Vasileios C Mastorodemos, Stefanos G Ioannidis, Efrosini Z Papadaki, Panayiotis D Mitsias
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) has only rarely been reported in patients with multiple sclerosis (MS). METHODS: Case report of a patient with relapsing remitting (RR) MS patient on interferon (INF) treatment, who developed posterior fossa PRES. RESULTS: A 46-year-old male diagnosed with RR MS in 2010 was placed on INF beta-1a therapy. He remained in clinical remission for seven years. He then presented with headache of one month duration and worsening upper extremity ataxia...
July 3, 2020: Multiple Sclerosis and related Disorders
Tomas P Labbe, Mariana Zurita, Cristian Montalba, Ethel L Ciampi, Juan P Cruz, Macarena Vasquez, Sergio Uribe, Nicolás Crossley, Claudia Cárcamo
BACKGROUND: Multiple Sclerosis produces changes in the functional connectivity of the brain. Resting-State fMRI is a useful tool for the study of functional changes in the human brain, and its metrics can be related to clinical findings involved in clinical decline. Social cognition has focused increasing interest because patients are exposed to experiencing social disorganization during the progression of the disease. fMRI has proved to be a useful tool for studying brain connectivity and its relation with social cognition both in resting-state and during socio-cognitive tasks...
June 24, 2020: Multiple Sclerosis and related Disorders
Juichi Fujimori, Kengo Uryu, Kazuo Fujihara, Mike P Wattjes, Chihiro Suzuki, Ichiro Nakashima
OBJECTIVES: Recent studies suggest that parameters of the corpus callosum (CC), such as the CC index (CCI) and fractional anisotropy (FA) of the CC, may be related to the degree of brain volume loss (BVL) in MS patients; however, cutoff values that determine the degree of BVL have not been set. METHODS: Seventy-five MS patients and 21 healthy controls (HCs) underwent volumetric MRI examinations. MS patients were also evaluated for T2 lesion load, the CCI, and FA of the CC...
July 8, 2020: Multiple Sclerosis and related Disorders
Giulia Magni, Silvia Pedretti, Matteo Audano, Donatella Caruso, Nico Mitro, Stefania Ceruti
Trigeminal neuralgia is often an early symptom of multiple sclerosis (MS), and it generally does not correlate with the severity of the disease. Thus, whether it is triggered simply by demyelination in specific central nervous system areas is currently questioned. Our aims were to monitor the development of spontaneous trigeminal pain in an animal model of MS, and to analyze: i) glial cells, namely astrocytes and microglia in the central nervous system and satellite glial cells in the trigeminal ganglion, and ii) metabolic changes in the trigeminal system...
July 10, 2020: Brain, Behavior, and Immunity
Sven G Meuth, Antonios Bayas, Boris Kallmann, Christoph Kleinschnitz, Ralf Linker, Peter Rieckmann, Mathias Mäurer
INTRODUCTION: Oral cladribine is a highly effective pulsed selective immune reconstitution therapy licensed for relapsing multiple sclerosis. A full treatment course comprises two treatment cycles given with 1 year of intermission. Further dosing is not routinely recommended in years 3 and 4. AREAS COVERED: The long-term management of patients treated with oral cladribine has not been fully defined on the basis of clinical studies as of yet. The authors provide their expert opinion on this...
July 13, 2020: Expert Opinion on Pharmacotherapy
Hui Huang, Haibiao Lin, Lixian Huang, Yanxin Li, Guohua Li, Jingchun Huang, Yanling Luo, Peifeng Ke
BACKGROUND: High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS). Biotin, as dietary supplement or therapy, may lead to analytical interference in biotin-streptavidin immunoassay. METHODS: Seven concentration gradients of biotin solutions were spiked to three different levels of Ca242 serum samples. All samples were tested by CanAg Ca242 ELISA kit to evaluate the interference from biotin. Serum samples with biotin concentration at 1,000 ng/mL were retested after absorption by streptavidin microparticles or direct analysis on the Mindray CL2000i platform...
July 1, 2020: Clinical Laboratory
Céline Louapre, Constantina A Treaba, Valeria Barletta, Caterina Mainero
PURPOSE OF REVIEW: Ultra-high field 7 T MRI has multiple applications for the in vivo characterization of the heterogeneous aspects underlying multiple sclerosis including the identification of cortical lesions, characterization of the different types of white matter plaques, evaluation of structures difficult to assess with conventional MRI (thalamus, cerebellum, spinal cord, meninges). RECENT FINDINGS: The sensitivity of cortical lesion detection at 7 T is twice than at lower field MRI, especially for subpial lesions, the most common cortical lesion type in multiple sclerosis...
August 2020: Current Opinion in Neurology
Kenji Ishibashi, Masashi Kameyama, Yoshiharu Miura, Jun Toyohara, Kenji Ishii
Three patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with F-THK5351 as well as Ki map, Ki/K1 map and SUV image with C-L-deprenyl were created. F-THK5351 BPND maps and SUV images clearly identified the lesions undergoing astrogliosis. C-L-deprenyl Ki/K1 maps were close to F-THK5351 images, but very noisy...
July 8, 2020: Clinical Nuclear Medicine
R Van Rensburg, V Pillay-Fuentes Lorente, M Blockman, K Moodley, J M Wilmshurst, E H Decloedt
The South African (SA) Constitutional Court recently decriminalised the private cultivation, possession and use of cannabis by adults. Cannabis contains varying amounts of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), depending on various cultivation factors. No commercial plant-derived cannabis products are currently registered by the SA Health Products Regulatory Authority (SAHPRA) for medical use. Such products are therefore unregulated, but are freely available in SA, and may be of inadequate quality and unverified composition, and not guaranteed to be safe or effective...
February 26, 2020: South African Medical Journal
Abdorreza Naser Moghadasi, Mohaddeseh Azadvari, Mohammad Ali Sahraian
No abstract text is available yet for this article.
July 1, 2020: Archives of Iranian Medicine
Yalçın Karaküçük, Haluk Gümüş, Serhat Eker
AIM: To determine changes in retinal microcirculation, caused by fingolimod (FTY720) use, via swept-source optical coherence tomography angiography (SS-OCTA) in relapsing-remitting multiple sclerosis (RR-MS) patients. MATERIALS AND METHODS: 80 patients with RR-MS, who were using fingolimod, and 50 healthy control subjects were included in the study. Group 1 consisted of 40 eyes from 40 RR-MS patients, who had been using fingolimod for less than six months, and Group 2 consisted of 40 eyes from 40 RR-MS patients, who had been using fingolimod for longer than six months...
July 12, 2020: Cutaneous and Ocular Toxicology
Il Han Yoo, WooJoong Kim, Youngkyu Shim, Sun Ah Choi, Soo Yeon Kim, Hunmin Kim, Byung Chan Lim, Hee Hwang, Jieun Choi, Ki Joong Kim, Yeseul Kim, Jae Won Hyun, Su Hyun Kim, Kyungho Choi, Ho Jin Kim, Jong Hee Chae
BACKGROUND AND PURPOSE: The myelin oligodendrocyte glycoprotein (MOG) antibody is detected at a high rate in childhood acquired demyelinating syndrome (ADS). This study aimed to determine the diagnostic value of the MOG antibody in ADS and the spectrum of MOG-antibody-positive demyelinating diseases in children. METHODS: This study included 128 patients diagnosed with ADS ( n =94) or unexplained encephalitis ( n =34). The MOG antibody in serum was tested using an in-house live-cell-based immunofluorescence assay...
July 2020: Journal of Clinical Neurology
Woojun Kim, Ho Jin Kim
Considerable progress has been made in treatments for multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) over the last several decades. However, the present treatments do not show satisfactory efficacy or safety in a considerable proportion of patients, who experience relapse or disability progression despite receiving treatment and suffer from side effects, which can be severe. Improvements in the understanding of the pathophysiologies of MS and NMOSD have led to numerous therapeutic approaches being proposed and developed...
July 2020: Journal of Clinical Neurology
Chunxia Peng, Li Li, Mo Yang, Da Teng, Junqing Wang, Mengying Lai, Haiyan Qian, Hongyang Li, Huanfen Zhou, Quangang Xu, Shihui Wei
PURPOSE: The ocular choroid is a sensitive biomarker of vascular perfusion in optic neuritis (ON) patients due to its vascular structures. The purpose of this study was to evaluate alterations in sub-macular choroidal thicknesses (sub-MCT) in aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) sero-positive neuromyelitis optica spectrum disease (AQP4-IgG+/NMOSD) and isolated ON (ION) patients using optical coherence tomography (OCT). METHODS: A total of 208 ON patients (275 eyes) and healthy controls (HCs) who underwent sub-MCT and retinal microstructure detection with OCT were enrolled in this study...
July 12, 2020: Acta Ophthalmologica
Alex Mabou Tagne, Barbara Pacchetti, Mikael Sodergren, Marco Cosentino, Franca Marino
Background: The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be used for the treatment of viral infection-related conditions. Aim and Methods: Therefore, we systematically retrieved and critically evaluated the scientific literature available on PubMed and the claims on the Internet, to assess the current state of knowledge on the use of CBD in viral diseases, and to provide suggestions for future research directions...
June 1, 2020: Cannabis and Cannabinoid Research
Michael Nagib, Preston Hood, Jerry Matteo
Head and facial pain are a burden to many people both directly and indirectly. This is manifested not only as a personal burden but also as a financial one in the form of sick leaves from work and loss of workplace productivity. These costs stem from emergency department visits, hospitalizations, preventative treatments, and medical management. Medical management of migraine headaches and other causes of facial pain often proves insufficient, and sphenopalatine ganglion block (SPGB) provides an innovative, adjunctive outpatient treatment option with excellent results in alleviating symptoms...
June 9, 2020: Curēus
Jennifer L Geurts
Inherited syndromes are important to recognize in the setting of a pancreatic neuroendocrine tumor (PNET) as there are significant implications for the patient's medical management and opportunity for early detection of subsequent manifestations. Although most PNETs are sporadic, approximately 10% are due to an inherited syndrome, which include multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 4 (MEN4), von Hippel-Lindau disease (VHL), neurofibromatosis type 1 (NF1), and tuberous sclerosis complex (TSC)...
June 2020: Journal of Gastrointestinal Oncology
David Jure Hunt, Anthony Traboulsee
There is a lack of literature documenting the use of alemtuzumab in pediatric multiple sclerosis (MS) patients. Here we describe a 16-year-old and a 17-year-old patient receiving alemtuzumab and being followed for 37 months and 20 months, respectively. Both patients experienced a 1.0 decrease in Expanded Disability Status Scale since initial alemtuzumab infusion and had stable disease. No serious infusion reactions, infections, or definite relapses were recorded on follow-up. Alemtuzumab has been relatively well-tolerated and effective; however, larger, longer-term studies are necessary to understand the specific risks and benefits of alemtuzumab in pediatric MS...
April 2020: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Angela Dziedzic, Agnieszka Morel, Elzbieta Miller, Michal Bijak, Tomasz Sliwinski, Ewelina Synowiec, Michal Ceremuga, Joanna Saluk-Bijak
The results of past research studies show that platelets are one of the main sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) to be found in the course of many pathological states. The aim of this study was to determine the level of oxidative/nitrative stress biomarkers in blood platelets obtained from multiple sclerosis (MS) patients ( n = 110) and to verify their correlation with the clinical parameters of the psychophysical disability of patients. The mitochondrial metabolism of platelets was assessed by measuring the intracellular production of ROS using the fluorescence method with DCFH-DA dye and by identification of changes in the mitochondrial membrane potential of platelets using the JC-1 dye...
2020: Oxidative Medicine and Cellular Longevity
Kristen M Krysko, Jennifer S Graves, Ruth Dobson, Ayse Altintas, Maria Pia Amato, Jacqueline Bernard, Simona Bonavita, Riley Bove, Paola Cavalla, Marinella Clerico, Teresa Corona, Anisha Doshi, Yara Fragoso, Dina Jacobs, Vilija Jokubaitis, Doriana Landi, Gloria Llamosa, Erin E Longbrake, Elisabeth Maillart, Monica Marta, Luciana Midaglia, Suma Shah, Mar Tintore, Anneke van der Walt, Rhonda Voskuhl, Yujie Wang, Rana K Zabad, Burcu Zeydan, Maria Houtchens, Kerstin Hellwig
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating central nervous system disorder that is more common in women, with onset often during reproductive years. The female:male sex ratio of MS rose in several regions over the last century, suggesting a possible sex by environmental interaction increasing MS risk in women. Since many with MS are in their childbearing years, family planning, including contraceptive and disease-modifying therapy (DMT) counselling, are important aspects of MS care in women...
2020: Therapeutic Advances in Neurological Disorders
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