Gina S Perez Giraldo, Sareen T Ali, Anthony K Kang, Tulsi R Patel, Shreya Budhiraja, Jordan I Gaelen, Grace K Lank, Jeffrey R Clark, Shreya Mukherjee, Tracey Singer, Aditi Venkatesh, Zachary S Orban, Patrick H Lim, Millenia Jimenez, Janet Miller, Carolyn Taylor, April L Szymanski, Jessica Scarpelli, Edith L Graham, Roumen D Balabanov, Bianca E Barcelo, Joshua G Cahan, Kaitlyn Ruckman, Alan G Shepard, Marc W Slutzky, Kathrin LaFaver, Priya U Kumthekar, Neil K Shetty, Katherine S Carroll, Sam U Ho, Rimas V Lukas, Ayush Batra, Eric M Liotta, Igor J Koralnik
OBJECTIVE: To characterize neurologic manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients. METHODS: Prospective study of the first 100 consecutive PNP and 500 NNP patients evaluated at a Neuro-COVID-19 clinic between 5/2020 and 8/2021. RESULTS: PNP were older than NNP patients (mean 53.9 vs 44.9 y; p < 0.0001) with a higher prevalence of pre-existing comorbidities. An average 6...
March 26, 2023: Annals of Neurology
Aylin Sariyildiz, Ilke Coskun Benlidayi, Ipek Turk, Serife Seyda Zengin Acemoglu, Ilker Unal
To identify the determinants of central sensitization (CS) in patients with axial spondyloarthritis (axSpA). Central Sensitization Inventory (CSI) was used to determine CS frequency. Disease-related variables including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP/-ESR), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) and Numeric Rating Scale (NRS)GLOBAL were assessed...
March 26, 2023: Rheumatology International
Thomas Bergmann, Jan Menkhaus, Wanzhi Ye, Markus Schemmel, Mario Hasler, Steffen Rietz, Gunhild Leckband, Daguang Cai
Novel QTLs and candidate genes for Sclerotinia-resistance were identified in B. villosa, a wild Brassica species, which represents a new genetic source for improving oilseed rape resistance to SSR. Sclerotinia stem rot (SSR), caused by Sclerotinia sclerotiorum, is one of the most destructive diseases in oilseed rape growing regions. To date, there is no effective genetic resistance against S. sclerotiorum in the B. napus germplasm and knowledge of the molecular plant-fungal interaction is also limited. To identify new resistance resources, we screened a set of wild Brassica species and identified B...
March 26, 2023: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Hui-Ju Wu, Shih-Jen Tsai, Ya-Mei Bai, Wei-Chung Mao, Pei-Chi Tu, Li-Fen Chen, Wei-Chi Li, Mu-Hong Chen
BACKGROUND: The benefits of low-dose ketamine for patients with treatment-resistant depression (TRD) and prominent suicidal ideation require further investigation. The effects of treatment refractoriness, the duration of the current depressive episode, and the number of prior antidepressant failures on ketamine efficacy also require clarification. METHODS: We recruited 84 outpatients with TRD and prominent suicidal ideation- defined as a score of ≥4 on Item 10 of the Montgomery-Asberg Depression Rating Scale (MADRS)-and randomized them into two groups to receive 0...
March 26, 2023: International Journal of Neuropsychopharmacology
Qian He, Kevin Chun Hei Wu, Adam N Bennett, Beifang Fan, Jundong Liu, Ruixuan Huang, Alice P S Kong, Xiaoyu Tian, Man Ki Maggie Kwok, Kei Hang Katie Chan
Previous observational studies reported associations between non-steroidal anti-inflammatory drugs (NSAIDs) and major depressive disorder (MDD), however, these associations are often inconsistent and underlying biological mechanisms are still poorly understood. We conducted a two-sample Mendelian randomisation (MR) study to examine relationships between genetic variants and NSAID target gene expression or DNA methylation (DNAm) using publicly available expression, methylation quantitative trait loci (eQTL or mQTL) data and genetic variant-disease associations from genome-wide association studies (GWAS of MDD)...
March 25, 2023: Pharmacogenomics Journal
Suonaa Lee, Jae Won Oh, Kyung Mee Park, San Lee, Eun Lee
Despite research into the development of digital cognitive behavioral therapy for insomnia (dCBT-I), research into the outcomes of dCBT-I on insomnia and the associated clinical conditions of depression and anxiety have been limited. The PubMed, PsycINFO (Ovid), Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) on adult patients with insomnia also having reported measures of depressive or anxiety symptoms. In total, 2504 articles were identified after duplicate removal, and 22 RCTs were included in the final meta-analysis...
March 25, 2023: NPJ Digital Medicine
Scott R Beach, James Luccarelli, Nathan Praschan, Mark Fusunyan, Gregory L Fricchione
Catatonia occurs secondary to both primary psychiatric and neuromedical etiologies. Emerging evidence suggests possible linkages between causes of catatonia and neuroinflammation. These include obvious infectious and inflammatory etiologies, common neuromedical illnesses such as delirium, and psychiatric entities such as depression and autism-spectrum disorders. Symptoms of sickness behavior, thought to be a downstream effect of the cytokine response, are common in many of these etiologies and overlap significantly with symptoms of catatonia...
March 23, 2023: Schizophrenia Research
Bret R Rutherford, Jongwoo Choi, Mark Slifstein, Kaleigh O'Boyle, Anissa Abi-Dargham, Patrick J Brown, Melanie W Wall, Nora Vanegas-Arroyave, Jayant Sakhardande, Yaakov Stern, Steven P Roose
No abstract text is available yet for this article.
March 23, 2023: Journal of Affective Disorders
Arash Veshkini, Fabrizio Ceciliani, Muriel Bonnet, Harald Michael Hammon
Cows fed total mixed rations (silage-based) may not receive as much essential fatty acids (EFAs) and conjugated linoleic acids (CLAs) as cows fed pasture-based rations (fresh grass) containing rich sources of polyunsaturated fatty acids. CLA-induced milk fat depression allows dairy cows to conserve more metabolisable energy, thereby shortening the state of negative energy balance and reducing excessive fat mobilisation at early lactation. EFAs, particularly α-linolenic acid, exert anti-inflammatory and antioxidative properties, thereby modulating immune functions...
March 7, 2023: Animal
Zhixin Zhang, Siyuan Li, Yang Wang, Jiahui Zhao
BACKGROUND: Prurigo nodularis (PN) is a chronic inflammatory skin condition that has a significant unmet needs for effective treatment options. OBJECTIVE: To assess the efficacy and safety of dupilumab in adult patients with PN refractory to traditional therapies. METHODS: This ongoing, real-life study examined dupilumab treatment in 8 adult patients diagnosed with PN for at least 6 months. The included patients were prescribed 300 mg dupilumab biweekly for at least 16 weeks...
March 23, 2023: Anais Brasileiros de Dermatologia
Yan Tereshko, Christian Lettieri, Enrico Belgrado, Sara Pez, Gian Luigi Gigli, Mariarosaria Valente
Botulinum toxin type A is an effective preventive therapy for chronic migraine. Although the guidelines suggest a 50U/ml dilution of OnabotulinumtoxinA (BoNT/A), many clinicians use more concentrated solutions. However, there are no studies regarding the effect and safety of 100U/ml BoNT/A dilution with the saline solution following the PREEMPT paradigm. Our primary goal was to evaluate the efficacy, in reducing migraine frequency, and safety of two different BoNT/A dilutions (100U/ml vs 50U/ml) in the treatment of Chronic migraine...
March 23, 2023: Toxicon: Official Journal of the International Society on Toxinology
Zsófia Csajbók, Dag Aarsland, Pavla Cermakova
BACKGROUND: e aimed to disentangle within-person and between-person effects in the temporal relationship between depressive symptoms and cognitive function. METHODS: We performed a prospective population-based cohort study on participants of the Survey of Health, Ageing and Retirement in Europe. Cognitive function was assessed by tests on verbal fluency, immediate recall and delayed recall. Depressive symptoms were measured with EURO-D scale. To determine the temporal order of the association between cognitive function and depressive symptoms, we employed the fully saturated cross-lagged panel model (between-person effects), and random intercept cross-lagged panel model (within-person effects)...
March 23, 2023: Journal of Affective Disorders
Yasmin Iles-Caven, Steven Gregory, Kate Northstone, Jean Golding, Stephen Nowicki
BACKGROUND: The COVID-19 pandemic resulted in increased rates of mental health problems. We examined the possible role of the personality characteristic, Locus of Control (LOC), in moderating pandemic-induced stress. METHODS: The UK-based Avon Longitudinal Study of Parents & Children (ALSPAC), 7021 adults (mean ages: women 57.6 (SD = 4.48); partners 60.5 (SD = 5.36)) responded to a 2020 questionnaire which included a generalised measure of LOC...
March 23, 2023: Journal of Affective Disorders
Ta-Chuan Yeh, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang
BACKGROUND: The mental health of children and adolescents with autism spectrum disorder (ASD) is a concern of recent years. However, a large-scale longitudinal study investigating the risk and the time course of subsequent psychiatric comorbidities is still lacking. METHODS: Using the Taiwan National Health Insurance Research Database, 13,382 children and adolescents with ASD, and 53,528 age- and sex-matched non-ASD controls were enrolled between 2001 and 2009, and followed to the end of 2011...
March 23, 2023: Journal of Affective Disorders
Zheng-Wu Peng, Cui-Hong Zhou, Shan-Shan Xue, Huan Yu, Qing-Qing Shi, Fen Xue, Yi-Huan Chen, Qing-Rong Tan, Hua-Ning Wang
BACKGROUND: Neural oscillations play a role in the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS). However, the effects of high-frequency rTMS on the neural oscillations of the medial prefrontal cortex (mPFC) and hippocampus (HPC) and its molecular mechanism have not been fully clarified. METHODS: The depressive-like behaviours, local field potentials (LFPs) of the ventral HPC (vHPC)-mPFC, and alternations of endocannabinoid system (ECS) in the HPC and mPFC were observed after rTMS treatment...
March 23, 2023: Journal of Affective Disorders
Jorge Rodrigues, Maria Inês Rocha, Francisco Teixeira, Beatriz Resende, Armando Cardoso, Susana I Sá, Ricardo Pinto Vaz, Kristof Raemdonck
BACKGROUND: Allergic rhinitis (AR) has been identified as a cause of olfactory dysfunction. Beyond the classic symptoms, AR has been associated with altered sleep patterns, a decline in cognitive performance and higher likelihood of depression and anxiety. The olfactory pathway has been postulated to be a possible link between nasal inflammation and central nervous system (CNS) modifications. Thus, we aimed to investigate the structural, functional and behavioral changes in the olfactory pathway and related areas in an animal model of AR...
March 23, 2023: Physiology & Behavior
Stella M Sanchez, Aki Tsuchiyagaito, Rayus Kuplicki, Heekyeong Park, Ivan Postolski, Michael Rohan, Martin P Paulus, Salvador M Guinjoan
BACKGROUND: Repetitive negative thinking (RNT) is a frequent symptom of depression (MDD) associated to poor outcomes and treatment resistance. While most studies on RNT have focused on structural and functional characteristics of gray matter, this study aimed to examine the association between white matter (WM) tracts and interindividual variability in RNT. METHODS: A probabilistic tractography approach was used to characterize differences in the size and anatomical trajectory of WM fibers traversing psychosurgery targets historically useful in the treatment of MDD (anterior capsulotomy, anterior cingulotomy, and subcaudate tractotomy), in patients with MDD and low (n = 53) or high RNT (n = 52), and healthy controls (HC, n = 54)...
March 23, 2023: Biological Psychiatry
Luciano Del Santo, Diogo Vasconcelos Macedo, Florencio Monje Gil
Several treatment modalities have been reported for patients with arthrogenous temporomandibular disorders. The most common temporomandibular disorder is internal derangement, usually accompanied by displacement of the articular disc. Most often anteriorly and medially displaced, patients may develop clicking, impaired jaw function, and pain. Articular disc repositioning has been described as an effective method to eliminate interference during mandibular translation, improving mandibular range of motion, and eliminating pain...
March 7, 2023: Journal of Oral and Maxillofacial Surgery
Lorenza Dall'Aglio, Fernando Estévez-López, Mónica López-Vicente, Bing Xu, Oktay Agcaoglu, Elias Boroda, Kelvin O Lim, Vince D Calhoun, Henning Tiemeier, Ryan L Muetzel
BACKGROUND: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. METHODS: We adopted a longitudinal design with repeated assessments to investigate associations between functional network connectivity (FNC) and psychiatric problems in youth (9- to 17-year-olds, two time points) from the general population...
March 20, 2023: NeuroImage: Clinical
Li-Jun Wang, Tian-Hua Cheng, Jia-Sen Geng, Juan Yang, Chang Liu, Guo-Hui Zhu, Jia-Cheng Luo, Gui-Zhen Wang, Xiang He Zhu, Yi Wang, Jia Huang, Yan-Yu Wang
BACKGROUND: Previous studies have found that patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) all have facial emotion recognition deficits, but the differences and similarities of these deficits in the three groups of patients under different social interaction situations are not clear. The present study aims to compare the ability of facial emotion recognition in three different conversation situations from a cross-diagnostic perspective. METHODS: Thirty-three participants with SCZ, 35 participants with MDD, and 30 participants with BD were recruited, along with 31 healthy controls...
March 21, 2023: Asian Journal of Psychiatry
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