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JOURNAL ARTICLE
Xin Ning, Wen-Ting Liu, Cong Wang, Yan-Ping Tian
Tomato (Solanum lycopersicum L.) is one of the most important vegetable crops in China. In October 2023, a new bacterial disease was discovered on tomato plants in a 0.3-acre farm's greenhouse (35.514806N, 118.996106E) in Longshan Town, Shandong Province, China. Over 50% of the tomato plants showed symptoms of stem rot, leaf wilt, or plant death. Three diseased tomato plants were collected for pathogen isolation and purification. Two leaf samples, each about 1 cm2, were cut from the junction area of healthy and diseased parts and disinfected with 75% alcohol for 60 s, followed by 0...
April 30, 2024: Plant Disease
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JOURNAL ARTICLE
Danielle Rios, Jake Ueckert, Kevin L Ong, Jose R Barillas, Stefano Costanzo
Silver bluestem [ Bothriochloa laguroides (DC.) Herter] is a warm-season grass native to Texas. This perennial grass plays a crucial role in maintaining ecological balance and supporting wildlife in the region. In September 2022, while investigating the ecological impact of invasive grass species on a grassland located near Pipe Creek (TX), B. laguroides plants were observed showing symptoms that included yellowing of the blades and occasionally brown discoloration of the midveins and stems (Fig. S1). Disease incidence was estimated as 2% of silver bluestem plants in the 2 hectares surveyed...
April 30, 2024: Plant Disease
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JOURNAL ARTICLE
Alfred N Fonteh, Xiaomeng Wu, Natalie Astraea, Tamara Elenberger, David P Buennagel, Caleb Sin, Mitchell Spezzaferri, Shant Rising, Anne Nolty, Helena C Chui, Yafa Minazad, Robert A Kloner, Xianghong Arakaki
BACKGROUND: The CSF amyloid to tau ratio can isolate cognitively healthy participants into normal Aβ42 /tau (CH-NAT) or a pathological Aβ42 /tau (CH-PAT) with a low or high risk of cognitive decline, respectively. We aim to determine if plasma Aβ42 /tau ratios can differentiate CH-NAT from CH-PAT participants. METHOD: Study participants (> 65 years of age) were recruited, and demographic, neurological, and neuropsychological data were obtained in an ongoing HMRI Brain Aging study...
December 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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JOURNAL ARTICLE
Anthony C Gordon, Narges Alipanah-Lechner, Lieuwe D Bos, Jose Dianti, Janet Victoria Diaz, Simon Finfer, Tomoko Fujii, Evangelos J Giamarellos-Bourboulis, Ewan C Goligher, Michelle Ng Gong, Eleni Karakike, Vincent Liu, Nuttha Lumlertgul, John C Marshall, David K Menon, Nuala J Meyer, Elizabeth S Munroe, Sheila N Myatra, Marlies Ostermann, Hallie C Prescott, Adrienne G Randolph, Edward J Schenck, Christopher W Seymour, Manu Shankar-Hari, Mervyn Singer, Marry R Smit, Aiko Tanaka, Fabio Silvio Taccone, B Taylor Thompson, Lisa K Torres, Tom Van der Poll, Jean-Louis Vincent, Carolyn S Calfee
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identify reproducible subpopulations that may respond differently to treatment. This article reviews the current state of the field and considers how to successfully transition to a precision medicine approach. In order to impact clinical care, identified subpopulations must do more than differentiate prognosis...
April 30, 2024: American Journal of Respiratory and Critical Care Medicine
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JOURNAL ARTICLE
Marlene Saßmannshausen, Senem Döngelci, Marc Vaisband, Leon von der Emde, Kenneth R Sloan, Jan Hasenauer, Frank G Holz, Steffen Schmitz-Valckenberg, Thomas Ach
PURPOSE: To longitudinally assess the impact of high-risk structural biomarkers for natural disease progression in non-exudative age-related macular degeneration (AMD) on spatially resolved mesopic and scotopic fundus-controlled perimetry testing. METHODS: Multimodal retinal imaging data and fundus-controlled perimetry stimuli points were semiautomatically registered according to landmark correspondences at each annual visit over a period of up to 4 years. The presence of sub-RPE drusen, subretinal drusenoid deposits, pigment epithelium detachments (PEDs), hyper-reflective foci (HRF), vitelliform lesions, refractile deposits, and incomplete RPE and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) were graded at each stimulus position and visit...
April 1, 2024: Investigative Ophthalmology & Visual Science
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REVIEW
Angelica Cristello Sarteau, Gabriella Ercolino, Rashmi Muthukkumar, Angela Fruik, Elizabeth J Mayer-Davis, Anna R Kahkoska
There is an emerging population of older adults (≥65 years) living with type 1 diabetes. Optimizing health through nutrition during this life stage is challenged by multiple and ongoing changes in diabetes management, comorbidities, and lifestyle factors. There is a need to understand nutritional status, dietary intake, and nutrition-related interventions that may maximize well-being throughout the life span in type 1 diabetes, in addition to nutrition recommendations from clinical guidelines and consensus reports...
April 30, 2024: Diabetes Care
#47
JOURNAL ARTICLE
Ryota Tozuka, Noriyuki Kadoya, Kazuhiro Arai, Kiyokazu Sato, Keiichi Jingu
Measurement-based verification is impossible for the patient-specific quality assurance (QA) of online adaptive magnetic resonance imaging-guided radiotherapy (oMRgRT) because the patient remains on the couch throughout the session. We assessed a deep learning (DL) system for oMRgRT to predict the gamma passing rate (GPR). This study collected 125 verification plans [reference plan (RP), 100; adapted plan (AP), 25] from patients with prostate cancer treated using Elekta Unity. Based on our previous study, we employed a convolutional neural network that predicted the GPRs of nine pairs of gamma criteria from 1%/1 mm to 3%/3 mm...
April 30, 2024: Radiological Physics and Technology
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JOURNAL ARTICLE
Laia Dotras, Amanda Barciela, Manuel Llana, Jordi Galbany, R Adriana Hernandez-Aguilar
Chimpanzees (Pan troglodytes) are categorized as Endangered by the International Union for Conservation of Nature, and habitat loss due to conversion of land for agriculture is one of the major threats to wild populations of this species. This challenging scenario can lead to negative human-chimpanzee interactions, including crop feeding. Chimpanzees consume crops across their geographical range, although little is known about this behavior in savanna habitats. Here we provide new evidence of crop feeding by savanna chimpanzees...
April 30, 2024: Primates; Journal of Primatology
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JOURNAL ARTICLE
Jing Hu, Mengyue Wang, Ruiyao Xiang
Emanuel syndrome is a rare autosomal disorder characterized by microcephaly, heart defects, cleft palate and developmental delay. However, there is a lack of specific prenatal screening for Emanuel syndrome. To screen for early diagnostic marker genes in fetuses with karyotype+der[22]t(11;22)(q23;q11) of Emanuel syndrome. Transcriptome sequencing and clinical trait data of t(11;22)(q23;q11) translocation samples were screened from the GEO database. The differentially expressed genes (DEGs) were screened by principal component analysis of gene expression by R package, and intersections were taken with balanced and unbalanced DEGs...
April 30, 2024: Biochemical Genetics
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JOURNAL ARTICLE
D O Vawda, Christopher King, L du Toit, R A Dyer, N J Masuku, D G Bishop
Hypothermia during obstetric spinal anaesthesia is a common and important problem, yet temperature monitoring is often not performed due to the lack of a suitable, cost-effective monitor. This study aimed to compare a noninvasive core temperature monitor with two readily available peripheral temperature monitors during obstetric spinal anaesthesia. We undertook a prospective observational study including elective and emergency caesarean deliveries, to determine the agreement between affordable reusable surface temperature monitors (Welch Allyn SureTemp® Plus oral thermometer and the Braun 3-in-1 No Touch infrared thermometer) and the Dräger T-core© (using dual-sensor heat flux technology), in detecting thermoregulatory changes during obstetric spinal anaesthesia...
April 30, 2024: Journal of Clinical Monitoring and Computing
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JOURNAL ARTICLE
Vincent Grosjean, Simon B Gressens, Tài Pham, Stéphane Gaudry, Hafid Ait-Oufella, Nicolas De Prost, Julien Mayaux, Emmanuel Guerot, Véronique Leflon-Guibout, Noémie Mayer, Frédéric Bert, Nathalie Gault, Clément R Massonnaud, Damien Roux
BACKGROUND: Alongside the recent worldwide expansion of hypervirulent Klebsiella pneumoniae (KP) infections, the available literature regarding cases of community acquired pneumonias (KP-CAP) remains scarce but reports a strikingly high and early mortality. We performed a retrospective multicenter study (7 ICU in France) between 2015 and 2019, comparing prognosis and severity of KP-CAP versus Streptococcus pneumoniae - CAP (SP-CAP). METHODS: For each KP-CAP, three SP-CAP admitted in ICUs within the same center and within the same 6-month window were selected...
April 30, 2024: Annals of Intensive Care
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JOURNAL ARTICLE
Anna M Kot, Paulina Laszek, Marek Kieliszek, Katarzyna Pobiega, Stanisław Błażejak
OBJECTIVES: This study aimed to isolate red yeast from sap, bark and slime exudates collected from Polish birch forests and then assessment of their biotechnological potential. RESULTS: 24 strains of red yeast were isolated from the bark, sap and spring slime fluxes of birch (Betula pendula). Strains belonging to Rhodotorula mucilaginosa (6), Rhodosporidiobolus colostri (4), Cystrofilobasidium capitaum (3), Phaffia rhodozyma (3) and Cystobasidium psychroaquaticum (3) were dominant...
April 30, 2024: Biotechnology Letters
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REVIEW
Charles R Wira, Thomas Kearns, Alex Fleming-Nouri, John D Tyrrell, Christina M Wira, Ani Aydin
PURPOSE OF REVIEW: To evaluate the adverse effects of common antihypertensive agents utilized or encountered in the Emergency Department. RECENT FINDINGS: All categories of antihypertensive agents may manifest adverse effects, inclusive of adverse drug reactions (ADRs), drug-to-drug interactions, or accidental overdose. Adverse effects, and specifically ADRs, may be stratified into the organ systems affected, might require specific time-sensitive interventions, could pose particular risks to vulnerable populations, and may result in significant morbidity, and potential mortality...
April 30, 2024: Current Hypertension Reports
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JOURNAL ARTICLE
Kristin N Sheehan, Lara M Khoury, Angela G Niehaus, William I Mariencheck, Katherine A Gershner, Travis L Dotson, Christina R Bellinger
PURPOSE: The use of endobronchial ultrasound (EBUS) is standard practice for lung cancer diagnosis and staging. Next generation sequencing (NGS) for detection of genetic alterations is recommended in advanced, non-squamous, non-small-cell lung cancer (NSCLC). Existing protocols for NGS testing are minimal and reported yields vary. This study aimed to determine the yield of EBUS samples obtained for NGS using a sampling protocol at our institution and assess predictive factors to form collection protocols...
April 30, 2024: Lung
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JOURNAL ARTICLE
Răzvan Alexandru Radu, Vincent Costalat, Michele Romoli, Basel Musmar, James E Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H Cuellar-Saenz, Ajith J Thomas, Ramanathan Kadirvel, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Joshua D Bernstock, Aman B Patel, James D Rabinov, Christopher J Stapleton, Nicole M Cancelliere, Thomas R Marotta, Vitor Mendes Pereira, Kareem El Naamani, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Lukas Meyer, Jens Fiehler, Tobias D Faizy, Helena Guerreiro, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Charbel Mounayer, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina M Chervak, Achala Vagal, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, Andrea M Alexandre, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Ymd, Jessica Jesser, Charlotte Weyland, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Cheng-Yang Hsieh, David S Liebeskind, Illario Tancredi, Robert Fahed, Boris Lubicz, Muhammed Amir Essibayi, Amanda Baker, David Altschul, Luca Scarcia, Erwah Kalsoum, Adam A Dmytriw, Adrien Guenego
BACKGROUND: Optimal anesthetic strategy for the endovascular treatment of stroke is still under debate. Despite scarce data concerning anesthetic management for medium and distal vessel occlusions (MeVOs) some centers empirically support a general anesthesia (GA) strategy in these patients. METHODS: We conducted an international retrospective study of MeVO cases. A propensity score matching algorithm was used to mitigate potential differences across patients undergoing GA and conscious sedation (CS)...
April 30, 2024: Clinical Neuroradiology
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JOURNAL ARTICLE
Kimberly Sakai, Ellen R Bradley, Joseph A Zamaria, Gabrielle Agin-Liebes, D Parker Kelley, Alexander Fish, Valeria Martini, Michelle C Ferris, Emma Morton, Erin E Michalak, Aoife O'Donovan, Joshua D Woolley
RATIONALE: Treatments with the serotonergic psychedelic psilocybin are being investigated for multiple neuropsychiatric disorders. Because many patients with these disorders use selective serotonin reuptake inhibitors (SSRIs), understanding interactions between psilocybin and SSRIs is critical for evaluating the safety, efficacy, and scalability of psilocybin-based treatments. Current knowledge about these interactions is limited, as most clinical psilocybin research has prohibited concomittant SSRI use...
April 30, 2024: Psychopharmacology
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JOURNAL ARTICLE
Susan S Lee, Saumya Nagar, Lakshmi Rajagopalan, Werhner Orilla, Karl G Csaky, Alexandra Almazan, Liuqing Yang, Michael R Robinson
Purpose: To investigate gel stent implantation with and without intraoperative sustained-release mitomycin C (MMC SR) in a rabbit model for gel stent implantation, and to examine aqueous humor outflow (AHO) postimplantation. Methods: Four groups of rabbits were included. Group 1 was untreated (control). Groups 2, 3, and 4 received the gel stent without MMC, with MMC solution (subconjunctival injection), and with MMC SR (subconjunctival injection), respectively. Intraocular pressure (IOP) and AHO were assessed via tonometry and indocyanine green-based angiography, respectively...
May 2, 2024: Journal of Ocular Pharmacology and Therapeutics
#58
JOURNAL ARTICLE
Weijun Zhao, Xilin Hu, Zixuan Chen, Xinjian Li
Major facilitator superfamily domain containing 12 (MFSD12) regulates lysosomal cysteine import and promotes the proliferation and survival of melanoma cells. However, the expression and function of MFSD12 in other cancers, particularly in lung cancer, remain unclear. The expression of MFSD12 across various types of cancers and corresponding control tissues was examined using TIMER. MFSD12 expression in lung adenocarcinoma (LUAD) and its correlation with distinct clinicopathological features of LUAD patients were analyzed with UALCAN...
April 30, 2024: DNA and Cell Biology
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JOURNAL ARTICLE
Xinlu Li, Elisabetta Groaz, Piet Herdewijn, Eveline Lescrinier
An acyclic phosphonate-linked nucleic acid backbone (ZNA) demonstrated the capability to support duplex formation and propagate genetic information in vivo, unveiling its potential for evolution into a synthetic genetic system (XNA). To determine the structural impact of such modification, modified Dickerson Drew DNA dodecamers (DDDs) were prepared by solid phase synthesis, each containing either an (R) or (S) isomeric form of a cytosine ZNA nucleotide. While the DDD is known to adopt a stable duplex, both duplex and hairpin forms were simultaneously observed for both modified oligonucleotides by NMR spectroscopy over a broad temperature range (5-65 °C)...
April 30, 2024: Chemistry: a European Journal
#60
REVIEW
Rodrigo Rosario-Cruz, Delia Inés Domínguez-García, Consuelo Almazán, Fernando Rosario Dominguez
Background: The control and prevention of ticks and tick borne diseases (TBDs) is often difficult, since it is necessary to disrupt a complex transmission cycle, involving ticks and vertebrate hosts, which interact in a changing environment, driven by constant environmental and ecological changes. Our view is that factors driving the spread of R. microplus are complex and intrinsically interconnected, something that has often been ignored in control strategies. Results: The aim of this review is to analyze the importance of the epidemiological surveillance of ticks and tick-borne diseases (TTBDs) for Public Health, with the One Health approach; emphasizing the knowledge, importance, and distribution of TTBDs...
April 30, 2024: Vector Borne and Zoonotic Diseases
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