Leila Safari Zanjani, Reza Shapoury, Mehrouz Dezfulian, Mehdi Mahdavi, Mehdi Shafieeardestani
BACKGROUND: Pseudomonas aeruginosa has an important role in nosocomial infections. OBJECTIVE: To evaluate biological activity of the detoxified LPS (D-LPS) entrapped into Poly lactic-co-glycolic acid (PLGA) nanoparticles. MATERIALS: LPS was extracted and detoxified from the P. aeruginosa strain PAO1. The D-LPS, conjugated to the PLGA nanoparticles with 1-ethyl-3-dimethyl aminopropyl carbodiimide (EDAC) and N-hydroxy-succinimide (NHS). The connection was evaluated by FTIR (Fourier transform infrared), Zetasizer, and Atomic Force Microscope (AFM)...
March 2020: Iranian Journal of Immunology: IJI
Faika Zanjani, Nancy Schoenberg, Catherine Martin, Richard Clayton
Objectives: Prevalent concomitant alcohol and medication use among older adults is placing this group at risk for adverse health events. Given limited existing interventions to address concomitant alcohol and medication risk (AMR), a brief educational intervention was demonstrated. The purpose of the current study was to examine change in AMR behaviors 3 months post-education among older adult drinkers. Methods: A convenience sample of 58 older adult drinkers (mean age = 72) was recruited and followed ( n = 40; 70% at follow-up), from four pharmacies in rural Virginia...
January 2020: Gerontology & Geriatric Medicine
Leili Saeednejad Zanjani, Zahra Madjd, Ulrika Axcrona, Maryam Abolhasani, Arezoo Rasti, Mojgan Asgari, Øystein Fodstad, Yvonne Andersson
B7-H3 and EpCAM are overexpressed in cancer and play a role in tumorigenesis and metastasis. In this study, the membranous, cytoplasmic and nuclear expression levels of B7-H3 and EpCAM biomarkers were mapped in three major subtypes of renal cell carcinoma (RCC). Expression of B7-H3 and EpCAM were evaluated using immunohistochemistry in RCC samples on tissue microarrays (TMAs), including clear cell RCCs (ccRCCs), type I and II papillary RCCs (pRCCs), and chromophobe RCCs (chRCCs). The association between B7-H3 and EpCAM expression and clinicopathological features as well as survival outcomes was determined...
February 25, 2020: Annals of Diagnostic Pathology
Hannah K Allen, Flavius Lilly, Kerry M Green, Faika Zanjani, Kathryn B Vincent, Amelia M Arria
Objective : This study evaluated variation in substance use and mental health among graduate student subgroups. Participants: A sample of 2,683 master's and doctoral students completed an online survey in October 2017. Methods : Subgroup variation in behavioral health by demographic and program characteristics, particularly degree type and academic discipline, was explored. Results : Compared with academic doctoral students (ie, PhD students), professional doctoral students (ie, MD, JD, etc.) were significantly more likely to report high stress levels and moderate or severe anxiety symptoms...
February 26, 2020: Journal of American College Health: J of ACH
Hamed Mohamadpour, Amir Azadi, Kobra Rostamizadeh, Sina Andalib, Mohammad Reza Saghatchi Zanjani, Mehrdad Hamidi
The objective of this study was to formulate and investigate the neuropharmacokinetic and pharmacodynamic of rivastigmine (Riv) loaded methoxy poly (ethylene glycol)-co-Poly (ε-caprolactone) (MPEG-PCL) nanoparticles (Riv-NPs) in rats after IV administration. The MPEG-PCL was synthesized via ring-opening polymerization of ε-caprolactone by MPEG and used to prepare Riv-NPs by nanoprecipitation method. Response surface D-optimal design was applied to optimize Riv-NPs drug delivery system. The optimized formulation showed a particle size (PS) of 98...
February 11, 2020: ACS Chemical Neuroscience
Ferdows Afghah, Mohib Ullah, Jamal Seyyed Monfared Zanjani, Pınar Akkuş Süt, Ozlem Sen, Melis Emanet, Burcu Saner Okan, Mustafa Culha, Yusuf Menceloglu, M Yildiz, Bahattin Koc
Scaffold-based tissue engineering approaches have been commonly used for skin regeneration or wound healings caused by diseases or trauma. For an ideal complete healing process, scaffold structures need to meet the criteria of biocompatibility, biodegradability, and antimicrobial properties, as well as to provide geometrical necessities for the regeneration of damaged tissue. In this study, design, synthesis and characterization of a three dimensional (3D) printable copolymer based on polycaprolactone-block-poly(1,3-propylene succinate)‎ (PCL-PPSu) including anti-microbial silver particles is presented...
February 7, 2020: Biomedical Materials
Mohammad Majid Oryadi-Zanjani
The aim of this study was to develop and validate the Childhood Nonverbal Communication Scale (CNCS) to assess nonverbal communication skills in children from birth to 18 months old. An extensive review of existing research provided evidence used to generate items representative of nonverbal communication behaviors. The final version of the CNCS includes 37 items divided in two dimensions (CNCS-1 and CNCS-2) showing high content validity (item-rated content validity index ≥ 0.75). The scale was administered to 428 Iranian Persian-speaking children 3 to 18 months old with normal development...
January 4, 2020: Journal of Autism and Developmental Disorders
Saeedeh Mokarian Zanjani, Mehmet C Onbaşlı
These data include detailed calculations and graphs based on our manuscript submitted to Journal of Magnetism and Magnetic Materials, entitled "Predicting New Iron Garnet Thin Films with Perpendicular Magnetic Anisotropy". These data are organized in two parts; first, we present the calculated plots of sensitivity of magnetic anisotropy field and anisotropy energy density for 49 epitaxial rare earth iron garnet (REIG) film/substrate pairs (a total of 98 plots, Figs. 1-15). In the second part, we present in Table 1 the complete details on the calculations for total magnetic anisotropy and all material constants used for each of 50 film/substrate pairs...
February 2020: Data in Brief
Behzad Eyvazi, Ahmad Jamshidi-Zanjani, Ahmad Khodadadi Darban
The co-precipitation method was used to synthesize nano-magnetic adsorbent MnFe2 O4 (nMFO), characterized through XRD, SEM, EDS, and BET techniques. The synthesized nMFO was used for hexavalent and trivalent chromium ions elimination from the aqueous phase. The optimum pH for the adsorption of Cr (VI) and Cr (III) was determined as 2 and 5, respectively. The chromium ions adsorption behavior was well interpreted through the pseudo-second order kinetics model. Furthermore, isotherm studies were conducted, and the obtained results indicated that Langmuir isotherm model could well justify the chromium ions adsorption process...
November 29, 2019: Environmental Pollution
James M Heather, Paisley T Myers, Feng Shi, Mohammad Ovais Aziz-Zanjani, Keira E Mahoney, Matthew Perez, Benjamin Morin, Christine Brittsan, Jeffrey Shabanowitz, Donald F Hunt, Mark Cobbold
The study of peptides presented by MHC class I and class II molecules is limited by the need for relatively large cell numbers, especially when studying post-translationally modified or otherwise rare peptide species. To overcome this problem, we pose the hypothesis that human cells grown as xenografts in immunodeficient mice should produce equivalent immunopeptidomes as cultured cells. Comparing human cell lines grown either in vitro or as murine xenografts, we show that the immunopeptidome is substantially preserved...
December 6, 2019: Scientific Reports
Bamdad Riahi-Zanjani, Mostafa Heidarzadegan, Hasan Badibostan, Gholamreza Karimi
Due to nutritional facts of milk in human life, the quality assessment of dairy products is of the utmost importance. The aim of the current study was to determine the 17β-estradiol level in commercial pasteurized and sterilized milk brands in Mashhad, Iran. In this regard, 160 samples including 80 pasteurized (40 high-fat and 40 low-fat) and 80 sterilized milk (40 high-fat and 40 low-fat) of widely used brands from different supermarkets were collected. The mean level of 17β-estradiol was 8.2 ± 0.59 pg/ml...
November 2019: Journal of Food Science and Technology
Ali Asghar Hakami Zanjani, Nicholas P Reynolds, Afang Zhang, Tanja Schilling, Raffaele Mezzenga, Joshua T Berryman
By combining atomistic and higher-level modelling with solution X-ray diffraction we analyse self-assembly pathways for the IFQINS hexapeptide, a bio-relevant amyloid former derived from human lysozyme. We verify that (at least) two metastable polymorphic structures exist for this system which are substantially different at the atomistic scale, and compare the conditions under which they are kinetically accessible. We further examine the higher-level polymorphism for these systems at the nanometre to micrometre scales, which is manifested in kinetic differences and in shape differences between structures instead of or as well as differences in the small-scale contact topology...
November 5, 2019: Scientific Reports
Farhad Safari Zanjani, Abbas Ali Gaeni, Dicle Aras, Cengiz Akalan
The roots of apoptosis caused by the use of certain drugs in patients with colorectal cancer and certain drugs could be induced the change in genes SSTR2 and SSTR5. SSTRs play a role in colorectal cancer and it's also known that exercise training has similar effects to certain drugs. Therefore, this study aims to evaluate the effects of a combined training program on hormonal and physiological changes in patients with colorectal cancer. Twenty patients with colorectal cancer were included in this study and divided into two groups as experimental (n=10) and control (n=10)...
August 2019: Journal of Exercise Rehabilitation
Nishan Parvez, Dhananjai M Rao, Mehdi B Zanjani
Over the past two decades, colloidal particles with a variety of shapes, sizes, and compositions have been synthesized and characterized successfully. One of the most important applications for colloidal building blocks is to engineer functional structures as mechanical, electrical, and optical metamaterials. However, complex interaction dynamics between the building blocks as well as sophisticated structure-property relationships makes it challenging to design structures with predictable target properties...
August 2, 2019: Journal of Physical Chemistry. B
Maryam Azizi-Lalabadi, Ali Ehsani, Mahmood Alizadeh-Sani, Arezou Khezerlou, Mina Mirzanajafi-Zanjani, Baharak Divband, Hajar Zolfaghari, Vahid Bagheri
Nowadays, distribution and microorganism resistance against antimicrobial compounds have caused crucial food safety problems. Hence, nanotechnology and zeolite are recognized as new approaches to manage this problem due to their inherent antimicrobial activity. Different studies have confirmed antimicrobial effects of Nano particles (NPs) (metal and metal oxide) and zeolite, by using various techniques to determine antimicrobial mechanism. This review includes an overview of research with the results of studies about antimicrobial mechanisms of nanoparticles and zeolite...
July 8, 2019: Current Pharmaceutical Biotechnology
Zahra Karami, Mohammad Reza Saghatchi Zanjani, Nadia Nasihatsheno, Mehrdad Hamidi
The aim of the present study was to develop modified nanoemulsions to improve the oral bioavailability and pharmacokinetics of a poor water-soluble drug, repaglinide (RPG). The repaglinide-loaded nanoemulsions (RPG-NEs) were prepared from olive oil as internal phase, span 80, tween 80, and poloxamer 188 as emulsifiers, using homogenization technique. The mean droplet size, zeta potential, and entrapment efficiency of RPG-NEs were 86.5 ± 3.4 nm, -33.8 ± 2.1 mV, and 96.3 ± 2.3%, respectively. The chitosan-coated RPG-NEs (Cs-RPG-NEs) showed an average droplet size of 149...
June 12, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Leila Safari Zanjani, Reza Shapouri, Mehrouz Dezfulian, Mehdi Mahdavi, Mehdi Shafiee Ardestani
Pseudomonas aeruginosa is the major infectious agent of concern for cystic fibrosis (CF) patients. Therefore, it is necessary to develop appropriate strategies for preventing colonization by this bacterium and/or neutralizing virulence factors. In this study, we formulated the encapsulation of exotoxin A into PLGA nanoparticles. The biological activities of the nanovaccine candidate were also characterized. Based on the results, ETA-PLGA can act as a suitable immunogen to stimulate the humoral and cellular immune response...
June 11, 2019: World Journal of Microbiology & Biotechnology
Elvira Jimenez Vera, Yi Vee Chew, Leigh Nicholson, Heather Burns, Patricia Anderson, Hsiao-Ting Chen, Lindy Williams, Karen Keung, Negar Talaei Zanjani, Suat Dervish, Ellis Patrick, Xin Maggie Wang, Shounan Yi, Wayne Hawthorne, Stephen Alexander, Philip J O'Connell, Min Hu
Understanding the immunological phenotype of transplant recipients is important to improve outcomes and develop new therapies. Immunophenotyping of whole peripheral blood (WPB) by flow cytometry is a rapid method to obtain large amounts of data relating to the outcomes of different transplant treatments with limited patient impact. Healthy individuals and patients with type 1 diabetes (T1D) enrolled in islet transplantation were recruited and WPB was collected. 46 fluorochrome-conjugated mouse-anti-human antibodies were used (43 of 46 antibodies were titrated)...
2019: PloS One
Mohammad Bagher Khorrami, Hamid Reza Sadeghnia, Alireza Pasdar, Majid Ghayour-Mobarhan, Bamdad Riahi-Zanjani, Alireza Hashemzadeh, Mohammad Zare, Majid Darroudi
Purpose: The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods: Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed...
2019: International Journal of Nanomedicine
Somayeh Shafiei, Elham Kalantari, Leili Saeednejad Zanjani, Maryam Abolhasani, Mohammad Hossein Asadi Lari, Zahra Madjd
Doublecortin-like kinase 1 (DCLK1) has been characterized as a novel potential cancer stem cell (CSC) marker in several types of cancer. It is considered as one of the most specific markers for distinguishing colorectal CSCs from normal stem cells. Yet, there are limited reports on the role of DCLK1 as a putative CSC marker in bladder cancer. Using immunohistochemistry, DCLK1 expression was examined in a well-defined tissue microarray series of 472 bladder cancer tissues. The association between DCLK1 protein expression and clinicopathological features, as well as survival outcomes, was assessed...
April 24, 2019: Experimental and Molecular Pathology
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