Taijyu Satoh, Nobuhiro Yaoita, Kotaro Nochioka, Shunsuke Tatebe, Hideka Hayashi, Saori Yamamoto, Haruka Sato, Hiroyuki Takahama, Hideaki Suzuki, Yosuke Terui, Kaito Yamada, Yusuke Yamada, Takumi Inoue, Tatsuo Aoki, Kimio Satoh, Koichiro Sugimura, Satoshi Miyata, Satoshi Yasuda
AIMS: The pathophysiology of pulmonary hypertension (PH) due to left-sided heart disease (Group 2 PH) is distinct from that of other groups of PH, yet there are still no approved therapies that selectively target pulmonary circulation. The increase in pulmonary capillary pressure due to left-sided heart disease is a trigger event for physical and biological alterations of the pulmonary circulation, including the nitric oxide (NO)-soluble guanylate cyclase-cyclic guanosine monophosphate axis...
September 29, 2023: ESC Heart Failure
Krit Dwivedi, Michael Sharkey, Samer Alabed, Curtis P Langlotz, Andy J Swift, Christian Bluethgen
OBJECTIVES: There is a need for CT pulmonary angiography (CTPA) lung segmentation models. Clinical translation requires radiological evaluation of model outputs, understanding of limitations, and identification of failure points. This multicentre study aims to develop an accurate CTPA lung segmentation model, with evaluation of outputs in two diverse patient cohorts with pulmonary hypertension (PH) and interstitial lung disease (ILD). METHODS: This retrospective study develops an nnU-Net-based segmentation model using data from two specialist centres (UK and USA)...
September 29, 2023: European Radiology
Sara A Assiri, Rahaf Ghazi Altwairqi, Raneem Alotaibi, Mohammed Ibrahim
The incidence of sebaceous carcinoma (SC) in the outer one-third of the external auditory canal is considered extremely rare, and only eight case reports have been published. We present a case of a male patient in his late 70s known case of hypertension on indapamide. His medical history included a postspinal tumour that had been treated with surgery and radiation more than 40 years ago and current complaints of right ear pain and purulent discharge. A right ear soft granular tissue mass was found. Complete debulking of the right ear mass was done in conjunction with middle ear exploration, moderately differentiated SC diagnosis was made based on the histopathological analysis...
September 29, 2023: BMJ Case Reports
Qasim Gohir, Shilajit Ghosh, Olivia Bosher, Emma Crawford, Koottalai Srinivasan, Harmesh Moudgil
Refractory hypoglycaemia in a patient with a solitary fibrous tumour (SFT) is very rare and was first reported in 1930 independently by Doege and Potter, leading to it being named 'Doege-Potter syndrome'. Here, we report the unusual case of a 77-year-old woman with a giant solitary fibrous pleural tumour who presented with complicating pulmonary hypertension and associated heart failure with hypoglycaemia, and subsequently underwent curative resection of the pleural mass with clinical improvement.
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Ruta Virsinskaite, Nina Karia, Tushar Kotecha, Benjamin E Schreiber, J Gerry Coghlan, Daniel S Knight
Pulmonary hypertension (PH) is common, with an estimated prevalence of approximately 1% that increases with age. Prompt and accurate diagnosis is key to institute timely and appropriate therapy to improve symptoms and prognosis. The international guidelines for the diagnosis and management of PH have recently been updated, with a lowering of the haemodynamic threshold for diagnosis to a mean pulmonary artery pressure >20 mmHg. New diagnostic algorithms and revised indications for screening in at-risk groups have been developed to facilitate early referral to specialist PH centres...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Taro Yasuma, Hajime Fujimoto, Corina N D'Alessandro-Gabazza, Esteban C Gabazza, Osamu Hataji, Tetsu Kobayashi
No abstract text is available yet for this article.
September 29, 2023: American Journal of Respiratory and Critical Care Medicine
Allison E Norlander, Anna R Hemnes, R Stokes Peebles
No abstract text is available yet for this article.
September 29, 2023: American Journal of Respiratory and Critical Care Medicine
Qinghou Zheng, Bin Zhang, Na Lu, Xinyi Li, Beibei Jin, Pingkui Jin
OBJECTIVE: This paper aimed to unveil the diagnostic values of serum brain natriuretic peptide (BNP), pentraxin 3 (PTX3), and vascular endothelial growth factor (VEGF) in acute pulmonary embolism complicated by pulmonary artery hypertension (APE-PAH) and their correlations with severity of PAH. METHODS: A total of 153 patients with APE were selected for our study and divided into the PAH and Non-PAH groups according to the measurement of pulmonary artery pressure by echocardiography...
September 2023: Immunity, Inflammation and Disease
Jessica L Fairley, Laura Ross, Andrew Burns, David Prior, Matthew Conron, Hannah Rouse, Julie McDonald, Andrew MacIsaac, André La Gerche, Kathleen Morrisroe, Nava Ferdowsi, Alannah Quinlivan, Zoe Brown, Wendy Stevens, Mandana Nikpour
Cardiopulmonary complications of connective tissue diseases (CTDs), particularly pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD), are major determinants of morbidity and mortality. Multidisciplinary meetings may improve diagnostic accuracy and optimise treatment. We review the literature regarding multidisciplinary meetings in CTD-ILD and PAH and describe our tertiary centre experience of the role of the multidisciplinary meeting in managing CTD-PAH.
September 29, 2023: Internal Medicine Journal
Anuradha Singh, Ailish Coblentz, Fatemeh Hadian, Rose Chami, Ben Traubici, David E Manson
BACKGROUND: Small air-filled peripheral subpleural cysts are a well-described feature of pulmonary anatomy at computerized tomographic (CT) scan in children with Trisomy 21, yet only anecdotally described in association with other pathologies. The significance of these cysts is unknown. OBJECTIVE: To investigate and explore the pathogenesis of these subpleural cysts in children. MATERIALS AND METHODS: A retrospective review of 16 cases with subpleural cysts diagnosed on CT chest was performed...
September 29, 2023: Pediatric Pulmonology
Adam Engel Sällberg, Sara Helleberg, Salaheldin Ahmed, Abdulla Ahmed, Göran Rådegran
AIMS: Patients with heart failure (HF) exhibit poor prognosis, which is further deteriorated by pulmonary hypertension (PH), with negative impact on morbidity and mortality. As PH due to left HF (LHF-PH) is among the most common causes of PH, there is an urge according to the 2021 European Society of Cardiology HF guidelines to find new biomarkers that aid in prognostication of this patient cohort. Given the role of tumour necrosis factor-alpha (TNF-α) in HF progression, we aimed to investigate the prognostic value of plasma proteins related to TNF-α in patients with LHF-PH, in relation to haemodynamic changes following heart transplantation (HT)...
September 29, 2023: ESC Heart Failure
Mei-Tzu Wang, Pei-Ling Chi, Chin-Chang Cheng, Wei-Chun Huang, Lee-Wei Chen
BACKGROUND: Current guideline-recommended multiparameters used to assess the risk levels of pulmonary arterial hypertension (PAH) are invasive hemodynamic measurements or effort-dependent exercise tests. Serum natriuretic peptide is only one kind of effort-free biomarker that has been adopted for risk assessment. This study aimed to investigate the application of homocysteine as a non-invasive and effort-free measurement for the risk assessment of patients with PAH. METHODS: Samples of 50 patients diagnosed with PAH via right heart catheterization were obtained, and the patients were divided into low-, intermediate- and high-risk groups for further analysis...
September 29, 2023: Cardiology Journal
Qian Li, Hu Zhang
Pulmonary arterial hypertension (PAH) is a rapidly progressing cardiopulmonary disease. It is characterized by increased pulmonary artery pressure and vascular resistance. The most notable histopathological characteristic is vascular remodeling. The changes in the basement membrane (BM) are believed to be related to vascular remodeling. It is crucial to identify potential biomarkers associated with the BM in PAH, to guide its treatment. The microarray datasets GSE117261 and GSE113439 were downloaded from the Gene Expression Omnibus...
2023: Open Life Sciences
Rajkumar Kundavaram, Praveen Kumar, Shikha Malik, Girish Bhatt, Priya Gogia, Amber Kumar
BACKGROUND: Asthma is characterized by chronic inflammation and remodeling of pulmonary vessels and airway wall resulting in pulmonary hypertension (PH). Increased afterload on right ventricle (RV) myocardium leads to RV diastolic dysfunction (RVDD). Echocardiography is an excellent tool to detect these changes early. Using echocardiography, we assessed the impact of clinical asthma phenotypes on myocardial performance and PH in children with asthma. MATERIALS AND METHODS: Sixty children with moderate or severe persistent asthma and 60 age and gender-matched healthy controls were enrolled...
August 2023: Curēus
Nia Dyah Rahmianti, Lucia Kris Dinarti, Hasanah Mumpuni, Fita Triastuti
OBJECTIVES: The objectives of the study were to determine the association between global longitudinal strain right ventricle (GLS-RV) and mean pulmonary artery pressure (mPAP) on secundum atrial septal defect (ASD) with pulmonary hypertension (PH). METHODS: This study was an analytic observational with the cross-sectional approach. This study was conducted with secundum ASD patients who underwent right heart catheterization (RHC) from February 2019 to July 2019 at Sardjito General Teaching Hospital Yogyakarta...
2023: Journal of Cardiovascular Echography
Dini Pusianawati, Alfonsus Zeus Suryawan, Kevin Dominique Tjandraprawira, Charlotte J Cool
Little awareness persists of how pregnancy worsens cardiac diseases. We wish to highlight the challenges in managing pulmonary hypertension (PH) in pregnancy, within low socioeconomic environments. A 31-year-old G3P1A1 of 5 months gestation presented with worsening dyspnea and extremital edema. She had a history of heart disease with no cardiologist follow-up. She was diagnosed with type I/II PH at 4 months gestation. Her ultrasound revealed intrauterine fetal death (IUFD). She was referred for pregnancy termination...
2023: SAGE Open Medical Case Reports
Seiji Hosaka, Yasuhiko Fujita, Teruyoshi Amagai
Symptomatic isolated celiac artery (CA) dissection (SICAD) is an extremely rare form of visceral artery dissection. It is diagnosed by a contrast abdominal computed tomography (CT) scan showing a CA dissection (CAD). There are 4 types of CAD: Type I-IV. Type I has entry and re-entry and no true luminal narrowing. All types other than type I have entry and re-entry. They have true lumen compression and true lumen constriction due to false lumen. We report a case with the longest follow-up, 120 months after symptom onset, without evidence of CAD exacerbation...
December 2023: Radiology Case Reports
Shuai-Shuai Zhao, Jinlong Liu, Qi-Cai Wu, Xue-Liang Zhou
Pulmonary arterial hypertension (PAH) is a severe disease resulting from progressive increases in pulmonary vascular resistance and pulmonary vascular remodeling, ultimately leading to right ventricular failure and even death. Hypoxia, inflammation, immune reactions, and epigenetic modifications all play significant contributory roles in the mechanism of PAH. Increasingly, epigenetic changes and their modifying factors involved in reprogramming through regulation of methylation or the immune microenvironment have been identified...
2023: Frontiers in Cell and Developmental Biology
Oleg V Mazurenko, Georgiy G Roshchin, Ivan Yo Slychko
INTRODUCTION: The Russian invasion of Ukraine in 2022 has affected more people and destroyed a local public health facility. When some territories in Ukraine were de-occupied, national and international mobile clinics (MCs) were involved for medical assistance to local inhabitants. Knowledge about population health, medical, and humanitarian needs after they have been de-occupied has to improve planning for health system response. OBJECTIVE: The aim of this study was to summarized the MC experience at the first month after the area was de-occupied, as well as to show out-patient visits and to identify a need for medicines and medical equipment in the MC...
September 29, 2023: Prehospital and Disaster Medicine
Timothy A Morris, Timothy M Fernandes, Jina Chung, Janine R E Vintch, W Cameron McGuire, Suman Thapamagar, Mona Alotaibi, Savannah Aries, Khadizhat Dakaeva
BACKGROUND: Chronic dyspnoea and exercise impairment are common after acute pulmonary embolism (PE) but are not defined and quantified sufficiently to serve as outcomes in clinical trials. The planned project will clinically validate a novel method to determine discrete, clinically meaningful diagnoses after acute PE. The method uses an algorithm entitled SEARCH, for <u>s</u>ymptom screen, <u>e</u>xercise testing, <u>a</u>rterial perfusion, <u>r</u>esting echocardiography, <u>c</u>onfirmatory imaging and <u>h</u>aemodynamic measurements...
September 28, 2023: BMJ Open
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