Irritable bowel

Hye Gyo Chung, Yang Won Min, Chansu Lee, Sung Noh Hong, Ji Young Won, Jin Ah Jang, Cheol-Hyun Kim, Dong Kyung Chang
Background/Aims: Dysbiosis is an important factor in the pathogenesis of irritable bowel syndrome (IBS). Several studies have reported promising results using probiotics for the treatment of IBS. This study evaluated the efficacy of novel probiotics isolated from Kimchi, a Korean fermented food, and the feces of healthy Vietnamese people in a murine model of IBS. Methods: Lactobacillus paracasei DK121 was isolated from Kimchi, and L. salivarius V4 and L. plantarum V7 were isolated from the feces of healthy Vietnamese people residing in Korea...
March 25, 2020: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Masoumeh Khalighi Sikaroudi, Marjan Mokhtare, Leila Janani, Amir Hossein Faghihi Kashani, Mohsen Masoodi, Shahram Agah, Narjes Abbaspour, Afsaneh Dehnad, Farzad Shidfar
OBJECTIVES: This study aimed to evaluate whether vitamin D deficiency is associated with the severity of symptoms of irritable bowel syndrome (IBS) patients. Stress and gut inflammation can increase the serum level of corticotropin-releasing hormone (CRH) and interleukin-6 (IL-6), leading to a change in bowel movements. The aim of this study was to evaluate the anti-inflammatory and psychological effects of vitamin D3 supplementation on the symptom improvement of patients with a diarrhea-predominant form of IBS (IBS-D)...
March 23, 2020: Complementary Medicine Research
Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Shima Kumei, Masumi Ohhira
We have recently demonstrated that N(6)-cyclopentyladenosine (CPA), an adenosine A1 receptor agonist, acts centrally to induce a visceral antinociception. Since serotonin (5-HT), cannabinoid (CB), dopamine or opioid signaling in the central nervous system is involved in the regulation of visceral sensation, we made a hypothesis that the signaling may play a role in the CPA-induced visceral antinociception. Visceral sensation was evaluated by colonic distension-induced abdominal withdrawal reflex (AWR) in conscious rats...
March 18, 2020: Physiology & Behavior
Piero Porcelli, Massimo De Carne, Gioacchino Leandro
OBJECTIVE: The clinical management of high symptom severity is a challenging task with patients with functional somatic disorders. We investigated the extent to which DCPR-revised (DCPR-R) syndromes and the DSM-5 category of Somatic Symptom Disorder (SSD) were able to predict symptom severity in 203 consecutive tertiary care patients with irritable bowel syndrome (IBS). METHOD: Semistructured interview were used for assessing DCPR-R and validated scales for SSD (combining PHQ-12 and WI-7), severity of symptoms (IBS-SSS), psychological distress (HADS), and psychosocial functioning (SF-12)...
March 18, 2020: General Hospital Psychiatry
Cheryl D Coon, Jennifer Hanlon, Jessica L Abel, J Jason Lundy, Robyn T Carson, David S Reasner
OBJECTIVES: The Diary for Irritable Bowel Syndrome Symptoms-Constipation (DIBSS-C) has been developed to assess the core signs and symptoms of irritable bowel syndrome with constipation (IBS-C). This article presents the psychometric evaluation of the DIBSS-C abdominal score. METHODS: Data for these analyses are from a multicenter phase IIb study in IBS-C patients (NCT02559206). Subjects completed a number of assessments via handheld electronic diary throughout the study...
March 2020: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Kiyon Rhew, Joshua D Brown, Jung Mi Oh
Atopic disease is associated with chronic inflammation, and anemia has been reported in patients with inflammatory disorders such as rheumatoid arthritis, chronic obstructive pulmonary disease, and irritable bowel disease. The objective of this study was to determine whether atopic disease is associated with an increased risk of anemia. A cross-sectional study with propensity score weighting was conducted using a health insurance review agency claims dataset comprised of randomized patients who used the Korean national health system at least once in 2016...
March 18, 2020: International Journal of Environmental Research and Public Health
Desiree F Baaleman, Carlo Di Lorenzo, Marc A Benninga, Miguel Saps
PURPOSE OF REVIEW: To evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice. RECENT FINDINGS: In 2016, the Rome IV criteria were published, providing an update of symptom-based criteria to diagnose children with functional gastrointestinal disorders (FGIDs). For neonates and toddlers, Wessel's criteria for diagnosing infant colic were abandoned, and a differentiation was made between toilet-trained and non-toilet-trained children in the diagnosis of functional constipation...
March 19, 2020: Current Gastroenterology Reports
Sharon Erdrich, Jason A Hawrelak, Stephen P Myers, Joanna E Harnett
BACKGROUND: The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia. METHODS: A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken...
March 20, 2020: BMC Musculoskeletal Disorders
Takao Miwa, Takuji Iwashita, Masashi Aiba, Takahiro Kochi, Katsuhisa Toda, Noriaki Nakamura, Naoki Katsumura, Masahito Shimizu
Bowel endometriosis is a condition caused by endometrial glands and stroma infiltrating the bowel wall and reaching the subserous fat tissue or the adjacent subserous plexus. A 42-year-old woman with changes in stool habits, nausea, and stomach aches experienced complete obstruction in the rectum. Endoscopic ultrasound demonstrated a low echoic lesion outside the rectal mucosa and endoscopic ultrasound-guided fine needle aspiration confirmed the diagnosis of bowel endometriosis. The clinical characteristics of bowel endometriosis are unspecific and this condition is sometimes misdiagnosed as a malignant tumor, irritable bowel syndrome, or any other colorectal disorder...
August 4, 2019: Medical Ultrasonography
Mohammad Z Asha, Sundos F H Khalil
Treatments that target alterations in gut microbiota may be beneficial for patients with irritable bowel syndrome (IBS). A systematic review and meta-analysis was conducted of randomised clinical trials (RCTs) evaluating the efficacy and safety of probiotics, prebiotics and synbiotics. Factors considered in the analysis included global IBS symptoms and/or abdominal pain, secondary symptoms and the frequency of adverse events. A total of 33 RCTs involving 4,321 patients were identified. Overall, probiotics significantly improved global IBS symptoms compared to placebos (standardised mean difference = -0...
February 2020: Sultan Qaboos University Medical Journal
Tsuneo Takenaka, Mikio Zeniya, Soichiro Miura, Takahiro Amano
Several intestinal secretagogues became available for the patients with irritable bowel syndrome. We report a case of symptomatic hyponatremia after lubiprostone ingestion. A male patient was visiting our office to manage chronic kidney disease. He suffered chronic hepatitis (type C), which was successfully treated with asunaprevir and daclatasvir. He took lubiprostone due to constipation, and then watery diarrhoea was frequently developed. Next morning, he came to our hospital due to consciousness disturbance...
March 17, 2020: BMJ Case Reports
Lifeng Fei, Yanjing Wang
Diarrhea-predominant irritable bowel syndrome (IBS-D) is one of the most common gastrointestinal disorders in the world, lacking effective therapies. The crucial roles of microRNAs (miRNAs) in IBS-D have attracted increasing attention. The aim of this study is to investigate the effects of miR-495 on the visceral sensitivity of the IBS-D through the PI3K/AKT signaling pathway by targeting PKIB. Microarray data analysis was employed to screen the differentially expressed genes related to IBS-D and regulatory miRNAs...
March 18, 2020: IUBMB Life
Gaston J H Franssen, Tessa M van Ginhoven, Johannes Hofland, Richard A Feelders, Wanda Geilvoet, Jan B van Lanschot
Small bowel neuroendocrine tumours (NET) are relatively rare malignancies. Due to the lack of specificity, the symptoms are usually initially attributed to irritable bowel syndrome. Frequently there is a delay of years after the onset of symptoms, before the diagnosis is made. We describe two patient cases with a small bowel NET that illustrate the typical course of the symptoms, as well as the complications of carcinoid syndrome, carcinoid heart disease, mesenteric venous congestion and arterial ischemia. On coloscopy the primary tumour can often not be reached...
January 22, 2020: Nederlands Tijdschrift Voor Geneeskunde
Jingming Zhao, Hui Li, Chong Shi, Tiezheng Yang, Baoshi Xu
Background: Irritable bowel syndrome (IBS) is a chronic functional bowel disease characterized by abdominal pain and changes in bowel habits in the absence of organic disease. Electroacupuncture (EA) has been shown to alleviate visceral hypersensitivity (VH) in IBS rat models by inhibiting the activation of astrocytes in the spinal cord. However, the underlying molecular mechanisms mediated by P2Y1 receptor of this effect of electroacupuncture remain unclear. Aim: To explore whether EA inhibits the activity of astrocytes in the spinal cord dorsal horn of rat with visceral hypersensitivity by inhibiting P2Y1 receptor and its downstream mitogen activated protein kinase/extracellular regulated kinase 1 (MAPK/ERK) pathway...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
Alexandre Carvalho, Jacky Lu, Jamisha D Francis, Rebecca E Moore, Kathryn P Haley, Ryan S Doster, Steven D Townsend, Jeremiah G Johnson, Steven M Damo, Jennifer A Gaddy
Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens...
2020: Gastroenterology Research and Practice
Shin Fukudo, Masatoshi Nakamura, Tatsuto Hamatani, Kiyoyasu Kazumori, Hiroto Miwa
BACKGROUND AND AIMS: Treatment options for irritable bowel syndrome with constipation (IBS-C) are limited-new prokinetic drugs are needed. We evaluated the efficacy and safety of minesapride (DSP-6952), a partial agonist with high affinity for 5-HT4 receptors, in patients with IBS-C in Japan. METHODS: We performed a double-blind phase 2 study of 171 patients with Rome III-defined IBS-C at 33 centers in Japan, from December 2012 through August 2013. Patients were randomly assigned to groups given minesapride (1, 4, 12, or 40 mg) or placebo once daily for 4 weeks...
March 14, 2020: Clinical Gastroenterology and Hepatology
Amy D DiVasta, Lori A Zimmerman, Allison F Vitonis, Ayotunde B Fadayomi, Stacey A Missmer
BACKGROUND: Gastroenterological (GI) symptoms are often reported by adults with endometriosis, leading to unnecessary diagnostic tests or complicated treatment. We investigated associations between endometriosis and irritable bowel syndrome (IBS) in adolescents and whether concurrent pain disorders affect these. METHODS: We collected data within The Women's Health Study: Adolescence to Adulthood, which is a US longitudinal study of premenopausal females with and without endometriosis...
March 14, 2020: Clinical Gastroenterology and Hepatology
Gian Paolo Caviglia, Chiara Rosso, Francesco Stalla, Martina Rizzo, Alessandro Massano, Maria Lorena Abate, Antonella Olivero, Angelo Armandi, Ester Vanni, Ramy Younes, Sharmila Fagoonee, Rinaldo Pellicano, Marco Astegiano, Giorgio Maria Saracco, Elisabetta Bugianesi, Davide Giuseppe Ribaldone
In patients with inflammatory bowel diseases (IBD) undergoing biologic therapy, biomarkers of treatment response are still scarce. This study aimed to evaluate whether serum zonulin, a biomarker of intestinal permeability; soluble CD163 (sCD163), a macrophage activation marker; and a panel of serum cytokines could predict the response to biologic treatment in patients with IBD. For this purpose, we prospectively enrolled 101 patients with IBD and 19 patients with irritable bowel syndrome (IBS) as a control group; 60 out of 101 patients underwent treatment with biologics...
March 15, 2020: Journal of Clinical Medicine
Arianna Cingolani, Danilo Paduano, Valentina Vecchiarelli, Manuela Demelas, Paola Teresa Corrias, Laura Casula, Paolo Usai
The low Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet has demonstrated excellent results in terms of symptom control and health-related quality of life (HRQoL) in irritable bowel syndrome (IBS) sufferers, but patients have complained about unsatisfying taste, difficulty in following the diet, and time consumption. To investigate the feasibility of the low FODMAP diet in an Italian (Sardinian) cohort, sixty consecutive eligible outpatients (11 men and 49 women) with IBS were enrolled and followed a low FODMAP diet (gluten allowed, restriction phase of four weeks, reintroduction phase of four weeks)...
March 8, 2020: Nutrients
Adam D Farmer, Emma Wood, James K Ruffle
No abstract text is available yet for this article.
March 16, 2020: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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