keyword
https://read.qxmd.com/read/36934457/virtual-resection-specimen-interaction-using-augmented-reality-holograms-to-guide-margin-communication-and-flap-sizing
#1
JOURNAL ARTICLE
Fabian N Necker, Marcello Chang, Christoph Leuze, Michael C Topf, Bruce L Daniel, Fred M Baik
Head and neck surgeons often have difficulty in relocating sites of positive margins due to the complex 3-dimensional (3D) anatomy of the head and neck. We introduce a new technique where resection specimens are 3D scanned with a smartphone, annotated in computer-assisted design software, and immediately visualized on augmented reality (AR) glasses. The 3D virtual specimen can be accurately superimposed onto surgical sites for orientation and sizing applications. During an operative workshop, a surgeon using AR glasses projected virtual, annotated specimen models back into the resection bed onto a cadaver within approximately 10 minutes...
March 19, 2023: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/36934452/a-prospective-study-of-psychological-distress-among-patients-with-advanced-cancer-and-their-caregivers
#2
JOURNAL ARTICLE
Irene Teo, Sean Ng, Filipinas Gines Bundoc, Chetna Malhotra, Semra Ozdemir, Jennifer L Steel, Eric A Finkelstein
BACKGROUND: Cancer can impact the psychological well-being of both patients and their informal caregivers. We investigated the joint trajectories of psychological distress among Singaporean advanced cancer patients-caregiver dyads. We also examined predictors of trajectory group membership. METHODS: This study utilised data from 299 patients with advanced solid cancer and their caregivers over 33 months (12 times points). Group-based trajectory modelling was used to examine the joint trajectories of patient anxiety, patient depression, caregiver anxiety and caregiver depression scores using the Hospital Anxiety and Depression Scale...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934451/prior-irinotecan-exposure-does-not-preclude-benefit-to-liposomal-irinotecan-in-patients-with-metastatic-pancreatic-ductal-adenocarcinoma
#3
JOURNAL ARTICLE
Kenneth H Yu, Paul Cockrum, Andy Surinach, Neil Lamarre, Shu Wang, Eileen M O'Reilly
BACKGROUND: Subgroup analyses of the NAPOLI-1 study identified that among patients who were irinotecan naïve prior to entering the clinical trial, a survival benefit was observed between the study arm and control arm. This treatment benefit was not observed among those previously exposed to irinotecan. This study sought to understand the impact of prior exposure to irinotecan on clinical outcomes among patients treated with liposomal irinotecan in the real-world setting. METHODS: This retrospective observational study utilized a nationwide electronic health record (EHR)-derived deidentified database...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934449/investigating-the-efficiency-of-lung-multi-disciplinary-team-meetings-a-mixed-methods-study-of-eight-lung-multi-disciplinary-teams
#4
JOURNAL ARTICLE
Magdalena Zasada, Jenny Harris, Johanna Groothuizen, Eunice Aroyewun, Jeewaka Mendis, Cath Taylor, Madeleine Hewish
BACKGROUND: Multidisciplinary team meetings (MDTMs), where treatment recommendations are discussed and agreed, are fundamental to effective cancer care. The increasing volume and complexity of caseloads has led to the need to transform MDTM pathways to improve efficiency and allow sufficient time for discussion of complex cases. Understanding of current functioning and inefficiencies is required to inform such transformation. METHODS: A mixed-methods observational study of all lung cancer MDTMs in one UK cancer network over 12 weeks (n = 8 MDTs, 96 MDT meetings)...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934442/intratumoral-heterogeneity-treatment-response-and-survival-outcome-of-er-positive-her2-positive-breast-cancer
#5
JOURNAL ARTICLE
Natsuki Teruya, Hiroaki Inoue, Rie Horii, Futoshi Akiyama, Takayuki Ueno, Shinji Ohno, Shunji Takahashi
BACKGROUND: ER+HER2+ breast cancer requires most types of systemic therapies perioperatively. However, treatment resistance is often experienced. The current study investigated the predictive and prognostic value of intratumoral heterogeneity and conventional clinicopathological factors in patients with ER+HER2+ breast cancer. METHODS: This research included two patient cohorts with ER+HER2+ breast cancer. Cohort A included patients who underwent surgery without neoadjuvant chemotherapy (NAC)...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934436/peripheral-lymphocyte-fluctuation-as-an-indicator-of-severe-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitors
#6
JOURNAL ARTICLE
Masafumi Haraguchi, Yasuhiko Nakao, Syouhei Narita, Kousuke Matsumoto, Masanori Fukushima, Ryu Sasaki, Takuya Honda, Satoshi Miuma, Hisamitsu Miyaaki, Kazuhiko Nakao
AIM: Immune checkpoint inhibitors (ICIs) have proven to be effective treatments for various cancers, but can also elicit immune-related adverse events (irAEs). Given that severe irAEs can be life-threatening, biomarkers that can predict the occurrence of irAEs are of paramount importance. ICIs affect the dynamics of lymphocytes, and alterations in these dynamics may play a role in the development and severity of irAEs. The aim of this study was to investigate the correlation between irAEs and changes in lymphocyte counts...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934434/a-systematic-review-of-neoadjuvant-and-definitive-immunotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma
#7
REVIEW
Udit Nindra, Joshua Hurwitz, Dion Forstner, Venessa Chin, Richard Gallagher, Jia Liu
BACKGROUND: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) require multi-modality treatment. Immune checkpoint inhibitors (ICIs) are now standard of care in management of recurrent/metastatic HNSCC. However, its role in the definitive and neoadjuvant setting remains unclear. METHODS: A literature search was conducted that included all articles investigating ICI in untreated locally advanced (LA) HNSCC. Data was extracted and summarised and rated for quality using the Cochrane risk of bias tool...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934433/competing-risk-model-for-prognostic-comparison-between-clear-cell-type-and-common-type-hepatocellular-carcinoma-a-population-based-propensity-score-matching-study
#8
JOURNAL ARTICLE
Xiao Zhong, Xingwang Hu, Xue-Gong Fan
BACKGROUND: Clear cell type hepatocellular carcinoma (HCC) is an uncommon neoplasm with an ambivalent prognosis compared to common type HCC. METHODS: First, patients with clear cell or common type HCC were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database, and their demographic and clinical characteristics were identified. Next, overall survival (OS), disease-specific survival (DSS), and subgroup analysis of the two types of HCC were performed...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934429/prognostic-risk-factor-of-major-salivary-gland-carcinomas-and-survival-prediction-model-based-on-random-survival-forests
#9
JOURNAL ARTICLE
Yufan Chen, Guoli Li, Wenmei Jiang, Rong Cheng Nie, Honghao Deng, Yingle Chen, Hao Li, Yanfeng Chen
Salivary gland malignancies are rare and are often acompanied by poor prognoses. So, identifying the populations with risk factors and timely intervention to avoid disease progression is significant. This study provides an effective prediction model to screen the target patients and is helpful to construct a cost-effective follow-up strategy. We enrolled 249 patients diagnosed with salivary gland tumors and analyzed prognostic risk factors using Cox proportional hazard univariable and multivariable regression models...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934426/depleting-the-19s-proteasome-regulatory-psmd1-subunit-as-a-cancer-therapy-strategy
#10
JOURNAL ARTICLE
Julia Adler, Roni Oren, Yosef Shaul
BACKGROUND: Proteasome inhibitors are in use in treating certain types of cancers. These drugs inhibit the catalytic activity of the 20S proteasome, shared by all the different proteasome complexes. Inhibitors of the 26S-associated deubiquitinating activity explicitly inhibit the 26S proteasomal degradation of ubiquitinylated substrates. We have previously reported an alternative strategy that is based on reducing the 26S/20S ratio by depleting PSMD1, 6, and 11, the subunits of the 19S proteasome regulatory complex...
March 19, 2023: Cancer Medicine
https://read.qxmd.com/read/36934420/the-roles-of-atp-binding-cassette-transporter-a1-and-its-substrate-cholesterol-in-head-and-neck-cancers
#11
REVIEW
Fatma Sanli, Omer F Karatas
Head and neck cancer (HNC), which is among the deadliest malignancies, is the seventh most common cancer worldwide. How cholesterol homeostasis is linked to human cancers has long been a source of curiosity. One of the few proteins that are involved in cholesterol homeostasis is ATP-binding cassette transporter A1 (ABCA1), which is broadly expressed in numerous tissues. ABCA1 increases cholesterol efflux, inhibits cholesterol deposition in cells, and modulates anticancer activities. Therefore, it is not surprising that decreased ABCA1 activity and altered cholesterol homeostasis are implicated in the patho-physiology of HNCs...
March 19, 2023: Cell Biology International
https://read.qxmd.com/read/36934410/samhd1-restricts-the-deoxyguanosine-triphosphate-pool-contributing-to-telomere-stability-in-telomerase-positive-cells
#12
JOURNAL ARTICLE
Giulia D'Aronco, Paola Ferraro, Valentina Sassano, Claudia Dagostino, Melissa Biancotto, Elisa Palumbo, Ettore Presot, Antonella Russo, Vera Bianchi, Chiara Rampazzo
SAMHD1 (Sterile alpha motif and histidine/aspartic acid domain-containing protein 1) is a dNTP triphosphohydrolase crucial in the maintenance of balanced cellular dNTP pools, which support genome integrity. In SAMHD1 deficient fibroblasts isolated from Aicardi-Goutières Syndrome (AGS) patients, all four DNA precursors are increased and markedly imbalanced with the largest effect on dGTP, a key player in the modulation of telomerase processivity. Here, we present data showing that SAMHD1, by restricting the dGTP pool, contributes to telomere maintenance in hTERT-immortalized human fibroblasts from AGS patients as well as in telomerase positive cancer cell lines...
April 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36934391/hypothyroidism-associated-immunosuppression-involves-induction-of-galectin-1-producing-regulatory-t-cells
#13
JOURNAL ARTICLE
Eduardo Valli, Tomás Dalotto-Moreno, Helena A Sterle, Santiago P Méndez-Huergo, María A Paulazo, Silvia I García, Carlos J Pirola, Alicia J Klecha, Gabriel A Rabinovich, Graciela A Cremaschi
Hypothyroidism exerts deleterious effects on immunity, but the precise role of the hypothalamic-pituitary-thyroid (HPT) axis in immunoregulatory and tolerogenic programs is barely understood. Here, we investigated the mechanisms underlying hypothyroid-related immunosuppression by examining the regulatory role of components of the HPT axis. We first analyzed lymphocyte activity in mice overexpressing the TRH gene (Tg-Trh). T cells from Tg-Trh showed increased proliferation than wild-type (WT) euthyroid mice in response to polyclonal activation...
April 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36934389/znf32-prevents-the-activation-of-cancer-associated-fibroblasts-through-negative-regulation-of-tgfb1-transcription-in-breast-cancer
#14
JOURNAL ARTICLE
Qin Li, Hang Yuan, Gang Zhao, Jie Zhang, Siqi Li, Di Gong, Tianyu Feng, Qiming Kou, Qijing Wang, Guanru Wang, Shan Li, Kai Li, Ping Lin
Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related deaths in women worldwide. Cancer-associated fibroblasts (CAFs) are one of the fundamental cellular components of the tumor microenvironment and play a critical role in the initiation, progression, and therapy resistance of breast cancer. However, the detailed molecular mechanisms of CAFs activation from normal fibroblasts (NFs) are still not well understood. In the present study, we reported that ZNF32 expression in breast cancer cells was negatively correlated with CAF-related markers (FSP1, α-SMA, and FAP) in stromal fibroblasts, and loss of ZNF32 promoted the activation of CAFs, as evidenced by the enhanced proliferation and contractility of CAFs...
April 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36934378/does-stage-migration-occur-as-a-consequence-of-omitting-completion-lymph-node-dissection-for-melanoma
#15
JOURNAL ARTICLE
Zachary J Senders, Edmund K Bartlett, Tyler J Mouw, Kelly M McMasters, Michael E Egger
INTRODUCTION: Completion lymph node dissection (CLND) is no longer recommended routinely in the treatment of melanoma. CLND omission may understage patients for whom the distinction between stage IIIA and IIIB-C could alter adjuvant therapy recommendations. The aim of this study is to determine if stage migration has occurred with the declining use of CLND. METHODS: Patients with clinically node-negative ≥ T1b cutaneous melanoma were identified from the National Cancer Database (NCDB) from 2012 to 2018...
March 19, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36934377/impact-of-programmed-death-ligand-1-expression-on-mismatch-repair-deficiency-and-epstein-barr-virus-status-on-survival-outcomes-in-patients-with-stage-ii-iii-gastric-cancer-after-surgery
#16
JOURNAL ARTICLE
Eigo Akimoto, Takeshi Kuwata, Kohei Shitara, Akihito Kawazoe, Naoya Sakamoto, Genichiro Ishii, Atsushi Ochiai, Takahiro Kinoshita
BACKGROUND: The aim of this study was to investigate the prognostic impact of mismatch repair (MMR) status, programmed death-ligand 1 (PD-L1) expression, and Epstein-Barr virus (EBV) status in stage II/III gastric cancer after surgery. METHODS: This study included 679 patients diagnosed with pathological stage II/III gastric cancer who underwent curative gastrectomy followed by adjuvant chemotherapy (AC) or observation between 2007 and 2015. Clinical outcomes were retrospectively reviewed and compared with stratification by AC and other clinicopathological factors...
March 19, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36934373/haplotype-gggt-in-long-non-coding-rna-malat1-inhibits-brain-metastatic-lung-cancer-and-lymph-nodes-of-lung-cancer-via-the-malat1-mir-328-katnb1
#17
JOURNAL ARTICLE
Tingting Liu, Jianpeng Ma, Dongmei Hou, Weiqi Wang, Hetao Cao
The up-regulation of Katanin P8 has been reported to be correlated with a larger tumor size and lymph node metastasis in non-small-cell lung cancer (NSCLC) patients. And lncRNA MALAT1 was demonstrated to promote the proliferation of chronic myeloid leukemia cells via modulating miR-328. 135 lung cancer patients were divided into 6 groups according to their genotypes of MALAT1. The expression of KATNB1 was negatively correlated with the GGGT genotype of MALAT1. Decreased lymph node size and tumor size of brain metastatic lung were observed in patients with GGGT genotype of MALAT1...
March 2, 2023: Aging
https://read.qxmd.com/read/36934368/pi3k-akt-mtor-inhibitors-as-potential-extracellular-matrix-modulators-for-targeting-emt-subtype-gastric-tumors
#18
JOURNAL ARTICLE
Ponmathi Panneerpandian, Kumaresan Ganesan
Targeting the extracellular matrix (ECM) is considered as a promising strategy in cancer therapeutics. This study was designed to identify the potential ECM modulators for gastric cancer therapeutics. Exploration of the expression profiles of gastric tumors revealed the elevated expression of ECM genes in gastric tumor tissues compared to the adjacent normal tissues with increased expression in diffuse subtype gastric tumors and specifically in epithelial to mesenchymal transition (EMT) molecular subtype tumors...
March 19, 2023: Medical Oncology
https://read.qxmd.com/read/36934365/chemotherapy-induced-peripheral-neuropathy-in-the-detroit-research-on-cancer-survivors-rocs-cohort
#19
JOURNAL ARTICLE
Kalyan Sreeram, Randell Seaton, Mark K Greenwald, Mandana Kamgar, Hadeel Assad, Tara Baird, Ann G Schwartz, Julie Ruterbusch, Michael S Simon
PURPOSE: Improved life expectancy has increased the likelihood for long-term complications from chemotherapy among cancer survivors. One burdensome complication is chemotherapy-induced peripheral neuropathy (CIPN). We evaluated rates of CIPN outcomes in the Detroit Research on Cancer Survivorship (ROCS) cohort. METHODS: The population included 1,034 African American (AA) survivors who received chemotherapy for breast, colorectal, lung or prostate cancer. CIPN prevalence was based on initial occurrence of worsening of self-reported pain, numbness or tingling after chemotherapy...
March 19, 2023: Cancer Causes & Control: CCC
https://read.qxmd.com/read/36934355/-reducing-the-risk-of-radiation-induced-cardiotoxicity-in-patients-with-left-breast-tumor
#20
JOURNAL ARTICLE
Zsófia Dankovics, Tamás Ungvári, Döme Szabó, András Heim, Béla Farkas, Balázs Kiss, András Csejtei, Judit Olajos
INTRODUCTION: Breast cancer is one of the most common malignancies affecting women. Treatment with drugs and radiotherapy increases the incidence of late cardiovascular disease. It is therefore particularly important to protect the heart from radiation exposure. METHOD: We prepared an irradiation plan for 45 patients with left breast cancer using deep breathing and normal breathing techniques. The plans were compared and analyzed. The irradiation plans were created in the Philips Pinnacle v...
March 19, 2023: Orvosi Hetilap
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