Adele Gabba, Riem Attariya, Sandra Behren, Christian Pett, Joost C van der Horst, Hajime Yurugi, Jin Yu, Moritz Urschbach, Juan Sabin, Gabriel Birrane, Edgar Schmitt, Sandra J van Vliet, Pol Besenius, Ulrika Westerlind, Paul V Murphy
Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans (e.g., Tn antigen). Dendritic cells (DCs) express lectins that bind to these tumor-associated carbohydrate antigens (TACAs) to modulate immune responses. Selectively targeting these receptors with synthetic TACAs is a promising strategy to develop anticancer vaccines and to overcome TACA tolerance. In this work, we prepared, via a solid phase peptide synthesis approach, a modular tripartite vaccine candidate, incorporating a high-affinity glycocluster based on a tetraphenylethylene scaffold, to target the macrophage galactose-type lectin (MGL) on antigen presenting cells...
June 6, 2023: Journal of the American Chemical Society
Rumeng Bai, Miaomiao Sun, Yuanyuan Chen, Shuaishuai Zhuo, Guoxin Song, Tianjun Wang, Zhihong Zhang
BACKGROUND: Angiogenesis is described as a complex process in which new microvessels sprout from endothelial cells of existing vasculature. This study aimed to determine whether long non-coding RNA (lncRNA) H19 induced the angiogenesis of gastric cancer (GC) and its possible mechanism. METHODS: Gene expression level was determined by quantitative real-time polymerase chain reaction and western blotting. Cell counting kit-8, transwell, 5-Ethynyl-2'-deoxyuridine (EdU), colony formation assay, and human umbilical vein endothelial cells (HUVECs) angiogenesis assay as well as Matrigel plug assay were conducted to study the proliferation, migration, and angiogenesis of GC in vitro and in vivo...
June 5, 2023: Chinese Medical Journal
Xiao Zhang, Shrita Sarkar, Akash Ashokan, Bapurao Surnar, Nagesh Kolishetti, Shanta Dhar
The metabolic preference of cells toward glycolysis often indicates a diseased state ranging from cancer to other dysfunctions. When a particular cell type utilizes glycolysis as a major energy production pathway, their mitochondria become impaired resulting a cascade of events which eventually contributes to resistance toward therapies to tackle such diseases. In abnormal tissues such as seen in the tumor microenvironment, when cancer cells utilize glycolysis, other cell types such as the immune cells switch their metabolism and prefer such glycolysis...
June 6, 2023: Bioconjugate Chemistry
(no author information available yet)
No abstract text is available yet for this article.
June 2, 2023: Rheumatology
(no author information available yet)
The antibody-drug conjugate trastuzumab deruxtecan shows promising activity across multiple types of HER2-expressing advanced solid tumors, including traditionally hard-to-treat malignancies, according to data from the DESTINY-PanTumor02 trial. The ongoing study may pave the way for approval of a tumor-agnostic therapy for HER2-expressing and HER2-mutated cancers.
June 6, 2023: Cancer Discovery
Cristina Collazo Abal, María Covadonga Fernández Marcos, Pedro Casado Rey, María Pía Vázquez Caamaño, Henrik Alfthan, Hannu Koistinen, Ulf-Håkan Stenman
OBJECTIVES: We describe a woman with constantly elevated hCG levels in serum. Since assay interference, pregnancy or cancer did not explain the elevated levels, we measured the concentrations of hCG, its β subunit (hCGβ) and its core fragment (hCGβcf) in serum and urine using specific assays, to understand the nature of the elevated hCG levels. METHODS: We used 3 assays for total hCG (these assays also recognize hCGβ and to various degrees hCGβcf), 3 for intact hCG heterodimer, 3 for free hCGβ and one for hCGβcf...
June 8, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
David Toro-Tobon, Ricardo Loor-Torres, Mayra Duran, Jungwei W Fan, Naykky M Singh Ospina, Yonghui Wu, Juan P Brito
BACKGROUND: The use of Artificial intelligence (AI) in healthcare has grown exponentially with the promise of facilitating biomedical research and enhancing diagnosis, treatment, monitoring, disease prevention and healthcare delivery. We aim to examine the current state, limitations, and future directions of AI in thyroidology. SUMMARY: AI has been explored in thyroidology since the 1990s, and currently, there is an increasing interest in applying AI to improve the care of patients with thyroid nodules, thyroid cancer, and functional or autoimmune thyroid disease...
June 6, 2023: Thyroid: Official Journal of the American Thyroid Association
Yusuke Kasuga, Ryota Ouda, Masashi Watanabe, Xin Sun, Miki Kimura, Shigetsugu Hatakeyama, Koichi S Kobayashi
Major histocompatibility complex (MHC) class I and II molecules play critical roles in the activation and regulation of adaptive immunity through antigen presentation to CD8+ and CD4+ T cells, respectively. Strict regulation of MHC expression is critical for proper immune responses. CIITA (MHC class II transactivator), an NLR (nucleotide-binding domain, leucine-rich-repeat containing) protein, is a master regulator of MHC class II (MHC-II) gene transcription. Although it has been known that CIITA activity is regulated at the transcriptional and protein levels, the mechanism to determine CIITA protein level has not been elucidated...
June 13, 2023: Proceedings of the National Academy of Sciences of the United States of America
Myungwoo Nam, Woojung Yang, Hye Sung Kim, Jewel Park, Gahee Park, Sukjun Kim, Sanghoon Song, Chan-Young Ock, Victor G Wang, Jeffrey H Chuang, Young Kwang Chae
Standard-of-care treatment options provide an excellent prognosis for papillary thyroid cancers (PTCs); however, approximately 10% of cases are advanced PTCs, resulting in less than 50% 5-year survival rates. Understanding the tumor microenvironment is essential for understanding cancer progression and investigating potential biomarkers for treatment, such as immunotherapy. Our study focused on tumor-infiltrating lymphocytes (TILs), which are the main effectors of anti-tumor immunity and related to the mechanism of immunotherapy...
June 1, 2023: Endocrine-related Cancer
Nidhi Singh, Hannelore V Heemers
Prostate cancer (CaP) remains the second leading cause of cancer-related mortality in American men. Systemic treatments for metastatic CaP, which causes the majority of deaths, include androgen deprivation therapy and chemotherapy. These treatments induce remissions but do not cure CaP. Novel and functionally diverse therapeutic targets that control the cell biology that drives aggressive CaP progression are needed to overcome treatment resistance. Because signal transduction that mediates CaP cell behavior is tightly regulated by phosphorylation, kinases have attracted interest as alternative targets for CaP treatments...
June 1, 2023: Endocrine-related Cancer
Christine Sempoux, Gunter Klöppel
Nesidioblastoma and nesidioblastosis were terms given to neoplastic and non-neoplastic lesions of the pancreas associated with pancreatogenous hyperinsulinemic hypoglycaemia. While nesidioblastoma was rapidly replaced by islet cell tumor, nesidioblastosis, defined as the proliferation of islet cells budding off from pancreatic ducts, was the diagnostic term associated with congenital hyperinsulinism of infancy (CHI) and adult non-neoplastic hyperinsulinemic hypoglycaemia (ANHH). When it was shown that nesidioblastosis was not specific for CHI or ANHH, it was no longer applied to CHI but kept for the morphological diagnosis of ANHH...
June 1, 2023: Endocrine-related Cancer
Minh Tung Phung, Pham Le An, Nguyen Nhu Vinh, Hong H T C Le, Karen McLean, Rafael Meza, Bhramar Mukherjee, Alice W Lee, Celeste Leigh Pearce
Cervical cancer is the second most common gynecologic cancer in Vietnam but based on the literature, only ~25% of Vietnamese women reported ever being screened for cervical cancer. To inform strategies to reduce the cervical cancer burden in Southern Vietnam where disease incidence is higher than the national average, this study examined behaviors, awareness, barriers, and beliefs about cervical cancer screening among rural and urban women in this geographical region. In October-November 2021, we conducted a cross-sectional study among 196 rural and 202 urban women in Southern Vietnam; participants completed a cervical cancer screening questionnaire...
2023: PLOS Glob Public Health
Gavin D Garland, Kiran R Patil, Suzanne D Turner, Anne E Willis
Most of the small-molecule drugs approved for the treatment of cancer over the past 40 years are based on natural compounds. Bacteria provide an extensive reservoir for the development of further anti-cancer therapeutics to meet the challenges posed by the diversity of these malignant diseases. While identifying cytotoxic compounds is often easy, achieving selective targeting of cancer cells is challenging. Here we describe a novel experimental approach (the Pioneer platform) for the identification and development of 'pioneering' bacterial variants that either show or are conduced to exhibit selective contact-independent anti-cancer cytotoxic activities...
2023: PloS One
Melissa Lubeck, Nick H Derkum, Ritam Naha, Rebecca Strohm, Marc D Driessen, Bengt-Frederik Belgardt, Michael Roden, Kai Stühler, Ruchika Anand, Andreas S Reichert, Arun Kumar Kondadi
Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating them are linked to diabetes. The development of diabetes is connected to the 'Mitochondrial Contact Site and Cristae Organising System' (MICOS) complex which is a large membrane protein complex defining the IM architecture. MIC26 and MIC27 are homologous apolipoproteins of the MICOS complex...
2023: PloS One
Mateusz Glembin, Aleksander Obuchowski, Barbara Klaudel, Bartosz Rydziński, Roman Karski, Paweł Syty, Patryk Jasik, Wojciech Józef Narożański
BACKGROUND Renal cell carcinoma is one of the most common cancers in Europe, with a total incidence rate of 18.4 cases per 100 000 population. There is currently significant overdiagnosis (11% to 30.9%) at times of planned surgery based on radiological studies. The purpose of this study was to create an artificial neural network (ANN) solution based on computed tomography (CT) images as an additional tool to improve the differentiation of malignant and benign renal tumors and to aid active surveillance. MATERIAL AND METHODS A retrospective study based on CT images was conducted...
June 6, 2023: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Xin Wang, Ana P Kutschat, Joana Aggrey-Fynn, Feda H Hamdan, Rondell P Graham, Alexander Q Wixom, Yara Souto, Swetlana Ladigan-Badura, Jennifer A Yonkus, Amro M Abdelrahman, Roberto Alva-Ruiz, Jochen Gaedcke, Philipp Strobel, Robyn Laura Kosinsky, Florian Wegwitz, Patrick Hermann, Mark J Truty, Jens T Siveke, Stephan A Hahn, Elisabeth Hessmann, Steven A Johnsen, Zeynab Najafova
A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therapy for defined molecular subtypes. In this work, we sought to gain further insight and identify molecular and epigenetic signatures of the basal-like A pancreatic ductal adenocarcinoma (PDAC) subgroup that can be applied to clinical samples for patient stratification and/or therapy monitoring. We generated and integrated global gene expression and epigenome mapping data from patient-derived xenograft (PDX) models to identify subtype-specific enhancer regions that were validated in patient-derived samples...
June 6, 2023: Molecular Cancer Research: MCR
Yin Sun, Yanli Xue, Pengkun Sun, Shuyi Mu, Hongbing Liu, Yu Sun, Lin Wang, Jingkai Wang, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Nian Liu, Hanxun Wang, Huali Yang, Dongmei Zhao, Maosheng Cheng
Polo-like kinase 4 (PLK4) is a master regulator of centriole replication and has been proposed as a therapeutic target for multiple cancers, especially TRIM37 -amplified breast cancer. The development of novel and effective therapeutic strategies for TRIM37 -amplified breast cancer therapy is challenging and extremely desirable. Herein, a structure-activity relationship (SAR) study with an emphasis on exploring different linker lengths and compositions was performed to report the discovery and characterization of SP27 as the first selective PLK4 proteolysis targeting chimera (PROTAC) degrader...
June 6, 2023: Journal of Medicinal Chemistry
Chad J Creighton, Flora Zhang, Yiqun Zhang, Patricia Castro, Rong Hu, Md Islam, Somiranjan Ghosh, Michael Ittmann, Bernard Kwabi-Addo
African American (AA) men have the highest incidence and mortality rate from Prostate cancer (PCa) than any other racial/ethnic group. To date, PCa genomic studies have largely under-represented tumour samples from AA men. We measured genome-wide DNA methylation in benign and tumor prostate tissues from AA men using the Illumina Infunium 850 K EPIC array. mRNA expression database from a subset of the AA biospecimen were used to assess correlation of transcriptome and methylation datasets. Genome-wide methylation analysis identified 11,460 probes that were significant (p < 0...
December 2023: Epigenetics: Official Journal of the DNA Methylation Society
Adedamola S Arojojoye, Chibuzor Olelewe, Sailajah Gukathasan, Jong H Kim, Hemendra Vekaria, Sean Parkin, Patrick G Sullivan, Samuel G Awuah
The preparation of cyclometalated complexes offers a path to stable materials, catalysts, and therapeutic agents. Here, we explore the anticancer potential of novel biphenyl organogold(III) cationic complexes supported by diverse bisphosphine ligands, Au-1-Au-5 , toward aggressive glioblastoma and triple negative breast cancer cells (TNBCs). The [C^C] gold(III) complex, Au-3 , exhibits significant tumor growth inhibition in a metastatic TNBC mouse model. Remarkably, Au-3 displays promising blood serum stability over a relevant therapeutic window of 24 h and alteration in the presence of excess L -GSH...
June 6, 2023: Journal of Medicinal Chemistry
Kanwal Khan, Karma Albalawi, Muhammad Naseer Abbas, Samiullah Burki, Ebraheem Abdu Musad Saleh, Abdulaziz Al Mouslem, Ahad Amer Alsaiari, Magdi E A Zaki, Afaq Ullah Khan, Ghallab Alotaibi, Khurshid Jalal
MCM7 (Minichromosome Maintenance Complex Component 7) is a component of the DNA replication licensing factor, which controls DNA replication. The MCM7 protein is linked to tumor cell proliferation and has a function in the development of several human cancers. Several types of cancer may be treated by inhibiting the protein, as it is strongly produced throughout this process. Significantly, Traditional Chinese Medicine (TCM), which has a long history of clinical adjuvant use against cancer, is rapidly gaining traction as a valuable medical resource for the development of novel cancer therapies, including immunotherapy...
June 6, 2023: Journal of Biomolecular Structure & Dynamics
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