Tyler D Harvey, Ryan J Watson, Kirsty A Clark
INTRODUCTION: Sexual and gender minority (SGM) youth, who experience high mental and behavioral health needs, are overrepresented in the criminal legal system, which may exacerbate these needs. This study examined associations among arrest history and mental and behavioral health among SGM youth. METHODS: Using cross-sectional survey data from the 2022 LGBTQ+ National Teen Survey, this study created a case-control sample of 287 SGM youth with an arrest history and 1148 propensity-matched SGM youth without an arrest history...
June 13, 2024: American Journal of Preventive Medicine
Bradyn N Swanson, Sydney A Lewis, Amarpreet Kaur, Jennifer N Berry
Although previous research has illustrated the effects of the consumption of alcohol and caffeine individually, less research has focused on the popular combination of the two drugs. The increase in alcohol consumption when combined with caffeine has led to the idea that the stimulant effects of caffeine may mask the depressant effects of alcohol, and this may contribute to increased binge drinking as the individual feels more awake and stimulated. Preclinical research has shown various effects of combined alcohol and caffeine where several studies show decreased alcohol consumption and others show increased alcohol consumption and even binge-like drinking...
June 13, 2024: Pharmacology, Biochemistry, and Behavior
Marla Beauchamp, Renata Kirkwood, MyLinh Duong, Terence Ho, Parminder Raina, Rebecca Kruisselbrink, Aaron Jones, Carla Girolametto, Andrew Costa
BACKGROUND: Limited data exist on post-severe COVID-19 functional trajectory, particularly considering premorbid status. We characterized 1-year functional recovery post-hospitalization for COVID-19, highlighting predictors of long-term recovery. METHODS: We enrolled adult patients with lab-confirmed SARS-CoV-2 infection and hospitalized for COVID-19 sequelae, from five major Ontario, Canada hospitals in a prospective cohort study. Assessments included telephone interviews on admission followed by telephone and in-person assessments at 3-, 6-, 9-, and 12-months post-discharge...
June 13, 2024: American Journal of Medicine
Sarah N Magee, Allison C Sereno, Melissa A Herman
Alcohol use disorder (AUD) is a major public health concern that despite its prevalence, lacks a widely-effective treatment due to the complexity of AUD pathology. AUD is highly comorbid with other psychiatric conditions including anxiety and mood disorders, however it is unclear how these disorders influence each other. The underlying etiology of these comorbidities is difficult to decipher and factors including sex, stress, and the environment further complicate both diagnosis and treatment strategies. To understand more about this bidirectional relationship between AUD and comorbid psychiatric disorders, we ran male and female C57Bl/6j mice through baseline behavioral testing followed by intermittent access-two bottle choice (IA-2BC) drinking...
June 13, 2024: Alcohol
Anna H Lee, Swapna Mahurkar-Joshi, Bruce Naliboff, Arpana Gupta, Jennifer Labus, Kirsten Tillisch, Emeran Mayer, Lin Chang
BACKGROUND AND AIMS: Adverse childhood experiences (ACE) are associated with increased risk of irritable bowel syndrome (IBS), a female-predominant chronic abdominal disorder. Factors contributing to this association have not been well-studied. We compared sex differences in ACE for adults with and without IBS and evaluated the impact of anxiety and resilience on the relationship between ACE and IBS. METHODS: Sex and disease differences in total score and ACE subtypes from the ACE Questionnaire in IBS and controls were assessed...
June 13, 2024: Clinical Gastroenterology and Hepatology
Yoonji Lee, Justin P Yuan, Anderson M Winkler, Katharina Kircanski, Daniel S Pine, Ian H Gotlib
OBJECTIVE: Adolescents face significant changes in many domains of their daily lives that require them to flexibly adapt to changing environmental demands. To shift efficiently among various goals, adolescents must reconfigure their brains, disengaging from previous tasks and engaging in new activities. METHOD: To examine this reconfiguration, we obtained resting-state and task-based fMRI scans in a community sample of 164 adolescents. We assessed the similarity of functional connectivity (FC) of the reward network between resting state and a reward processing state, indexing the degree of reward network reconfiguration required to meet task demands...
June 10, 2024: Journal of the American Academy of Child and Adolescent Psychiatry
Jade Dunot, Sebastien Moreno, Carine Gandin, Paula A Pousinha, Mascia Amici, Julien Dupuis, Margarita Anisimova, Alex Winschel, Magalie Uriot, Samuel J Petshow, Maria Mensch, Ingrid Bethus, Camilla Giudici, Heike Hampel, Benedikt Wefers, Wolfgang Wurst, Ronald Naumann, Michael C Ashby, Bodo Laube, Karen Zito, Jack R Mellor, Laurent Groc, Michael Willem, Hélène Marie
NMDA receptors (NMDARs) are ionotropic receptors crucial for brain information processing. Yet, evidence also supports an ion-flux-independent signaling mode mediating synaptic long-term depression (LTD) and spine shrinkage. Here, we identify AETA (Aη), an amyloid-β precursor protein (APP) cleavage product, as an NMDAR modulator with the unique dual regulatory capacity to impact both signaling modes. AETA inhibits ionotropic NMDAR activity by competing with the co-agonist and induces an intracellular conformational modification of GluN1 subunits...
June 7, 2024: Neuron
Elizabeth K C Schwartz, Alexandra N Palmisano, Ismene L Petrakis, Robert H Pietrzak, Mehmet Sofuoglu
INTRODUCTION: Avoidance is a well-documented risk factor for poor mental and physical health outcomes. However, limited research has explored this relationship specifically among trauma-exposed veterans, a population known to be particularly prone to avoidance behavior. Conceptually, avoidance is often divided into two distinct but overlapping constructs - experiential avoidance (resisting distressing internal states) and behavioral avoidance (avoiding or changing experiences that elicit distress)...
June 11, 2024: Journal of Psychiatric Research
Lidan Yi, Jing Chen, Sini Li, Wei Cui, Jianhe Li, Liubao Peng, Ciyan Peng
BACKGROUND: Combinations of Chinese patent medicines (CPM) with antidepressants (including selective serotonin reuptake inhibitors (SSRI), selective serotonin-norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants (TCA), and noradrenergic and specific serotonergic antidepressants (NaSSA)) are frequently utilized for treating depression in adults. However, the efficacy and safety of these combination treatments remain to be established. METHODS: Systematic search was conducted in seven electronic databases, regulatory websites and international registers of trials from 1994 to 2023 that included adult patients with depressive disorders who received CPM combined with antidepressants...
June 11, 2024: Journal of Psychiatric Research
Rosie Blackburn, Kate E Tonta, David M Erceg-Hurn, Bronwyn C Raykos, Peter M McEvoy
OBJECTIVE: To examine rates and predictors of attrition from referral through to treatment completion in an outpatient public psychology service's eating disorder program in Perth, Western Australia. METHOD: The proportion (number) of clients (N = 671; mean age = 23.8 years) transitioning between stages of pre-treatment and treatment was identified. Associations between demographic, treatment and clinical variables and attrition were investigated using logistic regression...
June 13, 2024: Eating Behaviors
Motoki Tamura, Atsushi Nakagomi, Kazushige Ide, Katsunori Kondo, Toshiyuki Ojima, Tomo Takasugi, Koichiro Shiba
BACKGROUND: Prior studies have underscored the importance of studying volunteering in the East Asian context. However, no study has conducted a holistic assessment of the relationship between volunteering and the multidimensional health and well-being outcomes of East Asian populations using a strong study design for causal inference. To address this gap, this study examined the associations between volunteer group participation and the subsequent health and well-being of Japanese older adults...
June 12, 2024: Archives of Gerontology and Geriatrics
Olga Goiana Martins Sampaio, Sacha Aubrey Alves Rodrigues Santos, Marina de Barros Mamede Vidal Damasceno, Larissa Brandão Joventino, Adriana Rolim Campos, Marcelo Borges Cavalcante
Controlled ovarian hyperstimulation (COH) is a common step for treating infertile couples undergoing assisted reproductive technologies and in female fertility preservation cycles. In some cases, undergoing multiple COHs is required for couples to conceive. Behavioral changes such as anxiety and depression can be caused by ovulation-inducing drugs. Sex steroids play a role in locomotor activity, behavioral changes, and nociception, specifically during fluctuations and sudden drops in estrogen levels. This study evaluated the effect of repeated ovarian hyperstimulation (ROH) on weight, locomotor activity, anxiety-like and depression-like behavior, and nociception in female mice...
June 13, 2024: Hormones and Behavior
Daniel A Cavalcante, Mariane Noto, Raphael de O Cerqueira, Giovany Oliveira Costa, Luccas Coutinho, Fernando Malinovski, Ana Olívia Fonseca, Marcos Leite Santoro, Vanessa Ota, Quirino Cordeiro, Rodrigo A Bressan, Sintia Belangero, Ary Gadelha, Cristiano Noto
INTRODUCTION: Schizophrenia is a debilitating disorder that affects a significant proportion of the population and leads to impaired functionality and long-term challenges. The first episode of psychosis (FEP) is a critical intervention stage for improving long-term outcomes. The GAPi program was established in São Paulo, Brazil to provide early intervention services and evaluate biomarkers in individuals with FEP. This article delineates the objectives of the GAPi program, detailing its innovative research protocol, examining the clinical outcomes achieved, and discussing the operational challenges encountered during its initial decade of operation...
June 3, 2024: Asian Journal of Psychiatry
Leah Shelef, Liat Itzhaky, Uzi Bechor, Lucian Tatsa-Laur, J John Mann
Veterans with PTSD are at higher risk for suicide. This study examined the specific associations of PTSD symptom clusters with suicidal ideation (SI) and death ideation (DI), independently from depressive symptom clusters. Participants included 695 Israeli male outpatient military veterans (M = 25.35 years, SD = 5.65), divided into subsamples of probable PTSD (PTSD Checklist for DSM-5 [PCL-5] ≥ 33) and subthreshold PTSD scores (PCL-5 < 33). Data were extracted from medical chartsand self-report questionnaires...
May 30, 2024: Psychiatry Research
Lenka Groeneveld, Joline Wj Beulens, Marieke T Blom, Annemieke van Straten, Tanja van der Zweerde, Petra Jm Elders, Femke Rutters
STUDY OBJECTIVES: Investigate whether aiding sleep by online cognitive behavioral therapy for insomnia (CBT-I) can improve glycemic and metabolic control, mood, quality of life (QoL) and insomnia symptoms in people with type 2 diabetes and assess the mediating role of lifestyle factors. METHODS: Adults with type 2 diabetes and insomnia symptoms were randomly assigned to CBT-I or care as usual. At baseline, three and six months we assessed HbA1c as primary outcome and glycemic control, metabolic outcomes, sleep, mood and QoL as secondary outcomes...
May 23, 2024: Sleep Medicine
Päivi Lappalainen, Katariina Keinonen, Raimo Lappalainen, Sanna Selinheimo, Aki Vuokko, Markku Sainio, Sanna Liesto, Asko Tolvanen, Tiina Paunio
OBJECTIVE: Persistent physical symptoms (PPS) represent a major health problem affecting daily functioning. This RCT aimed to examine whether a guided Internet-based treatment based on acceptance and commitment therapy (ACT) provided additional benefits compared to Treatment as Usual (TAU) in reducing somatic complaints and psychological distress in adults with PPS. METHODS: A total of 103 adults with PPS related to indoor environments, chronic fatigue or both conditions were assigned to receive either either a 14-week intervention (video-based case conceptualization + Internet-based ACT) combined with TAU (iACT + TAU; n = 50) or TAU alone (n = 53)...
June 13, 2024: Journal of Psychosomatic Research
Olivia D Chang, Kaitlin P Ward, Shawna J Lee
Early in the COVID-19 pandemic, studies documented a marked decline in mental health and well-being when compared with prepandemic levels. This study examined how different coping styles were associated with anxiety, depression, and sleep problems among U.S. adults March-April 2020 during the COVID-19 pandemic. Data from 535 U.S. adults across three time points were analyzed using longitudinal multilevel logistic and linear regression modeling. Avoidant-emotional coping was associated with greater odds of experiencing anxiety (OR = 1...
June 14, 2024: Health & Social Work
Dong-Young Lee, Yerin Chung, Beom Kim, Jae-Hon Lee, Kangbaek Lee, Young Lee, Yu Ho Lee, Shin Young Ahn, Yang Gyun Kim, Hyeon Seok Hwang, Ju-Young Moon, Jae-Hong Ryoo, Kayla M Teopiz, Roger S McIntyre
Depression and osteoporosis are common diseases in dialysis patients. In addition, patients with osteoporosis are more susceptible to depression. Contrary to previous anti-osteoporosis agents, denosumab and romosozumab could be used in dialysis patients and have similar action mechanisms for blocking RANKL. RANKL causes bone resorption after binding RANKL, but binding with OPG leads to suppress of bone resorption. In recent mice study, inhibition of RANKL with denosumab improved depressive-like phenotype. Besides, it was found that OPG was associated with depression...
June 15, 2024: Calcified Tissue International
Małgorzata Sobol, Agata Błachnio, Inna Hryhorchuk, Elzbieta Plucinska, Janusz Stasiniewicz, Aneta Przepiórka
PURPOSE: Using social media can have negative consequences. The present study aimed to examine how the partner's problematic social media use (SMU) was related to the pregnant woman's time perspective and prenatal depression. METHODS: The study included 30 pregnant women and their 30 male partners. Research was conducted twice: in the first and third trimesters of pregnancy. Women completed online measures: the Zimbardo Time Perspective Inventory Fatalism scale (ZTPI-Fat), the Dark Future Scale (DFS), and the Edinburgh Postpartum Depression Scale (EPDS)...
June 15, 2024: Archives of Women's Mental Health
Alia T Sadek, Leila Djerdjour, Ryan A Reyes, Greggory P Adams, Cara H Logan, Margaret A Smith, Sara G Biddle, Timothy S Wiles, Enrique Urrea-Mendoza, Tracie M McConnell, Fredy J Revilla, Jennifer L Trilk
INTRODUCTION: Persons with Parkinson's disease (PwPD) suffer from motor and non-motor symptoms which significantly affect their quality of life (QoL), and the QoL of their care partners (CP). Tandem cycling reduces PwPD motor symptoms; however, no studies have examined other benefits or included PwPD CP. We conducted an 8-week community virtual reality (VR) tandem cycling intervention to assess the feasibility and efficacy for PwPD and their CP (i.e., PD dyads). We hypothesized that dyadic tandem cycling would improve (1) PwPD motor and non-motor symptoms and (2) dimensions of PD dyads' QoL and physiologic health...
June 15, 2024: Neurology and Therapy
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