Luis Alameda, Angeline Christy, Victoria Rodriguez, Gonzalo Salazar de Pablo, Madeleine Thrush, Yi Shen, Beatriz Alameda, Edoardo Spinazzola, Eduardo Iacoponi, Giulia Trotta, Ewan Carr, Miguel Ruiz Veguilla, Monica Aas, Craig Morgan, Robin M Murray
Despite the accepted link between childhood abuse and positive psychotic symptoms, findings between other adversities, such as neglect, and the remaining dimensions in people with psychosis have been inconsistent, with evidence not yet reviewed quantitatively. The aim of this study was to systematically examine quantitatively the association between broadly defined childhood adversity (CA), abuse (sexual/physical/emotional), and neglect (physical/emotional) subtypes, with positive, negative, depressive, manic, and disorganized dimensions in those with psychosis...
April 9, 2021: Schizophrenia Bulletin
Mohamad El Haj, Jean-Louis Nandrino
Mind-wandering refers to the intentional and unintentional tendency to withdraw from the external environment and engage in internally generated thoughts. We investigated intentional and unintentional mind-wandering in patients with Korsakoff syndrome (KS). We invited 31 patients with KS and 33 control participants to answer a questionnaire probing intentional and unintentional mind-wandering. Analysis demonstrated higher intentional and unintentional mind-wandering in patients with KS than in controls. However, no significant differences were observed between intentional and unintentional mind-wandering in patients with KS or in controls...
April 2, 2021: Psychiatry Research
Lianne M Tomfohr-Madsen, Nicole Racine, Gerald F Giesbrecht, Catherine Lebel, Sheri Madigan
The study rapidly reviewed and meta-analyzed the worldwide prevalence of depression and anxiety among pregnant women during the COVID-19 pandemic. A systematic search of the literature and meta-analyses were conducted from December 2019 - February 2021 with a total of 46 studies meeting inclusion criteria. Depression was assessed in 37 studies (N = 47,677), with a pooled prevalence of 25.6%. Anxiety was assessed in 34 studies (N = 42,773), with a pooled prevalence of 30.5%; moderation by time showed that prevalence of anxiety was higher in studies conducted later in the pandemic...
April 1, 2021: Psychiatry Research
Nelson B Rodrigues, Roger S McIntyre, Orly Lipsitz, Yena Lee, Mehala Subramaniapillai, Kevin Kratiuk, Amna Majeed, Flora Nasri, Hartej Gill, Rodrigo B Mansur, Joshua D Rosenblat
Numerous clinical trials have reported that intravenous (IV) ketamine demonstrates rapid antidepressant and anti-suicidal effects in patients with treatment-resistant depression (TRD). These studies, however, have not characterized whether these antidepressant effects translate to improvements in workplace productivity and functionality. Adults with TRD received repeated doses of IV ketamine at a community-based clinic (n = 171). We evaluated patient outcomes at two timepoints of interest: (1) acute-phase (i...
March 15, 2021: Psychiatry Research
Mario Simjanoski, Karen Jansen, Thaíse Campos Mondin, Fernanda Pedrotti Moreira, Igor Soares Vieira, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Benicio N Frey, Taiane de Azevedo Cardoso, Flávio Kapczinski
AIM: To assess the differences in subjective cognitive dysfunction between major depressive disorder (MDD) and recently diagnosed Bipolar Disorder (BD) across euthymia and mood episodes. METHODS: This is a cross-sectional study corresponding to the second wave of a longitudinal study. The first wave consisted of subjects aged between 18 and 60 diagnosed with MDD. In the follow up after three years (second wave), conversion from MDD to BD diagnosis was assessed by qualified psychologists using the Mini International Neuropsychiatric Interview (MINI-Plus)...
March 21, 2021: Psychiatry Research
Kristína Krajčíková, Erika Semančíková, Katarína Zakutanská, Daria Kondrakhova, Jana Mašlanková, Marek Stupák, Ivan Talian, Natália Tomašovičová, Tatiana Kimáková, Vladimír Komanický, Katarína Dubayová, Dagmar Breznoščáková, Eva Pálová, Juraj Semančík, Vladimíra Tomečková
Spectroscopic methods represent a group of analytical methods that demonstrate high potential in providing clinically relevant diagnostic information, such as biochemical, functional or structural changes of macromolecular complexes that might occur due to pathological processes or therapeutic intervention. Although application of these methods in the field of psychiatric research is still relatively recent, the preliminary results show that they have the capacity to detect subtle neurobiological abnormalities in major depressive disorder (MDD)...
March 29, 2021: Journal of Psychiatric Research
Sophie Hsin-Yi Liang, Yi-Chen Lee, Brent Allan Kelsen, Vincent Chin-Hung Chen
BACKGROUND: No study has examined how child and maternal psychopathological difficulties and family factors contribute to the health-related quality of life (HRQOL) of mothers of children with attention deficit hyperactivity (ADHD). AIMS: To investigate the impact of children's diagnosis of ADHD, children's and maternal psychopathology and significant sociodemographic variables of the children, parents and family on HRQOL of mothers of children with ADHD and those of children with typical development (TD) in Taiwan...
April 6, 2021: Research in Developmental Disabilities
Nathália Stela Visoná de Figueiredo, Larissa Botelho Gaça, Idaiane Batista Assunção-Leme, Lenon Mazetto, Maria Teresa Fernandes Castilho Garcia, Gabriel Barbosa Sandim, Neide Barreira Alonso, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Andrea Parolin Jackowski, Henrique Carrete Júnior, Elza Márcia Targas Yacubian
Depression is the most frequent psychiatric comorbidity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS). This study aimed to confirm whether patients with comorbid depression have different volumetric patterns on magnetic resonance imaging, analysing the influence of HS sides. Psychiatrists conducted semi-structured interviews with 75 patients, who were divided into non-depression group (NDG, n = 52) and depression group (DG, n = 23), and compared with 98 controls. The FreeSurfer software was used in the volumetric analysis of the estimated total intracranial volume (eTIV), bilateral cortical and subcortical regions of interest (ROIs), and for presence of left (L-, n = 41) or right (R-, n = 34) MTLE-HS...
March 19, 2021: Psychiatry Research. Neuroimaging
Alejandro D Meruelo, Ty Brumback, Bonnie J Nagel, Fiona C Baker, Sandra A Brown, Susan F Tapert
BACKGROUND: Adolescents are at increased risk of developing major depressive disorder (MDD) than many other age groups. Although the neural correlates of MDD in adults have been studied prospectively, such adolescent depression studies are mainly cross-sectional. We extracted data regarding the relationship between cortical thickness and later development of adolescent MDD from a national community study that uses an accelerated longitudinal design to examine the psychological, environmental, and neural differences related to drinking and brain development...
March 31, 2021: Journal of Affective Disorders
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are suggested as the first-line treatment for patients with major depressive disorder (MDD), but the remission rate is unsatisfactory. We aimed to establish machine learning models and explore variables available at baseline to predict the 8-week outcome among patients taking SSRIs. METHODS: Data from 400 patients were used to build machine learnings. The last observation carried forward approach was used to determine the remitter/non-remitter status of the patients at week 8...
March 31, 2021: Journal of Affective Disorders
Rebecca L Casarez, Jair C Soares, Thomas D Meyer
INTRODUCTION: The purpose of this study was to test the feasibility and potential efficacy of a 7-week psychoeducation intervention implemented in a group setting. The intervention was based on Miklowitz's (2008) psychoeducation component of Family-Focused Therapy. METHOD: This was a feasibility randomized controlled trial study using a 2-group design (intervention and wait-list control). Twelve adult family members of those with bipolar disorder were randomized to receive 7 psychoeducation sessions immediately or after a 7-week waiting period...
March 31, 2021: Journal of Affective Disorders
Maaria Kortesniemi, Carolyn M Slupsky, Anna-Katariina Aatsinki, Jari Sinkkonen, Linnea Karlsson, Kaisa M Linderborg, Baoru Yang, Hasse Karlsson, Henna-Maria Kailanto
The composition of human milk is subject to considerable variation, but the effects of maternal stress are largely unknown. We studied differences in human milk metabolome between Finnish mothers (n = 120, secretors) with symptoms of prenatal symptoms of psychological distress and milk cortisol concentrations. Human milk samples acquired at 2.5 months postpartum were analyzed using targeted 1 H NMR metabolomics. Self-reported scores for depression (EPDS), overall anxiety (SCL-90), and pregnancy-related anxiety (PRAQ) were used to evaluate psychological distress...
March 20, 2021: Food Chemistry
Xinyi Liu, Cuili Wang, Xiaoxia Qiao, Huaxin Si, Yaru Jin
We aimed to explore the relationship between sleep quality and frailty, and depression as a mediator and its interaction with sleep quality on frailty. This was a cross-sectional study among 936 Chinese community-dwelling adults aged≥60 years. Sleep quality, frailty and depression were measured by the Pittsburgh Sleep Quality Index (PSQI), the Frailty Phenotype and the 5-item Geriatric Depression Scale (GDS-5), respectively. We found that depression mediated the association between poor sleep quality and physical frailty, attenuating the association between poor sleep and physical frailty by 51...
April 5, 2021: Geriatric Nursing
Xuemei Li, Xinyu Zhou, Teng Teng, Li Fan, Xueer Liu, Yajie Xiang, Yuanliang Jiang, Peng Xie, Dan Zhu
Major depressive disorder is a serious and complex mental illness, and multiple brain regions are involved in its pathogenesis. There is increasing evidence that the amygdala is involved in depression; however, the underlying molecular mechanisms remain unclear. In this study, we applied a combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomic and isobaric tags for relative and absolute quantitation (iTRAQ) proteomic to study changes in the amygdala in a chronic unpredictable mild stress (CUMS) rat model of depression...
April 6, 2021: Neuroscience
Danielle N Jones, Mary Ann Raghanti
Although it has been nearly 100 years since the first description of monoamine oxidase, we are still learning about its role in the healthy brain and how it is altered in various disease states. The present review provides a survey of our current understanding of monoamine oxidases, with a focus on their contributions to neuropsychiatric, neurodevelopmental, and neurodegenerative disease. Important species differences in monoamine oxidase function and development in the brain are highlighted. Sex-specific monoamine oxidase regulatory mechanisms and their implications for various neurological disorders are also discussed...
April 6, 2021: Journal of Chemical Neuroanatomy
Mo Xian Chen, Shu Cheng, Lei Lei, Xiao Fan Zhang, Qiang Liu, Aijin Lin, Chloe U Wallis, Michael James Lukowicz, Pak C Sham, Qi Li, Li Juan Ao
Fluoxetine (FLX), a commonly used selective serotonin reuptake inhibitor, is often used to treat depression during pregnancy. However, prenatal exposure to FLX has been associated with a series of neuropsychiatric illnesses. The use of a rodent model can provide a clear indication as to whether prenatal exposure to SSRIs, independent of maternal psychiatric disorders or genetic syndromes, can cause long-term behavioral abnormalities in offspring. Thus, the present study aimed to explore whether prenatal FLX exposure causes long-term neurobehavioral effects, and identify the underlying mechanism between FLX and abnormal behaviors...
April 6, 2021: Neurochemistry International
Kate Kennedy-Wood, Christi Anne S Ng, Seham Alaiyed, Patricia L Foley, Katherine Conant
Increased perineuronal net (PNN) deposition has been observed in association with corticosteroid administration and stress in rodent models of depression. PNNs are a specialized form of extracellular matrix (ECM) that may enhance GABA-mediated inhibitory neurotransmission to potentially restrict the excitation and plasticity of pyramidal glutamatergic neurons. In contrast, antidepressant administration increases levels of the PNN-degrading enzyme matrix metalloproteinase-9 (MMP-9), which enhances glutamatergic plasticity and neurotransmission...
April 6, 2021: Behavioural Brain Research
Kyle J Brymer, Erin Y Kulhaway, John G Howland, Hector J Caruncho, Lisa E Kalynchuk
The symptoms of human depression often include cognitive deficits. However, cognition is not frequently included in the behavioral assessments conducted in preclinical models of depression. For example, it is well known that repeated corticosterone (CORT) injections in rodents produce depression-like behavior as measured by the forced swim test, sucrose preference test, and tail suspension test, but the cognitive impairments produced by repeated CORT have not been thoroughly examined. The purpose of this experiment was to assess the effect of repeated CORT injections on several versions of object recognition memory and modulation of the acoustic startle response by relatively low intensity prepulses, along with the more traditional assessment of depression-like behavior using the forced swim test...
April 6, 2021: Behavioural Brain Research
David Kealy, Matt S Treeby, Simon M Rice
OBJECTIVES: This study examined associations between generalized shame and guilt, and suicidal ideation. METHODS: Individuals attending outpatient mental health services (N = 100) completed study measures at a single time point. Correlation and regression analyses examined associations between recent suicidal ideation and generalized shame and guilt, both concurrently and interacting, controlling for depressive symptoms and history of previous suicide attempt...
April 9, 2021: British Journal of Clinical Psychology
Zhiheng Su, Junxiang Ruan, Xi Liu, Hua Zheng, Jingzhou Ruan, Yuying Lu, Bang Cheng, Fang Wu, Jinxia Wu, Xuwen Liu, Fangming Song, Zhaoni Chen, Hui Song, Yonghong Liang, Hongwei Guo
OBJECTIVES: Milletia speciosa Champ (MS), a traditional Chinese medicine, has the abilities of antistress, antifatigue, anti-oxidation and so on. In our previous study, MS was found to antidepression while the underlying mechanism of which needs further elucidation. METHODS: Here, a proton nuclear magnetic resonance (1H-NMR)-based metabonomics combined network pharmacology research approach was performed to investigate the antidepressive mechanism of MS act on mouse with chronic unpredictable mild stress-induced depression...
April 9, 2021: Journal of Pharmacy and Pharmacology
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