Xiaohao Zhang, Wenbo Zhao, Xinxin Ma, Yuanqing Li, Hongli Shang, Jun Zhang, Zengchun Ye, Xun Liu, Tanqi Lou, Yu Peng, Hui Peng
BACKGROUND: Pulmonary hypertension is common in chronic kidney disease (CKD) patients. However, the prognostic value of pulmonary hypertension in Chinese predialytic CKD patients is rarely reported. We evaluated the relevant factors and prognostic value of pulmonary hypertension in CKD patients. METHODS: This retrospective cohort study enrolled 1092 predialytic patients from The Third Affiliated Hospital of Sun Yat-Sen University from May 1st, 2011, to December 31st, 2016...
August 7, 2020: International Urology and Nephrology
Zhaohuan Li, Jing Tan, Xuebing Liu, Wenjun Zhang, Qingguo Meng, Mi Zhou, Ni Lin, Fei Cao, Jing Lu, Jun Liu, Lixue Yin
Use of echocardiography to evaluate the characteristics of right heart and pulmonary artery of Tibetans with hepatic hydatidosis living in a high plateau area. We recruited 222 Tibetan adults diagnosed with hydatidosis from June 2016 to June 2017 in Shiqu and Seda areas of Tibet; 40 healthy control from the same area, denoted as the high plateau group. We also include 755 Healthy adults of Han nationality living in the plain from the EMINCA study as the low altitude group. Compared to high plateau group, hydatidosis individuals showed decreased RVADed, RVTDed, increased E(T)/A(T) and reduced RVFAC and TAPSE (p < 0...
August 6, 2020: International Journal of Cardiovascular Imaging
Anna Csiszar, Ferenc Jakab, Teresa G Valencak, Zsófia Lanszki, Gábor Endre Tóth, Gábor Kemenesi, Stefano Tarantini, Vince Fazekas-Pongor, Zoltan Ungvari
Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From the epidemiological data, the picture emerges that the more severe etiopathologies among COVID-19 patients are found in elderly people. The risk of death due to COVID-19 increases exponentially with age. Eight out of 10 COVID-19 related deaths occur in people older than 65 years of age. Older patients with comorbid conditions such as hypertension, heart failure, diabetes mellitus, asthma, chronic obstructive pulmonary disease, and cancer have a much higher case fatality rate...
August 7, 2020: GeroScience
Thibaud Soumagne, Jean-Baptiste Lascarrou, Sami Hraiech, Geoffroy Horlait, Julien Higny, Alain d'Hondt, David Grimaldi, Stéphane Gaudry, Romain Courcelle, Giuseppe Carbutti, Gauthier Blonz, Nadia Aissaoui, Christophe Vinsonneau, Benoit Vandenbunder, Julien Textoris, Piotr Szychowiak, Nicolas Serck, Bertrand Sauneuf, Michael Piagnerelli, Andre Ly, François Lejeune, Laurent Lefebvre, Gaël Piton
Risk factors associated with pulmonary embolism in coronavirus disease 2019 acute respiratory distress syndrome patients deserve to be better known. We therefore performed a post hoc analysis from the COronaVirus-Associated DIsease Study (COVADIS) project, a multicenter observational study gathering 21 ICUs from France ( n = 12) and Belgium ( n = 9). Three-hundred seventy-five consecutive patients with moderate-to-severe acute respiratory distress syndrome and positive coronavirus disease 2019 were included in the study...
July 2020: Critical care explorations
Ting Wu, Zhihong Zuo, Shuntong Kang, Liping Jiang, Xuan Luo, Zanxian Xia, Jing Liu, Xiaojuan Xiao, Mao Ye, Meichun Deng
This study aimed to provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development. Several online databases were searched for articles published until May 13, 2020. Two investigators independently selected trials, extracted data, and evaluated the quality of individual trials. Single-arm meta-analysis was performed to summarize the clinical features of confirmed COVID-19 patients. Fixed effects meta-analysis was performed for clinically relevant parameters that were closely related to the patients' various organ functions...
July 2020: Aging and Disease
Songqiao Liu, Huanyuan Luo, Yuancheng Wang, Luis E Cuevas, Duolao Wang, Shenghong Ju, Yi Yang
BACKGROUND: Coronavirus Disease-2019 (COVID-19) pandemic has become a major health event that endangers people health throughout China and the world. Understanding the factors associated with COVID-19 disease severity could support the early identification of patients with high risk for disease progression, inform prevention and control activities, and potentially reduce mortality. This study aims to describe the characteristics of patients with COVID-19 and factors associated with severe or critically ill presentation in Jiangsu province, China...
August 6, 2020: BMC Infectious Diseases
Jia Shi, Yi Yang, Anying Cheng, Gang Xu, Fan He
Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer of arteries and are essential for arterial physiology and pathology. It is becoming increasingly clear that VSMCs can alter their metabolism to fulfill the bio-energetic and biosynthetic requirements. During vascular injury, VSMCs switch from a quiescent "contractile" phenotype to a highly migratory and proliferative "synthetic" phenotype. Recent studies find that the phenotype switching of VSMCs is driven by a metabolic switch...
August 7, 2020: American Journal of Physiology. Heart and Circulatory Physiology
Shuji Nagatomi, Kazuhisa Matsumoto, Ryo Imada, Fumiya Ono, Shuji Tachioka, Yutaka Imoto
Iatrogenic atrial septal defect is an issue after percutaneous interventions for structural heart disease. A 63-year-old man, who had previously received 5 catheter ablations for paroxysmal atrial fibrillation, was found to have an iatrogenic atrial septal defect that persisted after the fourth intervention. Approximately 4 years later, he suffered exertional dyspnea. Pulmonary hypertension was caused by a left-to-right shunt via a large iatrogenic atrial septal defect. We performed surgical closure and the symptom improved...
August 6, 2020: Asian Cardiovascular & Thoracic Annals
V Katsi, G Skalis, G Vamvakou, D Tousoulis, T Makris
PURPOSE OF REVIEW: Hypertension affects approximately 10% of pregnancies and may persist in the postpartum period. Furthermore, de novo hypertension may present after delivery, but its exact prevalence is not verified. Both types of hypertension expose the mother to eventually severe complications like eclampsia, stroke, pulmonary edema, and HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome. RECENT FINDINGS: Until today, there are limited data regarding the risk factors, pathogenesis, and pathophysiology of postpartum hypertensive disorders...
August 6, 2020: Current Hypertension Reports
Philip Houck, Hari Dandapantula, Evan Hardegree, Janet Massey
Is the definition of heart failure too narrow, not allowing research into compensatory mechanisms, comorbidities, right heart function, and lymphatic function? A review of the absolute mortality of heart failure drugs and devices suggests a modest improvement in outcomes. Absolute mortality from common comorbidities, including renal insufficiency, arrhythmia, conduction deficits, pulmonary hypertension, anemia, obstructive sleep apnea, infection, inflammation, edema, ischemic heart disease, and diabetes II, is significant...
June 30, 2020: Curēus
Minxuan Liu, Gina Galli, Yilin Wang, Qiru Fan, Zhenzhong Wang, Xin Wang, Wei Xiao
Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways...
2020: Frontiers in Physiology
Lisa Duffett, Lana A Castellucci, Melissa A Forgie
Pulmonary embolism is a common and potentially fatal cardiovascular disorder that must be promptly diagnosed and treated. The diagnosis, risk assessment, and management of pulmonary embolism have evolved with a better understanding of efficient use of diagnostic and therapeutic options. The use of either clinical probability adjusted or age adjusted D-dimer interpretation has led to a reduction in diagnostic imaging to exclude pulmonary embolism. Direct oral anticoagulation therapies are safe, effective, and convenient treatments for most patients with acute venous thromboembolism, with a lower risk of bleeding than vitamin K antagonists...
August 5, 2020: BMJ: British Medical Journal
Esko Wiltshire, Alexia Sophie Peña, Karen MacKenzie, Geoffrey Shaw, Jennifer Couper
BACKGROUND: Pulmonary hypertension is a significant complication for some patients with COVID-19 pneumonia, especially those requiring intensive care. Tachyphylaxis to the current therapy, inhaled nitric oxide (iNO), is also common. In vitro, folic acid directly increases nitric oxide (NO) production and extends its duration of action; effects which could be of benefit in reversing pulmonary hypertension and severe hypoxaemia. Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS)...
July 26, 2020: Medical Hypotheses
Rosemary Gan, Nicholas P Rosoman, David J E Henshaw, Euan P Noble, Peter Georgius, Nigel Sommerfeld
SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a common fatal pulmonary profile but with striking differences in presentation, clinical course, and response to treatment. In contrast to SARS-CoV-1 (SARS), COVID-19 has presented as an often bi-phasic, multi-organ pathology, with a proclivity for severe disease in the elderly and those with hypertension, diabetes and cardiovascular disease. Whilst death is usually related to respiratory collapse, autopsy reveals multi-organ pathology...
June 23, 2020: Medical Hypotheses
Subham Das, K R Anu, Sumit Raosaheb Birangal, Ajinkya Nitin Nikam, Abhijeet Pandey, Srinivas Mutalik, Alex Joseph
Pandemic coronavirus disease-2019, commonly known as COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious disease with a high mortality rate. Various comorbidities and their associated symptoms accompany SARS-CoV-2 infection. Among the various comorbidities like hypertension, cardiovascular disease and chronic obstructive pulmonary disease, diabetes considered as one of the critical comorbidity, which could affect the survival of infected patients. The severity of COVID-19 disease intensifies in patients with elevated glucose level probably via amplified pro-inflammatory cytokine response, poor innate immunity and downregulated angiotensin-converting enzyme 2...
August 3, 2020: Life Sciences
Mountasser Al-Mouqdad, Adli Abdelrahim, Nabeel Abdullah Alodhaidan, Haider Hussein Sumaily, Thanaa Mustafa Khalil, Yasmeen Asfour, Suzan Suhail Asfour
BACKGROUND: Premature non-Saudi infants comprise a significant proportion of neonatal intensive care unit admissions in Saudi Arabia. Any differences in antenatal care of mothers and neonatal outcomes compared with premature Saudi infants are unreported. OBJECTIVE: Assess antenatal care of mothers and neonatal outcomes among premature Saudi and non-Saudi infants, and investigate possible reasons for disparities. DESIGN: Retrospective cohort study...
July 2020: Annals of Saudi Medicine
Avinash Khandagale, Mikael Åberg, Gerhard Wikström, Sara Bergström Lind, Ganna Shevchenko, Erik Björklund, Agneta Siegbahn, Christina Christersson
OBJECTIVE: Extracellular vesicles (EVs) have the potential to act as intercellular communicators. The aims were to characterize circulating EVs in patients with pulmonary arterial hypertension (PAH) and to explore whether these EVs contribute to endothelial activation and angiogenesis. Approach and Results: Patients with PAH (n=70) and healthy controls (HC; n=20) were included in this cross-sectional study. EVs were characterized and human pulmonary endothelial cells (hPAECs) were incubated with purified EVs...
August 6, 2020: Arteriosclerosis, Thrombosis, and Vascular Biology
Victoria Birlutiu, Rares Mircea Birlutiu, Alin Iulian Feiereisz
RATIONALE: Syncope is described as the loss of consciousness and postural muscle tone with a short duration and fast onset. Micturition syncope can be caused by abnormal vasovagal response or by the dysfunction of the blood pressure regulating mechanism, which occurs before, during, or immediately after urination. PATIENT CONCERNS: We present 4 cases of COVID-19 hospitalized in the Department of Infectious Diseases of the Academic Emergency Hospital Sibiu, Romania, cases that presented micturition syncope...
July 31, 2020: Medicine (Baltimore)
Kuang-Hsi Chang, Yi-Chao Hsu, Ing-Ming Chiu, Lih-Chyang Chen, Chih-Chao Hsu, Chang-Yin Lee, Hueng-Chuen Fan, Hsuan-Ju Chen, Ruey-Hwang Chou
Whether periodontitis is a risk factor for developing bipolar disorders (BD) has not been investigated. We aimed to determine whether periodontitis is associated with the subsequent development of BD and examine the risk factors for BD among patients with periodontitis.Using ambulatory and inpatient claims data from the National Health Insurance Research Database (NHIRD), we identified 12,337 patients who were aged at least 20 years and newly diagnosed with periodontitis between 2000 and 2004. The date of the first claim with a periodontitis diagnosis was set as the index date...
July 31, 2020: Medicine (Baltimore)
Fanhao Ye, Wenbing Jiang, Wei Lin, Yi Wang, Hao Chen, He Zou, Shiwei Huang, Ning Zhu, Sisi Han
RATIONALE: BMPR2 mutation is the most common cause of heritable pulmonary arterial hypertension (HPAH), but rare in hereditary hemorrhagic telangiectasia (HHT). ACVRL1, ENG and SMAD4 are the most common gene mutations reported in HPAH with HHT. PATIENT CONCERNS: We report a 11-year-old boy with a definite diagnosis of pulmonary hypertension and suspected HHT with recurrent epistaxis. The results of gene detection showed that there was a nosense mutation in BMPR2...
July 31, 2020: Medicine (Baltimore)
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