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JOURNAL ARTICLE
Jiaying Li, Daniel Yee Tak Fong, Kris Yuet Wan Lok, Janet Yuen Ha Wong, Mandy Man Ho, Edmond Pui Hang Choi, Vinciya Pandian, Patricia M Davidson, Wenjie Duan, Marie Tarrant, Jung Jae Lee, Chia-Chin Lin, Oluwadamilare Akingbade, Khalid M Alabdulwahhab, Mohammad Shakil Ahmad, Mohamed Alboraie, Meshari A Alzahrani, Anil S Bilimale, Sawitree Boonpatcharanon, Samuel Byiringiro, Muhammad Kamil Che Hasan, Luisa Clausi Schettini, Walter Corzo, Josephine M De Leon, Anjanette S De Leon, Hiba Deek, Fabio Efficace, Mayssah A El Nayal, Fathiya El-Raey, Eduardo Ensaldo-Carrasco, Pilar Escotorin, Oluwadamilola Agnes Fadodun, Israel Opeyemi Fawole, Yong-Shian Shawn Goh, Devi Irawan, Naimah Ebrahim Khan, Binu Koirala, Ashish Krishna, Cannas Kwok, Tung Thanh Le, Daniela Giambruno Leal, Miguel Ángel Lezana-Fernández, Emery Manirambona, Leandro Cruz Mantoani, Fernando Meneses-González, Iman Elmahdi Mohamed, Madeleine Mukeshimana, Chinh Thi Minh Nguyen, Huong Thi Thanh Nguyen, Khanh Thi Nguyen, Son Truong Nguyen, Mohd Said Nurumal, Aimable Nzabonimana, Nagla Abdelrahim Mohamed Ahmed Omer, Oluwabunmi Ogungbe, Angela Chiu Yin Poon, Areli Reséndiz-Rodriguez, Busayasachee Puang-Ngern, Ceryl G Sagun, Riyaz Ahmed Shaik, Nikhil Gauri Shankar, Kathrin Sommer, Edgardo Toro, Hanh Thi Hong Tran, Elvira L Urgel, Emmanuel Uwiringiyimana, Tita Vanichbuncha, Naglaa Youssef
BACKGROUND: Central and bridge nodes can drive significant overall improvements within their respective networks. We aimed to identify them in 16 prevalent chronic diseases during the coronavirus disease 2019 (COVID-19) pandemic to guide effective intervention strategies and appropriate resource allocation for most significant holistic lifestyle and health improvements. METHODS: We surveyed 16 512 adults from July 2020 to August 2021 in 30 territories. Participants self-reported their medical histories and the perceived impact of COVID-19 on 18 lifestyle factors and 13 health outcomes...
April 12, 2024: Journal of Global Health
#22
Regen K Morgan, Austin Wynn, Mary K Hanisee
Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by gas-filled cysts that develop in the mucosal and submucosal layers of the digestive tract. PCI is typically a benign disease but complications can occur that require surgical intervention. This patient presented to the emergency department with a two-day history of abdominal and back pain. A contrast-enhanced computed tomography (CT) scan of the abdomen and pelvis led to suspicion of free intraperitoneal air potentially due to bowel perforation, and exploratory laparotomy was indicated...
March 2024: Curēus
#23
REVIEW
Andreas Stallmach, Stefanie Quickert, Christian Puta, Philipp A Reuken
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which specific diagnostic markers or therapeutic concepts have not been established. Despite numerous indications of post-infectious neurological, immunological, endocrinal, and metabolic deviations, the exact causes and pathophysiology remain unclear...
2024: Frontiers in Immunology
#24
JOURNAL ARTICLE
Faezeh Shafiei, Mahmood Dehghani, Fahimeh Fathali Lavasani, Mehdi Manouchehri, Marjan Mokhtare
Studies have provided evidence for the effectiveness of intensive short-term dynamic psychotherapy (ISTDP) in treating medically unexplained symptoms (MUS). This study aimed to examine the effectiveness of ISTDP on individuals living with irritable bowel syndrome (IBS) in terms of, emotion regulation (ER) abilities, defense mechanisms, quality of life (QOL), and IBS symptoms. A total of 30 patients diagnosed with IBS were recruited and randomly assigned to either the intervention ( n = 15) or control ( n = 15) group...
2024: Frontiers in Psychology
#25
JOURNAL ARTICLE
Motasem M Alsmadi, Alla A Abudaqqa, Nasir Idkaidek, Nidal A Qinna, Ahmad Al-Ghazawi
The common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced pathophysiological changes. This work aimed to investigate the impact of these two diseases on pravastatin oral bioavailability. Rat models for IBS and IBD were used to experimentally test the effects of IBS and IBD on pravastatin pharmacokinetics. Then, the observations made in rats were extrapolated to humans using a mechanistic whole-body physiologically-based pharmacokinetic (wbPBPK) model...
April 11, 2024: AAPS PharmSciTech
#26
JOURNAL ARTICLE
Amir M Sadeghian, Farzad Dashti, Behnam Shariati, Marjan Mokhtare, Mohammadjavad Sotoudeheian
BACKGROUND: Psychosocial stressors contribute to the development of irritable bowel syndrome (IBS) and exacerbate the symptoms. The capability to cope with stress is an essential element in the management of IBS. This study assessed nine cognitive emotion regulation strategies (CERS) and their role in predicting symptom severity, quality of life (QOL), and resilience in IBS subjects. METHODS: The scores regarding nine subscales of CERS were obtained by cognitive emotion regulation questionnaire (CERQ) and compared between study patients based on the severity and subtypes of IBS using one-way ANOVA...
April 9, 2024: Clinics and Research in Hepatology and Gastroenterology
#27
JOURNAL ARTICLE
Sandra Utz, Miriam Bittel, Jost Langhorst
Phytotherapeutics are gaining influence in the treatment of gastroenterological diseases. Their popularity and growing evidence of efficacy contribute to their integration into medical guidelines. A systematic screening identified recommended phytotherapeutic approaches. Based on current scientific data, some recommendations for the use of phytotherapeutic agents are given. For <u>irritable bowel syndrome</u> the use of peppermint oil is "strongly recommended", especially for pain and flatulence...
April 11, 2024: Zeitschrift Für Gastroenterologie
#28
JOURNAL ARTICLE
René J D M Selker, Tim Y Koppert, Jan H Houtveen, Rinie Geenen
A key diagnostic criterion of Somatic Symptom and related Disorders (SSD) comprises significant distress and excessive time-and-energy consuming thoughts, feelings, and behavior pertaining to somatic symptoms. This diagnostic criterion is lacking in central sensitivity syndromes (CSS), such as fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome. This strong emphasis on disturbed psychological processing of somatic symptoms, suggests that psychological flexibility is low in SDD. Psychological flexibility is defined as the ability to approach difficult or challenging internal states (thoughts, emotions, and bodily sensations) in a non-judgmental, mindful way, and being committed to pursue one's values...
March 28, 2024: Journal of Psychiatric Research
#29
JOURNAL ARTICLE
Anthony J Lembo, Susan Edelstein, David P Rosenbaum, Ceciel Rooker, Jeffrey D Roberts, William D Chey
No abstract text is available yet for this article.
2024: Therapeutic Advances in Gastroenterology
#30
JOURNAL ARTICLE
Huihuan Wu, Jingwei Li, FeiFei Li, Weijian Lun
BACKGROUND: Recently, observational studies have reported that gastroesophageal reflux disease (GERD) is commonly associated with irritable bowel syndrome (IBS), but the causal relationship is unclear. METHODS: We conducted a two-sample Mendelian randomization study using summary data from genome-wide association studies (GWASs) to explore a causal relationship between GERD (N cases = 129,080) and IBS (N cases = 4,605) of European ancestry. Furthermore, the inverse-variance weighted (IVW) method and a series of sensitivity analyses were used to assess the accuracy and confidence of our results...
2024: Frontiers in Genetics
#31
JOURNAL ARTICLE
Ryo Katsumata, Tomoka Kaburagi, Takayuki Hosokawa, Noriaki Manabe, Manabu Ishii, Katsunori Ishii, Tomohiro Tanikawa, Noriyo Urata, Maki Ayaki, Ken Nishino, Takahisa Murao, Mitsuhiko Suehiro, Minoru Fujita, Miwa Kawanaka, Ken Haruma, Hirofumi Kawamoto, Toshihiro Takao, Tomoari Kamada
Objective Gastrointestinal (GI) disorders such as functional dyspepsia (FD), irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and inflammatory bowel disease (IBD) can exhibit overlapping GI symptoms, including abdominal pain and alterations in bowel habits. The symptoms of GI disorders are commonly considered to be triggered and exacerbated by fatty food intake. Therefore, this study aimed to compare the food preferences of patients with GI disorders. Methods Forty food images (including fatty and light foods) and 20 animal images were selected to evaluate food preferences...
April 9, 2024: Internal Medicine
#32
JOURNAL ARTICLE
Zheng-Yang Li, Yu-Qing Mao, Qian Hua, Yong-Hong Sun, Hai-Yan Wang, Xuan-Guang Ye, Jing-Xian Hu, Ya-Jie Wang, Miao Jiang
BACKGROUND: Serotonin receptor 2B (5-HT2B receptor) plays a critical role in many chronic pain conditions. The possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea (IBS-D) was investigated in the present study. AIM: To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with IBS-D. METHODS: Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy controls...
March 14, 2024: World Journal of Gastroenterology: WJG
#33
JOURNAL ARTICLE
Tianwen Lai, Chaole Luo, Yalian Yuan, Jia Fang, Yun Wang, Xiantong Tang, Lihuan Ouyang, Keyan Lin, Bin Wu, Weimin Yao, Ruina Huang
INTRODUCTION: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem. The relationship between the composition of intestinal microbiota and the important clinical factors affecting COPD remains unclear. This study aimed to identify specific intestinal microbiota with high clinical diagnostic value for COPD. METHODS: The fecal microbiota of patients with COPD and healthy individuals were analyzed by 16S rDNA sequencing...
2024: International Journal of Chronic Obstructive Pulmonary Disease
#34
JOURNAL ARTICLE
Erick J Rodríguez-Palma, Saul Huerta de la Cruz, Ana M Islas-Espinoza, Gabriela Castañeda-Corral, Vinicio Granados-Soto, Rajesh Khanna
Nociplastic pain, characterized by abnormal pain processing without an identifiable organic cause, affects a significant portion of the global population. Unfortunately, current pharmacological treatments for this condition often prove ineffective, prompting the need to explore new potential targets for inducing analgesic effects in patients with nociplastic pain. In this context, toll-like receptors (TLRs), known for their role in the immune response to infections, represent promising opportunities for pharmacological intervention because they play a relevant role in both the development and maintenance of pain...
April 5, 2024: Pain
#35
JOURNAL ARTICLE
Dalia Majumdar, Diane Webb, Stephanie Parsons, Elizabeth M Selwan-Lewis, Trisha Rettig, Emily Chastain, Winifred Obanor, Rob Birnberg, Amy Kuang
OBJECTIVE: Effective health communication is critical for understanding and acting on health information. This cross-sectional study explored participants' understanding of their health condition, their preferences for receiving health communications, and their interest in receiving clinical trial results across several therapeutic areas. METHODS: The study recruited participants via social media, email newsletters, and advocacy organizations. An online screener captured demographic information (health conditions, age, race/ethnicity, gender, and education)...
April 10, 2024: Current Medical Research and Opinion
#36
JOURNAL ARTICLE
Ignacio Hanna-Jairala, Douglas A Drossman
Irritable bowel syndrome are responsive to treatments using central neuromodulators. Central neuromodulators work by enhancing the synaptic transmission of 5-hydroxytryptamine, noradrenalin and dopamine, achieving a slower regulation or desensitization of their postsynaptic receptors. Central neuromodulators act on receptors along the brain-gut axis, so they are useful in treating psychiatric comorbidities, modifying gut motility, improving central downregulation of visceral signals and enhancing neurogenesis in patients with IBS...
April 9, 2024: American Journal of Gastroenterology
#37
JOURNAL ARTICLE
Xia-Xiao Yan, Yue-Lun Zhang, Yu-Pei Zhang, Ying-Yun Yang, Dong Wu
Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome (IBS) with a systematic review and meta-analysis. Methods We searched MEDLINE, EMBASE, the Cochrane Library, Web of Science, and IEEE Xplore databases until September 2023. Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified. We estimated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with a 95% confidence interval (CI), and plotted a summary receiver operating characteristic curve and evaluated the area under the curve...
April 10, 2024: Chinese Medical Sciences Journal
#38
JOURNAL ARTICLE
Darren M Brenner, Amol Sharma, Satish S C Rao, Adam P Laitman, Zeev Heimanson, Christopher Allen, Gregory S Sayuk
BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C). AIM: To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity. METHODS: Pooled phase 3 data (2 randomized, controlled IBS-C trials) from adults treated with plecanatide 3 mg or placebo for 12 weeks were analyzed. Patients were stratified post-hoc by baseline bloating severity (11-point scale: mild [≤ 5] and moderate-to-severe [> 5])...
April 9, 2024: Digestive Diseases and Sciences
#39
JOURNAL ARTICLE
Christina Lee, Supriya Rao, Howard J Cabral, Horst Christian Weber
Introduction : Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence rates of co-morbidities and possible differences in a multiracial/ethnic IBS cohort. Methods : Based on ICD-9-coded IBS diagnosis, 740 outpatients (≥18 years) were included in this retrospective study at Boston Medical Center...
March 4, 2024: Journal of Clinical Medicine
#40
JOURNAL ARTICLE
Kathleen Cheng, Christina Lee, Ramune Garniene, Howard Cabral, Horst Christian Weber
(1) Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of gut-brain interaction (DGBI) that is known to reduce the quality of life and raise healthcare costs. The aim of this study was to describe the epidemiology of IBS in a large multiracial academic safety-net hospital. (2) Methods: An electronic query was performed using ICD-9 codes to identify 740 IBS outpatients seen at the Boston Medical Center (BMC) between 1 January 2005 and 30 September 2007. Demographic data were collected from electronic medical records...
February 26, 2024: Journal of Clinical Medicine
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