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JOURNAL ARTICLE
Khan Mohammad Imran, Jessica Gannon, Holly A Morrison, Juselyn D Tupik, Benjamin Tintera, Margaret A Nagai-Singer, Hannah Ivester, Justin Markov Madanick, Alissa Hendricks-Wenger, Kyungjun Uh, David T Luyimbazi, Michael Edwards, Sheryl Coutermarsh-Ott, Kristin Eden, Christopher Byron, Sherrie Clark-Deener, Kiho Lee, Eli Vlaisavljevich, Irving C Allen
OBJECTIVE: New therapeutic strategies and paradigms are direly needed to treat pancreatic cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major limitation to biomedical device and therapeutic development. Traditionally, pigs have proven to be ideal models, especially in the context of designing human-sized instruments, perfecting surgical techniques and optimizing clinical procedures for use in humans. However, pig studies have typically focused on healthy tissue assessments and are limited to general safety evaluations because of the inability to effectively model human tumors...
August 16, 2023: Ultrasound in Medicine & Biology
#22
JOURNAL ARTICLE
Natasha Halasa, Laura D Zambrano, Justin Z Amarin, Laura S Stewart, Margaret M Newhams, Emily R Levy, Steven L Shein, Christopher L Carroll, Julie C Fitzgerald, Marian G Michaels, Katherine Bline, Melissa L Cullimore, Laura Loftis, Vicki L Montgomery, Asumthia S Jeyapalan, Pia S Pannaraj, Adam J Schwarz, Natalie Z Cvijanovich, Matt S Zinter, Aline B Maddux, Melania M Bembea, Katherine Irby, Danielle M Zerr, Joseph D Kuebler, Christopher J Babbitt, Mary Glas Gaspers, Ryan A Nofziger, Michele Kong, Bria M Coates, Jennifer E Schuster, Shira J Gertz, Elizabeth H Mack, Benjamin R White, Helen Harvey, Charlotte V Hobbs, Heda Dapul, Andrew D Butler, Tamara T Bradford, Courtney M Rowan, Kari Wellnitz, Mary Allen Staat, Cassyanne L Aguiar, Saul R Hymes, Adrienne G Randolph, Angela P Campbell
IMPORTANCE: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide. OBJECTIVE: To evaluate the characteristics and outcomes of RSV-related critical illness in US infants during peak 2022 RSV transmission. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used a public health prospective surveillance registry in 39 pediatric hospitals across 27 US states...
August 1, 2023: JAMA Network Open
#23
Beatriz Guillen-Guio, Megan L Paynton, Richard J Allen, Daniel P W Chin, Lauren J Donoghue, Amy Stockwell, Olivia C Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan, Fernando Martinez, Helen L Booth, William A Fahy, Ian P Hall, Simon P Hart, Mike R Hill, Nik Hirani, Richard B Hubbard, Robin J McAnulty, Ann B Millar, Vidya Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Ian Sayers, Martin D Tobin, Moira K B Whyte, Ayodeji Adegunsoye, Naftali Kaminski, Shwu-Fan Ma, Mary E Strek, Yingze Zhang, Tasha E Fingerlin, Maria Molina-Molina, Margaret Neighbors, X Rebecca Sheng, Justin M Oldham, Toby M Maher, Philip L Molyneaux, Carlos Flores, Imre Noth, David A Schwartz, Brian L Yaspan, R Gisli Jenkins, Louise V Wain, Edward J Hollox
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF and a prior association of the HLA-DQB1 gene with idiopathic fibrotic interstitial pneumonia (including IPF) has been reported. Due to the important role that the Human Leukocyte Antigen (HLA) region plays in the immune response, here we evaluated if HLA genetic variation was associated specifically with IPF risk...
July 24, 2023: medRxiv
#24
JOURNAL ARTICLE
Elizabeth Abels, Brian D Adkins, Elizabeth S Allen, Garrett S Booth, Margaret A DiGuardo, Jia Jennifer Ding, Juliana Guarente, Monica Klein, Laura D Stephens, Christopher A Tormey, Jennifer S Woo, Jeremy W Jacobs
No abstract text is available yet for this article.
July 20, 2023: American Journal of Clinical Pathology
#25
JOURNAL ARTICLE
Caitlin K Rollins, Johanna Calderon, David Wypij, Alex M Taylor, Tahera Sultana Davalji Kanjiker, Julia S Rohde, Moshe Maiman, Laura D Zambrano, Margaret M Newhams, Susan Rodriguez, Nicholas Hart, Jennifer Worhach, Suden Kucukak, Tina Y Poussaint, Mary Beth F Son, Matthew L Friedman, Shira J Gertz, Charlotte V Hobbs, Michele Kong, Aline B Maddux, Jennifer L McGuire, Paul A Licht, Mary Allen Staat, Lael M Yonker, Maitreyi Mazumdar, Adrienne G Randolph, Angela P Campbell, Jane W Newburger
IMPORTANCE: Acute neurological involvement occurs in some patients with multisystem inflammatory syndrome in children (MIS-C), but few data report neurological and psychological sequelae, and no investigations include direct assessments of cognitive function 6 to 12 months after discharge. OBJECTIVE: To characterize neurological, psychological, and quality of life sequelae after MIS-C. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional cohort study was conducted in the US and Canada...
July 3, 2023: JAMA Network Open
#26
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Taha Iqbal, Omkar Pathak, Otto Valladares, Amanda B Kuzma, Erin Abner, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M LaFerla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden R R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Stefan McDonough, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis...
July 8, 2023: medRxiv
#27
JOURNAL ARTICLE
Laura Glass Umfleet, Jessica Pommy, Alexander D Cohen, Margaret Allen, Shawn Obarski, Lilly Mason, Halle Berres, Malgorzata Franczak, Yang Wang
BACKGROUND: Cerebrovascular health plays an important role in cognitive health in older adults. Cerebrovascular reactivity (CVR), a measure of cerebrovascular health, changes in both normal and pathological aging, and is increasingly being conceptualized as contributory to cognitive decline. Interrogation of this process will yield new insights into cerebrovascular correlates of cognition and neurodegeneration. OBJECTIVE: The current study examines CVR using advanced MRI in prodromal dementia states (amnestic and non-amnestic mild cognitive impairment phenotypes; aMCI and naMCI, respectively) and older adult controls...
July 5, 2023: Journal of Alzheimer's Disease: JAD
#28
JOURNAL ARTICLE
Khan Mohammad Imran, Benjamin Tintera, Holly A Morrison, Juselyn D Tupik, Margaret A Nagai-Singer, Hannah Ivester, McAlister Council-Troche, Michael Edwards, Sheryl Coutermarsh-Ott, Christopher Byron, Sherrie Clark-Deener, Kyungjun Uh, Kiho Lee, Paul Boulos, Cliff Rowe, Christian Coviello, Irving C Allen
Pancreatic tumors can be resistant to drug penetration due to high interstitial fluid pressure, dense stroma, and disarrayed vasculature. Ultrasound-induced cavitation is an emerging technology that may overcome many of these limitations. Low-intensity ultrasound, coupled with co-administered cavitation nuclei consisting of gas-stabilizing sub-micron scale SonoTran Particles, is effective at increasing therapeutic antibody delivery to xenograft flank tumors in mouse models. Here, we sought to evaluate the effectiveness of this approach in situ using a large animal model that mimics human pancreatic cancer patients...
May 24, 2023: Pharmaceutics
#29
JOURNAL ARTICLE
Margaret E Crane, Philip C Kendall, Bruce F Chorpita, Matthew R Sanders, Allen R Miller, Carolyn Webster-Stratton, Jenna McWilliam, Judith S Beck, Ceth Ashen, Dennis D Embry, John A Pickering, Eric L Daleiden
BACKGROUND: To bring evidence-based interventions (EBIs) to individuals with behavioral health needs, psychosocial interventions must be delivered at scale. Despite an increasing effort to implement effective treatments in communities, most individuals with mental health and behavioral problems do not receive EBIs. We posit that organizations that commercialize EBIs play an important role in disseminating EBIs, particularly in the USA. The behavioral health and implementation industry is growing, bringing the implementation field to an important inflection point: how to scale interventions to improve access while maintaining EBI effectiveness and minimizing inequities in access to psychosocial intervention...
June 22, 2023: Implementation Science: IS
#30
JOURNAL ARTICLE
Margaret A Nagai-Singer, Holly A Morrison, Mackenzie K Woolls, Katerina Leedy, Khan Mohammad Imran, Juselyn D Tupik, Irving C Allen
Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique, understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors that regulates a variety of biological processes that are highly relevant to pancreatic cancer. The role of NLRX1 in cancer remains highly enigmatic, with some studies defining its roles as a tumor promoter, while others characterize its contributions to tumor suppression. These seemingly contradicting roles appear to be due, at least in part, to cell type and temporal mechanisms...
2023: Frontiers in Oncology
#31
JOURNAL ARTICLE
Evelyn Bracho-Sanchez, Fernanda G Rocha, Sean K Bedingfield, Brittany D Partain, Sabrina L Macias, Maigan A Brusko, Juan M Colazo, Margaret M Fettis, Shaheen A Farhadi, Eric Y Helm, Kevin Koenders, Alexander J Kwiatkowski, Antonietta Restuccia, Bethsymarie Soto Morales, Arun Wanchoo, Dorina Avram, Kyle D Allen, Craig L Duvall, Shannon M Wallet, Gregory A Hudalla, Benjamin G Keselowsky
The treatment of chronic inflammation with systemically administered anti-inflammatory treatments is associated with moderate-to-severe side effects, and the efficacy of locally administered drugs is short-lived. Here we show that inflammation can be locally suppressed by a fusion protein of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO) and galectin-3 (Gal3). Gal3 anchors IDO to tissue, limiting the diffusion of IDO-Gal3 away from the injection site. In rodent models of endotoxin-induced inflammation, psoriasis, periodontal disease and osteoarthritis, the fusion protein remained in the inflamed tissues and joints for about 1 week after injection, and the amelioration of local inflammation, disease progression and inflammatory pain in the animals were concomitant with homoeostatic preservation of the tissues and with the absence of global immune suppression...
September 2023: Nature Biomedical Engineering
#32
RANDOMIZED CONTROLLED TRIAL
Ann G Zauber, Sidney J Winawer, Michael J O'Brien, Glenn M Mills, John I Allen, Andrew D Feld, Paul A Jordan, Martin Fleisher, Irene Orlow, Reinier G S Meester, Iris Lansdorp-Vogelaar, Carolyn M Rutter, Amy B Knudsen, Margaret Mandelson, Aasma Shaukat, Robin B Mendelsohn, Anne I Hahn, Stephanie M Lobaugh, Brittany Soto Palmer, Victoria Serrano, Julie R Kumar, Sara E Fischer, Jennifer C Chen, Sharon Bayuga-Miller, Deborah Kuk, Kelli O'Connell, Timothy R Church
BACKGROUND & AIMS: Colorectal cancer (CRC) screening guidelines include screening colonoscopy and sequential high-sensitivity fecal occult blood testing (HSgFOBT), with expectation of similar effectiveness based on the assumption of similar high adherence. However, adherence to screening colonoscopy compared with sequential HSgFOBT has not been reported. In this randomized clinical trial, we assessed adherence and pathology findings for a single screening colonoscopy vs sequential and nonsequential HSgFOBTs...
July 2023: Gastroenterology
#33
JOURNAL ARTICLE
Margaret M Paschen-Wolff, Jeremy D Kidd, Emily Allen Paine
Purpose: Research on opioid misuse, opioid use disorder (OUD), and overdose (i.e., opioid outcomes) among lesbian, gay, bisexual, transgender, queer, and other populations within the LGBTQ umbrella (LGBTQ+) remains sparse. The purpose of this scoping review was to characterize the state of the research on opioid outcomes among LGBTQ+ populations, and identify gaps in the extant literature and areas for future research. Methods: We conducted a scoping review of peer-reviewed, English language articles published between 2011 and 2020 that examined opioid outcomes among LGBTQ+ populations in the CINAHL, Embase, PubMed, and PsycINFO databases...
October 31, 2022: LGBT Health
#34
JOURNAL ARTICLE
Corey A Krabbenhoft, George H Allen, Peirong Lin, Sarah E Godsey, Daniel C Allen, Ryan M Burrows, Amanda G DelVecchia, Ken M Fritz, Margaret Shanafield, Amy J Burgin, Margaret A Zimmer, Thibault Datry, Walter K Dodds, C Nathan Jones, Meryl C Mims, Catherin Franklin, John C Hammond, Sam Zipper, Adam S Ward, Katie H Costigan, Hylke E Beck, Julian D Olden
Knowing where and when rivers flow is paramount to managing freshwater ecosystems. Yet stream gauging stations are distributed sparsely across rivers globally and may not capture the diversity of fluvial network properties and anthropogenic influences. Here we evaluate the placement bias of a global stream gauge dataset on its representation of socioecological, hydrologic, climatic and physiographic diversity of rivers. We find that gauges are located disproportionally in large, perennial rivers draining more human-occupied watersheds...
April 25, 2022: Nature Sustainability
#35
JOURNAL ARTICLE
Faith Chesire, Marlyn Ochieng, Michael Mugisha, Ronald Ssenyonga, Matt Oxman, Allen Nsangi, Daniel Semakula, Laetitia Nyirazinyoye, Simon Lewin, Nelson K Sewankambo, Margaret Kaseje, Andrew D Oxman, Sarah Rosenbaum
BACKGROUND: Good health decisions depend on one's ability to think critically about health claims and make informed health choices. Young people can learn these skills through school-based interventions, but learning resources need to be low-cost and built around lessons that can fit into existing curricula. As a first step to developing and evaluating digital learning resources that are feasible to use in Kenyan secondary schools, we conducted a context analysis to explore interest in critical thinking for health, map where critical thinking about health best fits in the curriculum, explore conditions for introducing new learning resources, and describe the information and communication technology (ICT) infrastructure available for teaching and learning...
October 6, 2022: Pilot and Feasibility Studies
#36
JOURNAL ARTICLE
Juan Dubrot, Peter P Du, Sarah Kate Lane-Reticker, Emily A Kessler, Audrey J Muscato, Arnav Mehta, Samuel S Freeman, Peter M Allen, Kira E Olander, Kyle M Ockerman, Clara H Wolfe, Fabius Wiesmann, Nelson H Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M Schneider, Andrea N Rivera-Rosario, Ian C Kohnle, Hans W Pope, Austin Ayer, Gargi Mishra, Margaret D Zimmer, Sarah Y Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T Frederick, Genevieve M Boland, W Nicholas Haining, David E Root, John G Doench, Nir Hacohen, Kathleen B Yates, Robert T Manguso
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune checkpoint blockade (ICB). We identify immune evasion genes and important immune inhibitory checkpoints conserved across cancers, including the non-classical major histocompatibility complex class I (MHC class I) molecule Qa-1b /HLA-E. Surprisingly, loss of tumor interferon-γ (IFNγ) signaling sensitizes many models to immunity...
October 2022: Nature Immunology
#37
REVIEW
Jeffrey D Sachs, Salim S Abdool Karim, Lara Aknin, Joseph Allen, Kirsten Brosbøl, Francesca Colombo, Gabriela Cuevas Barron, María Fernanda Espinosa, Vitor Gaspar, Alejandro Gaviria, Andy Haines, Peter J Hotez, Phoebe Koundouri, Felipe Larraín Bascuñán, Jong-Koo Lee, Muhammad Ali Pate, Gabriela Ramos, K Srinath Reddy, Ismail Serageldin, John Thwaites, Vaira Vike-Freiberga, Chen Wang, Miriam Khamadi Were, Lan Xue, Chandrika Bahadur, Maria Elena Bottazzi, Chris Bullen, George Laryea-Adjei, Yanis Ben Amor, Ozge Karadag, Guillaume Lafortune, Emma Torres, Lauren Barredo, Juliana G E Bartels, Neena Joshi, Margaret Hellard, Uyen Kim Huynh, Shweta Khandelwal, Jeffrey V Lazarus, Susan Michie
No abstract text is available yet for this article.
September 14, 2022: Lancet
#38
JOURNAL ARTICLE
Xing Yi Woo, Anuj Srivastava, Philip C Mack, Joel H Graber, Brian J Sanderson, Michael W Lloyd, Mandy Chen, Sergii Domanskyi, Regina Gandour-Edwards, Rebekah A Tsai, James Keck, Mingshan Cheng, Margaret Bundy, Emily L Jocoy, Jonathan W Riess, William Holland, Stephen C Grubb, James G Peterson, Grace A Stafford, Carolyn Paisie, Steven B Neuhauser, R Krishna Murthy Karuturi, Joshy George, Allen K Simons, Margaret Chavaree, Clifford G Tepper, Neal Goodwin, Susan D Airhart, Primo N Lara, Thomas H Openshaw, Edison T Liu, David R Gandara, Carol J Bult
Patient-derived xenograft models (PDX) are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathological features, mutational profiles, gene expression, and copy number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models...
September 7, 2022: Cancer Research
#39
JOURNAL ARTICLE
Shireen Suliman, Karen D Könings, Margaret Allen, Ayad Al-Moslih, Alison Carr, Richard P Koopmans
PURPOSE: Medical students' transition to postgraduate training, given the complexity of new roles and responsibilities, requires the engagement of all involved stakeholders. This study aims to co-create a transition curriculum and determine the value of involving the key stakeholders throughout such transition in its design process. METHODS: We conducted a mixed-methods study involving faculty/leaders (undergraduate/postgraduate), final-year medical students, and chief residents...
August 31, 2022: Medical Teacher
#40
JOURNAL ARTICLE
Jacinta C Beehner, José Alfaro, Cloe Allen, Marcela E Benítez, Thore J Bergman, Margaret S Buehler, Sofia C Carrera, Emily M Chester, Tobias Deschner, Alexander Fuentes, Colleen M Gault, Irene Godoy, Katharine M Jack, Justin D Kim, Lev Kolinski, Nelle K Kulick, Teera Losch, Juan Carlos Ordoñez, Susan E Perry, Fernando Pinto, Olivia T Reilly, Elizabeth Tinsley Johnson, Michael D Wasserman
Hormone laboratories located "on-site" where field studies are being conducted have a number of advantages. On-site laboratories allow hormone analyses to proceed in near-real-time, minimize logistics of sample permits/shipping, contribute to in-country capacity-building, and (our focus here) facilitate cross-site collaboration through shared methods and a shared laboratory. Here we provide proof-of-concept that an on-site hormone laboratory (the Taboga Field Laboratory, located in the Taboga Forest Reserve, Costa Rica) can successfully run endocrine analyses in a remote location...
August 22, 2022: General and Comparative Endocrinology
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