keyword

Pharmacology, drugs, drug interactions and contraindications

keyword
https://read.qxmd.com/read/32107798/quality-of-evidence-supporting-major-psychotropic-drug-drug-interaction-warnings-a-systematic-literature-review
#1
Trinh Nguyen, Xinyue Liu, Wafa Abuhashem, Regina Bussing, Almut G Winterstein
Among pharmacodynamic and pharmacokinetic drug-drug interactions (DDIs), psychotropic DDIs (pDDIs) are of particular interest because psychopharmacologic agents mark one of the fastest growing therapeutic drug classes over the past two decades, and prescribing multiple psychotropic drugs has become increasingly prevalent in clinical practice. However, the documentation of pDDIs across drug references has lacked consistency. Thus, we set out to review the primary evidence directly supporting 58 pDDIs that were uniformly reported as "major" or "contraindicated" in three prominent drug references-Clinical Pharmacology, Micromedex, and Lexicomp...
February 27, 2020: Pharmacotherapy
https://read.qxmd.com/read/31872719/-drug-syndrome-of-ephedra-based-on-its-property-and-pharmacology
#2
Zhi-Gang Liu, Cheng-Zhi Chai
Ephedra is a classic herb in traditional Chinese medicine( TCM). The new effects of ephedra were gradually found,and the contraindications of the drug were broken in later ages. Because the principles of expanded application were not well elucidated,it is difficult to use in the clinical flexibility. Based on the characteristics of ephedra and its classic clinical application,the authors summarized the possible principles of clinical application of ephedra and the drug property and pharmacological characteristics of ephedra...
September 2019: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/31870860/pharmacists-and-the-future-of-cannabis-medicine
#3
Natalie Schmitz, Lucas Richert
OBJECTIVES: To summarize the history and evolution of cannabis use and policies and to review current therapeutic uses, safety, and the central role pharmacists can play. SUMMARY: Cannabis regulation and use have evolved over the centuries and are becoming more widely accepted, with over two-thirds of states in the United States having an approved cannabis program. However, changing policy and a paucity of controlled clinical trials has led to questions on the safety and effectiveness of cannabinoid therapies...
December 20, 2019: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/31749075/clinical-pharmacology-of-elagolix-an-oral-gonadotropin-releasing-hormone-receptor-antagonist-for-endometriosis
#4
REVIEW
Mohamad Shebley, Akshanth R Polepally, Ahmed Nader, Juki W Ng, Insa Winzenborg, Cheri E Klein, Peter Noertersheuser, Megan A Gibbs, Nael M Mostafa
The clinical pharmacology of elagolix was extensively evaluated in clinical studies in healthy subjects and in women with endometriosis. Elagolix pharmacokinetics (PK) show significant population variability, however they are minimally affected by patients' baseline characteristics and demographics, except for clinically relevant extrinsic and intrinsic factors such as coadministrated strong organic anion transporting polypeptide (OATP) 1B1 inhibitors and severe hepatic impairment, which are contraindications for the use of elagolix...
November 21, 2019: Clinical Pharmacokinetics
https://read.qxmd.com/read/31612362/repurposing-of-known-drugs-for-leishmaniasis-treatment-using-bioinformatic-predictions-in-vitro-validations-and-pharmacokinetic-simulations
#5
Christian Bustamante, Rodrigo Ochoa, Claudia Asela, Carlos Muskus
Leishmaniasis is a neglected tropical disease caused by Leishmania parasites and is associated to more than 1.3 million cases annually. Some of the pharmacological options for treating the disease are pentavalent antimonials, pentamidine, miltefosine, and amphotericin B. However, all are associated with a wide range of adverse effects and contraindications, as well as resistance from the parasite. In the present study, we looked for pharmacological alternatives to treat leishmaniasis, with a focus on drug repurposing...
October 14, 2019: Journal of Computer-aided Molecular Design
https://read.qxmd.com/read/31482727/drug-drug-interaction-prediction-using-pass
#6
A V Dmitriev, D A Filimonov, A V Rudik, P V Pogodin, D A Karasev, A A Lagunin, V V Poroikov
Simultaneous use of the drugs may lead to undesirable Drug-Drug Interactions (DDIs) in the human body. Many DDIs are associated with changes in drug metabolism that performed by Drug-Metabolizing Enzymes (DMEs). In this case, DDI manifests itself as a result of the effect of one drug on the biotransformation of other drug(s), its slowing down (in the case of inhibiting DME) or acceleration (in case of induction of DME), which leads to a change in the pharmacological effect of the drugs combination. We used OpeRational ClassificAtion (ORCA) system for categorizing DDIs...
September 4, 2019: SAR and QSAR in Environmental Research
https://read.qxmd.com/read/31177519/systematic-review-on-the-effects-of-medication-under-hyperbaric-conditions-consequences-for-the-diver
#7
Erik Hoencamp, Thijs Tcf van Dongen, Pieter-Jan Am van Ooij, Thijs T Wingelaar, Mees L Vervelde, Dave Aa Koch, Rob A van Hulst, Rigo Hoencamp
BACKGROUND: Physiological changes are induced by immersion, swimming and using diving equipment. Divers must be fit to dive. Using medication may impact the capacity to adapt to hyperbaric conditions. The aim of this systematic review is to assess the interaction of diving/hyperbaric conditions and medication and to provide basic heuristics to support decision making regarding fitness to dive in medicated divers. METHODS: This was a systematic review of human and animal studies of medications in the hyperbaric environment...
June 30, 2019: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/30899119/management-of-polypharmacy-and-drug-drug-interactions-in-hiv-patients-a-2-year-experience-of-a-multidisciplinary-outpatient-clinic
#8
Cristina Gervasoni, Tiziana Formenti, Dario Cattaneo
HIV-positive patients are treated with various antiretroviral-containing drug combinations to control their underlying disease, which may also be combined with drugs aimed to manage independent or secondary comorbidities. This can expose patients to drug-drug interactions (DDIs) that may lead to suboptimal drug exposure, an increased risk of therapeutic failure or poor tolerability, and a need to adopt alternative therapeutic strategies. Although such undesired responses to pharmacological therapies can be appropriately managed in some situations, the fact that the available information is usually incomplete which makes it difficult (if not impossible) to assess DDIs and the consequent adjustments of polytherapies in clinical practice...
2019: AIDS Reviews
https://read.qxmd.com/read/30770477/pharmacology-part-5-ct-and-mri-contrast-media
#9
REVIEW
Geoffrey M Currie
Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners. The scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is part of a series that aims to enhance understanding of pharmacologic principles relevant to nuclear medicine. This article will build on the introductory concepts, terminology, and principles of pharmacology explored in the first 2 articles in the series...
September 2019: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/30770476/pharmacology-part-4-nuclear-cardiology
#10
Geoffrey M Currie
Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners in nuclear cardiology. The scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is the fifth in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
February 15, 2019: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/30225777/potential-role-of-selective-serotonin-reuptake-inhibitors-in-improving-functional-outcome-after-stroke
#11
Janne Kaergaard Mortensen, Grethe Andersen
The great advances in acute stroke treatment during the last decades have changed life after stroke considerably. However, the use of intravenous thrombolysis and endovascular thrombectomy is limited by a relatively narrow time window or contraindications for treatment. Further, patients receiving acute reperfusion therapies may still have cognitive and emotional complications due to underlying brain infarcts even though physical problems may almost disappear. Consequently, stroke is still a frequent cause of adult disability and death worldwide, and an effort to identify additional treatments to enhance recovery, preferably also feasible in the time after the acute phase, is warranted...
October 2018: CNS Drugs
https://read.qxmd.com/read/30139885/pharmacology-part-3b-less-commonly-used-interventional-medications-and-adjunctive-medications-in-general-nuclear-medicine
#12
REVIEW
Geoffrey M Currie
The understanding of key principles in pharmacology is essential to the clinical and research nuclear medicine practitioner. The scope of practice of the nuclear medicine technologist requires understanding of the indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for interventional and adjunctive medications. This article is the companion to the third in a series of articles that aims to enhance the understanding of pharmacologic principles relevant to nuclear medicine...
March 2019: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/30122296/-supervised-off-label-prescribing-of-methylphenidate-in-adult-adhd
#13
L Carton, T Dondaine, S Deheul, C Marquié, F Brigadeau, A Amad, D Devos, T Danel, R Bordet, O Cottencin, S Gautier, O Ménard
OBJECTIVE: Off-label prescription is a common practice in psychiatry, raising health and economic concerns. Collegial consultation could allow a framed prescription of treatments that are not authorized in specific indications. Attention Deficit Hyperactivity in adult populations (ADHD) is a striking example of a pathology where off-label prescription is frequent. First considered to be a childhood disorder, the awareness of this condition in adults is increasing, leading to the development of new clinical practices and treatments...
August 16, 2018: L'Encéphale
https://read.qxmd.com/read/30076248/pharmacology-part-3a-interventional-medications-in-renal-and-biliary-imaging
#14
Geoffrey M Currie
Pharmacology principles provide key understanding that underpins the clinical and research roles of nuclear medicine practitioners. Indeed, the scope of practice of the nuclear medicine technologist demands knowledge and understanding of indications, contraindications, warnings, precautions, proper use, drug interactions, and adverse reactions for each medication to be used. This article is the third in a series of articles that aims to enhance the understanding of pharmacological principles relevant to nuclear medicine...
August 3, 2018: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/29739235/a-new-perspective-on-the-nitrate-phosphodiesterase-type-5-inhibitor-interaction
#15
Robert A Kloner, Paul Goggin, Irwin Goldstein, Geoffrey Hackett, Michael G Kirby, Ian Osterloh, John D Parker, Richard Sadovsky
BACKGROUND: Nitrates and nitrate-containing compounds are vasodilators used for the treatment of angina and heart failure. Phosphodiesterase type 5 inhibitors used for the treatment of erectile dysfunction are also vasodilators, and when taken together with nitrates, synergistic effects that enhance hypotensive effects may occur. Phosphodiesterase type 5 inhibitors are therefore contraindicated in patients taking organic nitrates. METHODS AND RESULTS: A literature review was performed to provide a historical overview of different phosphodiesterase type 5 inhibitors and nitrates and their interaction...
September 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://read.qxmd.com/read/29385731/benzodiazepines-i-upping-the-care-on-downers-the-evidence-of-risks-benefits-and-alternatives
#16
REVIEW
Jeffrey Guina, Brian Merrill
Benzodiazepines are some of the most commonly prescribed medications in the world. These sedative-hypnotics can provide rapid relief for symptoms like anxiety and insomnia, but are also linked to a variety of adverse effects (whether used long-term, short-term, or as needed). Many patients take benzodiazepines long-term without ever receiving evidence-based first-line treatments (e.g., psychotherapy, relaxation techniques, sleep hygiene education, serotonergic agents). This review discusses the risks and benefits of, and alternatives to benzodiazepines...
January 30, 2018: Journal of Clinical Medicine
https://read.qxmd.com/read/29338536/p2y-12-receptor-inhibitors-an-evolution-in-drug-design-to-prevent-arterial-thrombosis
#17
REVIEW
Danny Kupka, Dirk Sibbing
P2Y12 inhibitors are a critical component of dual antiplatelet therapy (DAPT), which is the superior strategy to prevent arterialthrombosis in patients with acute coronary syndromes (ACS) and undergoing stent implantation.. Areas covered: Basic science articles, clinical studies, and reviews from 1992-2017 were searched using Pubmed library to collet impactful literature. After an introduction to the purinergic receptor biology, this review summarizes current knowledge on P2Y12 receptor inhibitors. Furthermore, we describe the subsequent improvements of next-generation P2Y12 receptor inhibitors facing the ambivalent problem of bleeding events versus prevention of arterial thrombosis in a variety of clinical settings...
March 2018: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/28352949/from-prescription-only-rx-to-over-the-counter-otc-status-in-germany-2006-2015-pharmacological-perspectives-on-regulatory-decisions
#18
Eva Barrenberg, Edeltraut Garbe
PURPOSE: Little is known about the extent of switches from prescription-only (Rx) to over-the-counter (OTC) status in Europe and about the pharmacological properties of the switched substances. The objectives of this study were to provide an overview of the substances that were switched from Rx to OTC status in Germany between 2006 and 2015 and to assess their pharmacological properties. METHODS: Session minutes of the German Expert Advisory Committee for Prescription-Only Issues, changes to the German Ordinance on Prescription-Only Medicines and the Summary of Product Characteristics of the switched substances were analysed...
July 2017: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/28074989/-antidepressants-agents-in-breast-cancer-patients-using-tamoxifen-review-of-basic-and-clinical-evidence
#19
REVIEW
María Elisa Irarrázaval O, Leonardo Gaete G
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed to women with breast cancer not only for depression, but also for anxiety and hot flashes. Some AD are substrates or inhibitors of the Tmf metabolic pathway. Therefore there may be interactions when Tmf and AD are prescribed simultaneously. Oncologic protection afforded by Tmf may become less effective or null when AD are indicated, especially in poor metabolizing patients...
October 2016: Revista Médica de Chile
https://read.qxmd.com/read/27648725/essential-competencies-in-prescribing-a-first-european-cross-sectional-study-among-895-final-year-medical-students
#20
MULTICENTER STUDY
D J Brinkman, J Tichelaar, T Schutte, S Benemei, Y Böttiger, B Chamontin, T Christiaens, R Likic, R Maˇiulaitis, T Marandi, E C Monteiro, P Papaioannidou, Y M Pers, C Pontes, A Raskovic, R Regenthal, E J Sanz, B I Tamba, K Wilson, Tp de Vries, M C Richir, Ma van Agtmael
European medical students should have acquired adequate prescribing competencies before graduation, but it is not known whether this is the case. In this international multicenter study, we evaluated the essential knowledge, skills, and attitudes in clinical pharmacology and therapeutics (CPT) of final-year medical students across Europe. In a cross-sectional design, 26 medical schools from 17 European countries were asked to administer a standardized assessment and questionnaire to 50 final-year students. Although there were differences between schools, our results show an overall lack of essential prescribing competencies among final-year students in Europe...
February 2017: Clinical Pharmacology and Therapeutics
keyword
keyword
31094
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"