Bo Li, Xiao-Feng Jiang, Ying-Jie Dong, Yi-Piao Zhang, Xing-Li-Shang He, Cheng-Liang Zhou, Yan-Yan Ding, Ning Wang, Yi-Bin Wang, Wan-Qi Cheng, Ning-Hua Jiang, Jie Su, Gui-Yuan Lv, Su-Hong Chen
OBJECTIVES: To elucidate the therapeutic effects and mechanisms of Atractylodes macrocephala extract crystallize (BZEP) and BZEP self-microemulsion (BZEPWR) on metabolic dysfunction-associated fatty liver disease (MAFLD) induced by "high sugar, high fat, and excessive alcohol consumption" based on the gut-liver axis HDL/LPS signaling pathway. METHODS: In this study, BZEP and BZEPWR were obtained via isolation, purification, and microemulsification. Furthermore, an anthropomorphic MAFLD rat model of "high sugar, high fat, and excessive alcohol consumption" was established...
April 24, 2024: Biomedicine & Pharmacotherapy