keyword
https://read.qxmd.com/read/38536936/multiple-sclerosis-endophenotypes-identified-by-high-dimensional-blood-signatures-are-associated-with-distinct-disease-trajectories
#1
JOURNAL ARTICLE
Catharina C Gross, Andreas Schulte-Mecklenbeck, Olga V Steinberg, Timo Wirth, Sarah Lauks, Stefan Bittner, Patrick Schindler, Sergio E Baranzini, Sergiu Groppa, Judith Bellmann-Strobl, Nora Bünger, Claudia Chien, Eva Dawin, Maria Eveslage, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Barbara Gisevius, Jürgen Haas, Martin Kerschensteiner, Lucienne Kirstein, Catharina Korsukewitz, Lisa Lohmann, Jan D Lünemann, Felix Luessi, Gerd Meyer Zu Hörste, Jeremias Motte, Tobias Ruck, Klemens Ruprecht, Nicholas Schwab, Falk Steffen, Sven G Meuth, Friedemann Paul, Brigitte Wildemann, Tania Kümpfel, Ralf Gold, Tim Hahn, Frauke Zipp, Luisa Klotz, Heinz Wiendl
One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical manifestations and progression trajectories. It still remains to be elucidated whether this heterogeneity is reflected by discrete immune signatures in the blood as a surrogate of disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles is still not feasible. Using two independent multicentric longitudinal cohorts of patients with early multiple sclerosis ( n = 309 discovery and n = 232 validation), we were able to identify three distinct peripheral blood immunological endophenotypes by a combination of high-dimensional flow cytometry and serum proteomics, followed by unsupervised clustering...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536934/attenuation-of-fibroblast-activation-and-fibrosis-by-adropin-in-systemic-sclerosis
#2
JOURNAL ARTICLE
Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H W Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis-associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and in vivo experiments to characterize adropin as a potential regulator involved in fibroblast activation and tissue fibrosis in systemic sclerosis (SSc)...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#3
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38535979/understanding-multiple-sclerosis-as-a-disease-spectrum-above-and-below-the-clinical-threshold
#4
JOURNAL ARTICLE
Stephen Krieger, Karin Cook, Carrie M Hersh
PURPOSE OF REVIEW: Research in multiple sclerosis (MS) has long been predicated on clinical groupings that do not reflect the underlying biologic heterogeneity apparent within patient populations. This review explicates the various levels of explanation through which the spectrum of disease is described and investigated both above and below the clinical threshold of detection, as framed by the topographical model of MS, to help advance a cogent mechanistic framework. RECENT FINDINGS: Contemporary evidence has amended the view of MS as consisting of sequential disease phases in favor of a spectrum of disease with an admixture of interdependent and dynamic pathobiological axes driving tissue injury and progression...
March 28, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38535072/recent-insights-into-the-role-of-dna-methylation-and-histone-modifications-in-systemic-sclerosis-a-scoping-review
#5
REVIEW
Tsvetelina Kostova, Rositsa Karalilova, Zguro Batalov, Maria Kazakova, Victoria Sarafian, Anastas Batalov
Systemic sclerosis is a complex idiopathic disease originating from an intricate interplay between genetic susceptibility, environmental factors, and epigenetic modifications. This scoping review aims to map the advancements made regarding DNA methylation abnormalities and histone modifications in systemic sclerosis in the past decade. A literature search was conducted using three electronic databases (Scopus, Web of Science and PubMed) to identify relevant articles. A total of 44 studies were selected for this review, demonstrating the critical contribution of epigenetic perturbations in multiple cell types to disease pathogenesis...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38535052/automatic-active-lesion-tracking-in-multiple-sclerosis-using-unsupervised-machine-learning
#6
JOURNAL ARTICLE
Jason Uwaeze, Ponnada A Narayana, Arash Kamali, Vladimir Braverman, Michael A Jacobs, Alireza Akhbardeh
BACKGROUND: Identifying active lesions in magnetic resonance imaging (MRI) is crucial for the diagnosis and treatment planning of multiple sclerosis (MS). Active lesions on MRI are identified following the administration of Gadolinium-based contrast agents (GBCAs). However, recent studies have reported that repeated administration of GBCA results in the accumulation of Gd in tissues. In addition, GBCA administration increases health care costs. Thus, reducing or eliminating GBCA administration for active lesion detection is important for improved patient safety and reduced healthcare costs...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38534961/adult-neoneurogenesis-and-oligodendrogenesis-in-multiple-sclerosis-a-systematic-review-of-human-and-animal-studies
#7
JOURNAL ARTICLE
Andreas Liampas, Vasilis-Spyridon Tseriotis, Artemios Artemiadis, Panagiotis Zis, Chrysanthi Argyropoulou, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Georgios Vavougyios
INTRODUCTION: The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In Multiple Sclerosis (MS) this regenerative capability in halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with SVZ dysfunction in MS. MATERIALS AND METHODS: Our systematic review was reported according to the PRISMA-ScR statement...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38534551/evaluating-cognitive-motor-interference-in-multiple-sclerosis-a-technology-based-approach
#8
JOURNAL ARTICLE
Jessica Podda, Ludovico Pedullà, Giampaolo Brichetto, Andrea Tacchino
BACKGROUND: People with multiple sclerosis (PwMS) frequently present both cognitive and motor impairments, so it is reasonable to assume they may have difficulties in executing dual-tasks (DT). The aim of the present study is to identify novel technology-based parameters to assess cognitive-motor interference (CMI) in PwMS. In particular, we focused on the definition of dual-task cost (DTC) measures using wearable and portable tools such as insoles and mobile apps. METHODS: All participants underwent a verbal fluency task (cognitive single-task, ST), a motor ST of walking, and a combination of these tasks (DT)...
March 14, 2024: Bioengineering
https://read.qxmd.com/read/38534508/contractile-and-genetic-characterization-of-cardiac-constructs-engineered-from-human-induced-pluripotent-stem-cells-modeling-of-tuberous-sclerosis-complex-and-the-effects-of-rapamycin
#9
JOURNAL ARTICLE
Veniamin Y Sidorov, Tatiana N Sidorova, Philip C Samson, Ronald S Reiserer, Clayton M Britt, M Diana Neely, Kevin C Ess, John P Wikswo
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534424/the-impact-of-cytomegalovirus-infection-on-natural-killer-and-cd8-t-cell-phenotype-in-multiple-sclerosis
#10
JOURNAL ARTICLE
Valentina Perri, Maria Antonella Zingaropoli, Patrizia Pasculli, Federica Ciccone, Matteo Tartaglia, Viola Baione, Leonardo Malimpensa, Gina Ferrazzano, Claudio Maria Mastroianni, Antonella Conte, Maria Rosa Ciardi
Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established that viral infections influence the course of the disease. Cytomegalovirus (CMV) is a major pathogen involved in alterations of the immune system, including the expansion of highly differentiated cytotoxic CD8+ T cells and the accumulation of adaptive natural killer (NK) cells expressing high levels of the NKG2C receptor...
February 28, 2024: Biology
https://read.qxmd.com/read/38534341/gut-brain-interactions-and-their-impact-on-astrocytes-in-the-context-of-multiple-sclerosis-and-beyond
#11
REVIEW
Julia Zißler, Veit Rothhammer, Mathias Linnerbauer
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence of MS underscores the critical need for innovative therapeutic approaches. Recent advances in neuroimmunology have highlighted the significant role of the gut microbiome in MS pathology, unveiling distinct alterations in patients' gut microbiota. Dysbiosis not only impacts gut-intrinsic processes but also influences the production of bacterial metabolites and hormones, which can regulate processes in remote tissues, such as the CNS...
March 13, 2024: Cells
https://read.qxmd.com/read/38533855/-not-available
#12
JOURNAL ARTICLE
Mario Ranjeevan, Thor Petersen, Sigurdur Skarphédinsson, Henrik Boye Jensen
Lyme neuroborreliosis (LNB) is the most prevalent nervous system bacterial infection in Denmark. In a young man with LNB, brain MRI and cerebrospinal fluid (CSF) demonstrated findings compatible with multiple sclerosis. This case report underlines the requirement for testing for intrathecal Borrelia antibody production when the number of cells in the CSF is low or even normal. It also demonstrates the unchanged diagnostic delay of NBL observed during the last 20 years.
March 25, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533819/bruton-tyrosine-kinase-inhibitors-in-multiple-sclerosis-evidence-and-expectations
#13
JOURNAL ARTICLE
Julia Krämer, Heinz Wiendl
PURPOSE OF REVIEW: Despite availability of high-efficacy therapies for multiple sclerosis (MS), many patients experience significant disability worsening due to limited effects of currently available drugs on central nervous system (CNS)-compartmentalized inflammation. Bruton tyrosine kinase (BTK) is an intracellular signaling molecule involved in regulation of maturation, survival, migration, and activation of B cells and microglia, which are central players in the immunopathogenesis of progressive MS...
March 28, 2024: Current Opinion in Neurology
https://read.qxmd.com/read/38533708/body-fluid-markers-for-multiple-sclerosis-and-differential-diagnosis-from-atypical-demyelinating-disorders
#14
REVIEW
Angelika Bauer, Harald Hegen, Markus Reindl
INTRODUCTION: Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of the central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated in the current MS diagnostic criteria, could assist early MS diagnosis. AREAS COVERED: This review examines existing knowledge on a broad spectrum of body fluid markers in people with a first CNS demyelinating event, explores their potential to predict conversion to MS, to assess MS disease activity, as well as their utility to differentiate MS from atypical demyelinating disorders such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease...
March 27, 2024: Expert Review of Molecular Diagnostics
https://read.qxmd.com/read/38533505/ozanimod-mediated-remission-in-experimental-autoimmune-encephalomyelitis-is-associated-with-enhanced-activity-of-cns-cd27-low-nk-cell-subset
#15
JOURNAL ARTICLE
Doua Kamyan, Maya Hassane, Alanood Alnaqbi, Abdul-Kader Souid, Zakeya Al Rasbi, Abeer Al Tahrawi, Mariam Al Shamsi
BACKGROUND: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533153/the-safety-profile-of-common-covid-19-vaccines-in-patients-with-multiple-sclerosis
#16
JOURNAL ARTICLE
Yasser S Aladdin, Danah A Alqarni, Sheifa W Alamoudi, Abdulrahman A Alharbi, Waad A Fudhah, Ghaida Alghamdi, Ahmed Attar
Background and objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). In light of the COVID-19 pandemic that emerged in late 2019, the World Health Organization (WHO) has endorsed mass immunization to enhance the population's immunity against the virus. However, certain concerns have been raised about the safety of COVID-19 vaccines among patients with autoimmune disorders, including those with multiple sclerosis (MS). Further research is required to address these concerns and to gain deeper insights into the possible complications of COVID-19 vaccines among MS patients...
February 2024: Curēus
https://read.qxmd.com/read/38532803/sex-differences-in-multiple-sclerosis-relapse-presentation-and-outcome-a-retrospective-monocentric-study-of-134-relapse-events
#17
JOURNAL ARTICLE
Pauline Thränhardt, Admirim Veselaj, Christoph Friedli, Franca Wagner, Stefanie Marti, Lara Diem, Helly Hammer, Piotr Radojewski, Roland Wiest, Andrew Chan, Robert Hoepner, Anke Salmen
BACKGROUND: Reporting of sex-specific analyses in multiple sclerosis (MS) is sparse. Disability accrual results from relapses (relapse-associated worsening) and independent thereof (progression independent of relapses). OBJECTIVES: A population of MS patients during relapse treated per standard of care was analyzed for sex differences and short-term relapse outcome (3-6 months) as measured by Expanded Disability Status Scale (EDSS) change. DESIGN: Single-center retrospective study...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532143/early-prediction-of-unfavorable-evolution-after-a-first-clinical-episode-suggestive-of-multiple-sclerosis-the-eumus-score
#18
JOURNAL ARTICLE
Giulia Mallucci, Ottavia Eleonora Ferraro, Maria Trojano, Maria Pia Amato, Antonio Scalfari, Mauro Zaffaroni, Elena Colombo, Eleonora Rigoni, Pietro Iaffaldano, Emilio Portaccio, Lorenzo Saraceno, Damiano Paolicelli, Lorenzo Razzolini, Cristina Montomoli, Roberto Bergamaschi
BACKGROUND: Predicting disease progression in patients with the first clinical episode suggestive of multiple sclerosis (MS) is crucial for personalized therapeutic approaches. This study aimed to develop the EUMUS score for accurately estimating the risk of early evidence of disease activity and progression (EDA). METHODS: Retrospective analysis was conducted on data from 221 patients with a first clinical MS episode collected from four Italian MS centers. Various variables including socio-demographics, clinical features, cerebrospinal fluid analysis, evoked potentials, and brain MRI were considered...
March 26, 2024: Journal of Neurology
https://read.qxmd.com/read/38531713/extended-interval-dosing-of-natalizumab-more-evidence-in-support
#19
JOURNAL ARTICLE
Karlo Toljan, Devon S Conway
No abstract text is available yet for this article.
March 25, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38531361/twin-study-dissects-cxcr3-memory-b-cells-as-non-heritable-feature-in-multiple-sclerosis
#20
JOURNAL ARTICLE
Florian Ingelfinger, Kirsten L Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M van Luijn, Burkhard Becher
BACKGROUND: In multiple sclerosis (MS), B cells are considered main triggers of the disease, likely as the result of complex interaction between genetic and environmental risk factors. Studies on monozygotic twins discordant for MS offer a unique way to reduce this complexity and reveal discrepant subsets. METHODS: In this study, we analyzed B cell subsets in blood samples of monozygotic twins with and without MS using publicly available data. We verified functional characteristics by exploring the role of therapy and performed separate analyses in unrelated individuals...
March 18, 2024: Med
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