keyword
https://read.qxmd.com/read/32756654/annexin-a4-trimers-are-recruited-by-high-membrane-curvatures-in-giant-plasma-membrane-vesicles
#1
Christoffer Dam Florentsen, Alexander Kamp-Sonne, Guillermo Moreno-Pescador, Weria Pezeshkian, Ali Asghar Hakami Zanjani, Himanshu Khandelia, Jesper Nylandsted, Poul Martin Bendix
The plasma membrane (PM) of eukaryotic cells consists of a crowded environment comprised of a high diversity of proteins in a complex lipid matrix. The lateral organization of membrane proteins in the PM is closely correlated with biological functions such as endocytosis, membrane budding and other processes which involve protein mediated shaping of the membrane into highly curved structures. Annexin A4 (ANXA4) is a prominent player in a number of biological functions including PM repair. Its binding to membranes is activated by Ca2+ influx and it is therefore rapidly recruited to the cell surface near rupture sites where Ca2+ influx takes place...
August 5, 2020: Soft Matter
https://read.qxmd.com/read/32755827/diabetes-mellitus-and-the-impairment-of-male-reproductive-function-possible-signaling-pathways
#2
REVIEW
Sona Barkabi-Zanjani, Vajihe Ghorbanzadeh, Mohamadreza Aslani, Ataollah Ghalibafsabbaghi, Leila Chodari
BACKGROUND AND AIMS: Today, it has been shown that diabetes mellitus (DM) can affect male fertility. Glucose metabolism is a vital process in spermatogenesis that is impacted by diabetes condition. But the mechanisms by which DM causes male infertility are not wholly clarified. The aim of this review is to provide brief information about the influence of hyperglycemia on male fertility and specific emphasis on the molecular signaling pathway that is involved. METHODS: Broad literature search in the electronic database "Pubmed", "Google Scholar", the website of "World Health Organization" (WHO) and Control Disease and Prevention (CDC) took place...
July 18, 2020: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/32744376/the-healthy-meal-program-a-food-insecurity-screening-and-referral-program-for-urban-dwelling-older-adults
#3
Ana F Diallo, Katherine Falls, Krista Hicks, Ethlyn McQueen Gibson, Rawan Obaid, Patricia Slattum, Faika Zanjani, Elvin Price, Pamela Parsons
OBJECTIVE: To describe the Healthy Meal Program (HMP), a community-academic partnership that aims to address the food insecurity and social isolation in older adults living in an urban setting. PROGRAM IMPLEMENTATION: Low-income older adults were screened for food insecurity and social isolation. A partnership with the food bank and a farm-based organization helped provide a weekly congregate or home-delivered meal, pilot a cooking class, and offer a mobile market selling fresh vegetables at discounted prices...
August 3, 2020: Public Health Nursing
https://read.qxmd.com/read/32733985/novel-coronavirus-infection-in-orthopedic-patients-report-of-seven-cases
#4
Hamid Rabie, Mohammad Hasan Sharafi, Leila Oryadi Zanjani, Mohammad Hossein Nabian
During the course of novel coronavirus pandemic ,Shariati hospital in Tehran , as a tertiary center in both orthopedic trauma and COVID-19 , we detected 7 cases with definite diagnosis of COVID-19 and concomitant emergent orthopedic problem.This paper represents considerations and special issues in managing and decision making in these patients.
April 2020: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/32733984/orthopedic-trauma-surgeries-in-covid-19-pandemic-a-trauma-management-algorithm
#5
Mohammad Khak, Alireza Manafi-Rasi, Leila Oryadi Zanjani, Mohammad Hossein Nabian
After the COVID-19 outbreak worldwide, we will sooner or later encounter trauma patients with COVID-19 in the developing countries. It is a challenging decision-making process for an orthopedic surgeon to provide the patients with the best practice in the crisis. Here we discuss the issue in terms of clinical severity of COVID-19 pneumonia, priority of orthopedic surgical trauma procedures and standard of care for the treatment of trauma injuries. We finally propose an algorithm for better management of trauma patients in the setting of COVID-19 mass spread...
April 2020: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/32721320/a-review-on-different-methods-of-activating-tailings-to-improve-their-cementitious-property-as-cemented-paste-and-reusability
#6
REVIEW
Alieh Saedi, Ahmad Jamshidi-Zanjani, Ahmad Khodadadi Darban
Over the past few decades, as demand for minerals and metals has increased, the amount and volume of wastes and tailings has also increased dramatically. The management and reuse of mineral wastes and tailings not only help protect the environment but also are properly associated with economic benefits. As a result, mineral processing wastes disposal and storage has become a global issue. Along with the use of cemented paste as a backfill in underground spaces, the use of mineral processing wastes in the construction industry or as a substitute for cement is one of the new approaches to mineral tailings management...
September 15, 2020: Journal of Environmental Management
https://read.qxmd.com/read/32710437/circulating-vitamin-d-and-the-risk-of-gestational-diabetes-a-systematic-review-and-dose-response-meta-analysis
#7
Mehdi Sadeghian, Maryam Asadi, Sepideh Rahmani, Mohsen Akhavan Zanjani, Omid Sadeghi, Seyed Ahmad Hosseini, Ahmad Zare Javid
PURPOSE: Several meta-analyses of observational studies revealed a modest increase in the risk of gestational diabetes (GDM) among pregnant women with low levels of serum vitamin D. However, no study examined a dose-response meta-analysis as well as a high versus low analysis in this regard. METHODS: We systematically searched PubMed, Embase, ISI Web of Science, and Scopus up to August 2019 to find prospective observational studies investigating the association of serum 25(OH)D with the risk of developing GDM...
July 24, 2020: Endocrine
https://read.qxmd.com/read/32681293/low-level-expression-of-human-telomerase-reverse-transcriptase-predicts-cancer-related-death-and-progression-in-embryonal-carcinoma
#8
Marzieh Shahin, Leili Saeednejad Zanjani, Maryam Abolhasani, Mahtab Rahbar, Mojgan Asgari, Zahra Madjd
INTRODUCTION: hTERT (human telomerase reverse transcriptase) is a catalytic subunit of the enzyme telomerase and has a role in cell proliferation, cellular senescence, and human aging. MATERIALS AND METHODS: The purpose of this study was to evaluate the expression and significance of hTERT protein expression as a prognostic marker in different histological subtypes of testicular germ cell tumors (TGCTs), including 46 embryonal carcinomas, 46 yolk sac tumors, 38 teratomas, 84 seminomas as well as two main subtypes of seminomas and non-seminomas using tissue microarray (TMA) technique...
July 17, 2020: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/32663675/application-of-enhanced-electrokinetic-approach-to-remediate-cr-contaminated-soil-effect-of-chelating-agents-and-permeable-reactive-barrier
#9
Afshin Nasiri, Ahmad Jamshidi-Zanjani, Ahmad Khodadadi Darban
Enhanced electrokinetic (EK) technique was employed to remediate Cr-contaminated soil using a permeable reactive barrier (PRB) and chelating agents. Synthesized nanomagnetic Fe3 O4 was used as a reactive material in PRB. Moreover, EDTA and citric acid (CA) were used as chelating agents. Sequential extraction method (SEM) was employed to determine Cr-elimination mechanism during the EK process. The results revealed that EDTA (78% Cr removal) was more effective than CA (54% Cr removal) in eliminating Cr from the contaminated soil during the EK process...
July 9, 2020: Environmental Pollution
https://read.qxmd.com/read/32607404/report-of-acute-adaptive-policies-to-maximize-the-educational-efficacy-of-the-clinical-hospital-ward-during-covid-19-pandemia
#10
Leila Oryadi Zanjani, Amir Reza Farhoud, Saeed-Reza Mehrpour, Roya Nasle Seraji
No abstract text is available yet for this article.
April 2020: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/32483372/pth-1-34-treatment-and-or-mechanical-loading-have-different-osteogenic-effects-on-the-trabecular-and-cortical-bone-in-the-ovariectomized-c57bl-6-mouse
#11
Bryant C Roberts, Hector M Arredondo Carrera, Sahand Zanjani-Pour, Maya Boudiffa, Ning Wang, Alison Gartland, Enrico Dall'Ara
In preclinical mouse models, a synergistic anabolic response to PTH(1-34) and tibia loading was shown. Whether combined treatment improves bone properties with oestrogen deficiency, a cardinal feature of osteoporosis, remains unknown. This study quantified the individual and combined longitudinal effects of PTH(1-34) and loading on the bone morphometric and densitometric properties in ovariectomised mice. C57BL/6 mice were ovariectomised at 14-weeks-old and treated either with injections of PTH(1-34); compressive loading of the right tibia; both interventions concurrently; or both interventions on alternating weeks...
June 1, 2020: Scientific Reports
https://read.qxmd.com/read/32429644/effect-of-paroxetine-on-the-neuropathic-pain-a-molecular-study
#12
Malek Zarei, Masoumeh Sabetkasaei, Taraneh Moini-Zanjani
Background: Neuropathic pain due to damage to the peripheral nerve has influenced millions of people living all over the world. It has been shown that paroxetine can relieve neuropathic pain. Recently, the role of some proteins like BDNF, GABAA receptor, and KCC2 transporter in the occurrence of neuropathic pain has been documented. In the current study, the expression of these proteins affected by paroxetine was evaluated. Methods: Male Wistar rats were allocated into two main groups ofpre- and post-injury...
May 2, 2020: Iranian Biomedical Journal
https://read.qxmd.com/read/32365117/structure-and-functional-analysis-of-the-legionella-pneumophila-chitinase-chia-reveals-a-novel-mechanism-of-metal-dependent-mucin-degradation
#13
Saima Rehman, Lubov S Grigoryeva, Katherine H Richardson, Paula Corsini, Richard C White, Rosie Shaw, Theo J Portlock, Benjamin Dorgan, Zeinab S Zanjani, Arianna Fornili, Nicholas P Cianciotto, James A Garnett
Chitinases are important enzymes that contribute to the generation of carbon and nitrogen from chitin, a long chain polymer of N-acetylglucosamine that is abundant in insects, fungi, invertebrates and fish. Although mammals do not produce chitin, chitinases have been identified in bacteria that are key virulence factors in severe respiratory, gastrointestinal and urinary diseases. However, it is unclear how these enzymes are able to carry out this dual function. Legionella pneumophila is the causative agent of Legionnaires' disease, an often-fatal pneumonia and its chitinase ChiA is essential for the survival of L...
May 4, 2020: PLoS Pathogens
https://read.qxmd.com/read/32332767/pharmacologic-targeting-of-renal-ischemia-reperfusion-injury-using-a-normothermic-machine-perfusion-platform
#14
Ahmer M Hameed, David B Lu, Heather Burns, Nicole Byrne, Yi Vee Chew, Sohel Julovi, Kedar Ghimire, Negar Talaei Zanjani, Chow H P'ng, Daniel Meijles, Suat Dervish, Ross Matthews, Ray Miraziz, Greg O'Grady, Lawrence Yuen, Henry C Pleass, Natasha M Rogers, Wayne J Hawthorne
Normothermic machine perfusion (NMP) is an emerging modality for kidney preservation prior to transplantation. NMP may allow directed pharmacomodulation of renal ischemia-reperfusion injury (IRI) without the need for systemic donor/recipient therapies. Three proven anti-IRI agents not in widespread clinical use, CD47-blocking antibody (αCD47Ab), soluble complement receptor 1 (sCR1), and recombinant thrombomodulin (rTM), were compared in a murine model of kidney IRI. The most effective agent was then utilized in a custom NMP circuit for the treatment of isolated porcine kidneys, ascertaining the impact of the drug on perfusion and IRI-related parameters...
April 24, 2020: Scientific Reports
https://read.qxmd.com/read/32326222/interdisciplinary-synergy-to-reveal-mechanisms-of-annexin-mediated-plasma-membrane-shaping-and-repair
#15
REVIEW
Poul Martin Bendix, Adam Cohen Simonsen, Christoffer D Florentsen, Swantje Christin Häger, Anna Mularski, Ali Asghar Hakami Zanjani, Guillermo Moreno-Pescador, Martin Berg Klenow, Stine Lauritzen Sønder, Helena M Danielsen, Mohammad Reza Arastoo, Anne Sofie Heitmann, Mayank Prakash Pandey, Frederik Wendelboe Lund, Catarina Dias, Himanshu Khandelia, Jesper Nylandsted
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca2+ - and phospholipid-binding annexin proteins. Upon membrane damage, annexin family members are activated by a Ca2+ influx, enabling them to quickly bind at the damaged membrane and facilitate wound healing...
April 21, 2020: Cells
https://read.qxmd.com/read/32311316/amyloid-evolution-antiparallel-replaced-by-parallel
#16
Ali Asghar Hakami Zanjani, Nicholas P Reynolds, Afang Zhang, Tanja Schilling, Raffaele Mezzenga, Joshua T Berryman
Several atomic structures have now been found for micrometer-scale amyloid fibrils or elongated microcrystals using a range of methods, including NMR, electron microscopy, and X-ray crystallography, with parallel β-sheet appearing as the most common secondary structure. The etiology of amyloid disease, however, indicates nanometer-scale assemblies of only tens of peptides as significant agents of cytotoxicity and contagion. By combining solution X-ray with molecular dynamics, we show that antiparallel structure dominates at the first stages of aggregation for a specific set of peptides, being replaced by parallel at large length scales only...
April 7, 2020: Biophysical Journal
https://read.qxmd.com/read/32298285/combined-qtl-mapping-and-rna-seq-profiling-reveals-candidate-genes-associated-with-cadmium-tolerance-in-barley
#17
Behnam Derakhshani, Hossein Jafary, Bahram Maleki Zanjani, Karim Hasanpur, Kohei Mishina, Tsuyoshi Tanaka, Yoshihiro Kawahara, Youko Oono
The high toxicity of cadmium (Cd) and its ready uptake by plants has become a major agricultural problem. To investigate the genetic architecture and genetic regulation of Cd tolerance in barley, we conducted quantitative trait loci (QTL) analysis in the phenotypically polymorphic Oregon Wolfe Barley (OWB) mapping population, derived from a cross between Rec and Dom parental genotypes. Through evaluating the Cd tolerance of 87 available doubled haploid lines of the OWB mapping population at the seedling stage, one minor and one major QTL were detected on chromosomes 2H and 6H, respectively...
2020: PloS One
https://read.qxmd.com/read/32284953/geriatric-opioid-harm-reduction-interprofessional-student-learning-outcomes
#18
Faika Zanjani, Marshall Brooks, Leland Waters, Pamela Parsons, Patricia Slattum
Objective: Opioid harm reduction is increasingly important in the care of the older adults, who are at higher risk for negative opioid-related outcomes due to high prevalence of pain, multimorbidity, polypharmacy, and age-changes in metabolism. Our project aims to develop, implement, and evaluate an interprofessional opioid harm reduction service training. Method: This evaluation occurs in context of the Richmond Health and Wellness Program (RHWP), a community-based interprofessional wellness care coordination equity initiative, within buildings designated for low-income and disabled older adults...
January 2020: Gerontology & Geriatric Medicine
https://read.qxmd.com/read/32224543/protective-potential-of-conjugated-p-aeruginosa-lps-plga-nanoparticles-in-mice-as-a-nanovaccine
#19
Leila Safari Zanjani, Reza Shapoury, Mehrouz Dezfulian, Mehdi Mahdavi, Mehdi Shafieeardestani
BACKGROUND: Pseudomonas aeruginosa has an important role in nosocomial infections. OBJECTIVE: To evaluate biological activity of the detoxified LPS (D-LPS) entrapped into Poly lactic-co-glycolic acid (PLGA) nanoparticles. MATERIALS: LPS was extracted and detoxified from the P. aeruginosa strain PAO1. The D-LPS, conjugated to the PLGA nanoparticles with 1-ethyl-3-dimethyl aminopropyl carbodiimide (EDAC) and N-hydroxy-succinimide (NHS). The connection was evaluated by FTIR (Fourier transform infrared), Zetasizer, and Atomic Force Microscope (AFM)...
March 2020: Iranian Journal of Immunology: IJI
https://read.qxmd.com/read/32166107/reducing-medication-risks-in-older-adult-drinkers
#20
Faika Zanjani, Nancy Schoenberg, Catherine Martin, Richard Clayton
Objectives: Prevalent concomitant alcohol and medication use among older adults is placing this group at risk for adverse health events. Given limited existing interventions to address concomitant alcohol and medication risk (AMR), a brief educational intervention was demonstrated. The purpose of the current study was to examine change in AMR behaviors 3 months post-education among older adult drinkers. Methods: A convenience sample of 58 older adult drinkers (mean age = 72) was recruited and followed ( n = 40; 70% at follow-up), from four pharmacies in rural Virginia...
January 2020: Gerontology & Geriatric Medicine
keyword
keyword
30094
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"