Lcz

Due to the differences in land cover and natural surroundings within cities, residents in various regions face different thermal risks. Therefore, this study combined multi-source data to analyze the relationship between urban heat risk and local climate zones (LCZ). We found that in downtown Shenyang, the building-type LCZ was mainly found in urban centers, while the natural- type LCZ was mainly found in suburbs. Heat risk was highest in urban centers, gradually decreasing along the suburban direction. The thermal risk indices of the building-type LCZs were significantly higher than those of the natural types...

Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying probiotics-driven drug metabolism. We discovered that 75% (27/36 of the assayed drugs) were metabolized by five selected probiotics, and drugs containing nitro or azo groups were more readily metabolized. As proof-of-principle experiments, we showed that Lacticaseibacillus casei Zhang (LCZ) could metabolize racecadotril to its active products, S-acetylthiorphan and thiorphan, in monoculture, in a near-real simulated human digestion system, and in an ex vivo fecal co-culture system...

Landscape classification methods significantly impact the exploration of the mechanism of the relationship between landscapes and atmospheric particulate matter. This study compared the local climate zones (LCZs) and traditional land use/cover change (LUCC) landscape classification methods in explaining spatial differences in concentrations of atmospheric particulate matter (PM2.5 and PM10 ) and explored the mechanisms involved in how landscape elements affect atmospheric particulate matter. This was done by establishing a PM2...

Understanding the thermal characteristics and contribution ranking of local climate zones (LCZs) is essential since they can help in maintaining environmental harmony. However, previous studies only considered independent effects and could not analyze the combined effects of LCZ on land surface temperature (LST). In this study, we propose a new method to establish an interaction model between LCZs. Five first-level grids with different scales from 270 to 990 m were established to calculate the area proportion of LCZ...

Two shapes of ZnO clusters constructed by the growth of spindle-like (I-ZnO) and sheet-like (II-ZnO) microparticles added to Locust bean gum/carboxycellulose nanocrystal (LBG/C-CNC) coating for improving properties as the enhancers and antibacterial agents. Subsequently, active LBG/C-CNC/ZnO (LCZ) coatings were evaluated to combat the fruits rot triggered by microorganisms aiming to extend their shelf life. The results showed that II-ZnO clusters with flower-shape enhanced the properties more obviously due to more interaction sites...

Luliconazole (LCZ), a novel imidazole drug, has broad-spectrum and potential antifungal effects, which makes it a possible cure for fungal keratitis; nevertheless, its medical use in ocular infections is hindered by its poor solubility. The purpose of this study was to design and optimize LCZ nanoemulsion (LCZ-NE) formulations using the central composite design-response surface methodology, and to investigate its potential in improving bioavailability following ocular topical administration. The LCZ-NE formulation was composed of Capryol 90, ethoxylated hydrogenated castor oil, Transcutol® P and water...

Greece was affected by a prolonged and extreme heat wave (HW) event (July 28-August 05) during the abnormally hot summer of 2021, with the maximum temperature in Athens, the capital of the country, reaching up to 43.9 °C in the city center. This observation corresponds to the second highest maximum temperature recorded since 1900, based on the historical temperature time series of the National Observatory of Athens weather station at Thissio. In the present study, a multi-scale numerical modeling system is used to analyze the urban climate and thermal bioclimate in the Athens urban area (AUA) in the course of the HW event, as well as during 3 days prior to the heat wave and 3 days after the episode...

Luliconazole (LCZ) is a new antifungal agent containing imidazole moiety which revealed broad-spectrum antifungal activity. The aim of this research was to prepare water-in-oil (w/o) emulsion-based cream formulation of LCZ in addition to the development and validation of an analytical method by reverse-phase high-performance liquid chromatography (RP-HPLC). Cetostearyl alcohol (12.14%), light liquid paraffin (5.00%), white soft paraffin (2.75%), and Tween-80 (1.00%) appeared as the optimized concentration to give better consistency to the cream...

New construction has resulted in impervious surfaces increasingly replacing natural landscapes, altering surface radiation, thermal properties, and humidity in urban areas. Based on Landsat-8 data, the temporal and spatial impacts of the construction of Dalian Jinzhouwan Airport and Beijing Daxing Airport on the thermal environment were studied. The local thermal gradient (LTG) of the airport before and after construction is compared. The results showed that after the completion of the airport, the LTG value of Daxing Airport increased by 0...

High urban temperatures affect city livability and may be harmful for inhabitants. Analyzing spatial and temporal differences in surface temperature and the thermal impact of urban morphological heterogeneity can promote strategies to improve the insulation of the urban thermal environment. Therefore, we analyzed the diurnal variation of land surface temperature (LST) and seasonal differences in the Fifth Ring Road area of Beijing from the perspective of the Local Climate Zone (LCZ) using latest ECOSTRESS data...

Expansion of urban areas and alteration of natural land cover exacerbate the local climate change. To find out the effect of land cover changes on the local climate, in this study, the Local Climate Zone (LCZ) concept was utilized to detect urban morphology in Tehran Metropolis. LCZ and Land Surface Temperature (LST) can be identified and classified based on available remote sensing products. Firstly, LCZ maps of Tehran metropolis were extracted using Landsat imagery, and secondly, relationships between LCZ and LST were explored for three years (1990, 2004, and 2018)...

The novel concept of local climate zones (LCZs) provides a consistent classification framework for studies of the urban thermal environment. However, the development of urban climate science is severely hampered by the lack of high-resolution data to map LCZs. Using Gaofen-6 and Sentinel-1/2 as data sources, this study designed four schemes using convolutional neural network (CNN) and random forest (RF) classifiers, respectively, to demonstrate the potential of high-resolution images in LCZ mapping and evaluate the optimal combination of different data sources and classifiers...

Urban heat islands (UHIs) and their energy consumption are topics of widespread concern. This study used remote sensing images and building and meteorological data as parameters, with reference to Oke's local climate zone (LCZ), to divide urban areas according to the height and density of buildings and land cover types. While analyzing the heat island intensity, the neural network training method was used to obtain temperature data with good temporal as well as spatial resolution. Combining degree-days with the division of LCZs, a more accurate distribution of energy demand can be obtained by different regions...

BACKGROUND: Cyclophosphamide (CP) is a widely used chemotherapeutic drug. However, the associated nephrotoxicity restricts its clinical use. AIM: The present research was designed to study the impact of LCZ696 (LCZ); which is a combination of Sacubitril/Valsartan compared to valsartan (VAL) on CP-induced nephrotoxicity. MAIN METHODS: Sixty adult male Wistar rats were randomly and equally assigned into 6 groups as follows: Control, LCZ (30 mg/kg, p...

Onychomycosis is the most common fungal infection of the nail affecting the skin under the fingertips and the toes. Currently, available therapy for onychomycosis includes oral and topical therapies, either alone or in combination. Oral antifungal medication has been associated with poor drug bioavailability and potential gastrointestinal and systemic side effects. The objective of this study was to prepare and evaluate the luliconazole nail lacquer (LCZ-NL) for the effective treatment of onychomycosis. In the current work, LCZ-NL was formulated in combination with penetration enhancers to overcome poor penetration...

The Local Climate Zone (LCZ) classification is already widely used in urban heat island and other climate studies. The current classification method does not incorporate crucial urban auxiliary GIS data on building height and imperviousness that could significantly improve urban-type LCZ classification utility as well as accuracy. This study utilized a hybrid GIS- and remote sensing imagery-based framework to systematically compare and evaluate different machine and deep learning methods. The Convolution Neural Network (CNN) classifier outperforms in terms of accuracy, but it requires multi-pixel input, which reduces the output's spatial resolution and creates a tradeoff between accuracy and spatial resolution...

Here we provide Urban Heat Island (UHI) by local weather types (LWT) maps for the Lisbon Metropolitan Area (LMA). These maps were produced from the Copernicus Land Monitoring Service climate variables dataset that contains hourly air temperature raster data for 100 European cities (2008-2017), namely Lisbon and part of its metropolitan area. Over 61000 maps (2008-2014) were extracted in NetCDF format and processed in geographic-information-systems (GIS). An urban mask was created from the recently updated Local Climate Zones (LCZ) classification for this area and a cell of the LCZ class "Low Plants" (non-urban) was chosen to calculate the temperature difference...

Urban ventilation corridors introduce fresh air into urban interiors and improve urban livability, while mitigating the urban heat island (UHI) effect. However, few studies have assessed the impact of urban ventilation corridors on UHI intensity (UHII) from the perspective of the local climates of different cities. Therefore, this study integrated multisource data to construct ventilation corridors from the perspective of local climate zone (LCZ) and analyzed its impact on UHII. The results showed the following: (1) the average UHII of constructed LCZs was higher than that of natural LCZs, among which the building type LCZ10 (heavy industry) had the highest intensity (5...

A solar pond is a simple system that collects and stores heat for thermal and electrical applications. Heat storage and heat extraction are the key factors in the solar pond. Salt is added to the pond with fresh water to form a salinity gradient solar pond (SGSP). The solar pond comprises of three zones, namely, the upper convective zone (UCZ), the non-convective zone (NCZ) and the lower convective zone (LCZ). The LCZ is also called the storage zone. Generally, the LCZ stores the heat energy of the incoming solar radiation, and this heat may be used for various applications...

Bifidobacteria are health-promoting human gut inhabitants, but accurate species-level composition of the gut bifidobacteria and their responses to probiotic intervention have not been fully explored. This was a follow-up work of our previous study, in which 104 volunteers from six different Asiatic regions (Singapore, Indonesia, Xinjiang, Gansu, Inner Mongolia, Mongolia) were recruited. The gut microbiota and their responses towards Lactobacillus casei Zhang (LCZ) intervention were characterized (at days 0, 7, and 14; 14 days after stopping probiotic intake), and region-based differential responses were observed after LCZ intervention...