Xin Wang, Ana P Kutschat, Joana Aggrey-Fynn, Feda H Hamdan, Rondell P Graham, Alexander Q Wixom, Yara Souto, Swetlana Ladigan-Badura, Jennifer A Yonkus, Amro M Abdelrahman, Roberto Alva-Ruiz, Jochen Gaedcke, Philipp Strobel, Robyn Laura Kosinsky, Florian Wegwitz, Patrick Hermann, Mark J Truty, Jens T Siveke, Stephan A Hahn, Elisabeth Hessmann, Steven A Johnsen, Zeynab Najafova
A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therapy for defined molecular subtypes. In this work, we sought to gain further insight and identify molecular and epigenetic signatures of the basal-like A pancreatic ductal adenocarcinoma (PDAC) subgroup that can be applied to clinical samples for patient stratification and/or therapy monitoring. We generated and integrated global gene expression and epigenome mapping data from patient-derived xenograft (PDX) models to identify subtype-specific enhancer regions that were validated in patient-derived samples...
June 6, 2023: Molecular Cancer Research: MCR