D Ferraro, P Annovazzi, R Lanzillo, M Calabrese, R Fantozzi, G De Luca, C Cordioli, D Paolicelli, P Ragonese, A Gajofatto, S Lo Fermo, P Cavalla, C Tortorella, I Pesci, A Gallo, F Pinardi, M Di Filippo, G T Maniscalco, V Nociti, M Radaelli, V Tomassini, M C Buscarinu, M Moccia, V Camera, E Cocco, C Gasperini, C Solaro
The prevalence of trigeminal neuralgia (TN) in patients with Multiple Sclerosis (MS) is higher than in the general population and its management can be particularly challenging due to a number of reasons including high recurrence rates, lack of MS-specific treatment guidelines and uncertainties about pain pathophysiology. Aim of this cross-sectional, multicentre survey was to gather information on the current treatment modalities and options of MS-related TN across 23 Italian MS centres. Initial medical management (carbamazepine or oxcarbazepine) of MS-related TN was fairly homogeneous throughout Italian centres...
March 27, 2021: Journal of the Neurological Sciences
Eloy Roura, Grégory Maclair, Magí Andorrà, Ferran Juanals, Irene Pulido-Valdeolivas, Albert Saiz, Yolanda Blanco, Maria Sepulveda, Sara Llufriu, Eloy Martínez-Heras, Elisabeth Solana, Elena H Martinez-Lapiscina, Pablo Villoslada
BACKGROUND: Fractal geometry measures the morphology of the brain and detects CNS damage. We aimed to assess the longitudinal changes on brain's fractal geometry and its predictive value for disease worsening in patients with Multiple Sclerosis (MS). METHODS: We prospectively analyzed 146 consecutive patients with relapsing-remitting MS with up to 5 years of clinical and brain MRI (3 T) assessments. The fractal dimension and lacunarity were calculated for brain regions using box-counting methods...
March 29, 2021: NeuroImage: Clinical
Vasiliki Pantazou, Caroline Pot, Renaud Du Pasquier, Géraldine Le Goff, Marie Théaudin
BACKGROUND: Discontinuing fingolimod (FTY) in older patients is a growing concern with little evidence supporting the decision to pursue treatment and reasonable doubt for disease reactivation after withdrawal. OBJECTIVE: To estimate the incidence of recurrence of disease activity (RDA) and rebound after FTY withdrawal in patients older than 50 years. METHODS: Retrospective analysis of all MS patients in our clinic who discontinued FTY after at least 6 months of treatment, according to disease activity on FTY and age at discontinuation...
March 21, 2021: Multiple Sclerosis and related Disorders
Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Li-Juan Song, Guo-Guo Chu, Min-Fang Guo, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Xin-Yi Li, Cun-Gen Ma
Multiple sclerosis (MS) is mainly associated with the neuroinflammation and demyelination in the central nervous system (CNS), in which the failure of remyelination results in persistent neurological dysfunction. Fasudil, a typical Rho kinase inhibitor, has been exhibited beneficial effects on several models of neurodegenerative disorders. In this study, we showed that Fasudil promoted the uptake of myelin debris by microglia via cell experiments and through a cuprizone (CPZ)-induced demyelinating model. In vitro, microglia with phagocytic debris exhibited enhanced expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF), and the conditioned medium promoted the maturation of oligodendrocyte precursor cells (OPCs)...
April 7, 2021: Neuroscience Letters
Miaoli Lin, Stephen D Anesi, Peter Y Chang, Laura Eggenschwiler, Ambika Manhapra, Marisa Walsh, C Stephen Foster
OBJECTIVE: To investigate the clinical features, treatment, and visual outcome of occlusive retinal vasculitis (ORV), with a focal analysis on prognostic factors associated with poor visual outcome. METHODS: We conducted a retrospective cohort study in patients diagnosed with ORV with at least 6 months of follow-up. Demographic data, ocular features, best corrected visual acuity (BCVA), fluorescein angiography, therapy regimens, and outcomes were collected from the Massachusetts Eye Research and Surgery Institution database from 2006 to 2017...
April 7, 2021: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Guillaume Mathey, Thomas Ancel, Teresa Garot, Marc Soudant, Sophie Pittion-Vouyovitch, Francis Guillemin, Marc Debouverie, Jonathan Epstein
BACKGROUND: Patients with secondary progressive multiple sclerosis (SP MS) and clinical and/or radiological activity could be the more likely to benefit from disease modifying treatments. To evaluate the proportions each year after progression onset, we studied patients with SP MS onset between 2002 and 2012 from a population-based multiple sclerosis registry in North-Eastern France. METHODS: Progression onset was first identified by the neurologist's diagnosis (N cohort), then by using an automated data-driven definition (D cohort)...
April 10, 2021: European Journal of Neurology
Rebecca D Russell, Lucinda J Black, Andrea Begley
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease with no known cure. Numerous diets are promoted to reduce symptoms or even cure MS, despite insufficient evidence for any therapeutic diet. There are few qualitative studies exploring the experiences of people with MS in relation to diet, and no use of theory to explain the findings. PURPOSE: To explore the experiences of adults with MS when navigating dietary advice, their attitudes when making dietary decisions, and their needs regarding dietary resources and education...
April 10, 2021: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
Masoume Nazeri, Hanieh Bazrafshan, Amin Abolhasani Foroughi
Inflammation in a myelinated portion of the nervous system is the mainstay of multiple sclerosis (MS). Elevation of inflammatory markers such as procalcitonin, ESR and hs-CRP is suspected to occur in MS patients. However, their prognostic role and their relationship with the severity of clinical symptoms of MS and MRI evidences has remained unnoticed in the literature. Hence, we aim to evaluate the serum level of inflammatory markers in the acute attack of MS patients and demonstrate the potential prognostic role of these inflammatory markers...
April 9, 2021: Acta Neurologica Belgica
Michael K Tso, Paul Turgeon, Bert Bosche, Charles K Lee, Tian Nie, Josephine D'Abbondanza, Jinglu Ai, Philip A Marsden, R Loch Macdonald
Subarachnoid haemorrhage (SAH) is a type of hemorrhagic stroke that is associated with high morbidity and mortality. New effective treatments are needed to improve outcomes. The pathophysiology of SAH is complex and includes early brain injury and delayed cerebral ischemia, both of which are characterized by blood-brain barrier (BBB) impairment. We isolated brain endothelial cells (BECs) from mice subjected to SAH by injection of blood into the prechiasmatic cistern. We used gene expression profiling to identify 707 unique genes (2...
April 9, 2021: Scientific Reports
Whitney N Neal, Emma Richardson, Robert W Motl
The uptake and benefits of the Canadian Physical Activity Guidelines for Adults with Multiple Sclerosis (PAGs) have been validated, but there is limited understanding regarding the knowledge, needs, and preferences of people with multiple sclerosis (MS) for implementing the PAGs outside of clinical research. The authors conducted online, semistructured interviews with 40 persons with MS from across the United States seeking information on awareness of and potential approaches for increasing the uptake of the PAGs...
April 9, 2021: Adapted Physical Activity Quarterly: APAQ
Caroline Guglielmetti, Jelena Levi, Tony L Huynh, Brice Tiret, Joseph Blecha, Ryan Tang, Henry F Van Brocklin, Myriam M Chaumeil
Lymphocytes and innate immune cells are key drivers of multiple sclerosis (MS) and are the main target of MS disease modifying therapies (DMT). Ex vivo analyses of MS lesions have revealed cellular heterogeneity and variable T-cell levels, which may have important implication for patient stratification and choice of DMT. Although magnetic resonance imaging (MRI) has proven valuable to monitor DMT efficacy, its lack of specificity for cellular subtypes highlights the need for complementary methods to improve lesion characterization...
April 9, 2021: Journal of Nuclear Medicine
Leoni Rolfes, Steffen Pfeuffer, Jana Hackert, Marc Pawlitzki, Tobias Ruck, Wiebke Sondermann, Melanie Korsen, Heinz Wiendl, Sven G Meuth, Christoph Kleinschnitz, Refik Pul
OBJECTIVE: To report 77 patients with multiple sclerosis (MS) who developed skin-related adverse events (AEs) following treatment with cladribine. METHODS: We evaluated our prospective bicentric cladribine cohort. Cladribine-treated patients with a skin AE were identified. RESULTS: Two hundred thirty-nine cladribine-treated patients with MS were evaluated. Seventy-seven patients (32%) showed at least 1 skin AE at median 1 month after cladribine initiation (range: 1-12)...
May 2021: Neurology® Neuroimmunology & Neuroinflammation
I E H Kremer, P J Jongen, S M A A Evers, E L J Hoogervorst, W I M Verhagen, M Hiligsmann
BACKGROUND: Since decision making about treatment with disease-modifying drugs (DMDs) for multiple sclerosis (MS) is preference sensitive, shared decision making between patient and healthcare professional should take place. Patient decision aids could support this shared decision making process by providing information about the disease and the treatment options, to elicit the patient's preference and to support patients and healthcare professionals in discussing these preferences and matching them with a treatment...
April 9, 2021: BMC Medical Informatics and Decision Making
Matthew R Lincoln, Raphael Schneider, Jiwon Oh
No abstract text is available yet for this article.
April 9, 2021: Expert Review of Clinical Immunology
Ben J E Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, Takashi Yamamura
Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic disease course with progressive neurological dysfunctions (secondary progressive MS, SPMS), with the progression rate varying between patients and over time. SPMS pathogenesis is now linked to immune-cell-mediated processes, although the mechanisms driving SPMS transition and progression remain elusive, and SPMS lacks biomarkers and effective treatments...
March 16, 2021: Proceedings of the National Academy of Sciences of the United States of America
Annette Rademacher, Niklas Joisten, Sebastian Proschinger, Jonas Hebchen, Marit Lea Schlagheck, Wilhelm Bloch, Roman Gonzenbach, Jan Kool, Jens Bansi, Philipp Zimmer
PURPOSE: Cognitive impairment is a common symptom of multiple sclerosis (MS). Physical exercise represents a promising non-pharmacological therapy option, however, potential predictors for successful cognitive improvements mediated by exercise remain to be elucidated in order to optimize targeted exercise training regimens. One of the most promising exercise training regime in this context is high-intensity interval training (HIIT). Against this backdrop, this study i) analysed the effects of a three-week HIIT compared to moderate continuous exercise on cognitive performance and ii) investigated potential predictors for changes of cognitive performance following a three-week aerobic exercise intervention...
March 18, 2021: Multiple Sclerosis and related Disorders
Fatma Ayvat, Levent Özçakar, Ender Ayvat, Sibel Aksu Yıldırım, Muhammed Kılınç
BACKGROUND: Local vibration (LV) is a physiotherapy application that aims to reduce spasticity. The study aimed to compare the effects of 50 Hz vs. 100 Hz LV on mild-moderate spasticity, functional performance and muscle architecture. METHODS: Thirty-three patients were randomly divided into three groups: 50 Hz LV group, 100 Hz LV group and the control group. Physical therapy was applied for one hour a day, three days a week, for a total of eight weeks. LV was applied to the right and left medial gastrocnemius muscles for five minutes...
March 31, 2021: Multiple Sclerosis and related Disorders
Mohamed A El-Emam, Samar El Achy, Dalaal M Abdallah, Hanan S El-Abhar, Mennatallah A Gowayed
AIMS: The fact that physical activity besides central cholinergic enhancement contributes in improving neuronal function and spastic plasticity, recommends the use of the anticholinesterase and cholinergic drug galantamine with/without exercise in the management of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). MATERIALS AND METHODS: Sedentary and 14 days exercised male Sprague Dawley rats were subjected to EAE. Hereafter, exercised rats continued on rotarod for 30 min for 17 consecutive days...
April 6, 2021: Life Sciences
Anna Isabella Pisani, Antonio Scalfari, Francesco Crescenzo, Chiara Romualdi, Massimiliano Calabrese
BACKGROUND: At patient-level, the prognostic value of several features that are known to be associated with an increased risk of converting from relapsing remitting (RR) to secondary phase (SP) multiple sclerosis (MS), remain limited. METHODS: Among 262 RRMS patients followed up for ten years, we assessed the probability of developing the SP course based on clinical and conventional and non-conventional magnetic resonance imaging (MRI) parameters at diagnosis and after two years...
April 9, 2021: European Journal of Neurology
Tyrell J Simkins, Greg J Duncan, Dennis Bourdette
PURPOSE OF REVIEW: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both demyelination and axonal damage. However, due to incomplete remyelination most MS lesions remain chronically demyelinated. In parallel, there is axonal degeneration in the CNS of MS patients, contributing to progressive disability. There are currently no approved therapies that adequately restore myelin or protect axons from degeneration...
April 9, 2021: Current Neurology and Neuroscience Reports
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"