keyword
https://read.qxmd.com/read/33838606/red-and-processed-meat-consumption-and-cancer-outcomes-umbrella-review
#1
REVIEW
Yin Huang, Dehong Cao, Zeyu Chen, Bo Chen, Jin Li, Jianbing Guo, Qiang Dong, Liangren Liu, Qiang Wei
The purpose of this umbrella review was to evaluate the quality of evidence, validity and biases of the associations between red and processed meat consumption and multiple cancer outcomes according to existing systematic reviews and meta-analyses. The umbrella review identified 72 meta-analyses with 20 unique outcomes for red meat and 19 unique outcomes for processed meat. Red meat consumption was associated with increased risk of overall cancer mortality, non-Hodgkin lymphoma (NHL), bladder, breast, colorectal, endometrial, esophageal, gastric, lung and nasopharyngeal cancer...
March 27, 2021: Food Chemistry
https://read.qxmd.com/read/33838601/identification-of-cell-surface-targets-for-car-t-cell-therapies-and-antibody-drug-conjugates-in-breast-cancer
#2
F Schettini, P Barbao, F Brasó-Maristany, P Galván, D Martínez, L Paré, S De Placido, A Prat, S Guedan
BACKGROUND: Two promising therapeutic strategies in oncology are chimeric antigen receptor-T cell (CAR-T) therapies and antibody-drug conjugates (ADCs). To be effective and safe, these immunotherapies require surface antigens to be sufficiently expressed in tumors and less or not expressed in normal tissues. To identify new targets for ADCs and CAR-T specifically targeting breast cancer (BC) molecular and pathology-based subtypes, we propose a novel in silico strategy based on multiple publicly available datasets and provide a comprehensive explanation of the workflow for a further implementation...
April 7, 2021: ESMO Open
https://read.qxmd.com/read/33838596/bevacizumab-as-maintenance-therapy-in-patients-with-metastatic-colorectal-cancer-a-meta-analysis-of-individual-patients-data-from-3-phase-iii-studies
#3
REVIEW
Lisa Salvatore, Emilio Bria, Isabella Sperduti, Axel Hinke, Susanna Hegewisch-Becker, Thomas Aparicio, Karine Le Malicot, Valérie Boige, Dieter Koeberle, Daniela Baertschi, Daniel Dietrich, Giampaolo Tortora, Dirk Arnold
BACKGROUND: The real impact of bevacizumab maintenance as single agent in metastatic colorectal cancer (mCRC) remains unclear. SAKK-41/06 and PRODIGE-9 failed to demonstrate the non-inferiority and superiority of bevacizumab versus no maintenance, respectively, while AIO-KRK-0207 showed the non-inferiority of maintenance bevacizumab versus bevacizumab and fluoropyrimidines for time to strategy failure. METHODS: Bibliography electronic databases (PubMed, MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials) were searched for English published clinical trials prospectively randomizing mCRC patients to receive bevacizumab maintenance or not after first-line chemotherapy plus bevacizumab...
March 30, 2021: Cancer Treatment Reviews
https://read.qxmd.com/read/33838572/endometrial-stem-progenitor-cell-es-pc-marker-expression-profile-in-adenosarcoma-and-endometrial-stromal-sarcoma
#4
Ju-Yoon Yoon, Leanne de Kock, Colin J R Stewart, W Glenn McCluggage, William D Foulkes, Blaise A Clarke, Marjan Rouzbahman
BACKGROUND: The uterus is one of the most dynamic organs in the human body, and this dynamic homeostasis is supported by endometrial stem/progenitor cells (ES/PCs), which are heterogeneous in their phenotype and degree of differentiation. ES/PCs are generally localized in the endometrial stroma, the site of origin for adenosarcoma and endometrial stromal sarcoma (ESS). Subsets of ESSs and adenosarcomas harbor SUZ12 or DICER1 gene alterations, two genes with roles in embryonic stem cell biology...
March 31, 2021: Cancer Treatment and Research Communications
https://read.qxmd.com/read/33838571/learning-curve-in-robotic-assisted-lobectomy-for-non-small-cell-lung-cancer-is-not-steep-after-experience-in-video-assisted-lobectomy-single-surgeon-experience-using-cumulative-sum-analysis
#5
Saana E-M Andersson, Ilkka K Ilonen, Otto H Pälli, Jarmo A Salo, Jari V Räsänen
BACKGROUND: Robotic assistance in lung lobectomy has been suggested to enhance the adoption of minimally invasive techniques among surgeons. However, little is known of learning curves in different minimally invasive techniques. We studied learning curves in robotic-assisted versus video- assisted lobectomies for lung cancer. METHODS: A single surgeon performed his first 75 video-assisted thoracic surgery (VATS) lobectomies from April 2007 to November 2012, and his 75 first robotic-assisted thoracic surgery (RATS) lobectomies between August 2011 and May 2018...
April 2, 2021: Cancer Treatment and Research Communications
https://read.qxmd.com/read/33838570/active-surveillance-for-non-muscle-invasive-bladder-cancer-a-systematic-review-and-pooled-analysis
#6
REVIEW
Fausto Petrelli, Patrizia Giannatempo, Carmen Maccagnano, Roberto Contieri, Rodolfo Hurle
INTRODUCTION: One of the Non-Muscle Invasive Bladder Cancer (NMIBC) treatment options recently recommended by International Guidelines is represented by Active Surveillance (AS),. Herein we carried out a systematic review and pooled-analysis of currently available evidences in order to provide recommendations for daily urological practice. MATERIAL AND METHODS: The PubMed, EMBASE, and Coch rane Library databases were searched with the terms "Non-Muscle Invasive" or "pTa/pT1" and "Bladder Cancer" or "Bladder Tumor"...
April 3, 2021: Cancer Treatment and Research Communications
https://read.qxmd.com/read/33838560/design-synthesis-and-biological-evaluation-of-anilide-dicarboxylic-acid-shikonin-esters-as-antitumor-agents-through-targeting-pi3k-akt-mtor-signaling-pathway
#7
Yingying Ma, Xiaorong Yang, Hongwei Han, Zhongling Wen, Minkai Yang, Yahan Zhang, Jiangyan Fu, Xuan Wang, Tongming Yin, Guihua Lu, Jinliang Qi, Hongyan Lin, Xiaoming Wang, Yonghua Yang
Triple-negative breast cancer (TNBC) has an unfavorable prognosis attribute to its low differentiation, rapid proliferation and high distant metastasis rate. PI3K/Akt/mTOR as an intracellular signaling pathway plays a key role in the cell proliferation, migration, invasion, metabolism and regeneration. In this work, we designed and synthesized a series of anilide (dicarboxylic acid) shikonin esters targeting PI3K/Akt/mTOR signaling pathway, and assessed their antitumor effects. Through three rounds of screening by computer-aided drug design method (CADD), we preliminarily obtained sixteen novel anilide (dicarboxylic acid) shikonin esters and identified them as excellent compounds...
March 29, 2021: Bioorganic Chemistry
https://read.qxmd.com/read/33838550/dna-damage-response-and-pd-1-pd-l1-pathway-in-ovarian-cancer
#8
REVIEW
Tianyu Zhang, Shuangshuang Zheng, Yang Liu, Xiao Li, Jing Wu, Yue Sun, Guoyan Liu
Ovarian cancer has a poor prognosis due to drug resistance, relapse and metastasis. In recent years, immunotherapy has been applied in numerous cancers clinically. However, the effect of immunotherapy monotherapy in ovarian cancer is limited. DNA damage response (DDR) is an essential factor affecting the efficacy of tumor immunotherapy. Defective DNA repair may lead to carcinogenesis and tumor genomic instability, but on the other hand, it may also portend particular vulnerability of tumors and can be used as biomarkers for immunotherapy patient selection...
April 1, 2021: DNA Repair
https://read.qxmd.com/read/33838541/narrative-review-of-the-influence-of-diabetes-mellitus-and-hyperglycemia-on-colorectal-cancer-risk-and-oncological-outcomes
#9
REVIEW
Hsiu-Chung Cheng, Tsung-Kun Chang, Wei-Chih Su, Hsiang-Lin Tsai, Jaw-Yuan Wang
Diabetes mellitus (DM) and hyperglycemia have been shown to have significant effects on the incidence, chemoresistance, and prognosis of colorectal cancer (CRC), as well as the outcomes of localized and metastatic CRC. Inflammation and endocrine effects may act as central mechanisms of DM and cancer and stimulate the insulin-like growth factor 1-phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (IGF-1-PI3K-AKT-mTOR) pathway. Dysregulation of the AMP-activated protein kinase (AMPK) pathway leads to metabolic imbalance and indicates cancer risk...
April 7, 2021: Translational Oncology
https://read.qxmd.com/read/33838532/impact-of-covid-19-on-social-media-as-perceived-by-the-oncology-community-results-from-a-survey-in-collaboration-with-the-european-society-for-medical-oncology-esmo-and-the-oncoalert-network
#10
G Morgan, M Tagliamento, M Lambertini, B Devnani, B Westphalen, R Dienstmann, I Bozovic-Spasojevic, A Calles, C Criscitiello, A Curioni, A M Garcia, A Lamarca, S Pilotto, M Scheffler, M Strijbos, R Wong, E de Azambuja, S Peters
BACKGROUND: The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic. MATERIALS AND METHODS: A 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network...
April 7, 2021: ESMO Open
https://read.qxmd.com/read/33838515/coupled-mathematical-modeling-of-cisplatin-electroporation
#11
Ezequiel Goldberg, Alejandro Soba, Daniel Gandía, María Laura Fernández, Cecilia Suárez
The use of electrochemotherapy (ECT) is a well-established technique to increase the cellular uptake of cytotoxic agents within certain cancer treatment strategies. The study of the mechanisms that take part in this complex process is of high interest to gain a deeper knowledge of it, enabling the improvement of these strategies. In this work, we present a coupled multi-physics electroporation model based on a related previous one, to describe the effect of a set of electric pulses on cisplatin transport across the plasma membrane...
February 24, 2021: Bioelectrochemistry
https://read.qxmd.com/read/33838489/solid-variant-of-papillary-thyroid-carcinoma-an-analysis-of-28-cases-with-current-literature
#12
Çiğdem Vural, Umay Kiraz, Gupse Turan, Sevgiye Kaçar Özkara, Mehmet Sözen, Berrin Çetinarslan
INTRODUCTION: Solid variant papillary thyroid cancer (SVPTC) is a rare variant of papillary thyroid carcinoma (PTC) and its prognostic value is still unclear. Therefore, we re-evaluate the histopathological and clinicopathological features of 28 patients with SVPTC in the light of current literature. MATERIAL-METHODS: Of the 1308 cases were previously diagnosed with PTC and 28 (2,1%) of them which had been diagnosed with SVPTC were re-evaluated retrospectively. RESULTS: Of the 28 patients with SVPTC, 85...
March 31, 2021: Annals of Diagnostic Pathology
https://read.qxmd.com/read/33838487/cervical-elongation-caused-by-big-cervical-fibroid-resembling-malignant-cervical-prolapse-management-via-vaginal-surgery
#13
Fernandi Moegni, Surahman Hakim, Gita Nurul Hidayah, Suskhan, Tyas Priyatini, Alfa Putri Meutia, Budi Iman Santoso
INTRODUCTION: Cervical elongation could lead to cervical elongation thus worsen the descent of uterine prolapse. In certain cases, this hypertrophic and hyperplastic mass could have fragile surface with some bleeding and necrotic, resembling cervical cancer. As case of cervical elongation due to cervical fibroid is quite rare, such cases are valuable to be reported. We present two cases of cervical fibroid with cervical elongation resembling cervical malignancy. PRESENTATION OF CASE: First case was A 59-year-old lady with intractable vaginal mass since one day before admission...
March 29, 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33838484/successful-salvage-of-an-infected-breast-prothesis-by-changing-from-continuous-to-intermittent-suction-under-continuous-irrigation
#14
Mika Takeuchi, Masamitsu Kuwahara, Junji Ando, Riyo Miyata, Masayuki Harada, Saori Kanagawa
INTRODUCTION: Implant-based breast reconstruction is a widely performed procedure. However, prostheses are susceptible to infection and there are currently no established guidelines on treatment. In the present case, a prosthesis was salvaged by changing from continuous irrigation and suction to continuous irrigation and intermittent suction. This case report has been reported in line with the SCARE criteria [1]. PRESENTATION OF CASE: A 50-year-old female patient underwent implant-based breast reconstruction following surgery for breast cancer...
April 5, 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33838472/sustained-ikk%C3%AE-phosphorylation-and-nf-%C3%AE%C2%BAb-activation-by-superoxide-induced-peroxynitrite-mediated-nitrotyrosine-modification-of-b56%C3%AE-3-and-pp2a-inactivation
#15
Yi Hui Yee, Stephen Jun Fei Chong, Li Ren Kong, Boon Cher Goh, Shazib Pervaiz
Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector of oncogenic NF-κB signaling. Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2 - ) mediates sustained IKK phosphorylation, and induces downstream degradation of IκBα, leading to the nuclear localization and transcriptional activation of NF-κB...
December 18, 2020: Redox Biology
https://read.qxmd.com/read/33838468/two-different-patients-with-pulmonary-pleomorphic-carcinoma-response-to-pd-1-inhibitor-plus-anlotinib
#16
Yuxi Luo, Jianping Wei, Jing Zhang, Liangtao Zeng, Zhimin Zeng, Anwen Liu
Pulmonary pleomorphic carcinoma (PPC) is a rare and highly malignant subtype of non-small-cell lung cancer (NSCLC), and chemotherapy and radiotherapy are insensitive. Some clinical trials have shown that targetable driver gene mutations, such as EGFR, ALK or BRAF, have rarely been detected in PPC patients, but the incidence of MET exon 14 mutations is more frequent. For these patients with driver gene mutations, corresponding molecular targeted therapy may be valid. In addition, limited cases have suggested that immunotherapy may be effective for PPC without sensitising EGFR or ALK alterations, but the efficacy in patients with other driver mutations remains unclear...
March 26, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/33838467/prognostic-impact-of-kras-mutation-status-for-patients-with-stage-iv-adenocarcinoma-of-the-lung-treated-with-first-line-pembrolizumab-monotherapy
#17
A L Noordhof, R A M Damhuis, L E L Hendriks, A J de Langen, W Timens, B J W Venmans, W H van Geffen
OBJECTIVES: Monotherapy with pembrolizumab is the preferred first-line treatment for metastatic non-small cell lung cancer with programmed death-ligand 1 (PD-L1) expression ≥50 %, without targetable oncogenic drivers. Although targeted therapies are in development for patients with specific Kirsten rat sarcoma (KRAS) mutations, these are not available in daily care yet. It is not clear whether there is a difference in survival on first-line pembrolizumab for patients with a high PD-L1 status with or without a KRAS mutation...
April 5, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/33838462/sustainability-and-monitoring-of-the-european-code-against-cancer-recommendations
#18
Carolina Espina, Wendy Yared, David Ritchie, Satu Lipponen, Ahti Anttila, Kaarina Tamminiemi, Joachim Schüz
INTRODUCTION: As part of the third European Commission's Joint Action on Cancer (Innovative Partnership for Action Against Cancer, iPAAC), the International Agency for Research on Cancer (IARC) was commissioned to produce a report on recommendations to sustain and monitor future updates of the European Code Against Cancer (ECAC). MATERIALS AND METHODS: A co-creational consultation process, including a virtual workshop, was carried out. More than 100 experts in cancer prevention, public health, communication and representatives of European authorities provided input on the scope of future editions of the ECAC, including updating the scientific evidence and its maintenance, and on strategies for its implementation and dissemination across Europe...
April 7, 2021: Cancer Epidemiology
https://read.qxmd.com/read/33838461/projections-of-the-future-burden-of-cancer-in-australia-using-bayesian-age-period-cohort-models
#19
Jessica Katherine Cameron, Peter Baade
BACKGROUND: Accurate forecasts of cancer incidence, with appropriate estimates of uncertainty, are crucial for planners and policy makers to ensure resource availability and prioritize interventions. We used Bayesian age-period-cohort (APC) models to project the future incidence of cancer in Australia. METHODS: Bayesian APC models were fitted to counts of cancer diagnoses in Australia from 1982 to 2016 and projected to 2031 for seven key cancer types: breast, colorectal, liver, lung, non-Hodgkin lymphoma, melanoma and stomach...
April 7, 2021: Cancer Epidemiology
https://read.qxmd.com/read/33838456/diagnosis-of-primary-hyperfibrinolysis-and-in-vitro-investigation-of-the-inhibitory-effects-of-tranexamic-acid-in-a-group-of-dogs-with-sarcomas-a-pilot-study
#20
Rebecca Langhorn, Matilde K Poulsen, Pernille L Heidemann, Louise Bochsen, Christian Ritz, Annemarie T Kristensen, Lise N Nielsen
Primary hyperfibrinolysis is not well characterised in canine cancer. This prospective case-control pilot study aimed to evaluate tissue plasminogen activator-modified thromboelastography (tPA-TEG) for diagnosis of primary hyperfibrinolysis in dogs with cancer and establish the in vitro therapeutic concentration of tranexamic acid (TXA). Nine dogs with sarcomas and normocoagulable thromboelastograms and 11 healthy dogs were included. For each a whole blood tPA-TEG, and four tPA-TEGs with added TXA in different concentrations were analysed...
March 31, 2021: Research in Veterinary Science
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