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COMPARATIVE STUDY
Shuo Yang, Sukun Lu, Yinghui Guo, Wenjun Luan, Jianhua Liu, Le Wang
OBJECTIVES: The increasing prevalence of severe Mycoplasma pneumoniae pneumonia (SMPP) poses a significant threat to the health of children. This study aimed to characterise and assess the outcomes in children with SMPP. METHODS: We retrospectively analysed children hospitalised for M. pneumoniae pneumonia (MPP) between January and December 2022. Retrospectively, demographic, clinical, underlying diseases, laboratory and radiological findings, and treatment outcomes were collected and analysed...
April 26, 2024: BMC Infectious Diseases
#22
Hannah Walker, Jed Speers, Milena Fabry, Sameep Kadakia
Oral squamous cell carcinoma (OSCC) with metastasis to the thyroid gland is exceedingly rare, with limited documentation within the literature. Between 1984 and 2023, only 40 cases of head and neck squamous cell carcinoma (SCC) with thyroid gland metastasis were described in published literature. Herein, we present a distinctive case of second primary oropharyngeal SCC with metastasis to the thyroid, detected during surveillance positron emission tomography (PET) scanning subsequent to negative margin resection and radiation therapy for SCC originating from the hard palate...
April 16, 2024: American Journal of Otolaryngology
#23
JOURNAL ARTICLE
Juan Carlos Corrales, Antonio Sánchez, Xóchitl Hernández, Joaquín Amores-Iniesta, Antón Esnal, Christian de la Fe
Mycoplasma bovis ( M. bovis ) is one of the worldwide most important infectious agents involved in respiratory complex diseases (RCD). In Spain, the endemic presence of subtypes ST-2 and ST-3 with phenotypic differences linked to their susceptibility to fluoroquinolones opened the way to develop control strategies focused on previous diagnosis of the subtype and the use of directed therapies when M. bovis were involved in RCD. Surprisingly, microbiological studies conducted during 2023 evidenced for the first time the presence of Spanish isolates of a new polC -subtype, previously classified as ST-1, recovered from calves with respiratory symptoms and pneumonia in different areas of the country ( n = 16)...
April 16, 2024: Pathogens
#24
JOURNAL ARTICLE
Ji-Ho Park, Yejin Sung, SeongHoon Jo, Seung Ho Lee, Ju Hee Ryu, In-Cheol Sun, Cheol-Hee Ahn
Copper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their applications. In this study, we present Cu2+ -loaded silica nanoparticles fabricated through the chelation of Cu2+ ions by silanol groups. The integration of Cu2+ ions into uniformly sized silica nanoparticles imparts a photothermal therapy effect. Additionally, the amine functionalization of the silica coating facilitates the chemical conjugation of tumor-specific fluorescence probes...
March 25, 2024: Journal of Functional Biomaterials
#25
JOURNAL ARTICLE
Paulo Mergulhão, João Gonçalves Pereira, Antero Vale Fernandes, Andriy Krystopchuk, João Miguel Ribeiro, Daniel Miranda, Heloísa Castro, Carla Eira, Juvenal Morais, Cristina Lameirão, Sara Gomes, Dina Leal, Joana Duarte, Leonor Pássaro, Filipe Froes, Ignacio Martin-Loeches
Ventilator-associated pneumonia (VAP) is a prevailing nosocomial infection in critically ill patients requiring invasive mechanical ventilation (iMV). The impact of VAP is profound, adversely affecting patient outcomes and placing a significant burden on healthcare resources. This study assessed for the first time the contemporary VAP epidemiology in Portugal and its burden on the healthcare system and clinical outcomes. Additionally, resource consumption (duration of iMV, intensive care unit (ICU), hospital length of stay (LOS)) and empirical antimicrobial therapy were also evaluated...
March 22, 2024: Antibiotics
#26
REVIEW
Feifei Liao, Wenwen Yang, Linzi Long, Ruotong Yu, Hua Qu, Yuxuan Peng, Jieming Lu, Chenghuan Ren, Yueqi Wang, Changgeng Fu
Iron is essential for many physiological processes, and the dysregulation of its metabolism is implicated in the pathogenesis of various diseases. Recent advances in iron metabolism research have revealed multiple complex pathways critical for maintaining iron homeostasis. Molecular imaging, an interdisciplinary imaging technique, has shown considerable promise in advancing research on iron metabolism. Here, we comprehensively review the multifaceted roles of iron at the cellular and systemic levels (along with the complex regulatory mechanisms of iron metabolism), elucidate appropriate imaging methods, and summarize their utility and fundamental principles in diagnosing and treating diseases related to iron metabolism...
March 22, 2024: Current Issues in Molecular Biology
#27
REVIEW
Beatriz A Carneiro, Lívia N Franco Guerreiro-Costa, Daniel Lins-Silva, Daniela Faria Guimaraes, Lucca S Souza, Gustavo C Leal, Ana Teresa Caliman-Fontes, Graziele Beanes, Ryan Dos S Costa, Lucas C Quarantini
Despite the hardships of major depressive disorder (MDD), biomarkers for the diagnosis and pharmacological management of this condition are lacking. MicroRNAs are epigenetic mechanisms that could provide promising MDD biomarkers. Our aim was to summarize the findings and provide validation for the selection and use of specific microRNAs as biomarkers in the diagnosis and treatment of MDD. A systematic review was conducted using the PubMed/Medline, Cochrane, PsycINFO, Embase, and LILACS databases from March 2022 to November 2023, with clusters of terms based on "microRNA" and "antidepressant"...
March 2024: Curēus
#28
REVIEW
Rimei Zhong, Xiongjin Chen, Feng Liao, Zhijun Lin, Zhijian Zhang, Yusen Chen, Lili Cui
BACKGROUND: In recent years, simultaneous or sequential occurrence of MOG antibody disease and anti-NMDAR encephalitis in the same patient has been reported with increasing frequency. Scholars refer to the overlapping occurrence of these two disorders as MOG antibody disease and anti-NMDAR encephalitis overlap syndrome (MNOS). Cortical T2-weighted fluid-attenuated inversion recovery (FLAIR) -hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) is a rare clinical phenotype of MOGAD in which cortical FLAIR high-signal lesions are unilateral, with little spread to the cortex and meninges bilaterally...
April 25, 2024: BMC Neurology
#29
JOURNAL ARTICLE
Massimiliano Esposito, Francesco Sessa, Chiara Nannola, Maria Serenella Pignotti, Pantaleo Greco, Monica Salerno
Sudden unexpected postnatal collapse (SUPC) is a sudden collapse of the clinical conditions of a full-term or near-term newborn, within the first 7 days of life, that requires resuscitation with positive ventilation and who either dies, has hypoxic-ischemic encephalopathy, or requires intensive care. The incidence of SUPC is very low, and most often presents a negative prognosis. The BUB1B gene is a mitotic checkpoint of serine/threonine kinase B that encodes a protein crucial for maintaining the correct number of chromosomes during cell division...
April 26, 2024: International Journal of Legal Medicine
#30
REVIEW
Anirban Ganguly, Sumit Mukherjee, Kaushiki Chatterjee, Sheila Spada
Breast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition of different intra-tumoral regions, which in turn affect cancer progression within patients. In this mini review, we will highlight the mechanisms that generate cancer heterogeneity in BC and how they affect the responses to cancer therapies.
2024: International Review of Cell and Molecular Biology
#31
REVIEW
Zishan Xu, Wei Li, Xiangyang Dong, Yingying Chen, Dan Zhang, Jingnan Wang, Lin Zhou, Guoyang He
Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Recent advancements in genomic technologies and analytical approaches have revolutionized CRC research, enabling precision medicine. This review highlights the integration of multi-omics, spatial omics, and artificial intelligence (AI) in advancing precision medicine for CRC. Multi-omics approaches have uncovered molecular mechanisms driving CRC progression, while spatial omics have provided insights into the spatial heterogeneity of gene expression in CRC tissues...
April 23, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#32
JOURNAL ARTICLE
Anisa Shaker
PURPOSE OF REVIEW: Eosinophilic esophagitis (EoE) is a Th2 immune/antigen-mediated disorder characterized by esophageal dysfunction and eosinophilic inflammation. Worsening dysphagia and food impactions are significant complications associated with esophageal remodeling and fibrostenotic disease. This review highlights the most recent research findings pertaining to mechanisms of sub-epithelial fibrosis in EoE, current diagnostic tools, and therapeutic approaches. RECENT FINDINGS: Recent studies leveraging publicly available single cell sequencing databases and comparative proteomics have furthered our understanding of the mechanisms mediating fibrosis...
April 15, 2024: Current Opinion in Gastroenterology
#33
JOURNAL ARTICLE
Joseph Lownik, Jonathan Boiarsky, Ruemu Birhiray, Akil Merchant, Monica Mead
Several second- and third-line immunotherapeutic options for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) ineligible for autologous stem cell transplant are directed against the B-cell antigen CD19. The anti-CD19 monoclonal antibody tafasitamab, paired with the immunomodulator lenalidomide, mediates antibody-dependent cellular toxicity and cellular phagocytosis; the antibody-drug conjugate loncastuximab tesirine delivers the DNA-cross-linking agent tesirine via CD19 binding and internalization; and CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) products are engineered from autologous T cells...
April 25, 2024: Clinical Cancer Research
#34
REVIEW
Hui Zou, Ke Zhang, Xuan Chen, Sha Sha
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), a complex and multifaceted illness. COVID-19 is associated with various ocular manifestations including conjunctivitis, retinal vein occlusion and optic neuritis. However, the case of Vogt-Koyanagi-Harada (VKH) disease associated with SARS-CoV-2 is infrequent, and the specific association is still unclear. CASE PRESENTATION: In the present study, a 35-year-old female patient without any significant medical history presented with 1 week of bilateral blurred vision, occurring 2 weeks after a clinical course of COVID-19...
April 2024: Immunity, Inflammation and Disease
#35
REVIEW
Sandra von Hardenberg, Isabel Klefenz, Doris Steinemann, Nataliya Di Donato, Ulrich Baumann, Bernd Auber, Christian Klemann
New technologies in genetic diagnostics have revolutionized the understanding and management of rare diseases. This review highlights the significant advances and latest developments in genetic diagnostics in inborn errors of immunity (IEI), which encompass a diverse group of disorders characterized by defects in the immune system, leading to increased susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, and malignancies. Various diagnostic approaches, including targeted gene sequencing panels, whole exome sequencing, whole genome sequencing, RNA sequencing, or proteomics, have enabled the identification of causative genetic variants of rare diseases...
2024: Frontiers in Pediatrics
#36
REVIEW
Tianqing Zhang, Li Luo, Qi He, Sijie Xiao, Yuwei Li, Junpeng Chen, Tao Qin, Zhenni Xiao, Qingliang Ge
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF...
April 24, 2024: European Journal of Medical Research
#37
REVIEW
Yusuke Matoba, Kyle M Devins, Lara Milane, William B Manning, Varvara Mazina, Oladapo O Yeku, Bo R Rueda
Although many recent advancements have been made in women's health, perhaps one of the most neglected areas of research is the diagnosis and treatment of high-grade endometrial cancer (EnCa). The molecular classification of EnCa in concert with histology was a major step forward. The integration of profiling for mismatch repair deficiency and Human Epidermal Growth Factor 2 (HER2) overexpression, can further inform treatment options, especially for drug resistant recurrent disease. Recent early phase trials suggest that regardless of subtype, combination therapy with agents that have distinct mechanisms of action is a fruitful approach to the treatment of high-grade EnCa...
April 24, 2024: Reproductive Sciences
#38
JOURNAL ARTICLE
Pierre Bay, Etienne Audureau, Sébastien Préau, Raphaël Favory, Aurélie Guigon, Nicholas Heming, Elyanne Gault, Tài Pham, Amal Chaghouri, Matthieu Turpin, Laurence Morand-Joubert, Sébastien Jochmans, Aurélia Pitsch, Sylvie Meireles, Damien Contou, Amandine Henry, Adrien Joseph, Marie-Laure Chaix, Fabrice Uhel, Damien Roux, Diane Descamps, Malo Emery, Claudio Garcia-Sanchez, David Levy, Sonia Burrel, Julien Mayaux, Antoine Kimmoun, Cédric Hartard, Frédéric Pène, Flore Rozenberg, Stéphane Gaudry, Ségolène Brichler, Antoine Guillon, Lynda Handala, Fabienne Tamion, Alice Moisan, Thomas Daix, Sébastien Hantz, Flora Delamaire, Vincent Thibault, Bertrand Souweine, Cecile Henquell, Lucile Picard, Françoise Botterel, Christophe Rodriguez, Armand Mekontso Dessap, Jean-Michel Pawlotsky, Slim Fourati, Nicolas de Prost
BACKGROUND: During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11-28% of critically ill COVID-19 patients and associated with increased mortality. As new SARS-CoV-2 variants emerged, the characteristics of critically ill COVID-19 patients have evolved, particularly in the era of Omicron. The purpose of this study is to investigate the characteristics of CAPA in the era of new variants. METHODS: This is a prospective multicenter observational cohort study conducted in France in 36 participating intensive care units (ICU), between December 7th, 2021 and April 26th 2023...
April 24, 2024: Annals of Intensive Care
#39
JOURNAL ARTICLE
Xue-Lian Li, Meng-Fan Wang, Li-Zhen Zeng, Guo-Kui Li, Run-Yu Zhao, Fu-Dan Liu, Yun Li, Yu-Fei Yan, Qishuai Liu, Zhao Li, Hongbin Zhang, Xiaoxia Ren, Feng Gao
A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single-molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two-photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA-related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage...
April 24, 2024: Angewandte Chemie
#40
Artur Eduardo Martio, Daniel Marchi Kieling, Luciano Bambini Manzato, José Ricardo Vanzin
Nickel and cobalt are frequently found in metallic alloys used in the manufacture of aneurysm clips and endovascular prostheses, such as the pipeline embolization device (PED). Nickel hypersensitivity can affect up to 15% of the population, however, it is very rarely overt in patients who undergo endovascular stent placement. Here, we present the case of a 35-year-old woman who developed allergic symptoms after PED placement and was later confirmed to be allergic to both nickel and cobalt by patch testing. Fortunately, she responded well to pharmacologic treatment, rendering surgical intervention unnecessary...
2024: Brain Circulation
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