Alejandrina Cristia, Marvin Lavechin, Camila Scaff, Melanie Soderstrom, Caroline Rowland, Okko Räsänen, John Bunce, Elika Bergelson
In the previous decade, dozens of studies involving thousands of children across several research disciplines have made use of a combined daylong audio-recorder and automated algorithmic analysis called the LENAⓇ system, which aims to assess children's language environment. While the system's prevalence in the language acquisition domain is steadily growing, there are only scattered validation efforts on only some of its key characteristics. Here, we assess the LENAⓇ system's accuracy across all of its key measures: speaker classification, Child Vocalization Counts (CVC), Conversational Turn Counts (CTC), and Adult Word Counts (AWC)...
July 29, 2020: Behavior Research Methods
Valentina Becherucci, Stefano Ermini, Luisa Piccini, Silvia Bisin, Valentina Gori, Francesca Gentile, Riccardo Ceccantini, Elena De Rienzo, Barbara Bindi, Paola Pavan, Vanessa Cunial, Elisa Allegro, Francesca Brugnolo, Daniela Maggio, Daniela Calzolari, Erika Maccarelli, Silvia Galli, Sonia Muricci, Marco Berchielli, Veronica Tintori, Iacopo Sardi, Franco Bambi
BACKGROUND: PBSC collection using a blood cell separator in very low weight patients can be frequently complicated by severe adverse effects and technical difficulties. MATERIAL AND METHODS: From March 2013 to January 2017, 14 PBSC collections were performed in 12 children weighing less than 10 kg, affected by different solid tumours. PBSC collection was performed with a "homemade" aseptically assembled circuit. The circuit is composed by a 150 mL collection bag connected with a 4 stopcock ramp, perfused with ACD...
July 25, 2020: Journal of Clinical Apheresis
Priscila Grizante-Lopes, Marlene Pereira Garanito, Daniele Martins Celeste, Vera Lucia Jornada Krebs, Jorge David Aivazoglou Carneiro
OBJECTIVE: To report a single-center experience with thrombolytic therapy using recombinant tissue plasminogen activator (rt-PA) in preterm neonates with severe thrombotic events, in terms of thrombus resolution and bleeding complications. STUDY DESIGN: This retrospective study included 21 preterm neonates with severe venous thrombotic events admitted to the neonatal intensive care unit, identified in our pharmacy database from January 2001 to December 2016, and treated with rt-PA until complete or partial clot lysis, no-response or bleeding complications...
July 25, 2020: Pediatric Blood & Cancer
Verónica De la Maza, Macarena Manriquez, Magdalena Castro, Paola Viveros, María Fernandez, Evelyn Vogel, Erica Peña, María Elena Santolaya, Milena Villarroel, Juan Pablo Torres
OBJECTIVE: To assess the impact of a structured educational programme for caregivers of children with cancer on their level of knowledge about the disease and patient's clinical outcome. METHODS: This prospective, non-randomised, experimental study included caregivers of recently diagnosed children at two hospitals in Chile. Caregivers whose children were treated at the first centre were the structured education programme group (EPG), while the second hospital provided the standard care (SCG)...
July 24, 2020: European Journal of Cancer Care
Gillian L Fell, Bennet S Cho, Lorenzo Anez-Bustillos, Duy T Dao, Meredith A Baker, Prathima Nandivada, Alison A O'Loughlin, Alexis P Hurley, Paul D Mitchell, Shawn Rangel, Kathleen M Gura, Mark Puder
OBJECTIVES: To assess whether a 24-hour length of hospitalization and empiric antibiotic therapy to exclude central line-associated bloodstream infection (CLABSI) in children with intestinal failure is potentially as safe as 48 hours, which is the duration most commonly used but not evidence based. STUDY DESIGN: A prospective single-institution observational cohort study was conducted among pediatric patients with intestinal failure from July 1, 2015 through June 30, 2018 to identify episodes of suspected CLABSI...
July 17, 2020: Journal of Pediatrics
Jacob R Hirschl, Samir K Gadepalli, Brian A Derstine, Sven A Holcombe, Ethan A Smith, Stewart C Wang, Peter F Ehrlich, Marcus D Jarboe
PURPOSE: The key landmark for tip position of a central venous catheter (CVC) is the SVC-RA junction. In adults, localization of the SVC-RA junction may be assessed as a function of vertebral body units (VBU) below the carina during CVC placement. We investigated the relationship between the SVC-RA junction and the carina in children. MATERIALS AND METHODS: 584 CT scans of 0-18 years were analyzed. The carina was marked automatically by software while the SVC-RA junction and vertebrae were marked manually...
July 14, 2020: Pediatric Surgery International
Ryan J Good, Melanie Levin, Susan Feder, Michele M Loi, John S Kim, Brian R Branchford, Angela S Czaja, Todd C Carpenter
OBJECTIVES: Perform a needs assessment by evaluating accuracy of PICU provider bedside ultrasound measurement of femoral vein diameter prior to utilization of the catheter-to-vein ratio for central venous catheter size selection. DESIGN: Prospective observational cohort study. SETTING: PICU within a quaternary care children's hospital. PATIENTS: PICU patients greater than 30 days and less than 6 years without a femoral central venous catheter...
June 22, 2020: Pediatric Critical Care Medicine
Yuanyuan Wang, Rondeline Williams, Laura Dilley, Derek M Houston
Early language environment plays a critical role in child language development. The Language ENvironment Analysis (LENA™) system allows researchers and clinicians to collect daylong recordings and obtain automated measures to characterize a child's language environment. This meta-analysis evaluates the predictability of LENA's automated measures for language skills in young children. We systematically searched reports for associations between LENA's automated measures, specifically, adult word count (AWC), conversational turn count (CTC), and child vocalization count (CVC), and language skills in children younger than 48 months...
September 2020: Developmental Review: DR
J A A S Jayaweera, D Sivakumar
BACKGROUND: Indwelling central venous catheters (CVC) are used to provide long term hemodialysis. The commonest and the severe complication of CVC is the central line-associated bloodstream infection (CLABSI). This study was done to assess the etiology and infectious complications of CVC in children on long term hemodialysis. METHODS: Children newly undergoing hemodialysis and having indwelling CVC were included. They were followed up to a period of 2-years to assess infectious complications...
June 29, 2020: BMC Infectious Diseases
Nital Patel, Tara L Petersen, Pippa M Simpson, Mingen Feng, Sheila J Hanson
OBJECTIVES: Central venous access devices, including peripherally inserted central catheters and central venous catheters, are often needed in critically ill patients, but also are associated with complications, including central-line associated bloodstream infections and venous thromboembolism. We compared different central venous access device types and these complications in the PICU. DESIGN: Multicenter, cohort study. SETTING: One-hundred forty-eight participating Virtual PICU Systems, LLC hospital PICU sites...
June 24, 2020: Critical Care Medicine
Antonio Chiaretti, Mauro Pittiruti, Giovanni Sassudelli, Giorgio Conti, Marco Rossi, Silvia Maria Pulitanò, Aldo Mancino, Angela Pusateri, Antonio Gatto, Federica Tosi
BACKGROUND: Placement of central venous access devices is a clinical procedure associated with some risk of adverse events and with a relevant cost. Careful choice of the device, appropriate insertion technique, and proper management of the device are well-known strategies commonly adopted to achieve an optimal clinical result. However, the environment where the procedure takes place may have an impact on the overall outcome in terms of safety and cost-effectiveness. METHODS: We carried out a retrospective analysis on pediatric patients scheduled for a major neurosurgical operation, who required a central venous access device in the perioperative period...
June 22, 2020: Journal of Vascular Access
Marie-Claude Pelland-Marcotte, Nour Amiri, Maria L Avila, Leonardo R Brandão
BACKGROUND: The prevalence of children diagnosed with thrombotic events has been increasing in the last decades. The most common thrombosis risk factor in neonates, infants and children is the placement of a central venous catheter (CVC). It is unknown if anticoagulation prophylaxis with low molecular weight heparin (LMWH) decreases CVC-related thrombosis in children. This is an update of the Cochrane Review published in 2014. OBJECTIVES: To determine the effect of LMWH prophylaxis on the incidence of CVC-related thrombosis and major and minor bleeding complications in children...
June 18, 2020: Cochrane Database of Systematic Reviews
Austin Sellers, Avner Meoded, Javier Quintana, George Jallo, Ernest Amankwah, Anh Thy H Nguyen, Marisol Betensky, Katie Mills, Neil Goldenberg, Nir Shimony
INTRODUCTION: Cerebral sinovenous thrombosis (CSVT) represents the second most common type of venous thromboembolism (VTE) in children. Current literature includes limited evidence on risk factors for CSVT, particularly in the pediatric population. We sought to determine risk factors for CSVT in pediatric patients through a single-institutional case-control study. In addition, we evaluated thrombophilias, treatments and outcomes in CSVT among cases. METHODS: A case-control study was performed at Johns Hopkins All Children's Hospital on patients admitted from March 31, 2006 through April 1, 2018...
June 9, 2020: Thrombosis Research
Yasmeen Hamza, Areti Okalidou, Ann Dierckx, Astrid van Wieringen
OBJECTIVES: The present study investigated how children with cochlear implants (CIs), with optimal exposure to oral language, perform on sonority-related novel word learning tasks. By optimal oral language exposure, we refer to bilateral cochlear implantation below the age of 2 years. Sonority is the relative perceptual prominence/loudness of speech sounds of the same length, stress, and pitch. The present study is guided by a previous study that investigated the sonority-related novel word learning ability of a group of children with CIs, in the Greek language, of which the majority were implanted beyond the age of 2 unilaterally...
June 12, 2020: Ear and Hearing
Jennifer A Ormsby, Julie Cronin, Jane Carpenter, Dionne A Graham, Gail Potter-Bynoe, Ana M Vaughan, Lindsay Weir, Kathleen A Flaherty, Celeste J Chandonnet, Gregory P Priebe, Thomas J Sandora
OBJECTIVE: To institute facility-wide Kamishibai card (K-card) rounding for central venous catheter (CVC) maintenance bundle education and adherence and to evaluate its impact on bundle reliability and central-line-associated bloodstream infection (CLABSI) rates. DESIGN: Quality improvement project. SETTING: Inpatient units at a large, academic freestanding children's hospital. PARTICIPANTS: Data for inpatients with a CVC in place for ≥1 day between November 1, 2017 and October 31, 2018 were included...
June 4, 2020: Infection Control and Hospital Epidemiology
Aeshah AlAzmi, Wasil Jastaniah, Mona AlDabbagh, Naglla Elimam
BACKGROUND: There are a limited number of studies that address non-neutropenic fever episodes in children with cancer, and no standard approach exists. METHOD: We opt to retrospectively analyze the efficacy of the current clinical approach for management of non-neutropenic fever episodes and the associated risk factors among children with cancer at the Princess Noorah Oncology Center from May 2016 through December 2017. RESULTS: A total of 480 non-neutropenic fever episodes were identified in 131 children, of which 62 episodes were triaged as high-risk non-neutropenic fever and 418 as low-risk non-neutropenic fever...
May 31, 2020: Journal of Oncology Pharmacy Practice
R M Vesper, K Sprott, A L Haney, A Burnette, V Adams, A Savage, H Henderson
PURPOSE: Milrinone is utilized for hemodynamic support in heart failure (HF) patients. Due to reduced cardiac output and systemic blood flow, patients with HF are at increased risk of thrombosis. Central venous catheter (CVC) placement compounds this risk. The aim of this study was to determine the incidence of thrombosis, identify thrombosis risk factors, and determine the impact of anticoagulation in pediatric patients receiving continuous milrinone via CVC at the Medical University of South Carolina...
April 2020: Journal of Heart and Lung Transplantation
Yoshiyuki Shimizu, Takeshi Hatachi, Jun Takeshita, Yu Inata, Miyako Kyogoku, Yoshihiro Aoki, Masashi Taniguchi, Atsushi Kawamura, Jumpei Okumura, Muneyuki Takeuchi
OBJECTIVES: We aimed to identify the occurrence and risk factors for unplanned catheter removal due to catheter-associated complications and the effects on catheter survival probability in a PICU. DESIGN: Retrospective, single-center, observational study of cases involving conventional central venous catheters or peripherally inserted central venous catheters. SETTING: The PICU of a tertiary children's hospital. PATIENTS: Consecutive PICU patients with central venous catheters between April 2016 and February 2019...
May 20, 2020: Pediatric Critical Care Medicine
Osama A Bawazir, Tariq I Altokhais
BACKGROUND: The ideal technique for insertion of tunneled central venous catheters (CVCs) in children is still debatable. This study aimed to compare the outcomes of open versus percutaneous technique for the insertion of tunneled CVCs. METHODS: The study included 279 patients who had CVCs insertions from 2010 to 2020. Patients were divided into two groups according to the technique of insertion; group 1 (n= 90) included patients who had the open cut-down method, and group 2 (n= 189) included patients who had the percutaneous technique...
May 16, 2020: Annals of Vascular Surgery
Illya Martynov, Jessica Klima-Frysch, Wolfram Kluwe, Christoph Engel, Joachim Schoenberger
Tunneled central venous catheters (TCVCs) provide prolonged intravenous access for pediatric patients with severe primary immunodeficiency disease (PID) undergoing hematopoietic stem cell transplantation (HSCT). However, little is known about the epidemiology and clinical significance of TCVC-related morbidity in this particular patient group. We conducted the retrospective analysis of patients with severe PID who received percutaneous landmark-guided TCVC implantation prior to HSCT. We analyzed 92 consecutive TCVC implantations in 69 patients (median [interquartile range] age 3...
2020: PloS One
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