Elena Bignami, Nunzia Casamassima, Elena Frati, Chiara Lanzani, Laura Corno, Ottavio Alfieri, Stephen Gottlieb, Marco Simonini, Keyur B Shah, Anna Mizzi, Elisabetta Messaggio, Alberto Zangrillo, Mara Ferrandi, Patrizia Ferrari, Giuseppe Bianchi, John M Hamlyn, Paolo Manunta
OBJECTIVES: Acute kidney injury is a frequent complication of cardiac surgery and increases morbidity and mortality. As preoperative biomarkers predicting the development of acute kidney injury are not available, we have tested the hypothesis that preoperative plasma levels of endogenous ouabain may function as this type of biomarker. RATIONALE AND DESIGN: Endogenous ouabain is an adrenal stress hormone associated with adverse cardiovascular outcomes. Its involvement in acute kidney injury is unknown...
March 2013: Critical Care Medicine