Julie Schjødtz Hansen, Fernando Boix, Jørgen Bo Hasselstrøm, Lambert Kristiansen Sørensen, Mads Kjolby, Stefan Gustavsen, Rikke Middelhede Hansen, Thor Petersen, Finn Sellebjerg, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Eva Aggerholm Saedder, Kristina Bacher Svendsen
Information on the pharmacokinetics (PK) and pharmacodynamics (PD) of orally administered cannabis-based medicine (CBM) in capsule formulation in patient populations is sparse. In this exploratory study, we aimed to evaluate the PK and PD in a probable steady state of CBM in neuropathic pain and spasticity in a population of patients with multiple sclerosis (MS). Of 134 patients participating in a randomized, double-blinded, placebo-controlled, trial, 23 patients with MS (17 female) mean age 52 years (range 21-67) were enrolled in this substudy...
December 6, 2023: Clinical and Translational Science