support could give these patients the opportunity to undergo LT by reducing the risk of heart failure and reperfusion syndrome. In this case report, we present a case of veno-arterial ECMO (VA-ECMO) support started before LT surgery in a patient with severe pulmonary hypertension, mitral valve steno-insufficiency, and right heart dysfunction...
March 24, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
R Dale Brown, Kendall S Hunter, Min Li, Maria G Frid, Julie W Harral, Greta M Krafsur, Timothy N Holt, Jason Williams, Hui Zhang, Suzette R Riddle, Michael G Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B Graham, Lori A Walker, Franklyn B Garry, Peter M Buttrick, Tim Lahm, Vitaly O Kheyfets, Kirk C Hansen, Kurt R Stenmark
Right ventricular (RV) failure is the major determinant of outcome in pulmonary hypertension (PH). Calves exposed to 2-wks hypoxia develop severe PH and unlike rodents, hypoxia-induced PH in this species can lead to right heart failure. We therefore sought to examine the molecular and structural changes in the RV in calves with hypoxia-induced PH, hypothesizing that we could identify mechanisms underlying compensated physiological function in the face of developing severe PH. Calves were exposed to 14d of hypobaric hypoxia (PB =430 mm Hg, equivalent to 4570m elevation, n=29) or ambient normoxia (1525m, n=25)...
March 24, 2023: American Journal of Physiology. Heart and Circulatory Physiology
Bettina Hindsberger, Birgitte Lindegaard, Liv Rabøl Andersen, Simone Bastrup Israelsen, Lise Pedersen, Pal Bela Szecsi, Thomas Benfield
BACKGROUND: Chronic low-grade inflammation associated with a dysregulated adipose tissue might contribute to amplifying the inflammatory response in severe COVID-19. The aim of this study was to examine the association between levels of circulating leptin and adiponectin and the severity and mortality of COVID-19. METHODS: Serum levels of leptin and adiponectin were determined at admission in 123 individuals with confirmed COVID-19 and their association with 90-day mortality and respiratory failure was analyzed by logistic regression analysis and expressed as odds ratios (ORs) with 95% confidence intervals (CIs)...
2023: International Journal of Endocrinology
Fortune O Alabi, Christopher O Alabi, Brent Waldon, Fred C Umeh, George Palmer
Hyperbilirubinemia is a common gastrointestinal complication seen post-cardiac surgery. Here, we describe a case of a 72-year-old male with a past medical history of chronic obstructive pulmonary disease, chronic kidney disease (CKD), pulmonary hypertension, and valvular heart disease with severe aortic stenosis, severe mitral and tricuspid regurgitations who underwent elective aortic valve replacement (AVR), mitral valve replacement (MVR), and tricuspid valve (TV) repair; in addition, he required left thoracotomy for the repair of pulmonary artery perforation from a Swan-Ganz catheter that resulted in a large left pleural bleed...
February 2023: Curēus
Kyu Kyu, Tin Ko Ko, Zin Mar Lwin, May Kyi Soe, Kyaw Win Maw, Aung Myo Thant, Kyi Shin, Moe Kyaw Myint
Introduction During the coronavirus disease 2019 (COVID-19) pandemic, private hospitals in Mandalay started to manage COVID-19 infections according to national treatment guidelines since February 2021. Variations of clinical characteristics and their outcomes in different surges could be evaluated in the private hospital. This study aimed to assess the clinical profile and outcomes of COVID-19 patients admitted at a private hospital during three surges in Mandalay. Methods This study is a retrospective record review of the case series of COVID-19 patients admitted at City Hospital, Mandalay...
February 2023: Curēus
Abdulla Ahmed, Salaheldin Ahmed, Daniel Kempe, Göran Rådegran
AIMS: Estimation of prognosis in pulmonary arterial hypertension (PAH) has been influenced by that various risk stratification models use different numbers of prognostic parameters, as well as the lack of a comprehensive and time-saving risk assessment calculator. We therefore evaluated the various European Society of Cardiology (ESC)-/European Respiratory Society (ERS)-based three- and four-strata risk stratification models and established a comprehensive internet-based calculator to facilitate risk assessment...
March 2023: Eur Heart J Open
Yuen Tsang, Risho Singh, Sumit Verma, Sumeet Panjabi
INTRODUCTION: Patients with connective tissue disorders (CTD) and pulmonary arterial hypertension (PAH) have a poorer prognosis than those with other PAH etiologies. This study assessed the impact of CTD on healthcare outcomes among PAH patients with and without CTD comorbidities that were treated with oral selexipag. METHODS: The study utilized Optum's de-identified Clinformatics® Data Mart Database (2007-2021) from January 1, 2014 to June 30, 2019, and identified patients with PAH without CTD and PAH with CTD treated with oral selexipag...
March 23, 2023: Rheumatology and Therapy
Anindya Kumar Saha, Moumita Ghosh, Syamal Sardar, Somnath Pal
The aim of this study was to compare conventional and tissue Doppler echocardiography parameters between transient tachypnea of the newborn (TTN) and healthy control infants. This cross sectional pilot observational study was conducted in a level 3 neonatal care unit of India. Consecutively born late preterm and term infants (LPTI) with TTN were eligible for enrollment. Control group was selected from healthy LPTI. Conventional and tissue Doppler (myocardial velocities, myocardial performance index (MPI)) echocardiography was done within first 12 h (D1) and 48-72 h (D3) of life...
March 24, 2023: European Journal of Pediatrics
Badiaa Lyoussi, Meryem Bakour, Khadija Cherkaoui-Tangi, Jaouad El-Hilaly, Christophe Hano
Herbal medicine was used since the old time in the treatment of different types of diseases in Sefrou province, Morocco. However, few studies have been carried out to identify local medicinal flora and to scientifically document the knowledge of the traditional use of these medicinal plants by the population. This study aims to investigate the medicinal plants in Sefrou province, record their usage in folk medicine by the population and evaluate the hypotensive effect of selected plants using in vitro vascular activity...
March 13, 2023: Frontiers in Bioscience (Scholar Edition)
Rachael F Grace, Eduard J van Beers, Joan-Lluis Vives Corrons, Bertil Glader, Andreas Glenthøj, Hitoshi Kanno, Kevin H M Kuo, Carl Lander, D Mark Layton, Dagmar Pospíŝilová, Vip Viprakasit, Junlong Li, Yan Yan, Audra N Boscoe, Chris Bowden, Paola Bianchi
INTRODUCTION: Pyruvate kinase (PK) deficiency is a rare, under-recognised, hereditary condition that leads to chronic haemolytic anaemia and potentially serious secondary complications, such as iron overload, cholecystitis, pulmonary hypertension and extramedullary haematopoiesis. It is an autosomal recessive disease caused by homozygous or compound heterozygous mutations in the PKLR gene. Due to its rarity and clinical heterogeneity, information on the natural history and long-term clinical course of PK deficiency is limited, presenting major challenges to patient management, the development of new therapies and establishing disease-specific treatment recommendations...
March 23, 2023: BMJ Open
Thomas Koudstaal, Karin A Boomars
No abstract text is available yet for this article.
March 2023: European Respiratory Journal
Binghao Ma, Yuanyuan Cao, Jia Qin, Zhuo Chen, Gaoyun Hu, Qianbin Li
Pulmonary arterial hypertension (PAH) is a currently incurable pulmonary vascular disease. Since current research on PAH is mainly aimed at the middle and late stages of disease progression, no satisfactory results have been achieved. This has led researchers to focus on the early stages of PAH. This review highlights for the first time a key event in the early stages of PAH progression, namely, the occurrence of pulmonary arterial smooth muscle cell (PASMC) phenotypic switching. Summarizing the related reports of performance conversion provides new perspectives and directions for the early pathological progression and treatment strategies for PAH...
March 21, 2023: Drug Discovery Today
Yangyi Lin, Lingpin Pang, Shian Huang, Jieyan Shen, Weifeng Wu, Fangming Tang, Weiqing Su, Xiulong Zhu, Jingzhi Sun, Ruilin Quan, Tao Yang, Huijun Han, Jianguo He
INTRODUCTION: Pulmonary hypertension due to left heart failure (PH-LHF) is a disease with high prevalence and 3-year mortality rates. Consequently, timely identification of patients with high mortality risk is critical. This study aimed to build a nomogram for predicting 3-year mortality and screening high-risk PH-LHF patients. METHODS: This nomogram was developed on a training cohort of 175 patients with PH-LHF diagnosed by right heart catheterization (RHC). Multivariate Cox regression was used to identify independent predictors and develop this nomogram...
March 23, 2023: Cardiology
Prabhakar Shantha Rajiah, María José Sardá, Ravi Ashwath, Harold Goerne
Palliative procedures are performed for congenital heart diseases that are not amenable for definitive surgical procedures or as a component of hybrid procedures along with transcatheter interventions. Multimodality imaging plays an important role in the follow-up of these palliative procedures, mainly for the timely detection of complications and for planning any subsequent palliative or definitive procedure. Echocardiography is the first-line imaging modality, with CT and MRI used as complementary techniques in indeterminate cases...
April 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Rozenn Quarck, Harm Jan Bogaard, Marion Delcroix
No abstract text is available yet for this article.
March 23, 2023: American Journal of Respiratory and Critical Care Medicine
Dirk Van Raemdonck, Robin Vos, Geert M Verleden, Laurens J Ceulemans
No abstract text is available yet for this article.
March 23, 2023: European Journal of Cardio-thoracic Surgery
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