Yasmeen Hamza, Areti Okalidou, Ann Dierckx, Astrid van Wieringen
OBJECTIVES: The present study investigated how children with cochlear implants (CIs), with optimal exposure to oral language, perform on sonority-related novel word learning tasks. By optimal oral language exposure, we refer to bilateral cochlear implantation below the age of 2 years. Sonority is the relative perceptual prominence/loudness of speech sounds of the same length, stress, and pitch. The present study is guided by a previous study that investigated the sonority-related novel word learning ability of a group of children with CIs, in the Greek language, of which the majority were implanted beyond the age of 2 unilaterally...
June 12, 2020: Ear and Hearing
Jennifer A Ormsby, Julie Cronin, Jane Carpenter, Dionne A Graham, Gail Potter-Bynoe, Ana M Vaughan, Lindsay Weir, Kathleen A Flaherty, Celeste J Chandonnet, Gregory P Priebe, Thomas J Sandora
OBJECTIVE: To institute facility-wide Kamishibai card (K-card) rounding for central venous catheter (CVC) maintenance bundle education and adherence and to evaluate its impact on bundle reliability and central-line-associated bloodstream infection (CLABSI) rates. DESIGN: Quality improvement project. SETTING: Inpatient units at a large, academic freestanding children's hospital. PARTICIPANTS: Data for inpatients with a CVC in place for ≥1 day between November 1, 2017 and October 31, 2018 were included...
June 4, 2020: Infection Control and Hospital Epidemiology
Aeshah AlAzmi, Wasil Jastaniah, Mona AlDabbagh, Naglla Elimam
BACKGROUND: There are a limited number of studies that address non-neutropenic fever episodes in children with cancer, and no standard approach exists. METHOD: We opt to retrospectively analyze the efficacy of the current clinical approach for management of non-neutropenic fever episodes and the associated risk factors among children with cancer at the Princess Noorah Oncology Center from May 2016 through December 2017. RESULTS: A total of 480 non-neutropenic fever episodes were identified in 131 children, of which 62 episodes were triaged as high-risk non-neutropenic fever and 418 as low-risk non-neutropenic fever...
May 31, 2020: Journal of Oncology Pharmacy Practice
R M Vesper, K Sprott, A L Haney, A Burnette, V Adams, A Savage, H Henderson
PURPOSE: Milrinone is utilized for hemodynamic support in heart failure (HF) patients. Due to reduced cardiac output and systemic blood flow, patients with HF are at increased risk of thrombosis. Central venous catheter (CVC) placement compounds this risk. The aim of this study was to determine the incidence of thrombosis, identify thrombosis risk factors, and determine the impact of anticoagulation in pediatric patients receiving continuous milrinone via CVC at the Medical University of South Carolina...
April 2020: Journal of Heart and Lung Transplantation
Yoshiyuki Shimizu, Takeshi Hatachi, Jun Takeshita, Yu Inata, Miyako Kyogoku, Yoshihiro Aoki, Masashi Taniguchi, Atsushi Kawamura, Jumpei Okumura, Muneyuki Takeuchi
OBJECTIVES: We aimed to identify the occurrence and risk factors for unplanned catheter removal due to catheter-associated complications and the effects on catheter survival probability in a PICU. DESIGN: Retrospective, single-center, observational study of cases involving conventional central venous catheters or peripherally inserted central venous catheters. SETTING: The PICU of a tertiary children's hospital. PATIENTS: Consecutive PICU patients with central venous catheters between April 2016 and February 2019...
September 2020: Pediatric Critical Care Medicine
Osama A Bawazir, Tariq I Altokhais
BACKGROUND: The ideal technique for insertion of tunneled central venous catheters (CVCs) in children is still debatable. This study aimed to compare the outcomes of open versus percutaneous technique for the insertion of tunneled CVCs. METHODS: The study included 279 patients who had CVCs insertions from 2010 to 2020. Patients were divided into two groups according to the technique of insertion; group 1 (n= 90) included patients who had the open cut-down method, and group 2 (n= 189) included patients who had the percutaneous technique...
May 16, 2020: Annals of Vascular Surgery
Illya Martynov, Jessica Klima-Frysch, Wolfram Kluwe, Christoph Engel, Joachim Schoenberger
Tunneled central venous catheters (TCVCs) provide prolonged intravenous access for pediatric patients with severe primary immunodeficiency disease (PID) undergoing hematopoietic stem cell transplantation (HSCT). However, little is known about the epidemiology and clinical significance of TCVC-related morbidity in this particular patient group. We conducted the retrospective analysis of patients with severe PID who received percutaneous landmark-guided TCVC implantation prior to HSCT. We analyzed 92 consecutive TCVC implantations in 69 patients (median [interquartile range] age 3...
2020: PloS One
Zara Forbrigger, Ketan Kulkarni
Central venous catheter (CVC) dysfunction is often associated with thrombosis, which in turn has been linked with poorer survival outcomes in cancer patients. Our objective was to examine the association of tissue plasminogen activator (tPA) administration as a surrogate measure of CVC dysfunction with survival in pediatric cancer patients. The present study uses data from a population-based retrospective cohort of pediatric oncology patients from the Canadian Maritime provinces treated between 2000 and 2017 at the IWK Health Centre, Halifax, NS...
May 15, 2020: Pediatric Hematology and Oncology
Maria A Bedoya, Leslie Raffini, Rachelle Durand, Michael R Acord, Abhay Srinivasan, Ganesh Krishnamurthy, Seth Vatsky, Fernando Escobar, Anne Marie Cahill
BACKGROUND: Clotting factor replacement forms the pillar of treatment for children with hemophilia. Most children can be treated using peripheral venipuncture, but very young children and children with poor venous access might require a central venous catheter. Short-term and long-term complications of implantable venous access device placement (also known as port placement) can result in important morbidity and mortality in children with hemophilia. OBJECTIVE: The purpose of this study is to describe our experience with port placement in children and adolescents with severe hemophilia (<1% of the Factors VIII or IX)...
May 11, 2020: Pediatric Radiology
Indira Berrio, Diego H Caceres, Wilfrido Coronell R, Soraya Salcedo, Laura Mora, Adriana Marin, Carmen Varón, Shawn R Lockhart, Patricia Escandón, Elizabeth L Berkow, Sandra Rivera, Tom Chiller, Snigdha Vallabhaneni
BACKGROUND: Candida auris is an emerging multidrug-resistant yeast that can cause invasive infections and healthcare-associated outbreaks. Here, we describe 34 cases of pediatric C. auris bloodstream infections (BSIs) identified during July 2014-October 2017 in 2 hospitals in Colombia. METHODS: We conducted a retrospective review of microbiology records for possible C. auris cases in 2 hospitals in Barranquilla and Cartagena. BSIs that occurred in patients aged <18 years confirmed as C...
May 6, 2020: Journal of the Pediatric Infectious Diseases Society
Madan Mohan Maddali, Fathiya Al-Shamsi, Nishant Ram Arora, Sathiya Murthi Panchatcharam
OBJECTIVES: The primary objective was to identify the best among 4 techniques that could predict the length of central venous catheter insertion through the right internal jugular vein, which, in turn, would ensure the ideal placement of the catheter tip in pediatric cardiac surgical patients. The techniques evaluated were those based on operator experience, topography/landmark methods, and one that relied on a patient's height-related formula. Based on the outcome of the study, the possibility of arriving at a formula was investigated that would predict with reasonable certainty the ideal length of catheter to be inserted for the correct catheter placement through the right internal jugular vein in pediatric cardiac surgical patients belonging to the authors' geographic area...
March 14, 2020: Journal of Cardiothoracic and Vascular Anesthesia
Mohamed Amine Rahil, Achour Bouzgueg
Insertion of a peritoneal dialysis (PD) catheter is frequently done by interventional nephrologists, but these procedures are typically only performed for adults. Almost all invasive procedures in children are performed by pediatric surgeons. If a pediatric surgeon is unavailable, the initiation of PD in acute situations may be delayed, thus increasing the risk of complications and chronic kidney disease. For these patients, the main obstacle to initiating renal replacement therapy is access, even when involving central vein catheter (CVC) or peritoneal access...
January 2020: Case Reports in Nephrology and Dialysis
Natalie K Bradford, Rachel M Edwards, Raymond J Chan
BACKGROUND: Guidelines and clinical practice for the prevention of complications associated with central venous catheters (CVC) around the world vary greatly. Most institutions recommend the use of heparin to prevent occlusion; there is debate, however, regarding the need for heparin and evidence to suggest normal saline (0.9% sodium chloride) may be as effective. The use of heparin is not without risk, may be unnecessary and is also associated with increased cost. This is an update of the review published in 2015...
April 30, 2020: Cochrane Database of Systematic Reviews
Elizabeth W J Kerris, Matthew Sharron, David Zurakowski, Steven J Staffa, Greg Yurasek, Yaser Diab
OBJECTIVES: Critically ill children with cardiac disease are at significant risk for hospital-associated venous thromboembolism, which is associated with increased morbidity, hospital length of stay, and cost. Currently, there are no widely accepted guidelines for prevention of hospital-associated venous thromboembolism in pediatrics. We aimed to develop a predictive algorithm for identifying critically ill children with cardiac disease who are at increased risk for hospital-associated venous thromboembolism as a first step to reducing hospital-associated venous thromboembolism in this population...
March 11, 2020: Pediatric Critical Care Medicine
Anna Söderström, Maria S Nørgaard, Anna-Marie E Thomsen, Betina S Sørensen
INTRODUCTION: Central venous catheters (CVC) can facilitate a reliable blood flow for apheresis procedures, but the placement is time-consuming and costly and the incidence of catheter-related complications is high. Ultrasound can aid nurses to insert peripheral venous catheters (PVC), which is safer for the patients. METHODS AND MATERIALS: We evaluated the use of CVC vs PVC for all apheresis procedures 3 years after the implementation of structured training of apheresis nurses to perform ultrasound-guided PVC...
April 27, 2020: Journal of Clinical Apheresis
Christopher Gallo, Pezhman Foroughi, Elisabeth Meagher, Ranjith Vellody, Bhupender Yadav, Anthony Ho, Alican Demir, Dorothee Heisenberg, Kevin Cleary, Karun Sharma
INTRODUCTION: Vascular access for central venous catheter placement is technically challenging in children. Ultrasound guidance is recommended for pediatric central venous catheter placement, yet many practitioners rely on imprecise anatomic landmark techniques risking procedure failure due to difficulty mastering ultrasound guidance. A novel navigation system provides a visual overlay on real-time ultrasound images to depict needle trajectory and tip location during cannulation. We report the first pediatric study assessing feasibility and preliminary safety of using a computer-assisted needle navigation system to aid in central venous access...
April 27, 2020: Journal of Vascular Access
Alejandrina Cristia, Federica Bulgarelli, Elika Bergelson
Purpose The Language Environment Analysis (LENA) system provides automated measures facilitating clinical and nonclinical research and interventions on language development, but there are only a few, scattered independent reports of these measures' validity. The objectives of the current systematic review were to (a) discover studies comparing LENA output with manual annotation, namely, accuracy of talker labels, as well as involving adult word counts (AWCs), conversational turn counts (CTCs), and child vocalization counts (CVCs); (b) describe them qualitatively; (c) quantitatively integrate them to assess central tendencies; and (d) quantitatively integrate them to assess potential moderators...
April 17, 2020: Journal of Speech, Language, and Hearing Research: JSLHR
Javier J Lasa, Michael Gaies, Lauren Bush, Wenying Zhang, Mousumi Banerjee, Jeffrey A Alten, Ryan J Butts, Antonio G Cabrera, Paul A Checchia, Justin Elhoff, Angela Lorts, Joseph W Rossano, Kurt Schumacher, Lara S Shekerdemian, Jack F Price
BACKGROUND: Acute decompensated heart failure (ADHF) is a highly morbid condition among adults. Little is known about outcomes in children with ADHF. We analyzed the Pediatric Cardiac Critical Care Consortium registry to determine the epidemiology, contemporary treatments, and predictors of mortality in critically ill children with ADHF. METHODS: Cardiac intensive care unit (CICU) patients ≤18 years of age meeting Pediatric Cardiac Critical Care Consortium criteria for ADHF were included...
April 2020: Circulation. Heart Failure
Julie Jaffray, Neil Goldenberg
INTRODUCTION: Acutely ill and medically complex pediatric patients typically rely on central venous catheters (CVCs) for vascular access. CVCs can have serious complications, including venous thromboembolism (VTE). In children, CVCs are the most common risk factor for VTE. AREA COVERED: Studies focused on the prevention and treatment of CVC-related VTE in children have been lacking until recently. Currently, there is one U.S. Food and Drug Administration (FDA) approved anticoagulant, dalteparin, and phase 3 trial results for two direct oral anticoagulants (DOACs) in pediatrics have recently been published...
June 2020: Expert Review of Hematology
Stefano Benvenuti, Filippo Parolini, Rosanna Ceresoli, Paolo Orizio, Daniele Alberti
INTRODUCTION: The use of peripherally inserted central catheters (PICCs) in children is increasingly common due to their certain advantages and low rate of adverse events. Valved PICCs, when displaced, must be removed and new a PICC must be placed in another vein. We present our PICC replacement technique over a Seldinger guidewire using the same entrance vein. METHODS: This prospective study involved all consecutive patients with a previously inserted Groshong PICC requiring replacement due to displacement managed at our institution between January 2018 and January 2019...
April 9, 2020: Minerva Pediatrica
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