keyword
https://read.qxmd.com/read/38521450/vaccine-derived-yellow-fever-in-an-immunocompromised-patient-on-anti-cd20-antibody-therapy-and-its-treatment-with-sofosbuvir
#61
Tobias Weirauch, Gerrit Burger, Dániel Cadar, Martin Gabriel, Julia Koepsell, Gundolf Schüttfort, Philipp de Leuw, Markus Bickel, Maria J G T Vehreschild, Timo Wolf, Nils Wetzstein
Yellow fever (YF) is a potentially lethal viral hemorrhagic fever that can be prevented with the 17D live attenuated YF vaccine. However, this vaccination can cause severe adverse reactions including vaccine-associated YF. Here, we describe the case of a 32-year-old female who was permanently immunosuppressed with an anti-CD20 antibody due to multiple sclerosis. Following YF vaccination, the patient developed, a variety of symptoms such as febrile temperatures, muscle and joint pain, headaches, and dysuria...
March 21, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38521213/inhibitors-of-bruton-s-tyrosine-kinase-as-emerging-therapeutic-strategy-in-autoimmune-diseases
#62
REVIEW
Mirre De Bondt, Janne Renders, Sofie Struyf, Niels Hellings
Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor signal transducer, initially identified as an essential signaling molecule for B cells, with genetic mutations resulting in a disorder characterized by disturbed B cell and antibody development. Subsequent research revealed the critical role of BTK in the functionality of monocytes, macrophages and neutrophils. Various immune cells, among which B cells and neutrophils, rely on BTK activity for diverse signaling pathways downstream of multiple receptors, which makes this kinase an ideal target to treat hematological malignancies and autoimmune diseases...
March 21, 2024: Autoimmunity Reviews
https://read.qxmd.com/read/38521093/deciphering-the-shift-from-benign-to-active-relapsing-remitting-multiple-sclerosis-insights-into-t-regulatory-cell-dysfunction-and-apoptosis-regulation
#63
JOURNAL ARTICLE
Anat Achiron, Rina Falb, Shay Menascu, David Magalashvili, Mathilda Mandel, Polina Sonis, Michael Gurevich
BACKGROUND: Relapsing-remitting multiple sclerosis (RRMS), a common demyelinating disease among young adults, follows a benign course in 10-15% of cases, where patients experience minimal neurological disability for a decade following disease onset. However, there is potential for these benign cases to transition into a clinically active, relapsing state. OBJECTIVE: To elucidate the biological mechanisms underlying the transition from benign to active RRMS using gene expression analysis...
March 21, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38520949/the-measurement-of-fatigability-severity-in-individuals-with-multiple-sclerosis-and-healthy-controls
#64
JOURNAL ARTICLE
Mutasim D Alharbi, Fayaz Khan
BACKGROUND: Multiple Sclerosis (MS) is a chronic disease that substantially diminishes one's ability to undertake daily living activities. Fatigue has been reported by at least 80 % of persons with MS (PwMS). Yet, little is known concerning the quantification of fatigability using prolonged walking tests. OBJECTIVES: To compare fatigability severity measures using the 10-minute walk test for PwMS against age- and gender-matched healthy controls (HCs). METHODS: Participants included 53 ambulatory PwMS and 49 HCs...
March 20, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38520948/burden-of-treatment-and-quality-of-life-in-relapsing-remitting-multiple-sclerosis-patients-under-early-high-efficacy-therapy-in-argentina-data-from-the-argentinean-registry
#65
JOURNAL ARTICLE
Juan I Rojas, Edgar Carnero Contentti, Ricardo Alonso, Dario Tavolini, Marcos Burgos, Belén Federico, Liliana Patrucco, Edgardo Cristiano
UNLABELLED: The objective of this study was to describe and compare the burden of treatment (BOT) and the quality of life (QoL) in early high efficacy therapy (HET) vs. escalation therapy in relapsing remitting multiple sclerosis (RRMS) patients included in RelevarEM, the Argentinean registry of MS (RelevarEM, NCT 03,375,177). METHODS: cross sectional study conducted between September and December 2022. Participating patients were adults, RRMS patients who initiated (during the last three years) their treatment with a HET (natalizumab, ocrelizumab, alemtuzumab, cladribine) or with escalation treatment (beta interferon, glatiramer acetate, teriflunomide, dimethyl fumarate or fingolimod)...
March 16, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38520947/backwards-walking-speed-reserve-in-persons-with-multiple-sclerosis
#66
JOURNAL ARTICLE
Patrick G Monaghan, Michael VanNostrand, Nora E Fritz
BACKGROUND: Decreased gait speed is common in persons with Multiple Sclerosis (PwMS) and has been associated with elevated fall risk. The walking speed reserve (WSR) indicates the ability to increase gait speed on demand and has previously been examined in PwMS. Backward walking is a sensitive measure of fall risk in PwMS; however, no studies have reported on the utility of backward walking speed reserve (BW-WSR) as a clinical assessment tool of functional mobility or fall risk in PwMS, nor have they associated this measure with cognition...
March 19, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38520946/evidence-of-disease-activity-during-pregnancy-and-post-partum-in-ms-patients-treated-with-high-efficacy-therapies
#67
JOURNAL ARTICLE
Oussama Sahloul, Céline Louapre, Ysoline Beigneux, Catherine Lubetzki, Elisabeth Maillart, Thomas Roux
BACKGROUND: Multiple sclerosis (MS) predominantly affects women of childbearing age. Due to the risk of teratogenicity, women with active multiple sclerosis (MS) who require high-efficacy therapies (HET) may need to discontinue treatment during pregnancy. Fingolimod and Natalizumab withdrawal increases the risk of disease reactivation, a risk not commonly associated with anti-CD20 therapies. However, comparative data are limited during pregnancy and post-partum. Our aim was to compare evidence of disease activity during pregnancy and post-partum in women treated with HET (anti-CD20 therapies, Natalizumab or Fingolimod) before conception, whether or not exposed during pregnancy...
March 19, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38520895/quantitative-and-structural-changes-of-blood-platelet-cytoskeleton-proteins-in-multiple-sclerosis-ms
#68
JOURNAL ARTICLE
Angela Dziedzic, Sylwia Michlewska, Piotr Jóźwiak, Janusz Dębski, Michał Seweryn Karbownik, Łukasz Łaczmański, Dorota Kujawa, Sława Glińska, Elżbieta Miller, Marta Niwald, Malgorzata Kloc, Łucja Balcerzak, Joanna Saluk
Epidemiological studies show that cardiovascular events related to platelet hyperactivity remain the leading causes of death among multiple sclerosis (MS) patients. Quantitative or structural changes of platelet cytoskeleton alter their morphology and function. Here, we demonstrated, for the first time, the structural changes in MS platelets that may be related to their hyperactivity. MS platelets were found to form large aggregates compared to control platelets. In contrast to the control, the images of overactivated, irregularly shaped MS platelets show changes in the cytoskeleton architecture, fragmented microtubule rings...
March 22, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38520830/comparative-overview-of-multi-shell-diffusion-mri-models-to-characterize-the-microstructure-of-multiple-sclerosis-lesions-and-periplaques
#69
JOURNAL ARTICLE
Colin Vanden Bulcke, Anna Stölting, Dragan Maric, Benoît Macq, Martina Absinta, Pietro Maggi
In multiple sclerosis (MS), accurate in vivo characterization of the heterogeneous lesional and extra-lesional tissue pathology remains challenging. Marshalling several advanced imaging techniques - quantitative relaxation time (T1) mapping, a model-free average diffusion signal approach and four multi-shell diffusion models - this study investigates the performance of multi-shell diffusion models and characterizes the microstructural damage within (i) different MS lesion types - active, chronic active, and chronic inactive - (ii) their respective periplaque white matter (WM), and (iii) the surrounding normal-appearing white matter (NAWM)...
March 18, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38520815/vitamin-deficiencies-in-children-lessons-from-clinical-and-neuroimaging-findings
#70
JOURNAL ARTICLE
Gabrielle Dupuy, Charles-Joris Roux, Rémi Barrois, Apolline Imbard, Clément Pontoizeau, Marie Thérèse Dangles, Mélodie Aubart, Jean-Baptiste Arnoux, Diane Margoses, Anaïs Brassier, Clothilde Marbach, Claire-Marine Bérat, Eugénie Sarda, Cyril Gitiaux, Pascale de Lonlay, Nathalie Boddaert, Manuel Schiff, Isabelle Desguerre
BACKGROUND AND AIMS: Water-soluble vitamins play an essential coenzyme role in the nervous system. Acquired vitamin deficiencies are easily treatable, however, without treatment, they can lead to irreversible complications. This study aimed to provide clinical, laboratory parameters and neuroimaging data on vitamin deficiencies in an attempt to facilitate early diagnosis and prompt supplementation. METHODS: From July 1998 to July 2023, patients at Necker-Enfants-Malades Hospital presenting with acute neurological symptoms attributed to acquired vitamin deficiency were included...
February 26, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38520377/higher-order-functional-connectivity-analysis-of-resting-state-functional-magnetic-resonance-imaging-data-using-multivariate-cumulants
#71
JOURNAL ARTICLE
Rikkert Hindriks, Tommy A A Broeders, Menno M Schoonheim, Linda Douw, Fernando Santos, Wessel van Wieringen, Prejaas K B Tewarie
Blood-level oxygenation-dependent (BOLD) functional magnetic resonance imaging (fMRI) is the most common modality to study functional connectivity in the human brain. Most research to date has focused on connectivity between pairs of brain regions. However, attention has recently turned towards connectivity involving more than two regions, that is, higher-order connectivity. It is not yet clear how higher-order connectivity can best be quantified. The measures that are currently in use cannot distinguish between pairwise (i...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38520055/feasibility-acceptability-and-initial-efficacy-of-a-wheelchair-exercise-training-program-in-persons-with-multiple-sclerosis-study-protocol-for-a-parallel-group-randomized-controlled-trial
#72
JOURNAL ARTICLE
Stephanie L Silveira, Robert W Motl, Katherine Froehlich-Grobe, Mitch Kay
Purpose: This study is a randomized controlled trial (RCT) that examines the feasibility, acceptability, and initial efficacy of a home-based, remotely supported and supervised exercise training program that was developed using a three-step community engaged research process for persons with multiple sclerosis (MS) who are wheelchair users. Materials and Methods: The study design is a parallel group RCT (NCT05888727). We aim to enroll 24 wheelchair users with MS who will be randomly assigned using REDCap randomization module into exercise training or attention/contact wellness control conditions...
March 22, 2024: Disability and Rehabilitation. Assistive Technology
https://read.qxmd.com/read/38519434/clinical-correlates-of-respiratory-disorders-in-patients-with-severe-multiple-sclerosis-a-cross-sectional-cohort
#73
JOURNAL ARTICLE
Elisabeth Maillart, Stefania Redolfi, Céline Louapre, Marion Houot, Emeline Chaugne, Pierantonio Laveneziana, Aurelian Ungureanu, Bruno Stankoff, Isabelle Arnulf, Caroline Papeix, Benedetta Bodini, Thomas Similowski, Catherine Lubetzki, Capucine Morélot-Panzini
BACKGROUND: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. METHODS: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep...
March 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38519138/evaluation-of-ivim-in-the-spinal-cord-of-multiple-sclerosis-patients
#74
JOURNAL ARTICLE
Brian Johnson, Christine Heales
PURPOSE: To evaluate the ability of intravoxel incoherent motion (IVIM), a perfusion-weighted imaging technique, to differentiate microcirculation changes in the spinal cord of patients with multiple sclerosis (MS) compared with healthy individuals. METHODS: Fifteen healthy individuals and 15 individuals with MS underwent IVIM magnetic resonance (MR) imaging using a 3 T scanner with 2-D axial gradient recalled echo and 2-D axial diffusion-weighted imaging (DWI) sequences...
March 2024: Radiologic Technology
https://read.qxmd.com/read/38518598/gut-microbiota-in-neurological-diseases-melatonin-plays-an-important-regulatory-role
#75
REVIEW
Somayeh Ahmadi, Mohammad Taghizadieh, Elham Mehdizadehfar, Alka Hasani, Javad Khalili Fard, Hadi Feizi, Hammed Hamishehkar, Masood Ansarin, Mina Yekani, Mohammad Yousef Memar
Melatonin is a highly conserved molecule produced in the human pineal gland as a hormone. It is known for its essential biological effects, such as antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut is one of the primary known sources of melatonin. The gut microbiota helps produce melatonin from tryptophan, and melatonin has been shown to have a beneficial effect on gut barrier function and microbial population. Dysbiosis of the intestinal microbiota is associated with bacterial imbalance and decreased beneficial microbial metabolites, including melatonin...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518506/breakthrough-covid-19-in-people-with-multiple-sclerosis-on-disease-modifying-treatments-is-it-still-a-severe-disease
#76
JOURNAL ARTICLE
Paolo Immovilli, Irene Schiavetti, Alessandro Franceschini, Paola De Mitri, Lorenza Gelati, Eugenia Rota, Donata Guidetti
INTRODUCTION: Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the safety of people with MS (pwMS). The aim of the present study is to describe the effect of MS DMTs on COVID-19 vaccination and the risk of breakthrough infection in a cohort of pwMS...
March 8, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38518505/neonatal-outcomes-in-women-with-multiple-sclerosis-influence-of-disease-activity-a-danish-nationwide-cohort-study
#77
JOURNAL ARTICLE
Mette Louise Andersen, Line Riis Jølving, Maria Iachina, Pavithra Laxsen Anru, Egon Stenager, Torben Knudsen, Bente Mertz Nørgård
BACKGROUND: Maternal Multiple Sclerosis (MS) has been associated with an increased risk of adverse birth outcomes. We hypothesized that active disease during conception and pregnancy plays an important role in this context, which this study aims to address. METHODS: We used the Danish registers to conduct a nationwide cohort study. Information on maternal disease activity during pregnancy was retrieved using proxies from the linked registers (hospitalization, magnetic resonance imaging of the brain, and use of systemic corticosteroids during pregnancy)...
March 11, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38517926/incidence-of-type-2-diabetes-cardiovascular-disease-and-chronic-kidney-disease-in-patients-with-multiple-sclerosis-initiating-disease-modifying-therapies-retrospective-cohort-study-using-a-frequentist-model-averaging-statistical-framework
#78
JOURNAL ARTICLE
Alan J M Brnabic, Sarah E Curtis, Joseph A Johnston, Albert Lo, Anthony J Zagar, Ilya Lipkovich, Zbigniew Kadziola, Megan H Murray, Timothy Ryan
Researchers are increasingly using insights derived from large-scale, electronic healthcare data to inform drug development and provide human validation of novel treatment pathways and aid in drug repurposing/repositioning. The objective of this study was to determine whether treatment of patients with multiple sclerosis with dimethyl fumarate, an activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, results in a change in incidence of type 2 diabetes and its complications. This retrospective cohort study used administrative claims data to derive four cohorts of adults with multiple sclerosis initiating dimethyl fumarate, teriflunomide, glatiramer acetate or fingolimod between January 2013 and December 2018...
2024: PloS One
https://read.qxmd.com/read/38517521/persons-with-multiple-sclerosis-older-than-55%C3%A2-years-an-analysis-from-the-german-ms-registry
#79
JOURNAL ARTICLE
Yasemin Goereci, David Ellenberger, Paulus Rommer, Veronika Dunkl, Heidrun Golla, Uwe Zettl, Alexander Stahmann, Clemens Warnke
BACKGROUND: Persons with MS (PwMS) ≥ 55 years are underrepresented in therapy studies leading to a lack of evidence. OBJECTIVE AND METHODS: To study the subgroup of PwMS ≥ 55 years in the German MS registry in comparison with PwMS < 55 years. Endpoints of interest were the grade of disability, leading symptoms, clinical and magnetic resonance imaging activity, and use of disease modifying therapy...
March 22, 2024: Journal of Neurology
https://read.qxmd.com/read/38516846/pathogenic-potential-of-eomesodermin-expressing-t-helper-cells-in-neurodegenerative-diseases
#80
JOURNAL ARTICLE
Tomomi Kanazawa, Wakiro Sato, Ben J E Raveney, Daiki Takewaki, Atsuko Kimura, Hiromi Yamaguchi, Yuma Yokoi, Reiko Saika, Yuji Takahashi, Tsuneo Fujita, Shinji Saiki, Akira Tamaoka, Shinji Oki, Takashi Yamamura
Eomesodermin-expressing (Eomes+ ) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients...
March 22, 2024: Annals of Neurology
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