keyword
https://read.qxmd.com/read/38771944/unplanned-surgery-in-dually-eligible-beneficiaries-for-conditions-that-should-be-treated-electively
#21
JOURNAL ARTICLE
Shukri H A Dualeh, Sidra N Bonner, Nicholas J Kunnath, Andrew M Ibrahim
OBJECTIVE: To evaluate the rate of unplanned surgery among dually eligible beneficiaries for surgical conditions that should be treated electively. SUMMARY BACKGROUND DATA: Access-sensitive surgical conditions (e.g. abdominal aortic aneurysm repair, colectomy for colon cancer, ventral hernia repair) are ideally treated with elective surgery, but when left untreated have a natural history leading to unplanned surgery. Dually eligible beneficiaries may face systematic barriers to access surgical care...
May 21, 2024: Annals of Surgery
https://read.qxmd.com/read/38771917/antiproliferative-potential-of-essential-oil-from-the-leaves-of-croton-floribundus%C3%A2-euphorbiaceae-against-human-metastatic-melanoma-cell-lines
#22
JOURNAL ARTICLE
Daniela A Garcia, Lara P D M Costa, Welton Rosa, Ana Cláudia Ladvocat, Danielle F Dias, Marisi G Soares, Marisa Ionta, Daniela Aparecida Chagas de Paula
Melanoma is a cancer type with high lethality, metastatic capacity, and limited therapeutic options. Different essential oils have been reported with antitumoral potential.  Thus, the essential oil (EO) of the leaves of C. floribundus was obtained by hydrodistillation and analyzed by GC-MS. The majority of substances annotated were β-selinene, E-Caryophyllene, and Premnaspirodiene. The cytotoxic activity of EO was evaluated on three melanoma cell lines SKMEL-147, WM-1366, and CHL-1, which are representative of metastatic melanoma with different mutation profiles...
May 21, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38771898/the-interplay-between-metabolic-adaptations-and-diet-in-cancer-immunotherapy
#23
JOURNAL ARTICLE
Lena Espelage, Natalie Wagner, Jan Malte Placke, Selma Ugurel, Alpaslan Tasdogan
Over the past decade, cancer immunotherapy has significantly advanced through the introduction of immune checkpoint inhibitors, and the augmentation of adoptive cell transfer to enhance the innate cancer defense mechanisms. Despite these remarkable achievements, some cancers exhibit resistance to immunotherapy, with limited patient responsiveness and development of therapy resistance. Metabolic adaptations in both immune cells and cancer cells have emerged as central contributors to immunotherapy resistance...
May 21, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38771871/physical-immune-escape-weakened-mechanical-communication-leads-to-escape-of-metastatic-colorectal-carcinoma-cells-from-macrophages
#24
JOURNAL ARTICLE
Chen Yang, Xinrui Dong, Bingrui Sun, Ting Cao, Ruipei Xie, Yiyu Zhang, Ziyue Yang, Jing Huang, Ying Lu, Ming Li, Xiaochen Wang, Ye Xu, Fangfu Ye, Qihui Fan
The significance of biochemical cues in the tumor immune microenvironment in affecting cancer metastasis is well established, but the role of physical factors in the microenvironment remains largely unexplored. In this article, we investigated how the mechanical interaction between cancer cells and immune cells, mediated by extracellular matrix (ECM), influences immune escape of cancer cells. We focus on the mechanical regulation of macrophages' targeting ability on two distinct types of colorectal carcinoma (CRC) cells with different metastatic potentials...
May 28, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38771850/malignant-risk-of-pediatric-bethesda-category-iii-thyroid-nodules-subcategorized-by-nuclear-atypia-and-other-a-single-institution-experience
#25
JOURNAL ARTICLE
Xiaobing Jin, Xin Jing, Brian Smola, Amer Heider
BACKGROUND: The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) divides AUS diagnoses into two major subcategories: atypia of undetermined significance (AUS) nuclear atypia (AUS-N) and other (AUS-O). This study aims to compare the histological outcome and malignant rate of pediatric AUS thyroid nodules classified into AUS-N and AUS-O subcategories. DESIGN: A search of our institutional electronic pathology database for the period from January 2012 to July 2023 was conducted to identify pediatric (<21 years old) thyroid nodules that were interpreted as AUS and subsequently had surgery...
May 21, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38771847/vdx-111-targets-proliferative-pathways-in-canine-cancer-cell-lines
#26
JOURNAL ARTICLE
Kristen B Farrell, Sunetra Das, Steven K Nordeen, James R Lambert, Douglas H Thamm
VDX-111 (also identified as AMPI-109) is a vitamin D derivative which has shown anticancer activity. To further assess the function of this compound against multiple cancer types, we examined the efficacy of VDX-111 against a panel of 30 well characterized canine cancer cell lines. Across a variety of cancer types, VDX-111 induced widely variable growth inhibition, cell death, and migration inhibition, at concentrations ranging from 10 nM to 1 μM. Growth inhibition sensitivity did not correlate strongly with tumor cell histotype; however, it was significantly correlated with the expression of genes in multiple cell signaling pathways, including the MAPK and PI3K-AKT pathways...
2024: PloS One
https://read.qxmd.com/read/38771827/an-assessment-of-the-direct-and-indirect-costs-of-breast-cancer-treatment-in-leading-cancer-hospitals-in-ghana
#27
JOURNAL ARTICLE
Patience Gyamenah Okyere Asante, Adobea Yaa Owusu, Joseph Ransford Oppong, Kingsley E Amegah, Edward Nketiah-Amponsah
BACKGROUND: In Ghana, breast cancer remains the most common cancer and the leading cause of cancer deaths among women. The cost of treating cancer is huge and poses a great challenge for patients, their families, and health care systems. While comprehensive studies have been conducted on the economic burden of cancers in developed economies such as the EU and the US, there are limited studies in Africa, and Ghana, in particular. This study quantitatively assessed Ghana's direct and indirect costs of breast cancer treatment...
2024: PloS One
https://read.qxmd.com/read/38771811/stomach-cancer-prediction-model-scopm-an-approach-to-risk-stratification-in-a-diverse-u-s-population
#28
JOURNAL ARTICLE
Bechien U Wu, Elizabeth Y Dong, Qiaoling Chen, Tiffany Q Luong, Eva Lustigova, Christie Y Jeon, Wansu Chen
BACKGROUND AND AIMS: Population-based screening for gastric cancer (GC) in low prevalence nations is not recommended. The objective of this study was to develop a risk-prediction model to identify high-risk patients who could potentially benefit from targeted screening in a racial/ethnically diverse regional US population. METHODS: We performed a retrospective cohort study from Kaiser Permanente Southern California from January 2008-June 2018 among individuals age ≥50 years...
2024: PloS One
https://read.qxmd.com/read/38771787/automatic-quantification-of-tumor-stroma-ratio-as-a-prognostic-marker-for-pancreatic-cancer
#29
JOURNAL ARTICLE
Pierpaolo Vendittelli, John-Melle Bokhorst, Esther M M Smeets, Valentyna Kryklyva, Lodewijk A A Brosens, Caroline Verbeke, Geert Litjens
PURPOSE: This study aims to introduce an innovative multi-step pipeline for automatic tumor-stroma ratio (TSR) quantification as a potential prognostic marker for pancreatic cancer, addressing the limitations of existing staging systems and the lack of commonly used prognostic biomarkers. METHODS: The proposed approach involves a deep-learning-based method for the automatic segmentation of tumor epithelial cells, tumor bulk, and stroma from whole-slide images (WSIs)...
2024: PloS One
https://read.qxmd.com/read/38771764/predictive-role-of-preoperative-sarcopenia-for-long-term-survival-in-rectal-cancer-patients-a-meta-analysis
#30
JOURNAL ARTICLE
Qiutong Su, Jia Shen
PURPOSE: To identify the predictive role of sarcopenia in long-term survival among rectal cancer patients who underwent surgery based on available evidence. METHODS: The Medline, EMBASE and Web of Science databases were searched up to October 20, 2023, for relevant studies. Overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS) were the endpoints. Hazard ratios (HRs) and 95% confidence intervals (CIs) were combined to evaluate the association between sarcopenia and survival...
2024: PloS One
https://read.qxmd.com/read/38771739/evaluating-debio-1347-in-patients-with-fgfr-fusion-positive-advanced-solid-tumors-from-the-fuze-multicenter-open-label-phase-ii-basket-trial
#31
JOURNAL ARTICLE
Petros Grivas, Elena Garralda, Funda Meric-Bernstam, Ingo K Mellinghoff, Lipika Goyal, James J Harding, E Claire Dees, Rastislav Bahleda, Nilofer S Azad, Asha Karippot, Razelle Kurzrock, Josep Tabernero, Juha Kononen, Matthew C H Ng, Rutika Mehta, Nataliya V Uboha, Frédéric Bigot, Valentina Boni, Samantha E Bowyer, Valeriy Breder, Andres Cervantes, Nancy Chan, James M Cleary, Mallika Dhawan, Rikke L Eefsen, James Ewing, Donna M Graham, Tormod K Guren, Jin Won Kim, Krassimir Koynov, Do-Youn Oh, Rebecca Redman, Chia-Jui Yen, David Spetzler, Marie-Claude Roubaudi-Fraschini, Valerie Nicolas-Metral, Rafik Ait-Sarkouh, Claudio Zanna, Abdallah Ennaji, Anna Pokorska-Bocci, Keith T Flaherty
PURPOSE: This multicenter phase II basket trial investigated the efficacy, safety and pharmacokinetics of Debio 1347, an investigational, oral, highly selective, ATP-competitive, small molecule inhibitor of FGFR1-3, in patients with solid tumors harboring a functional FGFR1-3 fusion. PATIENTS AND METHODS: Eligible adults had a previously treated locally advanced (unresectable) or metastatic biliary tract (cohort 1), urothelial (cohort 2) or other histologic cancer type (cohort 3)...
May 21, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38771737/kat8-enhances-the-resistance-of-lung-cancer-cells-to-cisplatin-by-acetylation-of-pkm2
#32
JOURNAL ARTICLE
Zhenyu Li, Xiangji Lu, Jing Zhang, Tao Liu, Mingzhi Xu, Shuai Liu, Junguo Liang
Cisplatin (CDDP)-based chemotherapy resistance is a major challenge for lung cancer treatment. PKM2 is the rate-limiting enzyme of glycolysis, which is associated with CDDP resistance. KAT8 is an acetyltransferase that regulates lung cancer progression. Thus, we aimed to explore whether KAT8 regulates PKM2 acetylation to participate in CDDP resistance. CDDP resistance was analyzed by CCK-8, flow cytometry and western blotting. To explore the regulation of KAT8 on PKM2, coimmunoprecipitation (Co-IP), immunofluorescence and immunoprecipitation followed by western blotting were performed...
May 20, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38771731/tislelizumab-tevimbra-for-esophageal-cancer
#33
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 13, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38771720/eef1d-stabilized-by-srsf9-promotes-colorectal-cancer-via-enhancing-the-proliferation-and-metastasis
#34
JOURNAL ARTICLE
Rui Wang, Chi Lv, Donghao Li, Yutong Song, Zhaopeng Yan
Colorectal cancer (CRC) is the third most common cancer and causes high mortality worldwide. Although CRC has been studied widely, the molecular mechanism is not completely known. Eukaryotic translation elongation factor 1 delta (EEF1D) participates in the progression of various tumors, however, the effect of EEF1D on CRC remains unclear. Here, we aimed to identify the potential mechanism of EEF1D in CRC. The expression levels of EEF1D were assessed in CRC samples. Functional analysis of EEF1D in CRC was detected in vitro and in vivo...
May 21, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38771708/effects-of-recall-and-selection-biases-on-modeling-cancer-risk-from-mobile-phone-use-results-from-a-case-control-simulation-study
#35
JOURNAL ARTICLE
Liacine Bouaoun, Graham Byrnes, Susanna Lagorio, Maria Feychting, Abdellah Abou-Bakre, Rémi Beranger, Joachim Schüz
BACKGROUND: The largest case-control study (Interphone Study) investigating glioma risk related to mobile phone use showed a J-shaped relationship with reduced relative risks for moderate use and a 40% increased relative risk among the 10% heaviest regular mobile phone users, using a categorical risk model based on deciles of lifetime duration of use among ever regular users. METHODS: We conducted Monte-Carlo simulations examining whether the reported estimates are compatible with an assumption of no effect of mobile phone use on glioma risk when the various forms of biases present in the Interphone study are accounted for...
May 20, 2024: Epidemiology
https://read.qxmd.com/read/38771671/a-cyclometalated-ruthenium-ii-complex-induces-oncosis-for-synergistic-activation-of-innate-and-adaptive-immunity
#36
JOURNAL ARTICLE
Tao Feng, Zixin Tang, Jun Shu, Xianbo Wu, Hui Jiang, Zhuoli Chen, Yu Chen, Liangnian Ji, Hui Chao
An optimal cancer chemotherapy regimen should effectively address the drug resistance of tumors while eliciting antitumor-immune responses. Research has shown that non-apoptotic cell death, such as pyroptosis and ferroptosis, can enhance the immune response. Despite this, there has been limited investigation and reporting on the mechanisms of oncosis and its correlation with immune response. Herein, we designed and synthesized a Ru(II) complex that targeted the nucleus and mitochondria to induce cell oncosis...
May 21, 2024: Angewandte Chemie
https://read.qxmd.com/read/38771665/tumor-targeted-codelivery-of-cpg-and-sirna-by-a-dual-ligand-functionalized-curdlan-nanoparticle
#37
JOURNAL ARTICLE
Qingming Bao, Mingming Bao, Hai Xiao, Tsogzolmaa Ganbold, Shuqin Han, Huricha Baigude
The simultaneous delivery of CpG oligonucleotide along with short interfering RNA (siRNA) has the potential to significantly boost the anticancer impact of siRNA medications. Our previous research demonstrated that Curdlan nanoparticles functionalized with adenosine are capable of selectively delivering therapeutic siRNA to cancerous cells through endocytosis mediated by adenosine receptors. Herein, we synthesized a dual-ligand-functionalized Curdlan polymer (denoted by CuMAN) to simultaneously target tumor cells and tumor-associated macrophages (TAMs)...
May 21, 2024: Biomacromolecules
https://read.qxmd.com/read/38771655/bet-bromodomain-inhibition-potentiates-radiosensitivity-in-models-of-h3k27-altered-diffuse-midline-glioma
#38
JOURNAL ARTICLE
Jun Watanabe, Matthew R Clutter, Michael J Gullette, Takahiro Sasaki, Eita Uchida, Savneet Kaur, Yan Mo, Kouki Abe, Yukitomo Ishi, Nozomu Takata, Manabu Natsumeda, Samantha Gadd, Zhiguo Zhang, Oren J Becher, Rintaro Hashizume
Diffuse midline glioma (DMG) H3K27-altered is one of the devastating childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation anti-tumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DMG. Using high-throughput radiosensitivity screening, we identified bromo- and extra-terminal domain (BET) protein inhibitors as potent radiosensitizers in DMG cells...
May 21, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38771633/liver-resection-vs-nonsurgical-treatments-for-patients-with-early-multinodular-hepatocellular-carcinoma
#39
JOURNAL ARTICLE
Alessandro Vitale, Pierluigi Romano, Umberto Cillo, Andrea Lauterio, Angelo Sangiovanni, Giuseppe Cabibbo, Gabriele Missale, Mariarosaria Marseglia, Franco Trevisani, Francesco Giuseppe Foschi, Federica Cipriani, Simone Famularo, Fabio Marra, Carlo Saitta, Matteo Serenari, Gianpaolo Vidili, Filomena Morisco, Eugenio Caturelli, Andrea Mega, Filippo Pelizzaro, Daniele Nicolini, Francesco Ardito, Mattia Garancini, Alberto Masotto, Gianluca Svegliati Baroni, Francesco Azzaroli, Edoardo Giannini, Pasquale Perri, Andrea Scarinci, Andrea Pierluigi Fontana, Maurizia Rossana Brunetto, Maurizio Iaria, Maria Di Marco, Gerardo Nardone, Tommaso Dominioni, Quirino Lai, Cecilia Ferrari, Gian Ludovico Rapaccini, Sacco Rodolfo, Maurizio Romano, Simone Conci, Marco Zoli, Maria Conticchio, Matteo Zanello, Giuseppe Zimmitti, Luca Fumagalli, Albert Troci, Paola Germani, Antonio Gasbarrini, Giuliano La Barba, Michela De Angelis, Stefan Patauner, Sarah Molfino, Mauro Zago, Enrico Pinotti, Anna Chiara Frigo, Gian Luca Baiocchi, Antonio Frena, Luigi Boccia, Giorgio Ercolani, Paola Tarchi, Michele Crespi, Marco Chiarelli, Moh'd Abu Hilal, Matteo Cescon, Riccardo Memeo, Andrea Ruzzenente, Giacomo Zanus, Guido Griseri, Massimo Rossi, Marcello Maestri, Raffaele Della Valle, Alessandro Ferrero, Gian Luca Grazi, Fabrizio Romano, Felice Giuliante, Marco Vivarelli, Elio Jovine, Guido Torzilli, Luca Aldrighetti, Luciano De Carlis
IMPORTANCE: The 2022 Barcelona Clinic Liver Cancer algorithm currently discourages liver resection (LR) for patients with multinodular hepatocellular carcinoma (HCC) presenting with 2 or 3 nodules that are each 3 cm or smaller. OBJECTIVE: To compare the efficacy of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in patients with multinodular HCC. DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a retrospective analysis conducted using data from the HE...
May 15, 2024: JAMA Surgery
https://read.qxmd.com/read/38771567/analysis-of-the-incidence-and-mortality-trends-of-esophageal-cancer-in-cancer-registry-areas-of-china-and-japan
#40
JOURNAL ARTICLE
Dongli Guo, Jing Jin, Daojuan Li, Yutong He, Yingsong Lin
This study aims to analyze the prevalence trend of esophageal cancer in Japan and China to provide suggestions for the prevention and treatment of esophageal cancer. The results showed that the incidence rate for the years 2010-2018 significantly decreased with an APC of 5.66%, and the mortality rate from 2010 to 2015 had an APC of -5.87% in China. However, the incidence rate of Japanese women showed an upward trend, with an APC of 4.09% from 2010 to 2019. The mortality rate of esophageal cancer in Japan showed a downward trend, with an APC of -2...
May 21, 2024: International Journal of Cancer. Journal International du Cancer
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