Livia De Lucca Camargo, Silvia Cellone Trevelin, Guilherme Henrique Gatti da Silva, Ana Alice Dos Santos Dias, Maria Aparecida Oliveira, Olga Mikhaylichenko, Aline C D Androwiki, Celio Xavier Dos Santos, Lisa-Marie Holbrook, Graziela Scalianti Ceravolo, Alexandre Denadai-Souza, Izabela Martina Ramos Ribeiro, Simone Sartoretto, Francisco Rafael Martins Laurindo, Patricia Pereira Coltri, Vagner Roberto Antunes, Rhian Touyz, Francis J Miller, Ajay M Shah, Lucia Rossetti Lopes
Nox1 signaling is a causal key element in arterial hypertension. Recently, we identified protein disulfide isomerase A1 (PDI) as a novel regulatory protein that regulates Nox1 signaling in VSMCs. Spontaneously hypertensive rats (SHR) have increased levels of PDI in mesenteric resistance arteries compared with Wistar controls; however, its consequences remain unclear. Herein, we investigated the role of PDI in mediating Nox1 transcriptional upregulation and its effects on vascular dysfunction in hypertension...
June 1, 2024: Journal of Hypertension