Joanna Bukowska, Andrea Alarcon Uquillas, Xiying Wu, Trivia Fraazier, Katarzyna Walendzik, Mikaela Vanek, Dina Gaupp, Bruce A Bunnell, Paul Kosnik, Babak Mehrara, Adam J Katz, Barbara Gawronska-Kozak, Jeffrey Gimble
Pressure injuries/ulcers are frequent complications in elderly, paraplegic, and quadriplegic patients that account for considerable cost to the international health care economy and remain refractory to current treatment options. Autologous or allogeneic adult stromal/stem cells represent an alternative therapeutic approach. The current study extends prior findings by exploring the safety and efficacy of human adipose-derived stromal/stem cells (ASC) therapy in an established immunocompetent murine skin pressure ulcer model where dermal fibroblast cells (DFC) served as a control...
January 17, 2020: Stem Cells and Development