David Suárez-Iglesias, Iraia Bidaurrazaga-Letona, Miguel A Sanchez-Lastra, Susana María Gil, Carlos Ayán
BACKGROUND: Scientific evidence has shown that equine-assisted therapies (EAT) lead to improvements in the physical function and the quality of life (QoL) of people with disabilities through the practice of hippotherapy or therapeutic riding (TR). There is a need to confirm whether people with multiple sclerosis (PwMS) can also benefit from its practice. This review aimed to systematically evaluate and meta-analyze the available data on the potential health benefits of EAT in PwMS. METHODS: Four electronic databases (MEDLINE/PubMed, Web of Science, SPORTDiscus, and Scopus) were searched systematically from their inception until June 2021 for randomized controlled trials (RCTs) and comparative studies that provided information regarding the effects of EAT on PwMS...
July 23, 2021: Multiple Sclerosis and related Disorders
Samantha Epstein, Kathryn T Fong, Philip L De Jager, Libby Levine, Claire Riley, Sarah Wesley, Wendy S Vargas, Rebecca Farber
BACKGROUND: Seminal trials evaluating anti-CD20 therapy in progressive MS primarily found benefit in younger, less-disabled patients with more inflammatory disease activity. The risks and benefits of ocrelizumab use in older patients with progressive froms of MS are not known. METHODS: Retrospective chart review was performed for patients older than 55 with primary or secondary progressive MS at the time of ocrelizumab initiation. Clinical endpoints from 2 years prior to anti-CD20 therapy served as a within-subject control...
July 25, 2021: Multiple Sclerosis and related Disorders
Suzi B Claflin, Shannon Klekociuk, Julie A Campbell, Barnabas Bessing, Andrew J Palmer, Ingrid van der Mei, Bruce V Taylor
BACKGROUND: Despite their potential importance, little is known about the associations between multiple sclerosis (MS) knowledge and other outcomes among MS community members. OBJECTIVE: To examine the relationships between MS-related knowledge, health literacy, self-efficacy, resilience, quality of life (QoL), and MS symptom severity in a cohort of MS community members. METHODS: In this cross-sectional study (N = 1993), we assessed a cohort of Understanding MS online course enrolees using means and standard deviations...
July 21, 2021: Multiple Sclerosis and related Disorders
Sarah Erem, Mohammed S Razzaque
This review examines the beneficial effects of ultraviolet radiation on systemic autoimmune diseases, including multiple sclerosis and type I diabetes, where the epidemiological evidence for the vitamin D-independent effects of sunlight is most apparent. Ultraviolet radiation, in addition to its role in the synthesis of vitamin D, stimulates anti-inflammatory pathways, alters the composition of dendritic cells, T cells, and T regulatory cells, and induces nitric oxide synthase and heme oxygenase metabolic pathways, which may directly or indirectly mitigate disease progression and susceptibility...
July 27, 2021: Journal of Steroid Biochemistry and Molecular Biology
Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan, Marco Salvetti
BACKGROUND: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. OBJECTIVE: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test...
July 30, 2021: Multiple Sclerosis: Clinical and Laboratory Research
Dalia Rotstein, Colleen Maxwell, Karen Tu, Jodi Gatley, Priscila Pequeno, Alexander Kopp, Ruth Ann Marrie
BACKGROUND: Multiple sclerosis (MS) has been associated with certain comorbidities in general population studies, but it is unknown how comorbidity may affect immigrants with MS. OBJECTIVE: To compare prevalence of comorbidities in immigrants and long-term residents at MS diagnosis, and in matched control populations without MS. METHODS: We identified incident MS cases using a validated definition applied to health administrative data in Ontario, Canada, from 1994 to 2017, and categorized them as immigrants or long-term residents...
July 30, 2021: Multiple Sclerosis: Clinical and Laboratory Research
Marco Pitteri, Roberta Magliozzi, Richard Nicholas, Stefano Ziccardi, Anna Isabella Pisani, Francesco Pezzini, Damiano Marastoni, Massimiliano Calabrese
BACKGROUND: The cerebrospinal fluid (CSF) molecular milieu is a marker of diffuse intrathecal inflammation in the meninges that, in turn, targets the grey matter (GM) in multiple sclerosis (MS). Cognitive impairment (CI) is associated with brain damage in MS and is often present early in people with MS (pwMS). OBJECTIVE: To investigate whether a specific CSF inflammatory profile is associated with different degrees of CI in newly diagnosed pwMS. METHODS: Sixty-nine pwMS and 43 healthy controls (HCs) underwent neuropsychological testing...
July 30, 2021: Multiple Sclerosis: Clinical and Laboratory Research
Héctor Hugo Manzanilla-Romero, Denisa Weis, Simon Schnaiter, Sabine Rudnik-Schöneborn
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome caused by either TSC1 or TSC2 gene mutations. About 15% of TSC patients remain without genetic diagnosis by conventional analysis despite clinical evidence. It is important to identify somatic mosaics, as therapeutic options are now available in patients with TSC1 or TSC2 mutations. Here, we describe the clinical and genetic characteristics of four male TSC patients with low-level mosaicism. Patients presented at ages between 9 months and 32 years...
July 30, 2021: American Journal of Medical Genetics. Part A
Hanna M Hulshof, Barbora Benova, Pavel Krsek, Martin Kyncl, Maarten H Lequin, Anezka Belohlavkova, Petr Jezdik, Kees P J Braun, Floor E Jansen
OBJECTIVE: Patients with tuberous sclerosis complex (TSC) present with drug-resistant epilepsy in about 60% of cases, and evaluation for epilepsy surgery may be warranted. Correct delineation of epileptogenic zone (EZ) amongst multiple dysplastic lesions on MRI represents a challenging step in pre-surgical evaluation. METHODS: Two experienced neuroradiologists evaluated pre- and post-surgical MRIs of 28 epilepsy surgery patients with TSC, assessing characteristics of tubers, cysts, calcifications, and focal cortical dysplasia (FCD) - resembling lesions...
July 30, 2021: Epilepsia Open
Tamara Pérez-Jeldres, Manuel Alvarez-Lobos, Jesús Rivera-Nieves
No abstract text is available yet for this article.
July 30, 2021: Drugs
Samin Hajian, Mehrdokht Mazdeh, Fatemeh Nouri, Ghodratollah Roshanaei, Meysam Soleimani
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease described by inflammatory neuronal losses and resultant failures. The disease could abate by interferon-beta (IFN-β) therapy in MS patients. However, the drug response productivity is changeable between patients, and the accurate mechanism of action of the IFN-β is not obvious. The present study aims to investigate the role of interferon alpha and beta receptor subunit 1 (IFNAR1) promoter polymorphisms towards IFN-β treatment response in MS patients...
July 30, 2021: Molecular Biology Reports
Laura Cacciaguerra, Loredana Storelli, Marta Radaelli, Sarlota Mesaros, Lucia Moiola, Jelena Drulovic, Massimo Filippi, Maria A Rocca
OBJECTIVES: To apply a deep-learning algorithm to brain MRIs of seronegative patients with neuromyelitis optica spectrum disorders (NMOSD) and NMOSD-like manifestations and assess whether their structural features are similar to aquaporin-4-seropositive NMOSD or multiple sclerosis (MS) patients. PATIENTS AND METHODS: We analyzed 228 T2- and T1-weighted brain MRIs acquired from aquaporin-4-seropositive NMOSD (n = 85), MS (n = 95), aquaporin-4-seronegative NMOSD [n = 11, three with anti-myelin oligodendrocyte glycoprotein antibodies (MOG)], and aquaporin-4-seronegative patients with NMOSD-like manifestations (idiopathic recurrent optic neuritis and myelitis, n = 37), who were recruited from February 2010 to December 2019...
July 30, 2021: Journal of Neurology
Sanne C Lith, Carlie J M de Vries
Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells and is differentially expressed in chronically inflamed organs in human and experimental models. Furthermore, in a variety of animal models dedicated to study inflammatory diseases, changes in Nur77 expression alter disease outcome. The available studies comprise a wealth of information on the function of Nur77 in diverse cell types and tissues. Negative cross-talk of Nur77 with the NFκB signaling complex is an example of Nur77 effector function...
July 30, 2021: Essays in Biochemistry
Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Dalia M Kopustinskiene, Jesus Simal-Gandara, Jurga Bernatoniene, Saeed Samarghandian
Neurological diseases are responsible for a large number of morbidities and mortalities in the world. Flavonoids are phytochemicals that possess various health-promoting impacts. Chrysin, a natural flavonoid isolated from diverse fruits, vegetables, and even mushrooms, has several pharmacological activities comprising antioxidant, anti-inflammatory, antiapoptotic, anticancer, and neuroprotective effects. The current study was designed to review the relationship between chrysin administration and neurological complications by discussing the feasible mechanism and signaling pathways...
July 16, 2021: Biomedicine & Pharmacotherapy
Tomohisa Okada, Thai Akasaka
No abstract text is available yet for this article.
July 29, 2021: Journal of Magnetic Resonance Imaging: JMRI
S Viswanathan
No abstract text is available yet for this article.
October 2020: The Lancet Regional Health. Western Pacific
Masaomi Kubota, Nobumasa Tamura, Takaaki Hayashi, Euido Nishijima, Haruhiko Yanagisawa, Akira Kojima, Tadashi Nakano
Treatments for paraneoplastic optic neuropathy (PON), a tumor-related autoimmune disease, include immunosuppression, plasma exchange, and immunoglobulin therapies, as well as treatment of the underlying disease. Herein, we describe the clinical course of an older adult patient with PON whose loss of vision improved after switching between epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatments for cancer. A 76-year-old woman, who had been treated with gefitinib for lung adenocarcinoma for two years, presented with acute bilateral visual disturbances...
2021: Case Reports in Ophthalmological Medicine
Aman Saini, Colleen Cochran, Audrey Zucker-Levin, Sarah J Donkers, Pawan Kumar, Katherine B Knox, Jessica MacPherson, Hannah Salapa, Michael C Levin
Background: Knowledge translation (KT) models that represent an individual's perspective are a sign of effective KT. Some common challenges in KT include participant engagement, organization of the team, and time demands of the participants. We implemented a unique tripartite KT program to (1) share current research, (2) inform persons living with multiple sclerosis (pwMS) about the clinical research process, and (3) invite pwMS to immediately participate in clinical research. The primary aim was to determine participants' perspectives on the value and acceptability of an experiential research program offered at a patient and family educational conference...
2021: Multiple Sclerosis International
Hana Larassati, Riwanti Estiasari, Reyhan E Yunus, Paul M Parizel
Demyelinating diseases are more common in Indonesia than previously believed. However, it is still a challenge for a country such as Indonesia to implement the scientific medical advances, especially in the diagnostic process of demyelinating diseases, to achieve the best possible outcome for these groups of patients, within the constraints of what is socially, technologically, economically, and logistically achievable. In this review, we address the 4 major classes of demyelinating disease: multiple sclerosis (MS), neuromyelitis optica (NMO), anti-MOG-associated encephalomyelitis (MOG-EM), and acute disseminated encephalomyelitis (ADEM), and discuss their prevalence, demographics, clinical diagnosis workup, and imaging features in the Indonesian population, as well as the challenges we face in their diagnosis and therapeutic approach...
2021: Multiple Sclerosis International
Natasa Giedraitiene, Egle Drukteiniene, Rasa Kizlaitiene, Andrius Cimbalas, Rimvydas Asoklis, Gintaras Kaubrys
Background: Brain atrophy, which is associated with cognitive impairment and retinal nerve fiber layer (RNFL) atrophy, is the main biomarker of neurodegeneration in multiple sclerosis (MS). However, data on the relationship between inflammatory markers, such as oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF), and cognition, RNFL atrophy, and brain atrophy are scarce. The aim of this study was to assess the influence of RNFL thickness, brain atrophy markers, intrathecal OCBs, and the immunoglobulin G (IgG) index on cognitive decline over a 5-year period in patients with MS...
2021: Frontiers in Neurology
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