Asel S Arykbaeva, Dorottya K de Vries, Jason B Doppenberg, Marten A Engelse, Thomas Hankemeier, Amy C Harms, Leonie G Wijermars, Alexander F Schaapherder, Jaap A Bakker, Rutger J Ploeg, Ian P J Alwayn, Jan H N Lindeman
Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy. During NMP, the organ is maintained in a metabolically active state that may not only provide superior organ preservation, but which also facilitates viability testing prior to transplantation, and ex-situ resuscitation of marginal kidney grafts. While the prevailing perfusion protocols for renal NMP are refined from initial pioneering studies concerning short periods of NMP, it could be argued that these protocols are not optimally tailored to address the putatively compromised metabolic plasticity of marginal donor grafts (i...
April 12, 2021: Kidney International