Olga Beresneva, Jason Hall
Background: We hypothesized that increasing body mass index is a risk factor for surgical complications in surgery for diverticulitis. We assessed the relationship of body mass index and surgical complications following surgery for diverticular disease. Methods: We used National Surgical Quality Improvement Program database from 2005 to 2015. Patients undergoing surgery for diverticular disease during that period were included and stratified into 9 groups based on their body mass index (< 18...
October 2019: Surgery open science
Peter Stanko, Tomas Baka, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Andrej Barta, Pavol Janega, Michaela Adamcova, Ludovit Paulis, Fedor Simko
Hypertension-induced renal injury is characterized by structural kidney alterations and function deterioration. Therapeutics for kidney protection are limited, thus novel renoprotectives in hypertension are being continuously sought out. Ivabradine, an inhibitor of the If current in the sinoatrial node reducing heart rate (HR), was shown to be of benefit in various cardiovascular pathologies. Yet, data regarding potential renoprotection by ivabradine in hypertension are sparse. Thirty-six adult male Wistar rats were divided into non-diseased controls and rats with NG -nitro-L-arginine methyl ester (L-NAME)-induced hypertension to assess ivabradine's site-specific effect on kidney fibrosis...
2020: Frontiers in Medicine
U R Raaju, Siddharth Gosavi, K Sriharsha
Allopurinol is a xanthine oxidase inhibitor used in management of chronic gout. It acts by reducing the amount of uric acid by inhibiting purine metabolism. A middle-aged hypertensive female who was on allopurinol for 7 months presented with generalized weakness and exertional dyspnea. Investigations revealed pancytopenia: normocytic normochromic anemia (Hb-3.2g/dL, TLC-3400/mm3) and severe thrombocytopenia (Platelets-1000/mm3) with mild hepatosplenomegaly and grade 2 medico renal disease with normal cardiac status...
May 2020: Journal of Family Medicine and Primary Care
Moawia Gameraddin, Walaa Ismail Musa, Suzan Abdelmaboud, Sultan Alshoabi, Kamal Dahan Alsultan, Bushra A Abdelmalik
Background: Hypertension is one of the major world health problems. Ultrasonography plays a useful role in the assessment of morphologicalchanges at the kidneys in hypertensive patients. Aim: To assess sonographic findings of the kidneys in hypertensive patients' co-morbidities with type 2 diabetes mellitus and ischemic heart disease (IDH). Materials and Methods: This was a prospective cross-sectional study involved 100 participants with primary hypertension selected by a method of simple convenient sampling...
May 2020: Journal of Family Medicine and Primary Care
Omaima Mohamed Ali, Aml Ahmed Sayed, Wafaa Salah Mohammed, Ragaa Ramadan Mohammed
Background: The incidence of end-stage renal disease (ESRD) has increased by 30-40% in the last decade. These patients have a higher mortality rate of 3-8 times compared to the general population. In the present study, we aimed to detect cardiovascular complications and their relation to the first-year mortality rate in patients on hemodialysis in Aswan University Hospital, upper Egypt. Patients and Methods: Our study was a cross-sectional study which was done at the hemodialysis unit in Aswan University Hospital from May 2016 to May 2018...
2020: International Journal of General Medicine
Daisuke Nagata, Erika Hishida, Takahiro Masuda
When renal function declines, blood pressure rises, which in turn causes the kidneys to deteriorate. In order to stop this vicious cycle, it is necessary to lower the blood pressure to a "moderate" level in patients who have chronic kidney disease (CKD)-associated hypertension. Such optimization is problematic, since tight control of blood pressure might worsen the prognosis in elderly patients with CKD, especially those with advanced arteriosclerosis. Although renin-angiotensin system (RAS) inhibitors, angiotensinogen converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are first-line drugs for hypertensive patients with diabetes, they should be used with caution depending on the patients' conditions...
2020: International Journal of Nephrology and Renovascular Disease
Vaia D Raikou, Despina Kyriaki, Sotiris Gavriil
BACKGROUND: The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been included in the potential indices for atherosclerosis in chronic kidney disease (CKD). In this study, we addressed the role of the TG/HDL-C ratio on CKD prediction defined by both classified estimated glomerular filtration rate (eGFR) and classified urinary albumin-to-creatinine ratio (UACR) in non-diabetic participants. METHODS: One hundred and eighty-three subjects with a mean age 67...
August 1, 2020: Journal of Cardiovascular Development and Disease
Tae Hyung Kim, Yeon Seok Seo, Seong Hee Kang, Moon Young Kim, Sang Gyune Kim, Hyo Young Lee, Jeong-Hoon Lee, Young Sun Lee, Ji Hoon Kim, Soung Won Jung, Jae Young Jang, Ki Tae Suk, Young Kul Jung, Hyunggin An, Hyung Joon Yim, Young Seok Kim, Soon Ho Um
BACKGROUND & AIMS: This prospective observational study aimed to evaluate the best serum and urine markers to assess predictability for the prognosis of patients with decompensated cirrhosis. METHODS: Serum creatinine and cystatin C (CysC), and urinary N-acetyl-beta-D glucosaminidase (uNAG) and neutrophil gelatinase-associated lipocalin (uNGAL) levels were measured from hospitalized patients with decompensated cirrhosis. RESULTS: In total, 328 patients (mean age, 57...
August 4, 2020: Liver International: Official Journal of the International Association for the Study of the Liver
Victor Khou, Nicole L De La Mata, Rachael L Morton, Patrick J Kelly, Angela C Webster
BACKGROUND: Withdrawal from renal replacement therapy is common in patients with end-stage kidney disease (ESKD), but end-of-life service planning is challenging without population-specific data. We aimed to describe mortality after treatment withdrawal in Australian and New Zealand ESKD patients and evaluate death-certified causes of death. METHODS: We performed a retrospective cohort study on incident patients with ESKD in Australia, 1980-2013, and New Zealand, 1988-2012, from the Australian and New Zealand Dialysis and Transplant registry...
August 4, 2020: Nephrology, Dialysis, Transplantation
Ping Liang, Chuou Xu, Pratik Tripathi, Jiali Li, Anqin Li, Daoyu Hu, Ihab Kamel, Zhen Li
OBJECTIVES: To assess whether spatial labeling with multiple inversion pulses (SLEEK) sequence can be employed as a one-stop assessment method for evaluating renal function and displaying renal artery in hypertensive patients with suspected renal dysfunction. METHODS: A total of 78 patients with suspected hypertensive renal damage were enrolled in this retrospective study. All patients underwent MRI examinations, and both SLEEK and DWI sequences were performed simultaneously...
August 4, 2020: European Radiology
Sorasak Makmettakul, Adisak Tantiworawit, Arintaya Phrommintikul, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Kanda Fanhchaksai, Pimlak Charoenkwan, Suree Lekawanvijit
BACKGROUND: Cardiorenal syndrome (CRS), a serious condition with high morbidity and mortality, is characterized by the coexistence of cardiac abnormality and renal dysfunction. There is limited information about CRS in association thalassemia. This study aimed to investigate the prevalence of CRS in thalassemia patients and also associated risk factors. METHODS: Thalassemia patients who attended the out-patient clinic of a tertiary care university hospital from October 2016 to September 2017 were enrolled onto this cross-sectional study...
August 3, 2020: BMC Nephrology
Kentaro Nishi, Mai Sato, Masao Ogura, Mika Okutsu, Kenji Ishikura, Koichi Kamei
BACKGROUND: Thrombotic microangiopathy (TMA) is a histopathological entity associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ ischemic damage. Although TMA is caused by various diseases, there have been few reports regarding children with idiopathic nephrotic syndrome (NS) and TMA. Here we report two 1-year-old infants with steroid-resistant NS (SRNS) who presented with severe hypertension, acute kidney injury (AKI), and TMA. CASE PRESENTATION: The diagnosis of NS was complicated with anemia, AKI, and hypertension...
August 3, 2020: BMC Nephrology
Zhizhao Jiang, Jianan Ren, Zhiwu Hong, Huajian Ren, Gefei Wang, Guosheng Gu, Yuqi Liu
Background: The relation between deresuscitative fluid management after the resuscitation phase and clinical outcome in patients with abdominal sepsis is not completely clear. The aim of this study was to assess the contribution of deresuscitative management to death and organ dysfunction in abdominal sepsis. Methods: Consecutive patients with abdominal sepsis requiring fluid resuscitation were included in this study. According to the fluid management given in the later stage of resuscitation, a conservative group and a deresuscitative fluid management group were compared...
August 3, 2020: Surgical Infections
Lucas Ferreira de Almeida, Terezila Machado Coimbra
A congenital or programmed reduction in glomerular number increases the susceptibility to hypertension and kidney injury in adulthood thus, premature birth or low birth weight, leading to a low glomerular endowment, can be associated with these two diseases. Renal morphogenesis is sensitive to hypoxia which is a physiological trigger for the expression of vascular endothelial growth factor. On the other hand, hyperoxia increases oxidative stress and adversely affects glomerular and tubular development, and is associated with a substantial reduction of renal klotho expression in adulthood...
August 3, 2020: Journal of Maternal-fetal & Neonatal Medicine
Olga Eugenia Disoteo, Benedetta Zampetti, Andrea Garascia, Roberto Attanasio, Renato Cozzi
A 24-yo female was admitted for acute renal failure, melanoderma, hyponatremia and hyperkalemia. The clinical suspicion of Addison's disease was confirmed by laboratory test and the appropriate replacement therapy with corticosteroids and fludrocortisone was started. In the mean-time primary hypothyroidism and diabetes mellitus type 1 were disclosed and treated, thus fulfilling a diagnosis of autoimmune polyendocrine syndrome type 2. Eighteen months later she was admitted for right sided heart failure. The work-up allowed to diagnose pulmonary arterial hypertension...
July 31, 2020: Endocrine, Metabolic & Immune Disorders Drug Targets
Wei Guo, Yan Ji, Qi Han, Yao Yang, Fangjie Wang, Yongjian Yang, Youcai Deng, Xiongshan Sun, Xiaohui Li
OBJECTIVE: To assess the protective role of benazepril, an angiotensin-converting enzyme inhibitor, in renal damage caused by prenatal inflammation. METHODS: Saline or lipopolysaccharide were administered intraperitoneally to pregnant Sprague- Dawley rats on gestation days 8, 10, and 12. After birth, offspring received either tap water or benazepril in water between 7 and 68 weeks. Blood pressure, blood urea nitrogen, creatinine, and 24-h urine volume were measured as indices of renal function...
August 2020: Journal of Traditional Chinese Medicine
Mehdi Afsharinasab, Maryam Mohammad-Sadeghipour, Mohammad Reza Hajizadeh, Alireza Khoshdel, Vahid Mirzaiey, Mehdi Mahmoodi
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the hepatic disorders which is characterized by increasing fat deposits in the liver. This disorder may lead to elevation the activity of liver enzymes and is associated with obesity, dyslipidemia, hypertension, and type II diabetes. The aim of present study was to investigate the effect of Berberis integerrima extract on NAFLD patients compare to placebo. Methods: The present clinical trial was performed on 42 NAFLD patients who were randomly divided into two groups...
August 2020: Saudi Journal of Biological Sciences
Kathryn J Gray, Vesela P Kovacheva, Hooman Mirzakhani, Andrew C Bjonnes, Berta Almoguera, Melissa L Wilson, Sue Ann Ingles, Charles J Lockwood, Hakon Hakonarson, Thomas F McElrath, Jeffrey C Murray, Errol R Norwitz, S Ananth Karumanchi, Brian T Bateman, Brendan J Keating, Richa Saxena
OBJECTIVE: To assess whether women with a genetic predisposition to medical conditions known to increase preeclampsia risk have an increased risk of preeclampsia in pregnancy. DESIGN: Case-control study. SETTING AND POPULATION: Preeclampsia cases (n=498) and controls (n=1864) of European ancestry from 5 US sites genotyped on a cardiovascular gene-centric array. METHODS: Significant single nucleotide polymorphisms (SNPs) from 21 traits in 7 disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal, thrombophilia) with published genome-wide association studies (GWAS) were used to create a genetic instrument for each trait...
August 2, 2020: BJOG: An International Journal of Obstetrics and Gynaecology
Kazuomi Kario, Michael A Weber, Michael Böhm, Raymond R Townsend, Felix Mahfoud, Roland E Schmieder, Konstantinos Tsioufis, Sidney A Cohen, Martin Fahy, David E Kandzari
BACKGROUND: Catheter-based renal denervation (RDN) reduces blood pressure (BP) throughout the 24-h period, as reported in several randomized sham-controlled trials. Reduction of BP in the early morning hours is especially important due to increased cardiovascular risks during that time. OBJECTIVE: In this report, we examine the impact of RDN on systolic BP (SBP) and diastolic BP (DBP) during the critical morning surge period in a post-hoc analysis of patients in the SPYRAL HTN-ON MED trial...
August 1, 2020: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Chuanming Xu
: Although considerable success has been shown for antihypertensive medications, the resistant hypertension and hypertension-related organ damages are still the important clinical issues and pose as high health and economic pressure. Therefore, novel therapeutic techniques and antihypertensive drugs are needed to advance more effective therapy of hypertension and hypertension-related disease to ameliorate mortality and healthcare costs worldwide. In this review, we highlight the latest progress in supporting the therapeutic potential of Elabela (ELA), a recently discovered early endogenous ligand for G-protein-coupled receptor apelin peptide jejunum, apelin receptor...
July 27, 2020: Journal of Hypertension
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