Rong Sun, Zi-Jun Meng, Xuewen Hou, Yang Chen, Yi-Feng Yang, Guang Huang, Sheng-Dong Nie
To design an ensemble learning based prediction model using different breast DCE-MR post-contrast sequence images to distinguish two kinds of breast cancer subtypes (luminal and non-luminal). We retrospectively studied preoperative DCE-MRIs and molecular information of 266 breast cancer cases with either luminal subtype (luminal A and luminal B) or non-luminal subtype (human epidermal growth factor receptor 2 and triple negative). Then, multiple bounding boxes covering tumor lesions were acquired from three series of post-contrast DCE-MR sequence images which were determined by radiologists...
July 30, 2021: Physics in Medicine and Biology
Meng Lan, Zhaodi Kong, Fengjie Liu, Tengteng Zou, Lihong Li, Tiange Cai, Tian Huaqin, Yu Cai
Abnormal apoptosis can lead to uncontrolled cell growth, aberrant homeostasis or the accumulation of mutations. Therapeutic agents that re-establish the normal functions of apoptotic signaling pathways offer an attractive strategy for the treatment of breast cancer. Baicalin (BA) is one of the natural compounds with anti-proliferation and pro-apoptosis activities against numerous tumor cells. However, low bioavailability restricts the clinical application of BA. In order to improve its therapeutic efficacy and study the mechanism of actions, active targeting delivery systems were developed for targeting tumor environment and selective cell killing effects...
July 30, 2021: Nanotechnology
Laura Raquel Comini, Roxana Alasino, Victoria Leonhard, Karina Lilian Bierbrauer, Dante Miguel Beltramo
The use of nanoparticles is one of the strategies currently studied to minimize the toxicity and lack of tissue specificity of many cancer drugs used in chemotherapy. In this research the physicochemical and biological behavior of a novel self-assembled nanostructure of the antibiotic Teicoplanin (Teico) was characterized as a nanocarrier system for solubilizing highly hydrophobic drugs like Paclitaxel (Ptx) in aqueous media. The Teico micelles were loaded with Ptx in DMSO or PEG-400. The interaction between the loaded micelles and Albumin (HSA) was then studied by size exclusion chromatography...
July 30, 2021: Nanotechnology
Marissa B Lawson, Christoph I Lee, Daniel S Hippe, Shasank Chennupati, Catherine R Fedorenko, Kathleen E Malone, Scott D Ramsey, Janie M Lee
BACKGROUND: The purpose of this study was to determine factors associated with receipt of screening mammography by insured women before breast cancer diagnosis, and subsequent outcomes. PATIENTS AND METHODS: Using claims data from commercial and federal payers linked to a regional SEER registry, we identified women diagnosed with breast cancer from 2007 to 2017 and determined receipt of screening mammography within 1 year before diagnosis. We obtained patient and tumor characteristics from the SEER registry and assigned each woman a socioeconomic deprivation score based on residential address...
July 30, 2021: Journal of the National Comprehensive Cancer Network: JNCCN
Ayşegül Demiral, Nihan Verimli, S İrem Goralı, Hülya Yılmaz, Mustafa Çulha, S Sibel Erdem
It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface modification, serving as imaging and therapeutic agent, gold nanoparticles (AuNPs) draw attention as theranostic agents. It is beneficial to combine AuNPs with a second imaging and/or treatment modality such as photodynamic therapy (PDT). PDT is a non-mutagenic treatment approach in which photosensitizer is activated with light, generating reactive oxygen species and/or free radicals to destroy tumor cells...
July 16, 2021: Journal of Photochemistry and Photobiology. B, Biology
Kevin Callison, Cuiping Schiman, Jeffrey C Schiman
Cigarette smoking has long been viewed as a means to control body weight. However, studies on the association between smoking cessation and weight gain have reported mixed findings and, notably, there is limited evidence among the Chinese population - the world's largest smoker population. The extent to which smoking cessation is positively associated with body weight is of interest as excessive weight gain contributes to heart disease, diabetes, hypertension, musculoskeletal disorders, and some cancers. Additionally, concerns over weight gain may dissuade current smokers from quitting...
July 16, 2021: Economics and Human Biology
Meiqing Li, Danyi Lu, Yulian Cheng, Chunlei Wu, Jianchao Zhang, Wenli Shi, Zhihao Ding, Yanyan Li, Binghua Cheng, Xian Lin, Ximing Shao, Hongchang Li, Lijing Fang, Ke Liu, Wu Su
Aurora kinase A (Aurora A) plays a critical role in regulating cell mitotic progression and has been considered as a promising drug target for cancer therapy. To develop a novel molecule targeting Aurora A with high selectivity and efficacy, we designed and synthesized a pyrrole-imidazole polyamide (PIP) Hoechst conjugate, PIP-Ht, targeting to a cell-cycle regulated DNA sequence locating at the promoter of human Aurora A gene (AURKA). PIP-Ht potently suppressed AURKA promoter activities, mRNA expression and protein level, induced tumor cell cycle delay and inhibited tumor cell proliferation in vitro...
July 27, 2021: Biochemical and Biophysical Research Communications
Hanne Lefrère, Giuseppe Floris, Marjanka K Schmidt, Patrick Neven, Ellen Warner, Elyce Cardonick, Fedro A Peccatori, Sibylle Loibl, Charlotte Maggen, Hanne De Mulder, Katarzyna J Jerzak, Diether Lambrechts, Liesbeth Lenaerts, Frédéric Amant
BACKGROUND: In young women, a breast cancer diagnosis after childbirth increases the risk for metastasis and death. Studies in rodents suggest that post-weaning mammary gland involution contributes to the poor prognosis of postpartum breast cancers. However, this association has not been investigated in humans, mainly because of missing information on the patient's lactation status at diagnosis. PATIENTS AND METHODS: Clinicopathological data of 1180 young women with primary invasive breast cancer, diagnosed within 2 years postpartum (PP-BC), during pregnancy (Pr-BC), or nulliparous (NP-BC), were collected...
July 27, 2021: European Journal of Cancer
Tao Gong, Xiaoyu Wang, Qing Ma, Jing Li, Meining Li, Yu Huang, Wenting Liang, Dan Su, Rui Guo
Photo-chemotherapy (PCT) reveals great potential in hepatocellular carcinoma (HCC) treatment, therefore the construct of smart PCT nano-agents with high photothermal conversion efficiency and accurate drug delivery is of great significant. Herein, a novel hybrid nanomaterial MGO-TCA-FA has been designed and constructed by grafting the triformyl cholic acid (TCA) and folic acid (FA) on the surface of Fe3 O4 modified graphene oxide (MGO). The doxorubicin hydrochloride (DOX) as a model drug could be effectively loaded on the MGO-TCA-FA via hydrogen bonding and π-π stacking (the drug loading amount was 1040 mg/g)...
July 22, 2021: Journal of Inorganic Biochemistry
Tian-Wen Ni, Xiao-Chuan Duan, Meng Wang, Mei-Qi Jia, Ying Chen, Yang Yu, Nan Qin, Hong-Quan Duan
Breast cancer has become the number one killer of women. In our previous study, an active compound, ION-31a, with potential anti-metastasis activity against breast cancer was identified through the synthesis of ionone alkaloid derivatives. In the present study, we aimed to identify the therapeutic target of ION-31a. We used a fluorescence tag labeled probe, molecular docking simulation, and surface plasmon resonance (SPR) analysis to identify the target of ION-31a. The main target of ION-31a was identified as heat shock protein 90 (HSP90)...
July 22, 2021: Bioorganic Chemistry
Menna A Ewida, Heba A Ewida, Mahmoud S Ahmed, Heba Abdelrasheed Allam, Ramzia I ElBagary, Riham F George, Hanan H Georgey, Hussein I El-Subbagh
Inhibiting the Dihydrofolate reductase (DHFR) enzyme has been validated in multiple clinical manifestations related to bacterial infection, malaria, and multiple types of cancer. Herein, novel series of 3-methyl-imidazo[2,1-b] thiazole-based analogs were synthesized and biologically evaluated for their in vitro inhibitory profile towards DHFR. Compounds 22 and 23 exhibited potent inhibitory profile targeting DHFR (IC50 0.079 and 0.085 µM, respectively comparable to MTX IC50 0.087 µM). Compounds 22 and 23 showed promising cytotoxicity against MCF7 breast cancer cell lines inducing cell cycle arrest and apoptosis...
July 24, 2021: Bioorganic Chemistry
Katie Wang, Kento Nakano, Naghmeh Naderi, Mona Bajaj-Elliott, Afshin Mosahebi
PURPOSE: High prevalence, unreliable risk discrimination and poor clinical outcomes are observed in malignant and benign breast diseases (BD). The involvement of microbial communities in the development of BD has become topical, and distal influences of microbial dysregulation in the breast have been well established. Despite advances, the role of the breast skin microbiota in BD remains unclear. Interactions between the skin microbiota and the underlying mucosal immune system are complex...
July 21, 2021: Breast: Official Journal of the European Society of Mastology
Baoqi Zeng, Kai Yu, Le Gao, Xueyang Zeng, Qingxin Zhou
PURPOSE: We conducted a systematic review and meta-analysis to compare the screening performance of synthesized mammography (SM) plus digital breast tomosynthesis (DBT) with digital mammography (DM) plus DBT or DM alone. METHODS: Medline, Embase, Web of Science, and the Cochrane Library databases were searched from January 2010 to January 2021. Eligible population-based studies on breast cancer screening comparing SM/DBT with DM/DBT or DM in asymptomatic women were included...
July 22, 2021: Breast: Official Journal of the European Society of Mastology
Nicolò Bizzarri, Luca Boldrini, Gabriella Ferrandina, Francesco Fanfani, Luigi Pedone Anchora, Giovanni Scambia, Salvatore Gueli Alletti
Liu and colleagues performed a retrospective study to validate a computed tomography (CT) scan-based radiomic model to detect lymph node metastasis in cervical cancer. The proposed model incorporating the arterial and venous phase CT-scan features represented a non-invasive method exhibiting high sensitivity in the prediction of lymph node metastasis. It is well established that lymph node metastasis is one of the most significant prognostic factors in cervical cancer. For this reason, management of cervical cancer is strictly related to lymph node status, with international guidelines recommending definitive chemo-radiation in case of metastatic lymph node...
July 27, 2021: Translational Oncology
J A Perez-Fidalgo, A Cortés, E Guerra, Y García, M Iglesias, U Bohn Sarmiento, E Calvo García, L Manso Sánchez, A Santaballa, A Oaknin, A Redondo, M J Rubio, A González-Martín
BACKGROUND: There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status. PATIENTS AND METHODS: Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Patients with ≤4 previous lines (up to 5 in BRCA-mut) with at least one previous platinum-sensitive relapse were included; primary PROC was allowed only in case of BRCA-mut...
July 27, 2021: ESMO Open
B Markus Lange, Caleb F Conner
The pseudoalkaloid diterpene Taxol® (paclitaxel) emerged as a best-selling anti-cancer drug in the mid-1990s. The compound attracted considerable interest because of its unique mechanism to stabilize microtubules, thus reducing dynamicity and ultimately promoting mitotic arrest. Taxol was originally isolated from members of the genus Taxus. Over the last 50 years, close to 600 metabolites with taxane scaffolds were isolated from various Taxus species and their structures reported. The present review article provides an overview of the known chemical diversity of taxanes, with an emphasis on the functionalization of diterpene scaffolds...
July 27, 2021: Phytochemistry
Małgorzata Białek, Agnieszka Białek, Anna Ruszczyńska, Ewa Bulska, Kamil Zaworski, Marian Czauderna
BACKGROUND: The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer. METHODS: Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS)...
July 7, 2021: Journal of Trace Elements in Medicine and Biology
Ambika Chamoli, Abhishek S Gosavi, Urjita P Shirwadkar, Khushal V Wangdale, Santosh Kumar Behera, Nawneet Kumar Kurrey, Kiran Kalia, Amit Mandoli
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral cavity. The substantial risk factors for OCSCC are the consumption of tobacco products, alcohol, betel quid, areca nut, and genetic alteration. However, technological advancements have occurred in treatment, but the survival decreases with late diagnosis; therefore, new methods are continuously being investigated for treatment. In addition, the rate of secondary tumor formation is 3-7% yearly, which is incomparable to other malignancies and can lead to the disease reoccurrence...
July 27, 2021: Oral Oncology
Eliane R Nieuwenhuis, Barry Kolenaar, Alexander J M van Bemmel, Jurrit J Hof, Joop van Baarlen, Anke Christenhusz, Joost J Pouw, Bernard Ten Haken, Lejla Alic, Remco de Bree
OBJECTIVES: To assess the feasibility and merits of a complete magnetic approach for a sentinel lymph node biopsy (SLNB) procedure in oral cancer patients. MATERIALS AND METHODS: This study included ten oral cancer patients (stage cT1-T2N0M0) scheduled for elective neck dissection (END). Superparamagnetic iron oxide nanoparticles (SPIO) were administered peritumorally prior to surgery. A preoperative MRI was acquired to identify lymph nodes (LNs) with iron uptake...
July 27, 2021: Oral Oncology
Andrey Finegersh, Rohith S Voora, Bharat Panuganti, Farhoud Faraji, F Christopher Holsinger, Kevin T Brumund, Charles Coffey, Joseph Califano, Ryan K Orosco
BACKGROUND: Hypopharyngeal cancer is associated with poor survival. Robotic surgery is emerging as a treatment for hypopharyngeal tumors, but no rigorous data are available to assess its effect on survival. METHODS: The National Cancer Database (NCDB) was used to identify patients with T1 and T2 hypopharyngeal tumors undergoing robotic surgery, laser surgery, and primary radiation with or without chemotherapy from 2010 to 2016. All adult patients with available staging and no distant metastasis were included...
July 27, 2021: Oral Oncology
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