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Onabotulinumtoxina

keyword
https://read.qxmd.com/read/32226049/refractory-overactive-bladder-patients-who-chose-sacral-neuromodulation-therapy-after-failed-onabotulinumtoxina-treatment-a-systematic-review-and-meta-analysis
#1
Guang Yang, Yong Xu, Genyi Qu, Yulong Zhang
OBJECTIVE: To systematically review outcomes in patients with refractory overactive bladder (OAB) patients who underwent sacral neuromodulation therapy (SNM) therapy after unsuccessful onabotulinumtoxinA (BTX) therapy, and to compare outcomes with those who SNM as initial therapy. METHODS: A systematic search of Cochrane Library, Pubmed and Embase databases from July 2002 to November 2019, to analyze randomized controlled trials and retrospective studies of SNM therapy after failed initial BTX therapy...
2020: PloS One
https://read.qxmd.com/read/32192924/what-are-the-most-commonly-reported-complications-with-cosmetic-botulinum-toxin-type-a-treatments
#2
Kevin C Lee, Alexander B Pascal, Steven Halepas, Alia Koch
PURPOSE: The purpose of the present study was to determine the most commonly reported complications with cosmetic botulinum toxin type A (BTX-A) treatments. MATERIALS AND METHODS: The present study was a cross-sectional review of the US Food and Drug Administration (FDA) Adverse Event Reporting System. From January 2014 through September 2019, the records were included in the study sample if they implicated Botox (onabotulinumtoxinA), Dysport (abobotulinumtoxinA), Xeomin (incobotulinumtoxinA), or Jeuveau (prabotulinumtoxinA-xvfs), and if the indication for use had been to perform a cosmetic skin procedure...
February 21, 2020: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/32170665/safety-of-onabotulinumtoxina-with-concomitant-antithrombotic-therapy-in-patients-with-muscle-spasticity-a-retrospective-pooled-analysis-of-randomized-double-blind-studies
#3
Rozalina Dimitrova, Lynn James, Chengcheng Liu, Amelia Orejudos, Irina Yushmanova, Mitchell F Brin
BACKGROUND: OnabotulinumtoxinA is approved as a treatment across multiple indications. For the treatment of spasticity, onabotulinumtoxinA is injected directly into affected muscles. Intramuscular injections may result in local bleeding and related complications, especially in patients receiving anticoagulant therapy. Despite anticoagulants being commonly used, there is limited information in the medical literature regarding the safety of intramuscular medications in patients receiving oral anticoagulants...
March 13, 2020: CNS Drugs
https://read.qxmd.com/read/32166840/editorial-comment-to-onabotulinumtoxina-botulinum-toxin-type-a-for-the-treatment-of-japanese-patients-with-overactive-bladder-and-urinary-incontinence-results-of-single-dose-treatment-from-a-phase-iii-randomized-double-blind-placebo-controlled-trial-interim
#4
https://read.qxmd.com/read/32110406/recalcitrant-vulvar-hailey-hailey-disease-treated-with-alitretinoin-and-onabotulinumtoxina-a-case-report
#5
Alexandre Lemieux, Deana Funaro
Hailey-Hailey disease is an autosomal dominant genodermatosis leading to chronic hyperkeratotic and fissured lesions in the intertriginous areas. We present a 53-year-old woman with a case of vulvar and inguinal Hailey-Hailey disease resistant to usual treatments. She was efficiently treated with alitretinoin 10 mg daily combined with injections of onabotulinumtoxinA every 9 months. The combination led to an almost complete resolution of the lesions and symptoms at follow-ups.
2020: SAGE Open Medical Case Reports
https://read.qxmd.com/read/32108383/efficacy-and-tolerance-of-botulinum-toxin-injections-after-sacral-nerve-stimulation-failure-for-idiopathic-overactive-bladder
#6
Maximilien Baron, Marie-Aimée Perrouin-Verbe, Sandy Lacombe, Fanny Paret, Loïc Le Normand, Jean-Nicolas Cornu
INTRODUCTION: Management of idiopathic overactive bladder (iOAB) after the failure of sacral nerve modulation (SNM) is very challenging. To the best of our knowledge, no study has evaluated the use of botulinum toxin A (BoNT-A) after SNM failure for iOAB. The aim of this study is to evaluate the tolerance and efficacy of BoNT-A injection after the failure of SNM for iOAB. METHODS: We conducted a retrospective multicentric analysis of all patients who had received either onabotulinumtoxinA or abobotulinumtoxinA intradetrusor injection for iOAB after SNM failure, between January 2004 and December 2017...
February 27, 2020: Neurourology and Urodynamics
https://read.qxmd.com/read/32095419/neurotoxin-impurities-a-review-of-threats-to-efficacy
#7
Je-Young Park, Owen Sunga, Rungsima Wanitphakdeedecha, Jürgen Frevert
Recently launched esthetic botulinum toxin serotype A (BoNT/A) products include Nabota/Jeuveau, Meditoxin/Neuronox, and Botulax, which contain nontoxic accessory proteins and excipients. Clinical evidence supporting these formulations, including their purity and potential immunogenicity or their link to treatment failures, is limited. Any nonhuman protein, including nontoxin accessory proteins, can initiate immune reactions, especially if administered repeatedly, yet the issue of BoNT/A-induced immunogenicity is widely contested...
January 2020: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/32086801/short-and-mid-term-predictors-of-response-to-onabotulinumtoxina-real-life-experience-observational-study
#8
Alicia Alpuente, Víctor José Gallardo, Marta Torres-Ferrús, José Álvarez-Sabin, Patricia Pozo-Rosich
OBJECTIVE: To identify clinical predictors of excellent response to OnabotulinumtoxinA in patients with chronic migraine (CM) at 6 and 12 months of follow-up. BACKGROUND: Clinical predictors of response to OnabotulinumtoxinA are scarce and have not been clearly reproduced and analyzed in detail. So far, predictors of response to OnabotulinumtoxinA assess response in general or good response, but not an excellent response. METHODS: Cohort study of patients attended in a specialized Headache Clinic in treatment with OnabotulinumtoxinA were classified according to their improvement in frequency: no-response (<25%) and excellent response (≥75%)...
February 22, 2020: Headache
https://read.qxmd.com/read/32085542/comparing-the-efficacy-of-onabotulinumtoxina-sacral-neuromodulation-and-peripheral-tibial-nerve-stimulation-as-third-line-treatment-for-the-management-of-overactive-bladder-symptoms-in-adults-systematic-review-and-network-meta-analysis
#9
Chi-Wen Lo, Mei-Yi Wu, Stephen Shei-Dei Yang, Fu-Shan Jaw, Shang-Jen Chang
The American Urological Association guidelines for the management of non-neurogenic overactive bladder (OAB) recommend the use of OnabotulinumtoxinA, sacral neuromodulation (SNM), and peripheral tibial nerve stimulation (PTNS) as third line treatment options with no treatment hierarchy. The current study used network meta-analysis to compare the efficacy of these three modalities for managing adult OAB syndrome. We performed systematic literature searches of several databases from January 1995 to September 2019 with language restricted to English...
February 18, 2020: Toxins
https://read.qxmd.com/read/32085529/efficacy-and-safety-of-onabotulinumtoxina-400-units-in-patients-with-post-stroke-upper-limb-spasticity-final-report-of-a-randomized-double-blind-placebo-controlled-trial-with-an-open-label-extension-phase
#10
Masahiro Abo, Takashi Shigematsu, Hiroyoshi Hara, Yasuko Matsuda, Akinori Nimura, Yoshiyuki Yamashita, Kaoru Takahashi
In many countries, 400 units (U) is the maximum dose of onabotulinumtoxinA available to treat upper limb spasticity, but few studies have demonstrated the optimal use of this dose. In the double-blind phase of this randomized, controlled trial, we compared the efficacy and safety of 400 vs. 240 U onabotulinumtoxinA in patients with post-stroke upper limb spasticity. Both groups received 240 U onabotulinumtoxinA injected in the forearm. An additional 160 U onabotulinumtoxinA (400 U group) or placebo (240 U group) was injected in the elbow flexors...
February 18, 2020: Toxins
https://read.qxmd.com/read/32071728/economic-evaluation-of-abobotulinumtoxina-vs-onabotulinumtoxina-in-real-life-clinical-management-of-cervical-dystonia
#11
V P Misra, N Danchenko, P Maisonobe, J Lundkvist, M Hunger
Background: Botulinum neurotoxins type A (BoNT-As) are commonly used treatments for cervical dystonia (CD). Clinical trials have demonstrated the benefits of them in these patients, but data from real-life clinical practice as well as comparative data on the cost and outcome of different BoNT-A formulations are limited. The aim of this study was to compare abobotulinumtoxinA (aboBoNT-A) and onabotulinumtoxinA (onaBoNT-A) on their clinical outcomes and drug costs in real-life clinical practice...
2020: Journal of Clinical Movement Disorders
https://read.qxmd.com/read/32062446/onabotulinumtoxina-treatment-for-ms-tremor-modifies-fmri-tremor-response-in-central-sensory-motor-integration-areas
#12
Frederique M C Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt
BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little is known regarding its effects on the brain. The clinical presentation of tremor MS is shown to depend on subcortical neural damage and cortical neural plasticity. This study aimed to identify effects of onabotulinumtoxinA (BoNT-A) on brain activation in MS and upper-limb tremor using functional MRI. METHODS: Forty-three MS participants with tremor were randomized to receive intramuscular injections of placebo (n = 22) or BoNT-A (n = 21)...
February 5, 2020: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/32053326/cerebral-palsy-an-overview
#13
Kirsten Vitrikas, Heather Dalton, Dakota Breish
Cerebral palsy, which occurs in two to three out of 1,000 live births, has multiple etiologies resulting in brain injury that affects movement, posture, and balance. The movement disorders associated with cerebral palsy are categorized as spasticity, dyskinesia, ataxia, or mixed/other. Spasticity is the most common movement disorder, occurring in 80% of children with cerebral palsy. Movement disorders of cerebral palsy can result in secondary problems, including hip pain or dislocation, balance problems, hand dysfunction, and equinus deformity...
February 15, 2020: American Family Physician
https://read.qxmd.com/read/32052306/chronic-migraine-long-term-regular-treatment-with-onabotulinumtoxina-a-retrospective-real-life-observational-study-up-to-4-years-of-therapy
#14
Antonio Santoro, Massimiliano Copetti, Anna M Miscio, Maurizio A Leone, Andrea Fontana
INTRODUCTION: OnabotulinumtoxinA (BoNT-A) was proved effective and safe in chronic migraine (CM) prevention by the Phase III Research Evaluating Migraine Prophylaxis (PREEMPT) and Phase IV Chronic migraine OnabotulinuMtoxinA Prolonged Efficacy open-Label (COMPEL) trials over 1 and 2 years of treatment, respectively. Real-life studies highlighted BoNT-A sustained benefits up to 3 years of administration. Aim of this retrospective real-life study was observing within a 4-year timeframe the progress of a consecutive series of CM patients treated with BoNT-A and evaluating whether long-term quarterly treatment (up to 16 cycles) confirms the outcomes of previous studies over shorter periods of therapy...
February 12, 2020: Neurological Sciences
https://read.qxmd.com/read/32048535/effectiveness-of-interventions-aimed-at-improving-the-sexuality-of-women-with-multiple-sclerosis-a-systematic-review
#15
Antonio Esteve-Ríos, Sofia Garcia-Sanjuan, Antonio Oliver-Roig, María José Cabañero-Martínez
OBJECTIVE: To evaluate the effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis. DATA SOURCES: MEDLINE, CINAHL, PsycINFO, Web of Science, Scopus, Embase and the Cochrane Library, as well as doctoral thesis databases Teseo and ProQuest Dissertations & Theses Global and the grey literature database Opengrey were searched, last on 15 October 2019. Journals related to the topic were also consulted. The bibliographic references of the articles included were reviewed...
February 12, 2020: Clinical Rehabilitation
https://read.qxmd.com/read/32037549/a-randomized-trial-to-evaluate-onabotulinumtoxina-for-prevention-of-headaches-in-adolescents-with-chronic-migraine
#16
Paul K Winner, Marielle Kabbouche, Marcy Yonker, Veronica Wangsadipura, Arlene Lum, Mitchell F Brin
OBJECTIVE: As a post-approval commitment, this dose-ranging study was undertaken to evaluate efficacy and safety of onabotulinumtoxinA in adolescents. BACKGROUND: In adolescents, migraine is often undiagnosed or misdiagnosed and can present unique management challenges. OnabotulinumtoxinA was approved for prevention of chronic migraine (CM) in adults in 2010. METHODS: This multicenter, double-blind, parallel-group, randomized trial assessed a single treatment of onabotulinumtoxinA (155 U or 74 U) vs placebo (intramuscular saline) administered via the recommended fixed-dose fixed site paradigm in adolescents with CM aged 12 to <18 years...
February 9, 2020: Headache
https://read.qxmd.com/read/32029089/evaluation-and-treatment-of-overactive-bladder-in-women
#17
REVIEW
Rubin Raju, Brian J Linder
Overactive bladder (OAB) is a symptom complex that includes urinary urgency, frequency, urgency incontinence, and nocturia. It is highly prevalent, affecting up to 12% of the adult population, and can significantly impact quality of life. The diagnosis of OAB is made by history, physical examination, and a urinalysis to rule out underlying infection or other concerning potential etiologies. The need for additional testing is based on the initial evaluation findings, and is recommended in cases of underlying urinary tract infection, microscopic hematuria, obstructive voiding symptoms, and symptoms refractory to previous treatments...
February 2020: Mayo Clinic Proceedings
https://read.qxmd.com/read/32003950/onabotulinumtoxina-for-prevention-of-migraine-in-adults
#18
Margot Savoy
No abstract text is available yet for this article.
February 1, 2020: American Family Physician
https://read.qxmd.com/read/31985655/cost-effectiveness-of-long-term-targeted-onabotulinumtoxina-versus-peripheral-trigger-site-deactivation-surgery-for-the-treatment-of-refractory-migraine-headaches
#19
Anna R Schoenbrunner, Ibrahim Khansa, Jeffrey E Janis
BACKGROUND: Chronic migraines affect approximately 2 percent of the U.S. population and cost an estimated $17 billion per year. OnabotulinumtoxinA (botulinum toxin type A) is a U.S. Food and Drug Administration-approved prophylactic medication for chronic migraine headaches and is best injected in a targeted fashion into specific trigger sites. The purpose of this study was to determine the cost-effectiveness of long-term, targeted botulinum toxin type A versus peripheral trigger site deactivation surgery for the treatment of migraine headaches...
February 2020: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/31985313/cost-effectiveness-and-impact-on-quality-of-life-of-abobotulinumtoxina-and-onabotulinumtoxina-in-the-treatment-of-children-with-lower-limb-spasticity-in-canada
#20
Karissa Johnston, Natalya Danchenko, Ryan Hansen, Jerome Dinet, Anna Liovas, Ava Armstrong, Savreet Bains, Sean D Sullivan
BACKGROUND: Injectable botulinum neurotoxins are a mainstay of treatment for pediatric spasticity. AbobotulinumtoxinA and onabotulinumtoxinA are both injectable toxin therapies used to treat pediatric lower limb (PLL) spasticity in Canada. The objective of this study was to assess the cost-effectiveness of abobotulinumtoxinA vs. onabotulinumtoxinA in the treatment of PLL spasticity in Canada. METHODS: A probabilistic Markov cohort model with a 2-year time horizon was developed, with health states defined by response to therapy, as characterized by the goal attainment scale (GAS)...
January 27, 2020: Journal of Medical Economics
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