Carla Richardson, Tom Gilbert, Saadia Aslam, Cassandra L Brookes, Anvesha Singh, David E Newby, Marc R Dweck, Ralph Stewart, Paul S Myles, Tom Briffa, Joseph Selvanayagam, Clara K Chow, Gavin J Murphy, Enoch F Akowuah, Joanne Lord, Shaun Barber, Ana Suazo Di Paola, Gerry P McCann, Graham S Hillis MBedBiol
BACKGROUND: Aortic valve replacement in asymptomatic severe aortic stenosis is controversial. The Early valve replacement in severe ASYmptomatic Aortic Stenosis (EASY-AS) trial aims to determine whether early aortic valve replacement improves clinical outcomes, quality of life and cost-effectiveness compared to a guideline recommended strategy of 'watchful waiting'. METHODS: In a pragmatic international, open parallel group randomized controlled trial (NCT04204915), 2844 patients with severe aortic stenosis will be randomized 1:1 to either a strategy of early (surgical or transcatheter) aortic valve replacement or aortic valve replacement only if symptoms or impaired left ventricular function develop...
May 29, 2024: American Heart Journal