Junyan Jin, Liting Xiao, Yarong Wu, Zhulin Sun, Ziyao Xiong, Yanbing Li, Yanting Zhao, Wenwu Yao, Leiming Shen, Yiming Cui, Yafang Tan, Yanping Han, Zongmin Du, Yujun Cui, Ruifu Yang, Kai Song, Yajun Song
Yersinia pestis , the causative agent of plague, is a genetically monomorphic bacterial pathogen that evolved from Yersinia pseudotuberculosis approximately 7,400 years ago. We observed unusually frequent mutations in Y. pestis YPO0623, mostly resulting in protein translation termination, which implies a strong natural selection. These mutations were found in all phylogenetic lineages of Y. pestis , and there was no apparent pattern in the spatial distribution of the mutant strains. Based on these findings, we aimed to investigate the biological function of YPO0623 and the reasons for its frequent mutation in Y...
2023: Frontiers in Cellular and Infection Microbiology