Zoya Alteber, Gady Cojocaru, Roy Z Granit, Inbal Barbiro, Assaf Wool, Masha Frenkel, Amit Novik, Adi Shuchami, Yu Liang, Vered Daniel Carmi, Niv Sabath, Rob Foreman, Natalia Petrenko, Jieng He, Yossef Kliger, Adva Levy-Barda, Ram Eitan, Oded Raban, Eran Sadot, Omri Sulimani, Abraham Avi Nathan, Henry Adewoye, Pierre Ferre, Zurit Levine, Eran Ophir
Cancers that are poorly immune infiltrated pose a substantial challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (TSCM) have been identified as a subgroup of T cells that possess strong proliferative capacity and that can expand and differentiate following interactions with dendritic cells (DCs). In this study, we explored the pattern of expression of a recently discovered inhibitory receptor PVRIG and its ligand, PVRL2, in the human tumor microenvironment. Using spatial and single-cell RNA transcriptomics data across diverse cancer indications, we found that among the T-cell checkpoints, PVRIG is uniquely expressed on TSCM and PVRL2 is expressed on DCs in immune aggregate niches in tumors...
May 16, 2024: Cancer Immunology Research