Amal Mohamed Elhusein, Hammad Ali Fadlalmola, Eltayeb Mohammed Awadalkareem, Ekram Yahia Mahmowd Alhusain, Soad Mohamed Alnassry, Mukhlid Alshammari, Elsadig Eltahir Abdulrahman, Doaa El Sayed Fadila, Fatma M Ibrahim, Abdalrahman Abdallatif Mohmmed Saeed, Adel Abdalla, Hassan N Moafa, Ehab I El-Amin, Daniel Mon Mamanao
BACKGROUND: Multiple sclerosis presents a significant burden, with balance disturbances impacting patients' daily living. Conventional therapies have been supplemented with technological advancements like virtual reality (VR) and exergaming, providing engaging, multisensory rehabilitation options. OBJECTIVE: This study aimed to synthesize evidence on exergaming's role in multiple sclerosis treatment, particularly to evaluate the impact of exergaming on cognitive, motor, and psychological outcomes in patients with multiple sclerosis...
2024: Belitung nursing journal
Leah Chan, Nicholas Pereira
Optic neuritis represents a rare clinical entity leading to vision loss within the pediatric population. While not an urgent or life-threatening condition, optic neuritis may serve as a manifestation of various systemic diseases. When pediatric patients present with complaints of vision loss, it is imperative to consider optic neuritis as a potential differential diagnosis. This prompts further investigation to exclude systemic diseases capable of causing substantial morbidity. This article details a case report involving optic neuritis in a 15-year-old Hispanic female, outlining the investigation and management approach...
January 2024: Curēus
Ali Keyhani, Mohammad Javad Shabani, Farnaz Etesam, Nasim Rezaeimanesh, Amirreza Azimi, Abdorreza Naser Moghadasi
Background: The present study examined the prevalence of obsessive-compulsive disorder (OCD) among Iranian patients with multiple sclerosis (MS) and the relationship between OCD and the patient's demographic characteristics. Methods: The present study used a cluster sampling method to randomly select 297 patients with MS from the patients referred to the MS Clinic and Research Center of Sina University Hospital, Tehran, Iran, during 2018-2019. To gather the required data, a questionnaire consisting of demographic characteristics and disease information sections was used...
October 7, 2023: Current journal of neurology
Vahid Shaygannejad, Omid Mirmosayyeb, Aysa Shaygannejad, Saeed Vaheb, Sara Bagherieh, Mozhdeh Askari, Mahsa Ghajarzadeh
Background: Social support and anxiety are essential for patients with chronic diseases such as multiple sclerosis (MS). During coronavirus disease 2019 (COVID-19) pandemic, the psychological well-being of subjects with MS was an important issue, and we designed this study to assess anxiety, resilience, and social support in these patients during COVID-19 pandemic stage. Methods: We used convenience sampling for this study. Inclusion criteria were definite diagnosis of MS based on McDonald criteria and age more than 18 years...
October 7, 2023: Current journal of neurology
Josephine U Pierce Pucci, Heather M Soloria, Philip G Eye
Pediatric-onset multiple sclerosis (POMS) is the most common demyelinating disease in children. Patients suffer from physical disability, cognitive impairment, and psychosocial challenges. Management requires a multidisciplinary care team. Here we present a case of an 11-year-old boy with POMS who relocated to Guam prior to initiation of a disease-modifying treatment and who experienced a flare without immediate access to an MRI or a child neurologist. Care required the combined efforts of ophthalmology, pediatrics, and emergency medicine in Guam, real-time remote guidance by child neurology, and asynchronous collaboration with cardiology and child neurology...
February 29, 2024: Journal of Telemedicine and Telecare
Endre Bakke Aakrann, John Brincks
OBJECTIVE: Accurate and reliable balance measures are important for prescribing fall prevention treatments and monitoring their effectiveness. Thus, we aimed to systematically review the psychometric properties of the Six-Spot Step Test, an increasingly used measure of dynamic balance. DATA SOURCES: A literature search using the free-text term "Six-Spot Step Test" was performed on 12 February 2024, in Medline, Embase, Rehabilitation & Sports Medicine and SPORTDiscus...
February 29, 2024: Clinical Rehabilitation
Antonio Luchicchi, Gema Muñoz-Gonzalez, Saar T Halperin, Eva Strijbis, Laura H M van Dijk, Chrisa Foutiadou, Florence Uriac, Piet M Bouman, Maxime A N Schouten, Jason Plemel, Bert A 't Hart, Jeroen J G Geurts, Geert J Schenk
OBJECTIVE: Multiple sclerosis (MS) is a chronic central nervous system disease whose white matter lesion origin remains debated. Recently, we reported subtle changes in the MS normal appearing white matter (NAWM), presenting with an increase in myelin blisters and myelin protein citrullination, which may recapitulate some of the prodromal degenerative processes involved in MS pathogenesis. Here, to clarify the relevance of these changes for subsequent MS myelin degeneration we explored their prevalence in WM regions characterized by subtly reduced myelination (dubbed as micro-diffusely abnormal white matter, mDAWM)...
February 29, 2024: Annals of Clinical and Translational Neurology
Raja Majid Afzal, Jeppe Romme Christensen, Rosa Maja Møhring Gynthersen, Anne-Mette Lebech, Morten Blinkenberg, Helene Mens
OBJECTIVE: To describe a case of neoehrlichiosis, an emerging opportunistic tick-borne infection, in a patient with multiple sclerosis (MS) treated with ocrelizumab. METHODS: This is a case study. RESULTS: Our patient developed clinical infection over several months while on ocrelizumab and was ultimately diagnosed with neoehrlichiosis, caused by the bacteria Neoehrlichia mikurensis . Resolution of symptoms began within a few days after the initiation of antibiotic treatment...
February 29, 2024: Multiple Sclerosis: Clinical and Laboratory Research
Saniya Kari, Florence Bucciarelli, Thibault Angles, Anne-Cecile Oster, Pauline Cauboue, Karl Laviolette, Madeline Mougenot, Elena Morandi, Isabelle Bernard, Beatrice Pignolet, Chloé Bost, Joelle Thomas, Leonor Nogueira, Abdelhadi Saoudi, Roland Liblau, Anne L Astier
BACKGROUND: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown. OBJECTIVE: To investigate the presence and functional implications of sCD226 in persons with multiple sclerosis (pwMS) and other neurological diseases. METHODS: The mechanisms of sCD226 production were first investigated by analyzing CD226 surface expression levels and supernatants of CD3/CD226-coactivated T cells...
February 29, 2024: Multiple Sclerosis: Clinical and Laboratory Research
Pauline Gury, Maximilien Moulin, Raphaëlle Laroye, Marine Montazel, Marine Trachino, Pauline Narme, Nathalie Ehrlé
Sociocognitive impairment is well known in the relapsing-remitting form of multiple sclerosis (RR-MS). The purpose of the present study was to assess explicit and implicit humor abilities in this population. Based on clinical observation and contrary to the current cognitive model, we hypothesized that implicit performances (happy facial expressions) would be better than explicit ones (humor judgment assessed by explicit humor comprehension, subjective feeling of amusement as a conscious appreciation of funniness, and verbal justifications of funniness)...
February 29, 2024: Social Neuroscience
Chu Xie, Cong Sun, Mu-Sheng Zeng
No abstract text is available yet for this article.
February 29, 2024: Signal Transduction and Targeted Therapy
C Pierret, M Mainguy, E Leray
BACKGROUND: France is among the countries with high prevalence of multiple sclerosis (MS). The most recent estimates are from 2012 and need to be updated because MS prevalence has increased worldwide. OBJECTIVE: To estimate MS prevalence in France on December 31, 2021 and to describe the characteristics of the French MS population using data from the French national health insurance database (SNDS). MATERIAL AND METHODS: Persons with MS (PwMS) were identified in the SNDS database (99% of national coverage) using an algorithm with three criteria: long-term disease status, hospitalizations, and MS-specific drug reimbursements...
February 28, 2024: Revue Neurologique
Barbara Serafini, Lucia Benincasa, Barbara Rosicarelli, Francesca Aloisi
The presence of EBV infected B cells in postmortem multiple sclerosis (MS) brain tissue suggests immune evasion strategies. Using immunohistochemical techniques we analysed the expression of the immune checkpoint molecule PD-L1 and its receptor PD-1 in MS brains containing B cell-enriched perivascular infiltrates and meningeal follicles, a major EBV reservoir. PD-1 and PD-L1 immunoreactivities were restricted to CNS-infiltrating immune cells. PD-L1 was expressed on B cells, including EBV infected B cells, while PD-1 was expressed on many CD8+ T cells, including EBV-specific CD8+ T-cells, and fewer CD4+ T cells...
February 15, 2024: Journal of Neuroimmunology
Libak Abou, Joseph Peters, Bruno Freire, Jacob J Sosnoff
BACKGROUND: Fear of falling (FOF) is a common concern among persons with multiple sclerosis (MS) and affects the performance of their daily living activities. Falls may result in FOF, leading to worsening of symptoms of MS, physical deconditioning, and exposure to future falls. This may trigger a vicious cycle between FOF and falls. A better understanding of the relationship between FOF and symptoms of MS may be helpful to develop a conceptual model to guide fall prevention interventions...
February 16, 2024: Multiple Sclerosis and related Disorders
Mouna Maaloul, Sabrina Mejdoub, Salma Sakka, Hend Hachicha, Mariem Dammak, Faten Koubaa, Chokri Mhiri, Hatem Masmoudi, Sawsan Feki
Cerebrospinal fluid (CSF) isoelectrofocusing (IEF) is considered as the gold standard for detecting an intrathecal synthesis of IgG, which is a hallmark of multiple sclerosis (MS). This corresponds to the presence of CSF-restricted IgG oligoclonal bands (OCB) (typically type 2 pattern). Moreover, this technique can also detect a systemic immune reaction with passive transfer of IgG (type 3 and 4 patterns) for which the clinical relevance is less understood. The aim of our study was to determine the frequency and disease associations of IEF type 3 and 4 patterns and to investigate the potential usefulness of including quantitative data (IgG index and Reiber Diagram) in interpreting such IEF profiles...
February 18, 2024: Multiple Sclerosis and related Disorders
Nazire Pinar Acar Ozen, Ece Gok Dursun, Asli Tuncer, Rana Karabudak
BACKGROUND: This retrospective study, conducted between 2005 and 2016, investigated the outcomes of patients with multiple sclerosis (MS) who discontinued injectable first-line disease-modifying therapies (DMTs). The study aimed to identify factors influencing treatment discontinuation and assess the impact of discontinuation on disease progression. METHODS: Data was collected from 2,270 patients who received injectable DMTs for at least two years and subsequently discontinued treatment due to clinical and MRI remission, side effects, or noncompliance...
February 15, 2024: Multiple Sclerosis and related Disorders
Nisar Ali Shaikh, Xiao-Bing Zhang, Maisa I Abdalla, David J Baylink, Xiaolei Tang
Regulatory T (Treg) cells hold promise for the ultimate cure of immune-mediated diseases. However, how to effectively restore Treg function in patients remains unknown. Previous reports suggest that activated dendritic cells (DCs) de novo synthesize locally high concentrations of 1,25-dihydroxy vitamin D, i.e., the active vitamin D or 1,25(OH)2D by upregulating the expression of 25-hydroxy vitamin D 1α-hydroxylase. Although 1,25(OH)2D has been shown to induce Treg cells, DC-derived 1,25(OH)2D only serves as a checkpoint to ensure well-balanced immune responses...
2024: Critical Reviews in Immunology
Anastasiia D Shkodina, Mainak Bardhan, Hitesh Chopra, Onyekachi Emmanuel Anyagwa, Viktoriia A Pinchuk, Kateryna V Hryn, Anzhelina M Kryvchun, Dmytro I Boiko, Vinay Suresh, Amogh Verma, Mykhailo Yu Delva
Multiple sclerosis is a chronic inflammatory disease that affects the central nervous system and can cause various types of pain including ongoing extremity pain, Lhermitte's phenomenon, trigeminal neuralgia, and mixed pain. Neuropathic pain is a major concern for individuals with multiple sclerosis as it is directly linked to myelin damage in the central nervous system and the management of neuropathic pain in multiple sclerosis is challenging as the options available have limited efficacy and can cause unpleasant side effects...
February 29, 2024: CNS Drugs
Xiwen Ai, Haojun Yu, Yu Cai, Yangtai Guan
Neuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain-Barré syndrome, are characterized by the dysfunction of both the immune system and the nervous system. Increasing evidence suggests that extracellular vesicles and autophagy are closely associated with the pathogenesis of these disorders. In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications...
February 29, 2024: Neuroscience Bulletin
Louisa Scherer, Marc Soudant, Sophie Pittion-Vouyovitch, Marc Debouverie, Francis Guillemin, Jonathan Epstein, Guillaume Mathey
BACKGROUND: one of the most important therapeutic goals in relapse-onset multiple sclerosis is to preclude conversion to secondary progression. Our objective was to determine the risk of progression associated with natalizumab treatment in an registry-based cohort of patients and to identify determinant factors. METHODS: Patients with relapse-onset multiple sclerosis from the Registre Lorrain des Scléroses en Plaques (ReLSEP) were included if they had received one infusion of natalizumab between 2002 and 2021...
February 29, 2024: Journal of Neurology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.