R Camille Brewer, Tobias V Lanz, Caryn R Hale, Gregory D Sepich-Poore, Cameron Martino, Austin D Swafford, Thomas S Carroll, Sarah Kongpachith, Lisa K Blum, Serra E Elliott, Nathalie E Blachere, Salina Parveen, John Fak, Vicky Yao, Olga Troyanskaya, Mayu O Frank, Michelle S Bloom, Shaghayegh Jahanbani, Alejandro M Gomez, Radhika Iyer, Nitya S Ramadoss, Orr Sharpe, Sangeetha Chandrasekaran, Lindsay B Kelmenson, Qian Wang, Heidi Wong, Holly L Torres, Mark Wiesen, Dana T Graves, Kevin D Deane, V Michael Holers, Rob Knight, Robert B Darnell, William H Robinson, Dana E Orange
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of ISG15+ HLADRhi and CD48high S100A2pos monocytes, recently identified in inflamed RA synovia and blood of those with RA flares...
February 22, 2023: Science Translational Medicine