Reina Hoshi, Yosuke Watanabe, Yoshiaki Ishizuka, Takayuki Hirano, Eri Nagasaki-Maeoka, Shinsuke Yoshizawa, Shota Uekusa, Hiroyuki Kawashima, Kensuke Ohashi, Kiminobu Sugito, Noboru Fukuda, Hiroki Nagase, Masayoshi Soma, Toshinori Ozaki, Tsugumichi Koshinaga, Kyoko Fujiwara
Neuroblastoma is a childhood malignancy originating from the sympathetic nervous system and accounts for approximately 15% of all pediatric cancer-related deaths. To newly identify gene(s) implicated in the progression of neuroblastoma, we investigated aberrantly methylated genomic regions in mouse skin tumors. Previously, we reported that TFAP2E, a member of activator protein-2 transcription factor family, is highly methylated within its intron and its expression is strongly suppressed in mouse skin tumors compared with the normal skin...
April 2017: Oncology Reports