Zhouke Tan, Ze Wang, Qianglin Zeng, Xiaoyou Liu, Yamei Zhang, Shujue Li, Junlin Huang, Yunong Zeng, Zongshun Huang, Can Jin, Ningying Fu, Qian Zhao, Yingsong Mu, Ziyi Wang, Jie Xiao, Hong Yang, Guibao Ke
Renal fibrosis is a typical pathological change from chronic kidney disease (CKD) to end-stage renal failure, which presents significant challenges in prevention and treatment. The progression of renal fibrosis is closely associated with the "gut-kidney axis," therefore, although clinical intervention to modulate the "gut-kidney axis" imbalance associated with renal fibrosis brings hope for its treatment. In this study, we first identified the close relationship between renal fibrosis development and the intestinal microenvironment through fecal microtransplantation and non-absorbable antibiotics experiments...
March 2024: Clinical and Translational Science