Dingxue Hu, Ziteng Zhang, Xiaoyi Liu, Youchun Wu, Yunyun An, Wanqiu Wang, Mengqi Yang, Yuqi Pan, Kun Qiao, Changzheng Du, Yu Zhao, Yan Li, Jianqiang Bao, Tao Qin, Yue Pan, Zhaohua Xia, Xin Zhao, Kun Sun
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor transcriptome and patients' prognoses across cancers, we investigated dysregulated and prognosis-associated genes and catalogued such important genes in a cancer type-dependent manner. Utilizing the expression matrices of these genes, we built models to quantitatively evaluate the malignant levels of tumors across cancers, which could add value to the clinical staging system for improved prediction of patients' survival...
May 28, 2024: Journal of Translational Medicine