Michael S Placzek, Daniel K Wilton, Michel Weïwer, Mariah A Manter, Sarah E Reid, Christopher J Meyer, Arthur J Campbell, Besnik Bajrami, Antoine Bigot, Sarah Bricault, Agathe Fayet, Arnaud Frouin, Frederick Gergits, Mehak Gupta, Wei Jiang, Michelle Melanson, Chiara D Romano, Misha M Riley, Jessica M Wang, Hsiao-Ying Wey, Florence F Wagner, Beth Stevens, Jacob M Hooker
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurodegenerative and psychiatric disorders as a potential therapeutic target and biomarker. However, clinical studies with COX-2 have yielded inconsistent results, partly due to limited mechanistic understanding of how COX-2 activity relates to CNS pathology. Therefore, developing COX-2 positron emission tomography (PET) radiotracers for human neuroimaging is of interest...
May 22, 2024: ACS Central Science