Mark B Skeen
Our increasing understanding of the immunopathogenesis of multiple sclerosis has led to the development of many disease-modifying therapies that have revolutionized the care of patients with relapsing forms of the disease. Our understanding of the pathophysiologic basis of progressive forms of the disease is much more limited but has dramatically changed over the past several decades. We are now on the verge of developing therapies that promote remyelination, reduce axonal loss, and restore axonal function...
May 1, 2021: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Mark B Skeen
No abstract text is available yet for this article.
May 1, 2021: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Antonio Carotenuto, Teresa Costabile, Marcello Moccia, Fabrizia Falco, Maria Petracca, Barbara Satelliti, Cinzia Valeria Russo, Francesco Sacc, Roberta Lanzillo, Vincenzo Brescia Morra
Purpose: to evaluate the prevalence of bowel/bladder dysfunction in multiple sclerosis (MS) and the association with cognitive impairment. Methods: We prospectively enrolled 150 MS patients. Patients were administered the Symbol Digit Modality Test (SDMT), and filled the Neurogenic Bowel Dysfunction Score (NBDS) and the Actionable Bladder Symptom Screening Tool (ABSST). Association between bowel/bladder dysfunction and cognitive function was assessed through hierarchical regression models using SDMT and clinic-demographic features as independent variables and NBDS or ABSST score as dependent variables...
May 6, 2021: International Neurourology Journal
Rishab Marahatha, Kabita Gyawali, Kabita Sharma, Narayan Gyawali, Parbati Tandan, Ashma Adhikari, Grishma Timilsina, Salyan Bhattarai, Ganesh Lamichhane, Ashis Acharya, Ishwor Pathak, Hari Prasad Devkota, Niranjan Parajuli
Natural products and their derivatives are known to be useful for treating numerous diseases since ancient times. Because of their high therapeutic potentials, the use of different medicinal plants is possible to treat varied inflammation-mediated chronic diseases. Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Currently, available medications exert numerous systemic toxicities, including hypertension, immune suppression, osteoporosis, and metabolic abnormalities...
May 6, 2021: Phytotherapy Research: PTR
Jalal Dahham, Rana Rizk, Ingrid Kremer, Silvia M A A Evers, Mickaël Hiligsmann
BACKGROUND: Although the economic burden of multiple sclerosis (MS) in high-income countries (HICs) has been extensively studied, information on the costs of MS in low- and middle-income countries (LMICs) remains scarce. Moreover, no review synthesizing and assessing the costs of MS in LMICs has yet been undertaken. OBJECTIVE: Our objective was to systematically identify and review the cost of illness (COI) of MS in LMICs to critically appraise the methodologies used, compare cost estimates across countries and by level of disease severity, and examine cost drivers...
May 6, 2021: PharmacoEconomics
Raoof Negaresh, Reza Gharakhanlou, Mohammad Ali Sahraian, Maryam Abolhasani, Robert W Motl, Philipp Zimmer
BACKGROUND AND PURPOSE: Physical activity may represent a disease-modifying therapy in persons with multiple sclerosis (pwMS). To date, there is limited research regarding mechanisms based on brain imaging for understanding the beneficial effects of physical activity in pwMS. This study examined the relationship between physical activity levels and thalamic and hippocampal volumes and brain metabolism in pwMS. METHODS: The sample of 52 pwMS (37.3 ± 9.6 years of age; 35 females, 17 males) underwent a combination of volumetric magnetic resonance imaging and magnetic resonance spectroscopy...
May 6, 2021: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Darius Häusler, Katja Akgün, Lidia Stork, Hans Lassmann, Tjalf Ziemssen, Wolfgang Brück, Imke Metz
Natalizumab, a recombinant humanized monoclonal antibody directed against the α4 subunit of the integrins α4ß1 and α4ß7, has been approved for the treatment of active relapsing-remitting MS. Although natalizumab is a highly beneficial drug that effectively reduces the risk of sustained disability progression and the rate of clinical relapses, some patients do not respond to it, and some are at higher risk of developing progressive multifocal leukoencephalopathy (PML). The histopathological effects after natalizumab therapy are still unknown...
May 6, 2021: Brain Pathology
R Bhatia, L Bains, P Lal, G Bhagria
Angiomyolipoma is a benign solid renal neoplasm. A giant angiomyolipoma is more than 10cm by size, but it can grow to huge proportions. Our case appears to be the third largest angiomyolipoma and the largest among bilateral giant renal angiomyolipoma in the indexed literature. A 26-year-old man presented with large right abdominal swelling for the past three years, which was occupying his right flank and iliac region, extending beyond the midline. Computed tomography of the abdomen revealed a large well-defined mass in the right side of the abdomen, crossing the midline and measuring 35 × 20 × 12cm...
May 6, 2021: Annals of the Royal College of Surgeons of England
Marta Fichna, Piotr P Małecki, Bolesław Gębarski, Helena Gębarska, Marek Ruchała
BACKGROUND: Autoimmunity accounts for 90% of cases of primary adrenal insufficiency (Addison's disease, AD). Affected persons present a significant co-occurrence of autoimmune conditions, hence, clustering of autoimmunity is also predicted among their relatives. AIMS: The aim of our study was to evaluate the burden of autoimmunity in families of people with AD. METHODS: 116 individuals with AD were surveyed about the occurrence of 23 autoimmune diseases among their relatives...
May 5, 2021: Internal Medicine Journal
S H El Sharouny, M H Shaaban, R M Elsayed, A W Tahef, M K Abd ElWahed
Myelination is a sequential process that is tightly controlled by a number of intrinsic and extrinsic factors. Any CNS disease in which the neuronal myelin sheath is damaged is referred to as demyelinating disease. The present work was designed to study the histopathological, ultrastructural and immunohistochemical changes in rat brain, mainly corpus callosum (CC), following oral administration of cuprizone (CPZ), and the role of N-acetylcysteine (NAC) in reducing these changes. Demyelination was induced by CPZ administration for short (4Ws) and long (8Ws) periods...
May 6, 2021: Folia Morphologica (Warsz)
Brian C Healy, Bonnie I Glanz, Elyse Swallow, James Signorovitch, Kaitlin Hagan, Diego Silva, Corey Pelletier, Tanuja Chitnis, Howard Weiner
Background: Although confirmed disability progression (CDP) is a common outcome in multiple sclerosis (MS) clinical trials, its predictive value for long-term outcomes is uncertain. Objective: To investigate whether CDP at month 24 predicts subsequent disability accumulation in MS. Methods: The Comprehensive Longitudinal Investigation of Multiple Sclerosis at Brigham and Women's Hospital includes participants with relapsing-remitting MS or clinically isolated syndrome with Expanded Disability Status Scale (EDSS) scores ≤5 (N = 1214)...
April 2021: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Laleh Mavaddatiyan, Shiva Khezri, Seyyed Meysam Abtahi Froushani
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Previous studies have shown that myelin degradation during MS and EAE resulted in reduced expression of some of the proteins, e.g., the MBP (myelin basic protein), and increased expression of genes such as iNOS (Inducible nitric oxide synthase) and NOGO-A in the affected patients. In the present study, EAE was induced by immunizing Wistar rats (n=12) with homogenized spinal cord of guinea pig and Freund's complete adjuvant...
2021: Veterinary Research Forum
Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Leila Etemad, Vida Hojjati, Mahmoud Gorji-Valokola
Objectives: Multiple sclerosis (MS) causes extensive damage in the hippocampus. Vitamin B12 (vit B12) and estradiol benzoate (EB) have anti-inflammatory and re-myelination properties that make them proper in improvement of cognitive impairment. This study aimed to evaluate the effects of these compounds on learning and memory disturbances. Materials and Methods: 77 adult male rats were implanted with stainless steel guide cannula bilaterally into the hippocampal area...
February 2021: Iranian Journal of Basic Medical Sciences
Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J Zhang, Hsin-I Huang, Gianna Hammer, Donghai Wang
[This corrects the article DOI: 10.3389/fimmu.2021.641188.].
2021: Frontiers in Immunology
Curtis Wojcik, Tom A Fuchs, Hoan Tran, Michael G Dwyer, Dejan Jakimovski, Mahmut Unverdi, Bianca Weinstock-Guttman, Robert Zivadinov, Arman Eshaghi, Ralph Hb Benedict
BACKGROUND: The sequence in which cognitive domains become impaired in multiple sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed dysfunction temporally precedes other cognitive impairments, such as memory and executive function. OBJECTIVE: Determine the order in which different cognitive domains become impaired in MS and validate these findings using clinical and vocational outcomes. METHODS: In a longitudinal sample of 1073 MS patients and 306 healthy controls, we measured performance on multiple, consensus-standard, neurocognitive tests...
May 6, 2021: Multiple Sclerosis: Clinical and Laboratory Research
Mickael Bonnan, Emeline Berthelot, Philippe Cabre
BACKGROUND: Initial clinical manifestations of NMOSD may rarely overlap with MS. Fingolimod may trigger severe attacks in patients with NMOSD previously misdiagnosed as MS. These cases are rare and their pathophysiology remains elusive. METHODS: We recruited all NMOSD patients treated by fingolimod in a single-center cohort of Afro-Caribbean neuro-inflammatory patients in Fort-de-France (French West Indies). Six patients were collected from the literature. RESULTS: Among 622 patients followed locally for MS, 101 received fingolimod and two suffered severe attacks revealing a typical NMOSD presentation...
April 24, 2021: Multiple Sclerosis and related Disorders
James F Sumowski, Sam Horng, Rachel Brandstadter, Stephen Krieger, Victoria M Leavitt, Ilana Katz Sand, Michelle Fabian, Sylvia Klineova, Robin Graney, Claire S Riley, Fred D Lublin, Aaron E Miller, Andrew W Varga
OBJECTIVE: Sleep-dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but little is known about the contributions of sleep disturbance to memory in MS. We investigated whether subjective sleep disturbance is linked to worse memory in early MS independently of potential confounders. METHODS: Persons with early MS (n = 185; ≤5...
May 5, 2021: Annals of Clinical and Translational Neurology
Carl J J Herrmann, Antje Els, Laura Boehmert, Joao Periquito, Thomas Wilhelm Eigentler, Jason M Millward, Sonia Waiczies, Joseph Kuchling, Friedemann Paul, Thoralf Niendorf
PURPOSE: The characteristic MRI features of multiple sclerosis (MS) lesions make it conceptually appealing to pursue parametric mapping techniques that support simultaneous generation of quantitative maps of 2 or more MR contrast mechanisms. We present a modular rapid acquisition with relaxation enhancement (RARE)-EPI hybrid that facilitates simultaneous T2 and <mml:math xmlns:mml=""> <mml:msubsup> <mml:mi>T</mml:mi> <mml:mn>2</mml:mn> <mml:mo>∗</mml:mo> </mml:msubsup> </mml:math> mapping (2in1-RARE-EPI)...
May 5, 2021: Magnetic Resonance in Medicine
Daniel Golan, Smadar Sagiv, Lea Glass-Marmor, Ariel Miller
BACKGROUND: The applicability of mobile digital technology to promote clinical care of people with multiple sclerosis (pwMS) is gaining increased interest as part of the implementation of patient-centered approaches. We aimed at assessing adherence to a smartphone-based e-diary, which was designed to collect patient-reported outcomes (PROs). Secondary objectives were to evaluate the construct and predictive validity of e-diary derived PROs and to explore the various factors that were associated with changes in PROs over time...
2021: PloS One
Sabrina Aït Amiri, Cyrille Deboux, Feryel Soualmia, Nancy Chaaya, Maxime Louet, Eric Duplus, Sandrine Betuing, Brahim Nait Oumesmar, Nicolas Masurier, Chahrazade El Amri
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biological evaluation of KLK6's low-molecular-weight inhibitors, para -aminobenzyl derivatives...
May 5, 2021: Journal of Medicinal Chemistry
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