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Janice Hegewald, Uta E Wegewitz, Ulrike Euler, Jaap L van Dijk, Jenny Adams, Alba Fishta, Philipp Heinrich, Andreas Seidler
BACKGROUND: People with coronary heart disease (CHD) often require prolonged absences from work to convalesce after acute disease events like myocardial infarctions (MI) or revascularisation procedures such as coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Reduced functional capacity and anxiety due to CHD may further delay or prevent return to work. OBJECTIVES: To assess the effects of person- and work-directed interventions aimed at enhancing return to work in patients with coronary heart disease compared to usual care or no intervention...
March 14, 2019: Cochrane Database of Systematic Reviews
Masafumi Nakayama, Kazuhiro Satomi, Mikio Yuhara, Takashi Uchiyama, Yoshiyasu Aizawa, Yoshifusa Aizawa
Electrocardiogram records were surveyed for the presence of an atrial premature beat (APB) and J waves in patients with coronary heart disease and patients with noncardiac diseases. The prevalence and response of J waves to sudden shortening of the RR interval on the conducted APB were determined and compared between the 2 patients groups. The change in the QRS complexes on the APB was also determined. Among 17,013 patients, 243 patients who underwent percutaneous coronary intervention for acute myocardial infarction or angina pectoris had an APB, and J waves were observed in 16 patients (6...
January 24, 2019: American Journal of Cardiology
Wen Jian, Lang Li, Xiao-Min Wei, Cheng-Qiang Wu, Chun Gui
Patients with coronary heart disease (CHD) frequently have cardiovascular complications after undergoing PCI. Angiopoietin-2 (Ang-2) is an important proangiogenic factor that also plays an important role in atherosclerosis. This study aimed to evaluate the value of Ang-2 in predicting cardiovascular events after elective PCI.This prospective study enrolled 97 patients with CHD who underwent elective PCI from 2013 to 2014. Blood samples were collected in the first morning after admission and within 24 to 48 h after PCI...
February 2019: Medicine (Baltimore)
Y Zhang, L Song, Y Song, L J Xu, H H Wang, J J Xu, X F Tang, P Jiang, R Liu, X Y Zhao, Z Gao, L J Gao, J Chen, Y J Yang, R L Gao, S B Qiao, B Xu, J Q Yuan
Objective: To investigate the impact of coronary lesion calcification on the long-term outcome of patients with coronary heart disease after percutaneous coronary intervention. Methods: In this prospective observational study, a total of 10 119 consecutive patients with coronary heart disease undergoing percutaneous coronary intervention from January 1 to December 31, 2 103 in our hospital were enrolled. The patients were divided into non/mild calcification group (8 268 cases) and moderate/severe calcification group (1 851 cases) according to the angiographic results...
January 24, 2019: Zhonghua Xin Xue Guan Bing za Zhi
Manesh R Patel
Since the start of percutaneous coronary intervention (PCI), the field has seen a rapid explosion in technology from initial catheters, balloons, to metallic, now drug coated stents. However, unique to the field of coronary intervention in comparison to other areas of technological advances in medicine, the iterative advances have been progressively tested, and when possible, randomized against control groups to determine the best and most appropriate care. In fact, the field has matured in such rapid fashion over the 40 years since inception (1) in part due to the scientific culture started by the initial report of angioplasty from Grüntzig in which he concluded "A prospective randomized trial will be necessary to evaluate it usefulness in comparison with surgical and medical management...
November 11, 2018: Circulation
Ruixue Chen, Ya Xiao, Minghao Chen, Jingyi He, Mengtian Huang, Xitao Hong, Xin Liu, Taoran Fu, Jingzhi Zhang, Liguo Chen
Huoxue Huayu therapy (HXHY) has been widely used to treat cardiovascular diseases in traditional Chinese medicine (TCM), such as hypertension, and coronary heart disease (CHD). This study describes a meta-analysis of a series of prospective randomized, double-blind, placebo-controlled trials conducted to evaluate the effect of HXHY on patients with CHD after percutaneous coronary intervention (PCI).The Cochrane Library, PubMed, EMBASE, the China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Literature database and the Wanfang database were searched up until June 2018...
August 24, 2018: Bioscience Reports
Harsh Agrawal, Mohamed Teleb, Saba Lahsaei, Luis Carbajal, Ruben Montanez, Joseph P Carrozza
PURPOSE OF THE REVIEW: Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revascularization (CR) if at all possible. However, restenosis and stent thrombosis (ST) remain the Achilles heel of contemporary PCI with restenosis rates between 10 and 30% with bare metal stents to 5-15% after drug-eluting stents and ST rates of around 0...
March 6, 2018: Current Cardiology Reports
Suzanne H Richards, Lindsey Anderson, Caroline E Jenkinson, Ben Whalley, Karen Rees, Philippa Davies, Paul Bennett, Zulian Liu, Robert West, David R Thompson, Rod S Taylor
BACKGROUND: Coronary heart disease (CHD) is the most common cause of death globally, although mortality rates are falling. Psychological symptoms are prevalent for people with CHD, and many psychological treatments are offered following cardiac events or procedures with the aim of improving health and outcomes. This is an update of a Cochrane systematic review previously published in 2011. OBJECTIVES: To assess the effectiveness of psychological interventions (alone or with cardiac rehabilitation) compared with usual care (including cardiac rehabilitation where available) for people with CHD on total mortality and cardiac mortality; cardiac morbidity; and participant-reported psychological outcomes of levels of depression, anxiety, and stress; and to explore potential study-level predictors of the effectiveness of psychological interventions in this population...
April 28, 2017: Cochrane Database of Systematic Reviews
Xinyu Yang, Yanda Li, Xiaomeng Ren, Xingjiang Xiong, Lijun Wu, Jie Li, Jie Wang, Yonghong Gao, Hongcai Shang, Yanwei Xing
In this study, we assessed the effect of rehabilitation exercise after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). We performed a meta-analysis to determine the effects of exercise in patients after PCI. The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, the Embase database, China National Knowledge Internet (CNKI), China Biology Medicine (CBM), and the Wanfang Database were searched for randomized controlled trials (RCTs). The key words used for the searches were PCI, exercise, walking, jogging, Tai Chi, and yoga...
March 17, 2017: Scientific Reports
Hirofumi Hioki, Takashi Miura, Hirohiko Motoki, Hideki Kobayashi, Masanori Kobayashi, Hiroyuki Nakajima, Hikaru Kimura, Eiichiro Mawatari, Hiroshi Akanuma, Toshio Sato, Souichirou Ebisawa, Yusuke Miyashita, Uichi Ikeda, Shoji Hotta, Yuichi Kamiyoshi, Takuya Maruyama, Noboru Watanabe, Takayuki Eisawa, Shinichi Aso, Shinichirou Uchikawa, Naoto Hashizume, Noriyuki Sekimura, Takehiro Morita
OBJECTIVE: Little is known about the relationship between body composition indicators, including body mass index (BMI), fat mass index (FMI) and lean BMI (LBMI), and adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify this relationship. METHODS: The SHINANO registry is a prospective, observational, multicenter cohort registry that enrolled 1923 consecutive patients with coronary heart disease (CHD) from August 2012 to July 2013; 66 patients were excluded because of missing data...
2015: Heart Asia
Anurag Bajaj, Ankur Sethi, Parul Rathor, Nissi Suppogu, Arjinder Sethi
Coronary heart disease is a major cause of mortality and morbidity worldwide. The incidence of mechanical complications of acute myocardial infarction (AMI) has gone down to less than 1% since the advent of percutaneous coronary intervention, but although mortality resulting from AMI has gone down in recent years, the burden remains high. Mechanical complications of AMI include cardiogenic shock, free wall rupture, ventricular septal rupture, acute mitral regurgitation, and right ventricular infarction. Detailed knowledge of the complications and their risk factors can help clinicians in making an early diagnosis...
October 2015: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Lloyd Steele, Amelia Lloyd, James Fotheringham, Ayyaz Sultan, Javaid Iqbal, Ever D Grech
BACKGROUND: Cigarette smoking is a well-established risk factor for the development of coronary heart disease. However, the relationship between smoking and acute ST-segment elevation myocardial infarction (STEMI) is less well described. OBJECTIVE: To determine the relative risk of acute STEMI in smokers and ex-smokers, compared with individuals who had never smoked. METHODS: This observational study studied all patients with STEMI undergoing percutaneous coronary intervention (PCI) in South Yorkshire, UK from 1 January 2009 to 6 April 2012...
September 2015: Postgraduate Medical Journal
Hisashi Makino, Yoshihiro Miyamoto, Akie Kikuchi-Taura, Toshihiro Soma, Akihiko Taguchi, Ichiro Kishimoto
AIMS/INTRODUCTION: Circulating progenitor cells, including CD34 positive (CD34(+)) cells, play a key role in neovascularisation and the maintenance of vascular endothelial function. Several lines of evidence show an association between decreased levels of circulating CD34(+) cells and cardiovascular disease. However, the contribution of circulating CD34(+) cells to the occurrence of cardiovascular events in diabetic patients remains unclear. MATERIALS AND METHODS: In the present study with a median follow up of 4...
July 2015: Journal of Diabetes Investigation
Guangjin Luo, Qingman Li, Xiajun Zhang, Liang Shen, Jiahe Xie, Jingwen Zhang, Masafumi Kitakaze, Xiaobo Huang, Yulin Liao
Endoplasmic reticulum stress is a proapoptotic and profibrotic stimulus. Ablation of C/EBP homologous protein (CHOP) is reported to reverse cardiac dysfunction by attenuating cardiac endoplasmic reticulum stress in mice with pressure overload or ischemia/reperfusion, but it is unclear whether loss of CHOP also inhibits cardiac remodeling induced by permanent-infarction. In mice with permanent ligation of left coronary artery, we found that ablation of CHOP increased the acute phase mortality. For the mice survived to 4 weeks, left ventricular anterior (LV) wall thickness was larger in CHOP knockout mice than in the wildtype littermates, while no difference was noted on posterior wall thickness, LV dimensions, LV fractional shortening and ejection fraction...
August 14, 2015: Biochemical and Biophysical Research Communications
Bo-Da Zhou, Ling-Yun Zu, Lin Mi, Gui-Song Wang, Li-Jun Guo, Wei Gao
BACKGROUND: There are patients who underwent emergency coronary angiography (CAG) but did not receive percutaneous coronary intervention (PCI). The aim of this study was to analyze these reasons. METHODS: This is a single-center retrospective study. We recruited 201 consecutive patients who received emergency CAG but did not receive PCI. To investigate the value of the Global Registry of Acute Coronary Events (GRACE) score in predicting PCI possibilities in non-ST segment elevation acute coronary syndrome (NSTE-ACS) patients, we recruited 80 consecutive patients who presented with NSTE-ACS and received emergency CAG as well as emergency PCI...
May 2015: Journal of Geriatric Cardiology: JGC
Machaon M Bonafede, Barbara H Johnson, Akshara Richhariya, Shravanthi R Gandra
OBJECTIVES: This study descriptively examined acute and longer term direct medical costs associated with a major cardiovascular (CV) event among high-risk coronary heart disease risk-equivalent (CHD-RE) patients. It also gives a firsthand look at fatal versus nonfatal CV events. METHODS: The MarketScan(®) Commercial Claims and Encounters Database was used to identify adults with a CV event in 2006-2012 with hyperlipidemia or lipid-lowering therapy use in the 18 months prior to one of the following inpatient CV events: myocardial infarction, ischemic stroke, unstable angina, transient ischemic attack, percutaneous coronary intervention, or coronary artery bypass graft (CABG)...
2015: ClinicoEconomics and Outcomes Research: CEOR
Chen Mao, Xiao-Hong Fu, Jin-Qiu Yuan, Zu-Yao Yang, Vincent C H Chung, Ying Qin, Yafang Huang, Wilson Wai San Tam, Joey S W Kwong, Wei Xie, Jin-Ling Tang
BACKGROUND: Percutaneous coronary intervention (PCI) is a standard treatment for coronary heart disease (CHD). Restenosis, defined as a 50% reduction in luminal diameter at six months after PCI, indicates a need for revascularisation. Restenosis has proven to be a major drawback to PCI. Tong-xin-luo is one of the prophylactic strategies for cardiovascular events in patients after PCI that is widely used in China, but its efficacy and safety have not been systematically evaluated. OBJECTIVES: To systematically assess the efficacy and safety of Tong-xin-luo capsules in preventing cardiovascular events after PCI in patients with CHD...
May 21, 2015: Cochrane Database of Systematic Reviews
Jiao Wang, Zhi-Qiang Liu, Peng-Yi He, Yu-Chun Yang, Lei Zhang, Muhuyati
To discuss the risk factors and characteristics of coronary artery disease of Han, Uygur and Kazak patients with acute myocardial infarction in Xinjiang district. A retrospective analysis of clinical data of 262 cases of Han patients, 166 cases of Uygur patients and 86 cases of Kazak patients was conducted, whose age, body mass index, cholesterol, uric acid, hypertension, type 2 diabetes, smoking, drinking, family history of coronary heart disease, relationship between PCI history and pathogenesis of acute myocardial infarction, and coronary artery disease characteristics were observed and compared in different groups...
2015: International Journal of Clinical and Experimental Medicine
Taek Min Nam, Kyung Il Jo, Je Young Yeon, Seung Chyul Hong, Jong Soo Kim
The purpose of this study was to determine the prevalence and characteristics of symptomatic coronary heart disease (CHD) in patients with moyamoya disease (MMD). This retrospective study evaluated 456 patients who received examination for MMD between 1995 and 2012. We reviewed the patients' medical history and coronary imaging, including conventional coronary angiography and coronary computed tomography angiogram (CTA). Among 456 patients with MMD, 21 (4.6%) patients were found to have symptomatic CHD. Ten patients were treated with coronary artery bypass graft or percutaneous coronary intervention for unstable angina or myocardial infarction...
April 2015: Journal of Korean Medical Science
Hilde E Groot, Minke H T Hartman, Youlan L Gu, Bart J G L de Smet, Ad F M van den Heuvel, Erik Lipsic, Pim van der Harst
AIMS: Interleukin-6 receptor (IL-6R) signalling has been suggested to play a causal role in the development and outcome of coronary heart disease (CHD). The aim of this study was to investigate the association of sIL-6R levels with myocardial reperfusion after percutaneous coronary intervention (PCI) for acute ST-elevated myocardial infarction (STEMI). METHODS: Blood was sampled from 70 patients presenting with STEMI at 6 different time-points (baseline, post-PCI, t=1h, t=6h, t=24h, t=2w)...
June 2015: Cytokine
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