Natalie E Nieuwenhuizen, Geraldine Nouailles, Jayne S Sutherland, Joanna Zyla, Arja H Pasternack, Jan Heyckendorf, Björn C Frye, Kerstin Höhne, Ulrike Zedler, Silke Bandermann, Ulrike Abu Abed, Volker Brinkmann, Birgitt Gutbier, Martin Witzenrath, Norbert Suttorp, Gernot Zissel, Christoph Lange, Olli Ritvos, Stefan H E Kaufmann
Activin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB patients compared to healthy controls, including those with positive tuberculin skin tests, and paralleled severity of disease, assessed by X-ray scores. In pneumonia patients, serum activin A levels were also raised, but in sarcoidosis patients, levels were lower...
February 20, 2024: MBio