Ryan J Lowhorn, Mohammed Chowdhury, Symon Kimitei, Sammie Haskin, Mohammad Masum, A K M Fazlur Rahman
By August 17, 2021, 4.3 million people had died globally as a result of SARS-CoV-2 infection. While data collection is ongoing, it is abundantly obvious that this is one of the most significant public health crises in modern history. Consequently, global efforts are being made to attain a greater understanding of this disease and to identify risk factors associated with more severe outcomes. The goal of this study is to identify clinical characteristics and risk factors associated with COVID-19 mortality in Mexico...
2024: PloS One
Xu Lan, Fei Yi Dong, Jia Jia Duan
BACKGROUND Duplicate inferior vena cava (IVC) accompanied by deep venous thrombosis is rare. The optimal treatment plan is determined according to the results of imaging, including venography. In this report, we present a case of successful treatment of a patient with duplicate IVC and deep venous thrombosis (DVT). CASE REPORT An 84-year-old man with history of hypertension was admitted to the hospital because of 4 days of moderate left lower-limb edema. A thorough examination led to the diagnosis of the DVT...
April 17, 2024: American Journal of Case Reports
Matthew T Siuba, Megan G Sharpe, James Lane, David Toth, Deborah Paul, Xiaofeng Wang, Adriano R Tonelli
No abstract text is available yet for this article.
April 17, 2024: European Journal of Preventive Cardiology
R Corroenne, M Meot, L J Salomon, I Szezepanski, H Baghdadi, B Stos, M Levy, J Le Bidois, D Laux, R Gaudin, O Raisky, Y Ville, D Bonnet, J Stirnemann, S Malekzadeh-Milani
OBJECTIVE: We aimed to report our experience on fetal aortic valvuloplasty (FAV) for critical aortic stenosis (AS) focusing on the postnatal evolution of the patients. METHODS: This retrospective study was approved by our local Institutional Review Board (n°2002-0128143827). All fetuses with critical AS who underwent FAV in a single center between 01/2011 and 06/2022 were included. FAV were performed under ultrasound guidance. Technical success was based upon balloon inflation across the aortic valve and improvement of the anterograde aortic flow across the aortic valve...
April 17, 2024: Ultrasound in Obstetrics & Gynecology
Hiral Jhala, Mathew Thomas
BACKGROUND: Cardiac herniation occurs when there is a residual pericardial defect post thoracic surgery and is recognised as a rare but fatal complication. It confers a high mortality and requires immediate surgical correction upon recognition. We present a case of cardiac herniation occurring post thymectomy and left upper lobectomy. CASE PRESENTATION: Initial presentation: A 48-year-old male, hypertensive smoker presented with progressive breathlessness and was found to have a left upper zone mass confirmed on CT biopsy as carcinoid of unclear origin...
April 16, 2024: Journal of Cardiothoracic Surgery
Reza Eshraghi, Moein Rafiei, Zahra Hadian Jazi, Davood Shafie, Arash Raisi, Hamed Mirzaei
MicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend on the type of cell it is acting on and the specific target genes involved, resulting in different mechanisms of disease...
April 1, 2024: Pathology, Research and Practice
Kevin C Liu, Neelesh Bagrodia, Mary K Richardson, Amit S Piple, Nicholas Kusnezov, Jennifer C Wang, Jay R Lieberman, Nathanael D Heckmann
INTRODUCTION: Venous thromboembolism (VTE) remains a dangerous complication after total hip arthroplasty (THA), despite advances in chemoprophylactic measures. This study aimed to identify risk factors of developing pulmonary embolism (PE) and deep vein thrombosis (DVT) after THA using a modern cohort of patients reflecting contemporary practices. METHODS: The Premier Healthcare Database was queried for primary, elective THAs from January 1st, 2015, to December 31st, 2021...
April 10, 2024: Journal of the American Academy of Orthopaedic Surgeons
Sarah L Khan, Sonye K Danoff, Tejaswini Kulkarni, Janell Reichuber, Adrian Shifren, Oksana A Shlobin, Krishna Thavarajah, Krishnan Warrior, Amy Hajari Case
No abstract text is available yet for this article.
April 16, 2024: Annals of the American Thoracic Society
Fabien Robert, Marie-Caroline Certain, Audrey Baron, Raphaël Thuillet, Léa Duhaut, Mina Ottaviani, Mustapha Kamel Chelgham, Corinne Normand, Nihel Berrebeh, Nicolas Ricard, Valerie Furlan, Agnès Desroches-Castan, Emmanuel Gonzales, Emmanuel Jacquemin, Olivier Sitbon, Marc Humbert, Sabine Bailly, Audrey Coilly, Christophe Guignabert, Ly Tu, Laurent Savale
RATIONALE: Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilatation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced bone morphogenetic protein (BMP)-9 in maintaining pulmonary vascular integrity. OBJECTIVES: This study aimed to investigate the involvement of BMP-9 in human and experimental HPS. METHODS: Circulating BMP-9 levels were measured in 63 healthy controls and 203 cirrhotic patients, with or without HPS...
April 16, 2024: American Journal of Respiratory and Critical Care Medicine
Bin Liu, Mujahid Azfar, Ekaterina Legchenko, James A West, Shaun Martin, Chris Van den Haute, Veerle Baekelandt, John Wharton, Luke Howard, Martin R Wilkins, Peter Vangheluwe, Nicholas W Morrell, Paul D Upton
AIMS: Potential loss-of-function variants of ATP13A3, the gene encoding a P5B-type transport ATPase of undefined function, were recently identified in pulmonary arterial hypertension (PAH) patients. ATP13A3 is implicated in polyamine transport but its function has not been fully elucidated. Here, we sought to determine the biological function of ATP13A3 in vascular endothelial cells and how PAH-associated variants may contribute to disease pathogenesis. METHODS AND RESULTS: We studied the impact of ATP13A3 deficiency and overexpression in endothelial cell (EC) models (human pulmonary ECs, blood outgrowth ECs (BOECs) and HMEC-1 cells), including a PAH patient-derived BOEC line harbouring an ATP13A3 variant (LK726X)...
April 16, 2024: Cardiovascular Research
Cody C Blanchard, Lalita Gupta, Peter J Timoney
A 75-year-old male with a history of poorly controlled diabetes, hypertension, coronary artery disease, chronic obstructive pulmonary disease, and obesity presented with severe bilateral periorbital edema with necrosis and purulent discharge. Although hemodynamically stable, laboratory markers indicated systemic toxicity. Imaging showed bilateral periorbital edema extending into the frontal scalp, temporal fossa, and right orbit. Suspected to have necrotizing fasciitis, the patient underwent urgent debridement of bilateral upper and lower eyelids and was found to have postseptal extension of necrosis into the right orbit...
April 11, 2024: Ophthalmic Plastic and Reconstructive Surgery
Jasmina Marušić, Edhem Hasković, Anhel Koluh, Darko Tomić, Amer Ovčina, Ajdina Karić, Vedran Đido
UNLABELLED: Beakground: The prevalence of cardiovascular diseases in COVID-19 patients, such as hypertension, diabetes mellitus, and chronic obstructive pulmonary disease, which are the most common comorbid conditions in COVID-19 patients, is considered a risk factor for premature mortality in the population. The aim of the study is to compare the standard biochemical and hematological markers of COVID-19 patients on mechanical ventilation and those who have recovered, and to identify differences by gender and comorbidities, as well as the dominant marker in comorbidities that frequently shows statistical significance, in order to investigate its prognostic value in further research...
April 1, 2024: Clinical Laboratory
Maria J S de Oliveira, Fernando Anschau, Luciane Kopittke, Paulo V Worm, Taiani Vargas, Priscila S da Silva, Josi C C Cristaldo, Carlos A S Goncalves, Angela Wyse, Carlos A Netto
BACKGROUND: Identifying clinical characteristics and risk factors, comorbid conditions, and complications arising from SARS-CoV-2 infection is important to predict the progression to more severe forms of the disease among hospitalized individuals to enable timely intervention and to prevent fatal outcomes. The aim of the study is to assess the possible role of the neutrophil/lymphocyte ratio (NLR) as a biomarker of the risk of death in patients with comorbidities hospitalized with COVID-19 in a tertiary hospital in southern Brazil...
April 1, 2024: Clinical Laboratory
Harrison W Farber, Hayley D Germack, Nicole S Croteau, Jason C Simeone, Fei Tang, Carly J Paoli, Gurinderpal Doad, Sumeet Panjabi, Teresa De Marco
Information on factors leading to pulmonary arterial hypertension (PAH) treatment discontinuation is limited. This study analyzed 12,902 new PAH medication users to identify predictors of treatment discontinuation. Treatment by accredited pulmonary hypertension centers and combination therapy with PAH agents from different classes were less likely to result in discontinuation.
April 2024: Pulmonary Circulation
Mansi Satasia, Archit Garg, Kulani Weerasinghe, Chirag Patel, Mario Caldararo
Sarcoidosis is a systemic inflammatory condition characterized by noncaseating granulomas. Lung involvement is typical, while extrapulmonary manifestations, notably lymphadenopathy, are observed in a significant proportion of cases. The etiology involves complex interactions among immune cells and mediators, resulting in granuloma formation capable of independently producing 1,25-dihydroxyvitamin D, leading to unregulated hypercalcemia and hypercalciuria. Diagnosis can be challenging, especially when hypercalcemia is the initial symptom...
March 2024: Curēus
Robert James Adrian, Stephen Alerhand, Andrew Liteplo, Hamid Shokoohi
The presence of pulmonary hypertension (PH) may affect whether cardiac tamponade physiology develops from a pericardial effusion. Specifically, the increased intracardiac pressure and right ventricular hypertrophy associated with PH would seemingly increase the intrapericardial pressure threshold at which the right-sided chambers collapse. In this systematic review, we examined the impact of PH on the incidence, in-hospital and long-term mortality, and echocardiographic findings of patients with cardiac tamponade...
April 15, 2024: Internal and Emergency Medicine
Rui Zhou, Ran Li, Qi Ding, Yuwei Zhang, Hui Yang, Ying Han, Chuanchuan Liu, Jie Liu, Shenglan Wang
Hypoxic pulmonary hypertension (HPH) is a pulmonary vascular disease primarily characterized by progressive pulmonary vascular remodeling in a hypoxic environment, posing a significant clinical challenge. Leveraging data from the Gene Expression Omnibus (GEO) and human autophagy-specific databases, osteopontin (OPN) emerged as a differentially expressed gene, upregulated in cardiovascular diseases such as pulmonary arterial hypertension (PAH). Despite this association, the precise mechanism by which OPN regulates autophagy in HPH remains unclear, prompting the focus of this study...
April 15, 2024: Scientific Reports
Chan Kim, Sumin Kim, Hanna Kim, Jieun Hwang, Seung Hyun Kim, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil Chang
This study investigated whether late pulmonary hypertension (LPH) independently increases the risk of long-term mortality or neurodevelopmental delay (NDD) in extremely preterm infants (EPIs) with severe bronchopulmonary dysplasia (BPD). Using prospectively collected data from the Korean Neonatal Network, we included EPIs with severe BPD born at 22-27 weeks' gestation between 2013 and 2021. EPIs having severe BPD with LPH (LPH, n = 124) were matched 1:3 with those without pulmonary hypertension (PH) as controls (CON, n = 372), via propensity score matching...
April 15, 2024: Scientific Reports
Yuliya V Khramova, Veronika A Katrukha, Victoria V Chebanenko, Alexander I Kostyuk, Nikolay P Gorbunov, Oleg M Panasenko, Alexey V Sokolov, Dmitry S Bilan
Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function, etc. At the same time, hyperproduction of highly reactive compounds leads to the development of various socially significant diseases - asthma, pulmonary hypertension, oncological and neurodegenerative diseases, retinopathy, and many others. The main sources of (pseudo)hypohalous acids are enzymes from the family of heme peroxidases - myeloperoxidase, lactoperoxidase, eosinophil peroxidase, and thyroid peroxidase...
January 2024: Biochemistry. Biokhimii︠a︡
Zeying Zhang, Shelby Kutty, Wei Peng, Gaoming Zeng, Haiyan Luo, Zhenghui Xiao, Qiming Liu, Yunbin Xiao
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) often present with anxiety, depression and cognitive deterioration. Structural changes in the cerebral cortex in PAH patients have also been reported in observational studies. METHODS: PAH genome-wide association (GWAS) including 162,962 European individuals was used to assess genetically determined PAH. GWAS summary statistics were obtained for cognitive performance, depression, anxiety and alterations in cortical thickness (TH) or surface area (SA) of the brain cortex, respectively...
April 13, 2024: Journal of Affective Disorders
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